Gene: TST

7263
RDS
thiosulfate sulfurtransferase
protein-coding
22q12.3
Ensembl:ENSG00000128311 MIM:180370 Vega:OTTHUMG00000150533 UniprotKB:Q16762
NG_027994.1
PubMed
CD|OD|ND|AD
13   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.630e-1 (AD)  5.471e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACADS0.884
PHGDH0.858
ACAA20.844
TSC22D40.842
AGT0.84
SLC25A200.837
CSRP10.837
HTRA10.834
COMT0.832
CRYL10.823

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNH5-0.51
KCNH1-0.502
HS6ST3-0.491
CCDC68-0.487
EPHA3-0.48
HRH2-0.479
TRIM58-0.476
ARNTL2-0.474
KLHL38-0.474
ARHGAP20-0.473

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02761S-MercaptocysteineSmall Molecule5652-32-4ExperimentalTarget
DB09499Thiosulfuric acidSmall Molecule13686-28-7Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of TST mRNA"17547211
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TST mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TST mRNA"23196670
C0502243,5,5-trimethylhexanoylferrocene"3,5,5-trimethylhexanoylferrocene results in decreased expression of TST protein"22649188
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of TST mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of TST mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of TST mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of TST mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of TST mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TST mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TST mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of TST mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of TST protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TST mRNA16483693
D001280AtrazineAtrazine results in decreased expression of TST mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TST mRNA22228805
C038328BEP protocolBEP protocol results in increased expression of TST mRNA18987330
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TST mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of TST mRNA25047013
C006780bisphenol Abisphenol A affects the expression of TST mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of TST mRNA26496021
C013418bromfenacoumbromfenacoum results in increased expression of TST protein28903499
C584509C646 compoundC646 compound results in increased expression of TST mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TST mRNA11958953
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TST mRNA24982889
D002251Carbon Tetrachloride[Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of TST protein25303780
C084597chlorcyclizinechlorcyclizine affects the expression of TST mRNA21058326
C084597chlorcyclizinechlorcyclizine results in decreased expression of TST mRNA21058326
D002994ClofibrateClofibrate results in decreased expression of TST mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of TST mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in decreased expression of TST mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of TST mRNA19549813
C030123coumarincoumarin affects the expression of TST mRNA16963487
D003486Cyanides[Sulfur results in increased activity of TST protein] promotes the reaction [TST protein binds to and results in increased metabolism of Cyanides]19891443
D003486Cyanides[[Sulfur results in increased activity of TST protein] promotes the reaction [TST protein binds to and results in increased metabolism of Cyanides]] which results in increased chemical synthesis of thiocyanate19891443
D003486CyanidesTST protein binds to and results in increased metabolism of Cyanides19891443
D003486CyanidesTST protein results in increased metabolism of Cyanides23929717
D003486Cyanides[TST protein results in increased metabolism of Cyanides] which results in increased abundance of thiocyanate23929717
D016572CyclosporineCyclosporine results in decreased expression of TST mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of TST mRNA21198554
D003907DexamethasoneDexamethasone results in increased expression of TST mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TST mRNA28628672
D016264Dextran SulfateDextran Sulfate affects the activity of and results in decreased expression of TST protein19647029
D016264Dextran SulfateDextran Sulfate results in decreased expression of TST mRNA19647029
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TST mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TST mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TST mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of TST mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of TST mRNA25016146
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of TST mRNA27638505
C024629dimethyl phthalatedimethyl phthalate affects the expression of TST mRNA26924002
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TST protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TST mRNA17555576|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TST mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TST mRNA17108234
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TST mRNA23649840
D005419FlavonoidsFlavonoids results in decreased expression of TST mRNA18035473
D005472FluorouracilTST protein affects the susceptibility to Fluorouracil15548681
C056933fumonisin B1fumonisin B1 results in decreased expression of TST mRNA16221962
D017313FenretinideFenretinide results in decreased expression of TST mRNA28973697
D017313FenretinideFenretinide results in increased expression of TST mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of TST mRNA17183730
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TST mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TST mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TST mRNA27392435
C544151jinfukangjinfukang results in increased expression of TST mRNA27392435
C017461lead nitratelead nitrate results in increased expression of TST protein22525307
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of TST protein21605701
D008628MercuryMercury results in decreased expression of TST mRNA17547211
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of TST mRNA26924002
C523799MRK 003TST results in decreased susceptibility to MRK 00319903844
C568376MT19c compoundMT19c compound results in decreased expression of TST mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TST mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TST mRNA"25554681
C022838nickel chloridenickel chloride results in decreased expression of TST mRNA17547211
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of TST protein19716841
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TST mRNA"12756304
D000069463Olive Oil[Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of TST protein25303780
D010100OxygenOxygen deficiency results in decreased expression of TST mRNA24236059
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TST protein26879310
D010795Phthalic AcidsPhthalic Acids results in decreased expression of TST mRNA15728792
D011190Potassium CyanidePotassium Cyanide affects the activity of TST protein23929717
D011374ProgesteroneProgesterone results in increased expression of TST mRNA23018184
C045950propiconazolepropiconazole results in increased expression of TST mRNA16643972
C015586propiverinepropiverine binds to TST protein29273565
D011794QuercetinQuercetin results in increased expression of TST mRNA21632981
C059514resveratrolresveratrol affects the expression of TST mRNA15748624
D015474IsotretinoinIsotretinoin results in decreased expression of TST mRNA20436886
C079198S 1 (combination)TST protein results in increased susceptibility to S 1 (combination)16734730
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TST mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of TST mRNA12760830|2271453
C016104sodium bichromatesodium bichromate results in increased expression of TST mRNA12325037
D013455SulfurSulfur results in increased activity of TST protein19891443
D013455Sulfur[Sulfur results in increased activity of TST protein] promotes the reaction [TST protein binds to and results in increased metabolism of Cyanides]19891443
D013455Sulfur[[Sulfur results in increased activity of TST protein] promotes the reaction [TST protein binds to and results in increased metabolism of Cyanides]] which results in increased chemical synthesis of thiocyanate19891443
D013629TamoxifenTamoxifen affects the expression of TST mRNA17555576
D013739TestosteroneTestosterone results in decreased expression of TST mRNA20403060
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of TST mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TST mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TST mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TST mRNA21215274
D019284ThapsigarginThapsigargin results in increased expression of TST mRNA22378314
C031760thiocyanate[[Sulfur results in increased activity of TST protein] promotes the reaction [TST protein binds to and results in increased metabolism of Cyanides]] which results in increased chemical synthesis of thiocyanate19891443
C031760thiocyanate[TST protein results in increased metabolism of Cyanides] which results in increased abundance of thiocyanate23929717
C009495titanium dioxidetitanium dioxide results in decreased expression of TST mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TST mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TST mRNA15289447
D019772TopotecanTST protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in decreased expression of TST mRNA23724009
C032910triadimefontriadimefon results in decreased expression of TST mRNA16730040
C012589trichostatin Atrichostatin A affects the expression of TST mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TST mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of TST mRNA12732648
C057693troglitazone[troglitazone co-treated with TNF protein] results in decreased expression of TST mRNA12732648
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of TST mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of TST mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of TST mRNA17292431
D014638VanadatesVanadates results in decreased expression of TST mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TST gene25560391
C025643vinclozolinvinclozolin results in decreased expression of TST mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of TST mRNA22570695
D014800VitalliumVitallium analog results in decreased expression of TST mRNA23825117
D024483Vitamin K 3Vitamin K 3 affects the expression of TST mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004792thiosulfate sulfurtransferase activity-TAS-  
GO:00080975S rRNA binding-IDA20663881  21685364  
GO ID GO Term Qualifier Evidence PubMed
GO:0000098sulfur amino acid catabolic process-TAS-  
GO:0009440cyanate catabolic process-TAS9070219  
GO:0030855epithelial cell differentiation-IDA21492153  
GO:0035928rRNA import into mitochondrion-IMP20663881  
GO:0051029rRNA transport-IDA21685364  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA23580065  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00270Cysteine and methionine metabolism
hsa01100Metabolic pathways
hsa04122Sulfur relay system
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-1614517Sulfide oxidation to sulfateIEA
R-HSA-1614558Degradation of cysteine and homocysteineTAS
R-HSA-1614558Degradation of cysteine and homocysteineIEA
R-HSA-1614635Sulfur amino acid metabolismTAS
R-HSA-1614635Sulfur amino acid metabolismIEA
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-71291Metabolism of amino acids and derivativesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24189487The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence. (2014 Mar)Witkin JMPharmacol Ther
22334814Sources of variability in epidemiological studies of sleep using repeated nights of in-home polysomnography: SWAN Sleep Study. (2012 Feb 15)Zheng HJ Clin Sleep Med
24903943The association of smoking with IGRA and TST results in HIV-1-infected subjects. (2014 Jun)Aichelburg MCInt J Tuberc Lung Dis
25428131Tuberculin skin test and QuantiFERON-TB Gold In-tube Test for latent tuberculosis in Thai HIV-infected adults. (2015 Feb)Khawcharoenporn TRespirology
17958979Tuberculosis infection in drug users: interferon-gamma release assay performance. (2007 Nov)Grimes CZInt J Tuberc Lung Dis
27091532Oxidative Stress and Inflammation Differentially Elevated in Objective Versus Habitual Subjective Reduced Sleep Duration in Obstructive Sleep Apnea. (2016 Jul 1)DeMartino TSleep
25581693[Latent tuberculosis treatment results in patients that taken TNF-alpha blockers at Ankara Numune Training and Research Hospital Chest Diseases Clinic for last 8 years (2006-2013)]. (2014)Demir STuberk Toraks
29181439Rest-activity circadian rhythms and bone mineral density in elderly men. (2017 Dec)Rogers TSBone Rep
26512752Circadian regulation gene polymorphisms are associated with sleep disruption and duration, and circadian phase and rhythm in adults with HIV. (2015)Lee KAChronobiol Int
23056584Smoking, BCG and employment and the risk of tuberculosis infection in HIV-infected persons in South Africa. (2012)Oni TPLoS One
20351960Performance of QuantiFERON-TB Gold test compared to tuberculin skin test in detecting latent tuberculosis infection in HIV- positive individuals in Iran. (2010 Jan)Mardani MAnn Thorac Med
29485786QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent Tuberculosis Infection in Arthritis Patients Treated with Tumor Necrosis Factor Antagonists. (2017 Jun)Baricevic DActa Clin Croat
29704590Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats. (2018 Apr 25)Yawalkar RNeurochem Int