Gene: TSNAX

7257
TRAX
translin associated factor X
protein-coding
1q42.2
Ensembl:ENSG00000116918 MIM:602964 Vega:OTTHUMG00000039486 UniprotKB:Q99598
NC_000001.11
PubMed
0   ANCO-SNPs
OD|ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPP1R20.951
ATAD10.939
ANKRD13C0.937
TRAPPC130.931
ARL10.925
UBLCP10.924
ADSS0.924
UCHL50.922
PWP10.922
HMG20A0.921

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.552
OR4F29-0.533
FOXJ1-0.412
C7orf61-0.408
CCDC102A-0.397
EVC2-0.372
MTRNR2L9-0.371
WDR38-0.369
MTRNR2L6-0.367
CSAG1-0.358

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TSNAX mRNA"19692669
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of TSNAX mRNA25607892
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of TSNAX mRNA"23195993
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of TSNAX mRNA25607892
D001241AspirinAspirin results in increased expression of TSNAX mRNA11906190
C006780bisphenol Abisphenol A affects the methylation of TSNAX promoter27334623
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of TSNAX mRNA25607892
C006780bisphenol Abisphenol A results in increased expression of TSNAX mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TSNAX gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TSNAX mRNA28628672
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of TSNAX mRNA25607892
C018475butyraldehydebutyraldehyde results in increased expression of TSNAX mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TSNAX gene20938992
D007464Clioquinol[Clioquinol binds to Copper] which results in increased expression of TSNAX protein18346929
D002994ClofibrateClofibrate results in increased expression of TSNAX protein16470657
D003300Copper[Clioquinol binds to Copper] which results in increased expression of TSNAX protein18346929
D003300Copper[Thiosemicarbazones binds to Copper] which results in increased expression of TSNAX protein20931265
D016572CyclosporineCyclosporine results in decreased expression of TSNAX mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TSNAX mRNA28628672
C000944dicrotophosdicrotophos results in decreased expression of TSNAX mRNA28302478
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TSNAX mRNA"22485181
C070609EMD 53998EMD 53998 analog results in decreased expression of TSNAX mRNA24977338
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of TSNAX mRNA25607892
D005485FlutamideFlutamide results in increased expression of TSNAX mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TSNAX gene20938992
D005839GentamicinsGentamicins results in increased expression of TSNAX mRNA22061828
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of TSNAX mRNA22467014
C492448ICG 001ICG 001 results in decreased expression of TSNAX mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TSNAX mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TSNAX mRNA28628672
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TSNAX gene20938992
C051752nefazodonenefazodone results in increased expression of TSNAX mRNA24136188
D009532NickelNickel results in decreased expression of TSNAX mRNA23195993
C025589ochratoxin Aochratoxin A results in decreased acetylation of TSNAX promoter29098329
C025589ochratoxin A[ochratoxin A results in decreased acetylation of TSNAX promoter] which results in decreased expression of TSNAX mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in decreased expression of TSNAX mRNA29098329
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of TSNAX mRNA25607892
D017239PaclitaxelPaclitaxel analog results in increased expression of TSNAX mRNA15585946
D017239PaclitaxelPaclitaxel results in increased expression of TSNAX mRNA15585946
D013467SulindacSulindac results in decreased expression of TSNAX mRNA11906190
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of TSNAX mRNA22467014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TSNAX mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TSNAX mRNA16962184
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of TSNAX protein20109541
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in increased expression of TSNAX protein20931265
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TSNAX mRNA28065790

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-TAS9013868  
GO:0003697single-stranded DNA binding-IBA21873635  
GO:0003723RNA binding-HDA22681889  
GO:0004521endoribonuclease activity-IBA21873635  
GO:0005515protein binding-IPI15919079  16189514  18330356  21552258  25416956  26496610  
27107014  
GO:0008565protein transporter activity-TAS9013868  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0015031protein transport-IEA-  
GO:0030154cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005794Golgi apparatus-IEA-  
GO:0005829cytosol-TAS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-211000Gene Silencing by RNATAS
R-HSA-426486Small interfering RNA (siRNA) biogenesisTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25555482Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans. (2015 Mar 1)Gelernter JBiol Psychiatry