Gene: TTF1

7270
TTF-1|TTF-I
transcription termination factor 1
protein-coding
9q34.13
Ensembl:ENSG00000125482 MIM:600777 Vega:OTTHUMG00000020836 UniprotKB:Q15361
NC_000009.12
PubMed
0   ANCO-SNPs
ND
14   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.591e-1 (AD)  7.255e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MTMR20.913
RPS6KC10.909
SRP720.908
API50.906
TGOLN20.905
JAKMIP20.899
RRM10.898
TRIP120.898
CSE1L0.897
RUFY30.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.576
OR4F5-0.568
PLA2G5-0.344
PTGDR2-0.298
WNT7B-0.289
EYA2-0.289
MTRNR2L6-0.289
ADAMTSL5-0.281
MTRNR2L10-0.275
PPP1R3G-0.268

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TTF1 mRNA19933214
C5301712,2,2,-trichloro-1-(3,4-dichlorophenyl)-ethylacetate"2,2,2,-trichloro-1-(3,4-dichlorophenyl)-ethylacetate results in increased expression of TTF1 mRNA"22119440
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTF1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TTF1 mRNA19770486
D006710HomocysteineHomocysteine results in decreased expression of TTF1 mRNA17326132
D001280AtrazineAtrazine affects the expression of TTF1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TTF1 mRNA17879257
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of TTF1 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TTF1 mRNA15034205
D004958EstradiolEstradiol promotes the reaction [CREBBP protein binds to TTF1 promoter]19698761
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to TTF1 promoter]19698761
C006780bisphenol Abisphenol A results in increased expression of TTF1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of TTF1 mRNA25181051
D001839BombesinBombesin inhibits the reaction [nitrofen results in increased expression of TTF1 mRNA]25487476
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of TTF1 mRNA21356183
C018021cobaltous chloridecobaltous chloride results in increased expression of TTF1 mRNA19376846
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of TTF1 mRNA21356183
D003300CopperCopper results in decreased expression of TTF1 mRNA21356183
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of TTF1 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of TTF1 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of TTF1 mRNA22077320
D016572CyclosporineCyclosporine results in increased expression of TTF1 mRNA25562108
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of TTF1 mRNA24690739
C017461lead nitratelead nitrate affects the reaction [TTF1 affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [TTF1 affects the expression of MT2 mRNA]11891201
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TTF1 mRNA23649840
D008774MethylphenidateMethylphenidate results in increased expression of TTF1 mRNA22470460
D009151Mustard GasMustard Gas results in increased expression of TTF1 mRNA15674843
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of TTF1 mRNA"29244179
C007350nitrofenBombesin inhibits the reaction [nitrofen results in increased expression of TTF1 mRNA]25487476
C007350nitrofennitrofen results in increased expression of TTF1 mRNA25487476
D010416PentachlorophenolPentachlorophenol results in increased expression of TTF1 mRNA24642059
C011272perfosfamideperfosfamide results in decreased expression of TTF1 mRNA19429390
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTF1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TTF1 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of TTF1 mRNA23557933
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TTF1 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TTF1 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TTF1 mRNA15034205
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TTF1 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of TTF1 mRNA21924320
D014212TretinoinTretinoin results in increased expression of TTF1 mRNA15328022
D014212TretinoinTretinoin results in increased expression of TTF1 mRNA15328022
D014635Valproic AcidValproic Acid affects the expression of TTF1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of TTF1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TTF1 gene25560391
D014810Vitamin EVitamin E results in decreased expression of TTF1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006353DNA-templated transcription, termination-NAS7597036  
GO:0006363termination of RNA polymerase I transcription-TAS-  
GO:0008156negative regulation of DNA replication-IEA-  
GO:0044267cellular protein metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005634nucleus-NAS7597036  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-427389ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionIEA
R-HSA-427413NoRC negatively regulates rRNA expressionIEA
R-HSA-5250913Positive epigenetic regulation of rRNA expressionIEA
R-HSA-5250941Negative epigenetic regulation of rRNA expressionIEA
R-HSA-5668914Diseases of metabolismTAS
R-HSA-5683826Surfactant metabolismTAS
R-HSA-5687613Diseases associated with surfactant metabolismTAS
R-HSA-5688031Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)TAS
R-HSA-73762RNA Polymerase I Transcription InitiationTAS
R-HSA-73854RNA Polymerase I Promoter ClearanceTAS
R-HSA-73863RNA Polymerase I Transcription TerminationIEA
R-HSA-73863RNA Polymerase I Transcription TerminationTAS
R-HSA-73864RNA Polymerase I TranscriptionTAS
R-HSA-73864RNA Polymerase I TranscriptionIEA
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27354614Prognostic Factors Including the Expression of Thyroid Transcription Factor 1 (TTF1) in Patients Irradiated for Limited-disease Small Cell Lung Cancer. (2016 Jul)Kasmann LAnticancer Res
26208325Comprehensive Molecular Analysis of NSCLC; Clinicopathological Associations. (2015)Chatziandreou IPLoS One
26793845EGFR MUTATIONS IN NON-SMALL CELL LUNG CANCER: LOCAL EPIDEMIOLOGY AND CLINICAL IMPORTANCE. (2015 Oct-Dec)Rusu-Cordunean FRev Med Chir Soc Med Nat Iasi
23988776EGFR, KRAS, BRAF and ALK gene alterations in lung adenocarcinomas: patient outcome, interplay with morphology and immunophenotype. (2014 Mar)Warth AEur Respir J
28468033[Clinicopathologic features and genetic profile of the redefined large cell lung carcinoma]. (2017 May 8)Hou LKZhonghua Bing Li Xue Za Zhi
22036089Establishing an EGFR mutation screening service for non-small cell lung cancer - sample quality criteria and candidate histological predictors. (2012 Jan)Leary AFEur J Cancer
24390215Cribriform adenocarcinoma of the lung: clinicopathologic, immunohistochemical, and molecular analysis of 15 cases of a distinctive morphologic subtype of lung adenocarcinoma. (2014 Aug)Mackinnon AC JrMod Pathol
25066934Usual interstitial pneumonia and smoking-related interstitial fibrosis display epithelial to mesenchymal transition in fibroblastic foci. (2014 Sep)Fabro ATRespir Med
25926253Lung adenocarcinoma: Sustained subtyping with immunohistochemistry and EGFR, HER2 and KRAS mutational status. (2015 May-Jun)Sousa VRev Port Pneumol (2006)
27992557An Analysis of EGFR Mutations among 1506 Cases of Non-Small Cell Lung Cancer Patients in Guangxi, China. (2016)Wei WEPLoS One
27282326[Breast metastases from lung cancers with the EGFR mutation]. (2017 Jan)Assouline PRev Mal Respir
12968312[Solitary fibrous pseudopapillary tumor of the lung: pulmonary fibroadenoma and adenofibroma revisited]. (2003 Jun)Cavazza APathologica
27943404The prevalence of ALK rearrangement in pulmonary adenocarcinomas in an unselected Caucasian population from a defined catchment area: impact of smoking. (2017 May)Skov BGHistopathology
29434341Hyalinizing clear cell carcinoma of the bronchial glands: presentation of three cases and pathological comparisons with salivary gland counterparts and bronchial mucoepidermoid carcinomas. (2018 Feb 12)Takamatsu MMod Pathol