Gene: TUB

7275
RDOB|rd5
tubby bipartite transcription factor
protein-coding
11p15.4
Ensembl:ENSG00000166402 MIM:601197 Vega:OTTHUMG00000165690 UniprotKB:P50607
NG_029912.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.687e-1 (AD)  8.170e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1406095chr11:8073135 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYFIP20.951
SEPT30.951
MTA30.947
ARHGEF90.946
USP220.941
C1orf210.94
ABR0.939
ASTN10.936
RBFOX20.936
IPO90.935

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.612
OR4F29-0.555
TFPI2-0.442
SGMS2-0.441
CSAG1-0.44
SNHG18-0.42
BEST3-0.416
SPINK8-0.414
RAI14-0.409
CST7-0.408

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02028(1R,2R,3S,4R,6S)-3,4,6-Trihydroxy-5-{[(S)-hydroxy(3-hydroxy-2-oxopropoxy)phosphoryl]oxy}-1,2-cyclohexanediyl bis[dihydrogen (phosphate)]Small MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TUB mRNA"23146750
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TUB mRNA"23146750
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TUB mRNA"23146750
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TUB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TUB mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TUB mRNA26690555
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TUB mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TUB mRNA24449571
D004958EstradiolEstradiol affects the expression of TUB mRNA22574217
C044887beta-methylcholinebeta-methylcholine affects the expression of TUB mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of TUB mRNA23146750
C006780bisphenol Abisphenol A results in increased expression of TUB mRNA25912373|2927551
C006780bisphenol Abisphenol A results in decreased expression of TUB mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TUB protein16249038
D002994ClofibrateClofibrate results in decreased expression of TUB mRNA12851107
D003300CopperCopper deficiency results in increased expression of TUB mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of TUB mRNA19549813
C057862cyanoginosin LRcyanoginosin LR affects the expression of TUB protein modified form22000993
C057862cyanoginosin LRcyanoginosin LR results in decreased acetylation of TUB protein22000993
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of TUB mRNA24317228
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of TUB mRNA]21095227
D003976DiazinonDiazinon results in increased methylation of TUB gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TUB mRNA27392435
D002945CisplatinCisplatin results in increased expression of TUB mRNA27392435
D002117CalcitriolCalcitriol results in decreased expression of TUB mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of TUB mRNA21592394
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TUB mRNA29097150
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TUB mRNA27392435
C544151jinfukangjinfukang results in increased expression of TUB mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TUB mRNA23430699
D007854LeadLead affects the expression of TUB mRNA28903495
C045463leflunomideleflunomide results in decreased expression of TUB mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of TUB mRNA12057914
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TUB mRNA12057914
D009532NickelNickel results in decreased expression of TUB mRNA24768652|2558310
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TUB mRNA23146750
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TUB mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TUB mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in decreased expression of TUB mRNA23608068
C059514resveratrolresveratrol results in increased expression of TUB mRNA25436977
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of TUB mRNA]21095227
C017947sodium arsenitesodium arsenite affects the methylation of TUB gene28589171
D018038Sodium SeleniteSodium Selenite results in decreased expression of TUB mRNA18175754
D013629TamoxifenTamoxifen results in increased expression of TUB mRNA25123088
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of TUB mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of TUB mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TUB mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TUB mRNA19465110
D014520UrethaneUrethane results in decreased expression of TUB mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of TUB mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TUB mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of TUB gene29154799
D014635Valproic AcidValproic Acid affects the expression of TUB mRNA17963808
D014638VanadatesVanadates results in increased expression of TUB mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0035091phosphatidylinositol binding-IBA21873635  
GO:0044877protein-containing complex binding-IDA20889716  
GO ID GO Term Qualifier Evidence PubMed
GO:0006910phagocytosis, recognition-IEA-  
GO:0007605sensory perception of sound-IEA-  
GO:0009725response to hormone-IEA-  
GO:0045494photoreceptor cell maintenance-IEA-  
GO:0050766positive regulation of phagocytosis-IDA19837063  
GO:0060041retina development in camera-type eye-IEA-  
GO:0061512protein localization to cilium-IBA21873635  
GO:0097500receptor localization to non-motile cilium-IBA21873635  
GO:1903546protein localization to photoreceptor outer segment-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-TAS11000483  
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0005929cilium-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28596927Necrotizing Pseudomonas aeruginosa Community-Acquired Pneumonia: A Case Report and Review of the Literature. (2017)Maharaj SCase Rep Infect Dis