Gene: TTK

7272
CT96|ESK|MPH1|MPS1|MPS1L1|PYT
TTK protein kinase
protein-coding
6q14.1
Ensembl:ENSG00000112742 MIM:604092 Vega:OTTHUMG00000015088 UniprotKB:P33981
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.139e-1 (AD)  9.978e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MGAT4A0.553
KIF230.552
PIK3CG0.543
PBRM10.538
ATP11B0.527
CPD0.526
PTBP30.517
PRKAB20.513
DCP20.511
ZNF4680.509

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC13A5-0.38
SLC7A10-0.377
GRIN2C-0.371
PPP1R3G-0.368
BTBD17-0.363
PIPOX-0.362
PLA2G5-0.36
RLBP1-0.345
PYGM-0.344
MMD2-0.342

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB017822,6-Dihydroanthra/1,9-Cd/Pyrazol-6-OneSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TTK mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TTK mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of TTK mRNA"19167446
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TTK mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TTK mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TTK mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TTK mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TTK mRNA"25510870
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TTK mRNA"16120219
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTK mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TTK mRNA26690555|2906747
D000082AcetaminophenAcetaminophen results in increased expression of TTK mRNA22230336
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of TTK mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TTK mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of TTK mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TTK protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TTK mRNA23630614
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TTK mRNA21298039
D006710HomocysteineHomocysteine results in decreased expression of TTK mRNA17326132
D001374Azacitidine[Azacitidine co-treated with Thalidomide] affects the expression of TTK mRNA18720364
D001379AzathioprineAzathioprine results in decreased expression of TTK mRNA22623647
C547126AZM551248AZM551248 results in increased expression of TTK mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of TTK mRNA23656968
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TTK mRNA16120219|2006483
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TTK mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TTK mRNA"20018196|2038263
D004958EstradiolEstradiol results in increased expression of TTK mRNA18310284|1916744
C044887beta-methylcholinebeta-methylcholine affects the expression of TTK mRNA21179406
C006780bisphenol Abisphenol A affects the expression of TTK mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TTK mRNA29027980
C006780bisphenol Abisphenol A results in decreased expression of TTK mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of TTK mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of TTK mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of TTK mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TTK mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TTK mRNA17484886
D002509CephaloridineCephaloridine results in decreased expression of TTK mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TTK gene20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of TTK mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TTK mRNA]17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of TTK mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TTK mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of TTK mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of TTK mRNA19167446
C024015cryptolepinecryptolepine results in decreased expression of TTK mRNA16120219
D003471CuprizoneCuprizone results in increased expression of TTK mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of TTK mRNA20106945|2163298
D000069439DasatinibDasatinib results in decreased expression of TTK mRNA20579391
D003976DiazinonDiazinon affects the expression of TTK mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TTK mRNA17361019|2126653
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of TTK mRNA28962523
D002945CisplatinCisplatin promotes the reaction [Piroxicam results in decreased expression of TTK mRNA]21858171
D002945CisplatinCisplatin results in increased expression of TTK mRNA21151649
D002945CisplatinCisplatin results in decreased expression of TTK mRNA22023808
C000944dicrotophosdicrotophos results in decreased expression of TTK mRNA28302478
D004026DieldrinDieldrin affects the expression of TTK mRNA22546817
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TTK mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TTK mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TTK mRNA]17854601
D002117CalcitriolCalcitriol results in decreased expression of TTK mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of TTK mRNA21592394
D004317DoxorubicinTTK protein affects the susceptibility to Doxorubicin16217747
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TTK mRNA22079256
D005047EtoposideEtoposide results in decreased expression of TTK mRNA16120219
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TTK gene20938992
C070081fulvestrant[fulvestrant co-treated with Sirolimus] results in decreased expression of TTK mRNA19016759
C070081fulvestrantfulvestrant results in decreased expression of TTK mRNA19016759
C039281furanfuran results in increased expression of TTK mRNA25539665
D019833GenisteinGenistein affects the expression of TTK mRNA18847459
C492448ICG 001ICG 001 results in decreased expression of TTK mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TTK mRNA25613284
C051890irinotecanirinotecan metabolite results in decreased expression of TTK mRNA15956246
C051890irinotecanirinotecan results in decreased expression of TTK mRNA15956246
C011890kojic acidkojic acid results in decreased expression of TTK mRNA16595896
D007840LatexLatex analog results in increased expression of TTK mRNA24768652
C045463leflunomideleflunomide results in decreased expression of TTK mRNA28988120
D008094LithiumLithium results in increased expression of TTK mRNA21711903
D008154LucanthoneLucanthone results in decreased expression of TTK mRNA21148553
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of TTK mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of TTK mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TTK gene20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of TTK mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TTK mRNA26011545
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of TTK mRNA25270620
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TTK mRNA24810058
C008493methylselenic acidmethylselenic acid results in decreased expression of TTK mRNA18548127
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of TTK mRNA24128854
D009151Mustard GasMustard Gas results in decreased expression of TTK mRNA25102026
D009151Mustard GasMustard Gas results in decreased expression of TTK mRNA18955075
D009151Mustard GasMustard Gas results in increased expression of TTK mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TTK mRNA"15585362
D009532NickelNickel results in increased expression of TTK mRNA25583101
C022838nickel chloridenickel chloride affects the expression of TTK mRNA22546817
C028007nickel monoxidenickel monoxide results in increased expression of TTK mRNA19167457
C570897NSC668394NSC668394 results in decreased expression of TTK mRNA27137931
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TTK mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of TTK mRNA25729387
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of TTK mRNA25658374
D010126OzoneOzone results in increased expression of TTK mRNA25658374
C500026palbociclibpalbociclib results in decreased expression of TTK mRNA22869556
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TTK mRNA"25510870
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TTK mRNA24535843
D010634PhenobarbitalPhenobarbital results in increased expression of TTK mRNA23091169
D048789PhytoestrogensPhytoestrogens results in increased expression of TTK mRNA18310284
D010894PiroxicamCisplatin promotes the reaction [Piroxicam results in decreased expression of TTK mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of TTK mRNA21858171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TTK mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TTK mRNA22079256
C005556propionaldehydepropionaldehyde results in decreased expression of TTK mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of TTK mRNA24780913
D011794QuercetinQuercetin results in decreased expression of TTK mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of TTK mRNA19167446
C059514resveratrolresveratrol results in decreased expression of TTK mRNA15767336
C059514resveratrolresveratrol results in increased expression of TTK mRNA19167446
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of TTK mRNA19564919
D020123Sirolimus[fulvestrant co-treated with Sirolimus] results in decreased expression of TTK mRNA19016759
C017947sodium arsenitesodium arsenite results in decreased expression of TTK mRNA17998272
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of TTK mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of TTK mRNA21592394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of TTK mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TTK mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TTK mRNA22298810|2257421
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TTK mRNA26377647
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TTK mRNA25613284
D013792Thalidomide[Azacitidine co-treated with Thalidomide] affects the expression of TTK mRNA18720364
D019284ThapsigarginThapsigargin results in increased expression of TTK mRNA19442820
C009495titanium dioxidetitanium dioxide affects the expression of TTK mRNA17656681
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TTK mRNA25729387
D019772TopotecanTopotecan results in decreased expression of TTK mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of TTK mRNA"17951470
D014241TrichloroethyleneTrichloroethylene results in increased methylation of TTK gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTK mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TTK mRNA26272509
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TTK mRNA19042947
C001899triptolidetriptolide results in increased expression of TTK mRNA23639586
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TTK mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of TTK mRNA19140230
D014527Uric AcidNLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TTK mRNA]23619996
D014527Uric AcidUric Acid results in decreased expression of TTK mRNA23619996
D014635Valproic AcidValproic Acid results in decreased expression of TTK mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TTK gene25560391
D014747VinblastineTTK protein affects the susceptibility to Vinblastine16217747
C029297vinylidene chloridevinylidene chloride results in increased expression of TTK mRNA26682919
C088658zoledronic acidzoledronic acid results in decreased expression of TTK mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IEA-  
GO:0004712protein serine/threonine/tyrosine kinase activity-IEA-  
GO:0004713protein tyrosine kinase activity-IEA-  
GO:0005515protein binding-IPI19273613  
GO:0005524ATP binding-IEA-  
GO:0042803protein homodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007051spindle organization-TAS10366450  
GO:0007052mitotic spindle organization-TAS7737118  
GO:0007094mitotic spindle assembly checkpoint-TAS10366450  
GO:0008284positive regulation of cell proliferation-TAS1639825  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-TAS19018011  
GO:0016321female meiosis chromosome segregation-IEA-  
GO:0018105peptidyl-serine phosphorylation-IEA-  
GO:0018107peptidyl-threonine phosphorylation-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0033316meiotic spindle assembly checkpoint-IEA-  
GO:0034501protein localization to kinetochore-IEA-  
GO:0046777protein autophosphorylation-IEA-  
GO:0051304chromosome separation-IEA-  
GO:1903096protein localization to meiotic spindle midzone-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000776kinetochore-IEA-  
GO:0005737cytoplasm-IDA25468996  
GO:0005819spindle-TAS10366450  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
hsa04110Cell cycle
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19336859The prevalence of oral mucosal lesions in alcohol misusers in Chennai, south India. (2009 Jan-Mar)Rooban TIndian J Dent Res