Gene: TTC3

7267
DCRR1|RNF105|TPRDIII
tetratricopeptide repeat domain 3
protein-coding
21q22.13
Ensembl:ENSG00000182670 MIM:602259 Vega:OTTHUMG00000086654 UniprotKB:P53804
NC_000021.9
PubMed
0   ANCO-SNPs
ND
2   
7.230e-1 (AD)  3.870e-1 (ND)   (Frontal_Cortex)
8.957e-1 (AD)  2.796e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP9A0.949
PAFAH1B10.941
FAM20B0.938
SPIN10.937
IPO90.937
SLC30A90.936
PLEKHB20.932
LRPPRC0.932
CALM10.931
TATDN20.93

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.642
OR4F29-0.62
CSAG1-0.407
PDZK1IP1-0.391
TGIF1-0.385
CLEC2B-0.375
S100A12-0.372
EVC2-0.37
TMEM102-0.365
S100A8-0.36

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of TTC3 mRNA"19162173
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTC3 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTC3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTC3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTC3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTC3 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC3 mRNA"27188386
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of TTC3 mRNA20829426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TTC3 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TTC3 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TTC3 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TTC3 mRNA24449571
C547126AZM551248AZM551248 results in increased expression of TTC3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TTC3 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TTC3 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TTC3 mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of TTC3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TTC3 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TTC3 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of TTC3 mRNA26079696
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of TTC3 mRNA19840844
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TTC3 mRNA23650126
D002737ChloropreneChloroprene results in increased expression of TTC3 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of TTC3 mRNA19320972
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of TTC3 mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of TTC3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TTC3 mRNA25562108
C014347decitabinedecitabine affects the expression of TTC3 mRNA23300844
D013759DronabinolDronabinol results in increased expression of TTC3 mRNA16597638
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TTC3 mRNA21266533
D002945CisplatinCisplatin affects the expression of TTC3 mRNA23300844
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of TTC3 mRNA21858171
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of TTC3 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of TTC3 mRNA]19850644
D004237DiuronDiuron results in decreased expression of TTC3 mRNA21551480
D005485FlutamideFlutamide results in decreased expression of TTC3 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of TTC3 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of TTC3 mRNA16111024
C001277geldanamycingeldanamycin results in increased expression of TTC3 mRNA26705709
D005839GentamicinsGentamicins results in increased expression of TTC3 mRNA22061828
D017313FenretinideFenretinide results in increased expression of TTC3 mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TTC3 protein18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TTC3 mRNA18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased secretion of TTC3 mRNA21179422
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TTC3 mRNA25613284
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TTC3 mRNA26378955
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to TTC3 promoter]20348232
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TTC3 mRNA26272509
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TTC3 mRNA19465457
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TTC3 mRNA"26251327
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of TTC3 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of TTC3 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of TTC3 mRNA19840844
D008777MethyltestosteroneMethyltestosterone results in increased expression of TTC3 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TTC3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TTC3 mRNA"25554681|2562005
C051752nefazodonenefazodone results in decreased expression of TTC3 mRNA24136188
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of TTC3 mRNA19840844
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTC3 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in decreased expression of TTC3 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of TTC3 mRNA19159669
D010634PhenobarbitalPhenobarbital results in decreased expression of TTC3 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of TTC3 mRNA18301758|2081375
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of TTC3 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of TTC3 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of TTC3 mRNA20631399
D011374ProgesteroneProgesterone results in increased expression of TTC3 mRNA23012394
C045950propiconazolepropiconazole results in decreased expression of TTC3 mRNA21278054
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of TTC3 mRNA19244175
D012643SeleniumSelenium results in decreased expression of TTC3 mRNA19244175
D018038Sodium SeleniteSodium Selenite results in increased expression of TTC3 mRNA18175754
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TTC3 mRNA26378955
C061133tamibarotenetamibarotene results in decreased expression of TTC3 mRNA15498508
C004648testosterone enanthatetestosterone enanthate affects the expression of TTC3 mRNA17440010
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of TTC3 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of TTC3 mRNA19840844
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TTC3 mRNA25613284
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TTC3 protein18951874
D024505TocopherolsTocopherols results in increased expression of TTC3 mRNA17654050
C483909torcetrapibtorcetrapib results in increased expression of TTC3 mRNA23228038
D014212TretinoinTretinoin results in decreased expression of TTC3 mRNA15498508
D014212TretinoinTretinoin results in increased expression of TTC3 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased methylation of TTC3 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of TTC3 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of TTC3 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of TTC3 mRNA23179753|2484967
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TTC3 gene25560391
C025643vinclozolinvinclozolin affects the expression of TTC3 mRNA19015723
D014750VincristineVincristine results in decreased expression of TTC3 mRNA23649840
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of TTC3 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of TTC3 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of TTC3 mRNA20829426
C111237vorinostatvorinostat results in decreased expression of TTC3 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-IDA20059950  
GO:0005515protein binding-IPI20059950  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006511ubiquitin-dependent protein catabolic process-IDA20059950  
GO:0070936protein K48-linked ubiquitination-IDA20059950  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA20059950  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21778238Cigarette smoke induces Akt protein degradation by the ubiquitin-proteasome system. (2011 Sep 16)Kim SYJ Biol Chem
28849146Nicotine induces H9C2 cell apoptosis via Akt protein degradation. (2017 Nov)Huang CMol Med Rep