Gene: TTN

7273
CMD1G|CMH9|CMPD4|EOMFC|HMERF|LGMD2J|MYLK5|SALMY|TMD
titin
protein-coding
2q31.2
Ensembl:ENSG00000155657 MIM:188840 Vega:OTTHUMG00000154448 UniprotKB:Q8WZ42
NG_011618.3
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.246e-2 (AD)  3.289e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17355446chr2:178724514 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XIRP20.891
AMPD10.815
NEB0.813
KLHL410.811
LMOD20.796
MYPN0.745
FLG0.738
TRIM630.736
NRAP0.728
HOXC90.722

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLEC11A-0.382
CLDND2-0.368
FAM229A-0.341
CCL27-0.338
C4orf48-0.312
BTBD17-0.311
FAM69C-0.307
HAGHL-0.299
PEMT-0.293
JOSD2-0.292

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine affects the expression of TTN mRNA]18096819
C5185762-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate"2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate results in decreased expression of TTN mRNA"17327690
D000082AcetaminophenAcetaminophen affects the expression of TTN mRNA17562736
C063261acetylleucyl-leucyl-norleucinalacetylleucyl-leucyl-norleucinal inhibits the reaction [Doxorubicin results in increased degradation of TTN protein]22532871
D020106AcrylamideAcrylamide results in decreased expression of TTN mRNA22197712
D020106AcrylamideAcrylamide results in increased expression of TTN mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TTN gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TTN mRNA16483693
D001280AtrazineAtrazine results in increased expression of TTN mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of TTN mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of TTN mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of TTN gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TTN mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TTN mRNA22228805
D004958EstradiolEstradiol results in decreased expression of TTN mRNA19484750|2521013
C006780bisphenol Abisphenol A affects the expression of TTN mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of TTN mRNA27178563
C006780bisphenol Abisphenol A results in increased expression of TTN mRNA18180321
D019274Botulinum Toxins, Type A"Botulinum Toxins, Type A results in decreased expression of TTN protein"19260067
D019274Botulinum Toxins, Type A"Botulinum Toxins, Type A results in increased expression of TTN mRNA"18603602
D002101Cacodylic AcidCacodylic Acid results in increased expression of TTN mRNA17441966
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TTN mRNA20360939
D002118CalciumCalcium affects the localization of TTN protein15662726
D002118Calcium[Ryanodine results in decreased abundance of Calcium] which affects the localization of TTN protein14745949
D002922CiguatoxinsCiguatoxins affects the expression of TTN mRNA18353800
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of TTN mRNA19000754
D002994ClofibrateClofibrate results in decreased expression of TTN mRNA22300585
D019327Copper SulfateCopper Sulfate results in increased expression of TTN mRNA19549813
C089595cylindrospermopsincylindrospermopsin results in decreased expression of TTN mRNA24921660
D003907DexamethasoneDexamethasone results in increased expression of TTN mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TTN mRNA21266533
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TTN mRNA20360939
D004317Doxorubicinacetylleucyl-leucyl-norleucinal inhibits the reaction [Doxorubicin results in increased degradation of TTN protein]22532871
D004317DoxorubicinDoxorubicin results in decreased expression of TTN mRNA22532871
D004317DoxorubicinDoxorubicin results in increased degradation of TTN protein22532871
C118739entinostatentinostat results in decreased expression of TTN mRNA27188386
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TTN protein18951874
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TTN mRNA"24972896
D008694MethamphetamineMethamphetamine results in increased expression of TTN mRNA26307267
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TTN mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine affects the methylation of TTN promoter"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TTN mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TTN protein26558463
C070571ML 7ML 7 affects the localization of TTN protein15662726
C523184mocetinostatmocetinostat results in decreased expression of TTN mRNA27255383
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of TTN mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of TTN protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of TTN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TTN mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TTN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TTN mRNA"25620056
D009532NickelNickel results in increased expression of TTN mRNA24768652
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of TTN mRNA27206323
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TTN mRNA27935865
C025256nonylphenolnonylphenol results in increased expression of TTN mRNA22982499
D052638Particulate Matter[TTN gene mutant form affects the susceptibility to Particulate Matter] which results in increased expression of TTN mRNA21222557|2122255
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TTN mRNA26794494
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TTN mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of TTN mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in decreased expression of TTN mRNA23608068
C045950propiconazolepropiconazole results in decreased expression of TTN mRNA21278054
D011794QuercetinQuercetin results in decreased expression of TTN protein19207037
C502851quinocetonequinocetone results in increased expression of TTN mRNA27046791
C059514resveratrolresveratrol results in decreased expression of TTN mRNA22610192
D012433RyanodineRyanodine affects the localization of TTN protein15662726
D012433Ryanodine[Ryanodine results in decreased abundance of Calcium] which affects the localization of TTN protein14745949
C017947sodium arsenitesodium arsenite results in increased expression of TTN mRNA28229933
D012969Sodium FluorideSodium Fluoride results in decreased expression of TTN mRNA27862939
D013096SpermineSpermine results in increased expression of TTN mRNA18673383
D014284Triiodothyronine2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine affects the expression of TTN mRNA]18096819
D014284TriiodothyronineAKT1 protein affects the reaction [Triiodothyronine affects the expression of TTN mRNA]18096819
D014284TriiodothyronineTriiodothyronine affects the expression of TTN mRNA18096819
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TTN mRNA21889950
D013792ThalidomideThalidomide results in decreased expression of TTN mRNA26006729|2621778
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TTN protein18951874
C009495titanium dioxidetitanium dioxide results in decreased expression of TTN mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TTN mRNA20133372
D014635Valproic AcidValproic Acid results in decreased methylation of TTN gene29154799
D001335Vehicle Emissions[TTN gene mutant form affects the susceptibility to Vehicle Emissions] which results in increased expression of TTN mRNA21222557|2122255
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TTN gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI9642272  
GO:0004674protein serine/threonine kinase activity-IDA9804419  
GO:0004713protein tyrosine kinase activity-IDA18765796  
GO:0005509calcium ion binding-IDA7607248  
GO:0005515protein binding-IPI7607248  9501083  11101506  11448995  11846417  12482578  
14583192  15582318  16902413  16962094  18157088  19622741  
20133654  20489725  20860623  23414517  25447537  
GO:0005516calmodulin binding-IPI7607248  
GO:0005516calmodulin binding-TAS10481174  
GO:0005524ATP binding-IEA-  
GO:0008307structural constituent of muscle-IBA21873635  
GO:0008307structural constituent of muscle-IMP9817758  11846417  
GO:0008307structural constituent of muscle-TAS7569978  
GO:0019899enzyme binding-IPI18310072  
GO:0019901protein kinase binding-IPI23283722  
GO:0031433telethonin binding-IPI11846417  15582318  
GO:0031433telethonin binding-ISS-  
GO:0042802identical protein binding-IPI9804419  23414517  
GO:0042805actinin binding-IDA9501083  
GO:0042805actinin binding-IPI11846417  
GO:0043621protein self-association-IDA9804419  
GO:0051015actin filament binding-IBA21873635  
GO:0051015actin filament binding-IDA9501083  
GO:0051371muscle alpha-actinin binding-IBA21873635  
GO:0051371muscle alpha-actinin binding-IPI9501083  
GO:0097493structural molecule activity conferring elasticity-TAS23283722  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0003300cardiac muscle hypertrophy-IMP11846417  
GO:0006936muscle contraction-NAS10481174  
GO:0006936muscle contraction-TAS11911777  
GO:0006941striated muscle contraction-IBA21873635  
GO:0006941striated muscle contraction-TAS7569978  
GO:0007015actin filament organization-IBA21873635  
GO:0007076mitotic chromosome condensation-IEP9548712  
GO:0010628positive regulation of gene expression-IGI25152160  
GO:0010628positive regulation of gene expression-IMP25152160  
GO:0010737protein kinase A signaling-IMP25152160  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0030049muscle filament sliding-TAS-  
GO:0030240skeletal muscle thin filament assembly-IBA21873635  
GO:0030240skeletal muscle thin filament assembly-IMP9817758  
GO:0030241skeletal muscle myosin thick filament assembly-IBA21873635  
GO:0030241skeletal muscle myosin thick filament assembly-IMP9817758  
GO:0035995detection of muscle stretch-IDA18765796  
GO:0035995detection of muscle stretch-TAS12507422  
GO:0045214sarcomere organization-IBA21873635  
GO:0045214sarcomere organization-IMP9817758  11846417  
GO:0045859regulation of protein kinase activity-IMP9804419  
GO:0048739cardiac muscle fiber development-IBA21873635  
GO:0048739cardiac muscle fiber development-IMP9817758  
GO:0048769sarcomerogenesis-IMP9817758  
GO:0050714positive regulation of protein secretion-IGI25152160  
GO:0050714positive regulation of protein secretion-IMP25152160  
GO:0050790regulation of catalytic activity-IMP9804419  
GO:0051592response to calcium ion-IDA7607248  
GO:0055003cardiac myofibril assembly-IBA21873635  
GO:0055003cardiac myofibril assembly-IMP9817758  11846417  
GO:0055008cardiac muscle tissue morphogenesis-IBA21873635  
GO:0055008cardiac muscle tissue morphogenesis-IMP9817758  
GO:0060048cardiac muscle contraction-IMP11846417  
GO:0071688striated muscle myosin thick filament assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000794condensed nuclear chromosome-IDA9548712  
GO:0005576extracellular region-TAS-  
GO:0005829cytosol-TAS-  
GO:0005859muscle myosin complex-IBA21873635  
GO:0005865striated muscle thin filament-IBA21873635  
GO:0030018Z disc-IBA21873635  
GO:0030018Z disc-IDA9501083  9817758  19850579  
GO:0031430M band-IBA21873635  
GO:0031674I band-IDA9817758  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-390522Striated Muscle ContractionTAS
R-HSA-397014Muscle contractionTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal