Gene: TTPA

7274
ATTP|AVED|TTP1|alphaTTP
alpha tocopherol transfer protein
protein-coding
8q12.3
Ensembl:ENSG00000137561 MIM:600415 Vega:OTTHUMG00000164367 UniprotKB:P49638
NG_016123.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.603e-1 (AD)  6.872e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RANBP3L0.861
GPAM0.854
SLC4A40.843
PPARA0.841
FAT10.837
GOLIM40.832
NT5E0.831
EDNRB0.828
TMEM470.826
PAX60.826

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HS3ST2-0.43
RHO-0.404
GAL-0.395
CACNA1F-0.395
DUSP27-0.394
NRG1-0.393
FHL2-0.391
DPP4-0.389
TRPV2-0.388
TRABD2A-0.384

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00163Vitamin ESmall Molecule59-02-9Approved|NutraceuticalCarrier
DB020801-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)BenzeneSmall MoleculeExperimentalCarrier
DB14001alpha-Tocopherol succinateSmall Molecule4345-03-3Approved|NutraceuticalCarrier
DB14002D-alpha-Tocopherol acetateSmall Molecule58-95-7Approved|NutraceuticalCarrier
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of TTPA mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of TTPA mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTPA mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTPA mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTPA mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTPA mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTPA mRNA"25510870
D000082AcetaminophenAcetaminophen results in decreased expression of TTPA mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in decreased expression of TTPA mRNA18346771
C006418adrenocorticotropin zincadrenocorticotropin zinc results in increased expression of TTPA mRNA19920212
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TTPA protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TTPA mRNA27153756
D024502alpha-TocopherolTTPA protein affects the export of alpha-Tocopherol11752462
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TTPA mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TTPA mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of TTPA mRNA22323515
D004958EstradiolEstradiol results in decreased expression of TTPA mRNA20106945
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of TTPA mRNA19693291
C006780bisphenol Abisphenol A results in decreased expression of TTPA mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TTPA mRNA18346771
D000068579CelecoxibCelecoxib results in increased expression of TTPA mRNA28201806
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of TTPA mRNA]16940432
D003300CopperCopper results in decreased expression of TTPA mRNA26293553
D016572CyclosporineCyclosporine results in decreased expression of TTPA mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of TTPA mRNA19770486
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TTPA mRNA]27941970
C000944dicrotophosdicrotophos results in decreased expression of TTPA mRNA28302478
D004026DieldrinDieldrin results in decreased expression of TTPA mRNA23153324
D004041Dietary FatsDietary Fats results in decreased expression of TTPA mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of TTPA mRNA19638242
D004317DoxorubicinDoxorubicin results in decreased expression of TTPA mRNA16404146
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TTPA mRNA16872691
D005485FlutamideFlutamide results in decreased expression of TTPA mRNA24136188|2479361
C039281furanfuran results in decreased expression of TTPA mRNA26194646
D005897GlafenineGlafenine results in decreased expression of TTPA mRNA24136188
D005912GliotoxinGliotoxin results in decreased expression of TTPA mRNA18346771
D007213IndomethacinIndomethacin results in increased expression of TTPA mRNA28201806
D028421IsoprostanesTTPA affects the abundance of Isoprostanes11095717
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TTPA mRNA24796395|2675264
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of TTPA mRNA"18346771
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of TTPA mRNA27167697
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of TTPA mRNA]16940432
C029938nickel sulfatenickel sulfate results in decreased expression of TTPA mRNA22714537
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of TTPA mRNA17616710
D010126OzoneGCLM gene mutant form promotes the reaction [Ozone results in increased expression of TTPA mRNA]20417186
D010126OzoneTTPA protein affects the reaction [Ozone results in decreased expression of ATP1A3 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in decreased expression of CD19 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in decreased expression of CR2 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in decreased expression of IFITM6 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in decreased expression of IGFBP3 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in decreased expression of NR1D1 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of AFP mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of AKR1B8 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of ANLN mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of AREG mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of ARG2 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of ASF1B mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of BIRC5 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of BRWD3 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of BUB1 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of CALCA mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of CCNA2 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of CCNB1 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of CCNB2 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of CDCA3 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of CEP55 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of CH25H mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of CKS1B mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of CLIP4 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of CTPS mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of CTSK mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of ECT2 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of EGR2 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of ERRFI1 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of F7 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of FIGNL1 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of GCLC mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of GINS4 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of HELLS mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of KIF22 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of KIF23 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of KPNA2 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of LCN2 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of LRG1 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of MAD2L1 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of MAL mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of MARCO mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of MBD1 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of MKI67 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of NCAPG2 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of NUSAP1 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of PBK mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of POLE mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of PRC1 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of PTGS2 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of RAD51 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of RETNLA mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of SAA3 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of SERPINA3N mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of SHCBP1 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of SLC26A4 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of SOCS3 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of SPAG5 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of SPC25 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of SPP1 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of TACC3 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of TC2N mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of TCF19 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of TIMP1 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of TK1 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of TNC mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of TNFSF9 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of TOP2A mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of TUBA6 mRNA]19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of UHRF1 mRNA]19555225
D010269ParaquatParaquat affects the expression of TTPA mRNA16854511
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTPA mRNA"25510870
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TTPA mRNA27153767
D010795Phthalic AcidsPhthalic Acids results in increased expression of TTPA mRNA21061450
D011192Potassium DichromatePotassium Dichromate results in increased expression of TTPA mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of TTPA mRNA19693291
D011441PropylthiouracilPropylthiouracil results in increased expression of TTPA mRNA24780913
D012834SilverSilver affects the expression of TTPA mRNA27131904
D012999SomanSoman results in decreased expression of TTPA mRNA19281266
D013739TestosteroneTestosterone results in increased expression of TTPA mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TTPA mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TTPA mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TTPA mRNA18796159|2121527
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of TTPA mRNA28973375
C009495titanium dioxidetitanium dioxide results in increased expression of TTPA mRNA23409001
D014241TrichloroethyleneTrichloroethylene results in increased expression of TTPA mRNA19448997
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TTPA mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TTPA mRNA29024780
C057693troglitazonetroglitazone results in increased expression of TTPA protein21315101
D014520UrethaneUrethane results in decreased expression of TTPA mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of TTPA mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of TTPA gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TTPA gene25560391
D014810Vitamin ETTPA gene mutant form results in decreased abundance of Vitamin E15300460|1956649
D014810Vitamin ETTPA protein mutant form results in decreased abundance of Vitamin E10896705|1530046
D014810Vitamin ETTPA results in increased susceptibility to Vitamin E20826775
D014810Vitamin ETTPA affects the abundance of Vitamin E11095717
D014810Vitamin ETTPA protein binds to Vitamin E20826775

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-ISS-  
GO:0008431vitamin E binding-IBA21873635  
GO:0008431vitamin E binding-ISS-  
GO:0043325phosphatidylinositol-3,4-bisphosphate binding-ISS-  
GO:0120013intermembrane lipid transfer activity-IBA21873635  
GO:0120013intermembrane lipid transfer activity-IEA-  
GO:1902936phosphatidylinositol bisphosphate binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001892embryonic placenta development-IEA-  
GO:0006629lipid metabolic process-TAS7887897  
GO:0007584response to nutrient-IEA-  
GO:0009268response to pH-IEA-  
GO:0009636response to toxic substance-IEA-  
GO:0042360vitamin E metabolic process-IBA21873635  
GO:0042360vitamin E metabolic process-TAS-  
GO:0051180vitamin transport-IBA21873635  
GO:0051180vitamin transport-ISS-  
GO:0051452intracellular pH reduction-IEA-  
GO:0060548negative regulation of cell death-IEA-  
GO:0090212negative regulation of establishment of blood-brain barrier-IEA-  
GO:0120009intermembrane lipid transfer-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005770late endosome-IBA21873635  
GO:0005770late endosome-IEA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-8877627Vitamin ETAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301419Ataxia with Vitamin E Deficiency (1993)Schuelke M-