Gene: PHLDA2

7262
BRW1C|BWR1C|HLDA2|IPL|TSSC3
pleckstrin homology like domain family A member 2
protein-coding
11p15.4
Ensembl:ENSG00000181649 MIM:602131 Vega:OTTHUMG00000010926 UniprotKB:Q53GA4
NG_009266.1
PubMed
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.251e-1 (AD)  1.734e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDF0.689
TGFBR3L0.684
TMEM1600.666
SLC39A30.661
TRAPPC50.637
ENDOG0.635
FAM173A0.626
TUBB30.619
UBE2S0.618
TPGS10.617

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARD3B-0.421
ITGB8-0.417
PDK4-0.416
BAZ2B-0.406
STON2-0.401
PELI2-0.398
TRPS1-0.391
CDC14A-0.387
GRAMD1C-0.382
RHOBTB3-0.381

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of PHLDA2 mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PHLDA2 mRNA"25614096
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PHLDA2 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PHLDA2 mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of PHLDA2 mRNA16788091
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PHLDA2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of PHLDA2 mRNA"26238291
D000082AcetaminophenAcetaminophen affects the expression of PHLDA2 mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of PHLDA2 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of PHLDA2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of PHLDA2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PHLDA2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PHLDA2 mRNA21641981|2210060
C068073Am 580Am 580 results in decreased expression of PHLDA2 mRNA16982809
D000638AmiodaroneAmiodarone affects the expression of PHLDA2 mRNA25064622
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PHLDA2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of PHLDA2 mRNA15761015
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in increased expression of PHLDA2 mRNA17639512
D001379AzathioprineAzathioprine results in increased expression of PHLDA2 mRNA22623647
D001507BeclomethasoneBeclomethasone results in increased expression of PHLDA2 mRNA23656298
C487081belinostatbelinostat results in increased expression of PHLDA2 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PHLDA2 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PHLDA2 mRNA"19150397|2623829
D004958EstradiolEstradiol affects the expression of PHLDA2 mRNA22574217
D004958EstradiolEstradiol results in increased expression of PHLDA2 mRNA23019147
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PHLDA2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of PHLDA2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of PHLDA2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of PHLDA2 mRNA23410634
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PHLDA2 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of PHLDA2 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of PHLDA2 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of PHLDA2 mRNA25979313
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of PHLDA2 mRNA26272509
D002746ChlorpromazineChlorpromazine affects the expression of PHLDA2 mRNA25064622
D004390ChlorpyrifosChlorpyrifos results in increased expression of PHLDA2 mRNA21356183
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PHLDA2 mRNA28472532
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of PHLDA2 mRNA19524605
C018021cobaltous chloridecobaltous chloride results in increased expression of PHLDA2 mRNA24612858
C018021cobaltous chloridecobaltous chloride results in decreased expression of PHLDA2 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of PHLDA2 mRNA19376846
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of PHLDA2 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of PHLDA2 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PHLDA2 mRNA"19167446
D003520CyclophosphamideCyclophosphamide results in increased expression of PHLDA2 mRNA17403535
D016572CyclosporineCyclosporine affects the expression of PHLDA2 mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of PHLDA2 mRNA20106945|2163298
C089595cylindrospermopsincylindrospermopsin results in increased expression of PHLDA2 mRNA24921660
C014347decitabinedecitabine results in increased expression of PHLDA2 mRNA21856257
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PHLDA2 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of PHLDA2 gene22964155
D002945CisplatinCisplatin affects the reaction [Piroxicam results in decreased expression of PHLDA2 mRNA]21858171
D002945CisplatinPHLDA2 results in increased susceptibility to Cisplatin22021909
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PHLDA2 mRNA21527772
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of PHLDA2 mRNA24535843
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PHLDA2 mRNA17547211
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of PHLDA2 mRNA28939011
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of PHLDA2 mRNA24690739
C118739entinostatentinostat results in increased expression of PHLDA2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
D015251EpirubicinPHLDA2 results in increased susceptibility to Epirubicin22021909
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PHLDA2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PHLDA2 mRNA25064622
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHLDA2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PHLDA2 mRNA23550701
D005557FormaldehydeFormaldehyde results in increased expression of PHLDA2 mRNA23649840
C039281furanfuran results in increased expression of PHLDA2 mRNA25539665|2619464
C419708gefitinibPHLDA2 protein affects the susceptibility to gefitinib15496427
D019833GenisteinGenistein results in increased expression of PHLDA2 mRNA15256057|2301914
C412815GW 4064GW 4064 results in increased expression of PHLDA2 mRNA26655953
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PHLDA2 mRNA20044591|2341063
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PHLDA2 mRNA28628672
C051890irinotecanirinotecan results in increased expression of PHLDA2 mRNA20185912
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PHLDA2 mRNA28628672
C533894LG 100815LG 100815 results in decreased expression of PHLDA2 mRNA16951191
D015122MercaptopurineMercaptopurine results in decreased expression of PHLDA2 mRNA23358152
C042720mercuric bromidemercuric bromide results in increased expression of PHLDA2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PHLDA2 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C568376MT19c compoundMT19c compound results in decreased expression of PHLDA2 mRNA21781307
D009151Mustard GasMustard Gas results in increased expression of PHLDA2 mRNA15674844
C022838nickel chloridenickel chloride results in increased expression of PHLDA2 mRNA24612858
C022838nickel chloridenickel chloride results in increased expression of PHLDA2 mRNA17547211
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in decreased expression of PHLDA2 mRNA"16951191
C507134ON 01910ON 01910 results in increased expression of PHLDA2 mRNA22351695
D009966OrphenadrineOrphenadrine affects the expression of PHLDA2 mRNA23665939
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PHLDA2 mRNA26272509
D010269ParaquatParaquat affects the expression of PHLDA2 mRNA25064622
D052638Particulate MatterParticulate Matter results in increased expression of PHLDA2 mRNA15046786
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of PHLDA2 mRNA18593933
C046012pentanalpentanal results in increased expression of PHLDA2 mRNA26079696
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of PHLDA2 mRNA17097637
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of PHLDA2 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of PHLDA2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of PHLDA2 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PHLDA2 mRNA26272509
D010894PiroxicamCisplatin affects the reaction [Piroxicam results in decreased expression of PHLDA2 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of PHLDA2 mRNA21858171
D010936Plant ExtractsPlant Extracts results in decreased expression of PHLDA2 mRNA23557933
D010938Plant OilsPlant Oils results in increased expression of PHLDA2 mRNA23370395
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PHLDA2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PHLDA2 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of PHLDA2 protein23718831
D011374ProgesteroneProgesterone results in increased expression of PHLDA2 mRNA18037150
D011441PropylthiouracilPropylthiouracil results in decreased expression of PHLDA2 mRNA24780913
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in increased expression of PHLDA2 mRNA17639512
D011794QuercetinQuercetin results in increased expression of PHLDA2 mRNA21632981
D015474IsotretinoinIsotretinoin results in decreased expression of PHLDA2 mRNA20436886
C089730rosiglitazonerosiglitazone results in decreased expression of PHLDA2 mRNA16982809
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PHLDA2 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of PHLDA2 mRNA21281968
C016104sodium bichromatesodium bichromate results in increased expression of PHLDA2 mRNA24612858
D012999SomanSoman results in decreased expression of PHLDA2 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PHLDA2 mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PHLDA2 mRNA26238291
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHLDA2 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of PHLDA2 mRNA25975270
D013752TetracyclineTetracycline affects the expression of PHLDA2 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of PHLDA2 mRNA25064622
D013853ThioacetamideThioacetamide results in increased expression of PHLDA2 mRNA23411599
D019772TopotecanTopotecan results in increased expression of PHLDA2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PHLDA2 mRNA23830798
D014212TretinoinTretinoin results in decreased expression of PHLDA2 mRNA16788091
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PHLDA2 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PHLDA2 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of PHLDA2 mRNA19140230
D014520UrethaneUrethane results in increased expression of PHLDA2 mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of PHLDA2 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of PHLDA2 mRNA25064622
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PHLDA2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PHLDA2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of PHLDA2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased expression of PHLDA2 mRNA15046786
D024483Vitamin K 3Vitamin K 3 affects the expression of PHLDA2 mRNA20044591|2341063
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHLDA2 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of PHLDA2 mRNA26272509
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of PHLDA2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001890placenta development-IEA-  
GO:0006915apoptotic process-TAS9328465  
GO:0009887animal organ morphogenesis-IEA-  
GO:0010468regulation of gene expression-IEA-  
GO:0030334regulation of cell migration-IEA-  
GO:0060721regulation of spongiotrophoblast cell proliferation-IEA-  
GO:0070873regulation of glycogen metabolic process-IEA-  
GO:1903547regulation of growth hormone activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11. (2010 May)Edenberg HJAlcohol Clin Exp Res
22444668Maternal inheritance of a promoter variant in the imprinted PHLDA2 gene significantly increases birth weight. (2012 Apr 6)Ishida MAm J Hum Genet