Gene: C5

727
C5D|C5a|C5b|CPAMD4|ECLZB
complement C5
protein-coding
9q33.2
Ensembl:ENSG00000106804 MIM:120900 Vega:OTTHUMG00000020579 UniprotKB:P01031
NG_007364.1
PubMed
0   ANCO-SNPs
ND|AD
19   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.094e-1 (AD)  2.152e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYO60.826
FAM227B0.796
ZMAT10.795
TMEM1360.791
CYP4V20.784
MYH150.778
CTPS20.778
DHTKD10.776
BCKDHB0.774
ERLIN20.772

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPPIN-0.416
MIP-0.413
GPR68-0.412
BEND4-0.411
HCN4-0.393
FAM160A1-0.39
PNOC-0.382
LAMB3-0.382
KLRG1-0.38
KCNK12-0.377

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00028Immune Globulin HumanBiotechDrug9007-83-4Approved|InvestigationalTarget
DB01257EculizumabBiotechDrug219685-50-4Approved|InvestigationalTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0389831,3-dimethylthiourea"1,3-dimethylthiourea inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of C5 protein]"10777245
C0389831,3-dimethylthiourea"1,3-dimethylthiourea inhibits the reaction [Asbestos, Serpentine results in increased cleavage of C5 protein]"10777245
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]19346296
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]19346296
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [C5 protein results in increased phosphorylation of MAPK1 protein]16116186
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [C5 protein results in increased phosphorylation of MAPK3 protein]16116186
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]19346296
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]19346296
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of C5 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of C5 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of C5 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of C5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of C5 mRNA"27188386
C0314338-(4-sulfophenyl)theophylline8-(4-sulfophenyl)theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]10947063
D000082AcetaminophenAcetaminophen results in decreased expression of C5 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of C5 mRNA26690555
D020106AcrylamideAcrylamide affects the expression of C5 mRNA28959563
C096064acteinactein results in increased expression of C5 mRNA19527300
D016604Aflatoxin B1Aflatoxin B1 affects the expression of C5 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of C5 mRNA27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of C5 mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of C5 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of C5 mRNA27829220
D017638Asbestos, Crocidolite"1,3-dimethylthiourea inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of C5 protein]"10777245
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of C5 mRNA"25351596
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased cleavage of C5 protein"10777245
D017638Asbestos, Crocidolite"Ascorbic Acid inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of C5 protein]"10777245
D017638Asbestos, Crocidolite"Deferoxamine inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of C5 protein]"10777245
D017638Asbestos, Crocidolite"Dithionite inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of C5 protein]"10777245
D017638Asbestos, Crocidolite"[Egtazic Acid co-treated with Asbestos, Crocidolite] results in increased cleavage of C5 protein"10777245
D017638Asbestos, Crocidolite"[Ethylene Glycol co-treated with Asbestos, Crocidolite] results in increased cleavage of C5 protein"10777245
D001205Ascorbic Acid"Ascorbic Acid inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of C5 protein]"10777245
D001205Ascorbic Acid"Ascorbic Acid inhibits the reaction [Asbestos, Serpentine results in increased cleavage of C5 protein]"10777245
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of C5 mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of C5 mRNA25912373
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of C5 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of C5 mRNA24534842
C006780bisphenol Abisphenol A results in decreased expression of C5 mRNA25181051
D0200011-Butanol1-Butanol inhibits the reaction [C5 protein results in increased activity of RELA protein]19284563
D0200011-Butanol1-Butanol inhibits the reaction [C5 protein results in increased activity of SPHK1 protein]19284563
D0200011-Butanol1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]19346296
D0200011-Butanol1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]19346296
D0200011-Butanol1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of MAPK1 protein]19284563
D0200011-Butanol1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of MAPK3 protein]19284563
D0200011-Butanol1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]19346296
D0200011-Butanol1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]19346296
D0200011-Butanol1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of MAPK1 protein]19284563
D0200011-Butanol1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of MAPK3 protein]19284563
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of C5 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of C5 mRNA26079696
D002104CadmiumC5 protein binds to Cadmium23896426
D019256Cadmium ChlorideCadmium Chloride results in increased expression of C5 mRNA18804290
D002118Calcium[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium19284563|1934629
D002118Calciumresveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium]19284563|1934629
D002118Calcium[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium19346296
D002118Calciumresveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium]19346296
D002509CephaloridineCephaloridine results in decreased expression of C5 mRNA18500788
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of C5 mRNA27344345
D002809Chondroitin SulfatesChondroitin Sulfates analog results in increased cleavage of C5 protein18434646
C018021cobaltous chloridecobaltous chloride results in decreased expression of C5 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of C5 mRNA24386269
C016310cobra venom factorcobra venom factor results in increased expression of C5 protein19428933
C016310cobra venom factorcobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]9250166
D003300CopperC5 protein binds to Copper23896426
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of C5 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of C5 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of C5 mRNA"19167446
D016572CyclosporineCyclosporine affects the expression of C5 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of C5 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased expression of C5 mRNA21632981
D003571Cytochalasin B[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein18776917
D003571Cytochalasin B[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein18776917
D003571Cytochalasin B[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein18776917
D003571Cytochalasin BDexamethasone analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]18776917
D003571Cytochalasin Bresveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein]18776917
D003571Cytochalasin Bresveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein]18776917
D003571Cytochalasin Bresveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]18776917
C515055darinaparsindarinaparsin results in increased expression of C5 mRNA22535156
C014347decitabinedecitabine affects the expression of C5 mRNA23300844
D003676Deferoxamine"Deferoxamine inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of C5 protein]"10777245
D003676Deferoxamine"Deferoxamine inhibits the reaction [Asbestos, Serpentine results in increased cleavage of C5 protein]"10777245
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased expression of C5 mRNA18709148
D003907DexamethasoneDexamethasone analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]18776917
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of C5 mRNA28628672
D002945CisplatinCisplatin affects the expression of C5 mRNA23300844
C000944dicrotophosdicrotophos results in decreased expression of C5 mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of C5 mRNA19638242
D004227Dithionite"Dithionite inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of C5 protein]"10777245
D004227Dithionite"Dithionite inhibits the reaction [Asbestos, Serpentine results in increased cleavage of C5 protein]"10777245
D004533Egtazic Acid"[Egtazic Acid co-treated with Asbestos, Crocidolite] results in increased cleavage of C5 protein"10777245
D004533Egtazic Acid"[Egtazic Acid co-treated with Asbestos, Serpentine] results in increased cleavage of C5 protein"10777245
C118739entinostatentinostat results in decreased expression of C5 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of C5 mRNA"27188386
D019855Ethylene Glycol"[Ethylene Glycol co-treated with Asbestos, Crocidolite] results in increased cleavage of C5 protein"10777245
D019855Ethylene Glycol"[Ethylene Glycol co-treated with Asbestos, Serpentine] results in increased cleavage of C5 protein"10777245
D005485FlutamideFlutamide results in decreased expression of C5 mRNA24136188|2479361
D037741FullerenesFullerenes analog results in increased expression of C5 mRNA22342292
C039281furanfuran results in decreased expression of C5 mRNA25539665|2619464
D005897GlafenineGlafenine results in increased expression of C5 mRNA24136188
D005978GlutathioneGlutathione deficiency results in decreased expression of C5 mRNA20621112
D006493HeparinHeparin results in decreased expression of C5 protein7948777
D007975Leukotriene B4C5 protein results in increased abundance of Leukotriene B410477617
D007975Leukotriene B4MK 0591 inhibits the reaction [C5 protein results in increased abundance of Leukotriene B4]10477617
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of C5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of C5 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of C5 mRNA27392435
D007854LeadLead results in increased expression of C5 mRNA19921347
C045463leflunomideleflunomide results in increased expression of C5 mRNA24136188
D064704LevofloxacinLevofloxacin results in increased expression of C5 mRNA24136188
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in decreased expression of C5 mRNA"23090859
D008727MethotrexateMethotrexate results in increased expression of C5 mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of C5 mRNA28001369
C078266MK 0591MK 0591 inhibits the reaction [C5 protein results in increased abundance of Leukotriene B4]10477617
C078266MK 0591MK 0591 results in decreased susceptibility to C5 protein10477617
C470794N-((4-dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide"N-((4-dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide inhibits the reaction [Trichloroethylene promotes the reaction [C5AR1 protein binds to C5 protein]]"26095957
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of C5 mRNA27344345
C051752nefazodonenefazodone results in decreased expression of C5 mRNA24136188
D009532NickelC5 protein binds to Nickel23896426
C028007nickel monoxidenickel monoxide results in increased expression of C5 mRNA19167457
C061800N,N-dimethylsphingosine"N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein]"19284563
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of C5 mRNA20971185
C076029olanzapineolanzapine affects the phosphorylation of C5 protein25821032
D010047Ovalbumin[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of C5 mRNA19176365
C002669parthenolideparthenolide inhibits the reaction [C5 protein results in increased activity of RELA protein]19284563
D052638Particulate MatterParticulate Matter results in decreased expression of C5 mRNA22178795
D052638Particulate Matter[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of C5 mRNA19176365
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of C5 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of C5 mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of C5 mRNA26794494
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]16116186
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein]16116186
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [C5 protein results in increased phosphorylation of MAPK1 protein]16116186
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [C5 protein results in increased phosphorylation of MAPK3 protein]16116186
D010656PhenylephrineC5 protein affects the susceptibility to Phenylephrine10750764
C029217phenyl-N-tert-butylnitronephenyl-N-tert-butylnitrone results in decreased expression of C5 protein23199288
C014153pirimiphos methylpirimiphos methyl results in increased expression of C5 mRNA27845199
D028321Plant PreparationsPlant Preparations results in increased expression of C5 protein28284660
D011374ProgesteroneProgesterone results in decreased expression of C5 mRNA23012394
D011692Puromycin AminonucleosideCR1 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]9250166
D011692Puromycin Aminonucleosidecobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]9250166
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]9250166
D011794QuercetinQuercetin results in decreased expression of C5 mRNA21632981
C059514resveratrolresveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein]18776917
C059514resveratrolresveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein]18776917
C059514resveratrolresveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]18776917
C059514resveratrolresveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium]19284563|1934629
C059514resveratrolresveratrol inhibits the reaction [C5 protein results in increased activity of RELA protein]19284563|1934629
C059514resveratrolresveratrol inhibits the reaction [C5 protein results in increased expression of CCL3 protein]19284563|1934629
C059514resveratrolresveratrol inhibits the reaction [C5 protein results in increased expression of IL1B protein]19284563|1934629
C059514resveratrolresveratrol inhibits the reaction [C5 protein results in increased expression of IL6 protein]19284563|1934629
C059514resveratrolresveratrol inhibits the reaction [C5 protein results in increased expression of TNF protein]19284563|1934629
C059514resveratrolresveratrol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]19346296
C059514resveratrolresveratrol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]19346296
C059514resveratrolresveratrol results in decreased activity of [C5 protein results in increased localization of and results in increased activity of PLD1 protein]19284563
C059514resveratrol[resveratrol results in decreased activity of SPHK1 protein] inhibits the reaction [C5 protein results in increased activity of RELA protein]19284563
C059514resveratrolresveratrol results in decreased susceptibility to C5 protein19284563
C059514resveratrolresveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium]19346296
C059514resveratrolresveratrol inhibits the reaction [C5 protein results in increased expression of CCL3 protein]19284563|1934629
C059514resveratrolresveratrol inhibits the reaction [C5 protein results in increased expression of IL1B protein]19284563|1934629
C059514resveratrolresveratrol inhibits the reaction [C5 protein results in increased expression of IL6 protein]19284563|1934629
C059514resveratrolresveratrol inhibits the reaction [C5 protein results in increased expression of TNF protein]19284563|1934629
C059514resveratrolresveratrol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]19346296
C059514resveratrolresveratrol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]19346296
C539676rEV576 protein, tick"rEV576 protein, tick binds to and results in decreased activity of C5 protein"15699138|1744582
C539676rEV576 protein, tick"rEV576 protein, tick binds to and results in increased stability of and results in decreased activity of C5 protein"18536718
C539676rEV576 protein, tick"rEV576 protein, tick binds to and results in decreased activity of C5 protein"17215252
C539676rEV576 protein, tick"rEV576 protein, tick results in decreased activity of C5 protein"18844789
C539676rEV576 protein, tick"rEV576 protein, tick results in decreased activity of C5 protein"19194881
D017632Asbestos, Serpentine"1,3-dimethylthiourea inhibits the reaction [Asbestos, Serpentine results in increased cleavage of C5 protein]"10777245
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased cleavage of C5 protein"10777245
D017632Asbestos, Serpentine"Ascorbic Acid inhibits the reaction [Asbestos, Serpentine results in increased cleavage of C5 protein]"10777245
D017632Asbestos, Serpentine"Deferoxamine inhibits the reaction [Asbestos, Serpentine results in increased cleavage of C5 protein]"10777245
D017632Asbestos, Serpentine"Dithionite inhibits the reaction [Asbestos, Serpentine results in increased cleavage of C5 protein]"10777245
D017632Asbestos, Serpentine"[Egtazic Acid co-treated with Asbestos, Serpentine] results in increased cleavage of C5 protein"10777245
D017632Asbestos, Serpentine"[Ethylene Glycol co-treated with Asbestos, Serpentine] results in increased cleavage of C5 protein"10777245
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of C5 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of C5 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of C5 protein27428020
D012822Silicon DioxideSilicon Dioxide results in increased expression of C5 mRNA22431001
D012834SilverSilver results in decreased expression of C5 mRNA22342292
D013205Staphylococcal Protein AStaphylococcal Protein A results in increased expression of C5 protein alternative form15384034
C024075styrofoamstyrofoam analog results in increased expression of C5 protein19428933
D013481Superoxides8-(4-sulfophenyl)theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]10947063
D013481SuperoxidesC5 protein modified form results in increased abundance of Superoxides10947063
D013481SuperoxidesTheophylline inhibits the reaction [C5 protein modified form results in increased abundance of Superoxides]10947063
D013481SuperoxidesTheophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]10947063
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of C5 mRNA15056799|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of C5 mRNA11489354
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of C5 mRNA22298810
D019284ThapsigarginThapsigargin results in increased expression of C5 mRNA22378314
D013806TheophyllineTheophylline inhibits the reaction [C5 protein modified form results in increased abundance of Superoxides]10947063
D013806TheophyllineTheophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]10947063
C009495titanium dioxidetitanium dioxide results in increased expression of C5 mRNA19695317|2234229
C009495titanium dioxidetitanium dioxide results in increased secretion of C5 protein20005940
C066340tolcaponetolcapone results in increased expression of C5 mRNA24136188
D014241Trichloroethylene"N-((4-dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide inhibits the reaction [Trichloroethylene promotes the reaction [C5AR1 protein binds to C5 protein]]"26095957
D014241TrichloroethyleneTrichloroethylene promotes the reaction [C5AR1 protein binds to C5 protein]26095957
D014241TrichloroethyleneTrichloroethylene results in increased expression of C5 protein26095957
D014635Valproic AcidValproic Acid results in decreased expression of C5 mRNA28001369|2915479
D014638VanadatesVanadates results in decreased expression of C5 mRNA22714537
C009687wortmanninwortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA]16116186
C009687wortmanninwortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]16116186
C009687wortmanninwortmannin inhibits the reaction [C5 protein results in decreased expression of IL12B mRNA]16116186
C009687wortmanninwortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA]16116186
C009687wortmanninwortmannin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein]16116186
D015032ZincC5 protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004866endopeptidase inhibitor activity-IEA-  
GO:0005102signaling receptor binding-TAS9590258  10820279  
GO:0005515protein binding-IPI21217642  25416956  
GO:0008009chemokine activity-TAS10820279  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-TAS7649993  
GO:0001701in utero embryonic development-IEA-  
GO:0006935chemotaxis-TAS10820279  
GO:0006954inflammatory response-IEA-  
GO:0006957complement activation, alternative pathway-IEA-  
GO:0006958complement activation, classical pathway-IEA-  
GO:0007166cell surface receptor signaling pathway-TAS10820279  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0010575positive regulation of vascular endothelial growth factor production-IDA14566334  16452172  
GO:0010760negative regulation of macrophage chemotaxis-IDA14566334  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0019835cytolysis-IEA-  
GO:0030449regulation of complement activation-TAS-  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0060326cell chemotaxis-IEA-  
GO:0090197positive regulation of chemokine secretion-IDA14566334  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005579membrane attack complex-IDA22832194  
GO:0005615extracellular space-TAS9218605  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa05020Prion diseases
hsa05150Staphylococcus aureus infection
hsa05322Systemic lupus erythematosus
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-166658Complement cascadeTAS
R-HSA-166665Terminal pathway of complementTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-174577Activation of C3 and C5TAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
2983591Alveolar macrophage function and inflammatory stimuli in smokers with and without obstructive lung disease. (1985 Mar)McLeod RAm Rev Respir Dis
22023374Application of back propagation artificial neural network on genetic variants in adiponectin ADIPOQ, peroxisome proliferator-activated receptor-gamma, and retinoid X receptor-alpha genes and type 2 diabetes risk in a Chinese Han population. (2012 Mar)Shi HDiabetes Technol Ther
19909405Single nucleotide polymorphisms of complement component 5 and periodontitis. (2010 Jun)Chai LJ Periodontal Res
22232964[The influence of parents personality and DRD4 and 5HTT genes polymorphisms on predisposition to alcohol dependence in their sons]. (2011 May-Jun)Samochowiec APsychiatr Pol
27555999Postoperative Delayed Cervical Palsies: Understanding the Etiology. (2016 Sep)Planchard RFGlobal Spine J
16893949Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough. (2006 Dec)Park HKThorax
20439292Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep)van der Helm-van Mil AHAnn Rheum Dis
27175676Superior Glucose Tolerance and Metabolomic Profiles, Independent of Adiposity, in HIV-Infected Women Compared With Men on Antiretroviral Therapy. (2016 May)Koethe JRMedicine (Baltimore)
23471467Predictors of objective cough frequency in chronic obstructive pulmonary disease. (2013 May 1)Sumner HAm J Respir Crit Care Med
22155226Dysphagia after anterior cervical spine surgery: incidence and risk factors. (2012 Jan)Kalb SWorld Neurosurg
7235362Quantitation and stability of the fifth component of complement (C5) in bronchoalveolar lavage fluids obtained from non-human primates. (1981 Feb)Kolb WPAm Rev Respir Dis
17760784Isoform-specific enhancement of adenylyl cyclase activity by n-alkanols. (2007 Sep)Kou JAlcohol Clin Exp Res
21465850The influence of parents personality measured by temperamental and character inventory (TCI) on course of alcoholism characterized by Cloninger's and Lesch's typologies. (2010)Samochowiec AAnn Acad Med Stetin
18242045[Systemic lupus erythematosus: news and therapeutic perspectives]. (2008 Mar)Sibilia JPresse Med
29279246Complement system biomarkers in first episode psychosis. (2017 Dec 23)Kopczynska MSchizophr Res
29649666A retrospective study: Does cigarette smoking induce cervical disc degeneration? (2018 May)Chen ZInt J Surg
21689990Cervical spine bone mineral density as a function of vertebral level and anatomic location. (2011 Jul)Anderst WJSpine J
23288628Genetics of rheumatoid arthritis - a comprehensive review. (2013 Oct)Kurko JClin Rev Allergy Immunol
20046016[Is rheumatoid arthritis without anti-citrullinated peptide antibody a genetically distinct subset?]. (2009 Dec)Ohmura KNihon Rinsho Meneki Gakkai Kaishi