Gene: TTR

7276
ATTR|CTS|CTS1|HEL111|HsT2651|PALB|TBPA
transthyretin
protein-coding
18q12.1
Ensembl:ENSG00000118271 MIM:176300 Vega:OTTHUMG00000131984 UniprotKB:P02766
NG_009490.1
PubMed
ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.841e-1 (AD)  6.017e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLIC60.595
AGTR10.557
AOX10.553
KBTBD130.552
TRDN0.535
FOXD20.534
GZMK0.533
IRX50.531
IRF60.519
RASSF90.515

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZFHX2-0.344
HIC2-0.336
FEZF2-0.331
RECQL4-0.324
PLK1-0.316
ANKRD24-0.316
GRAMD4-0.313
PROM2-0.312
DNASE1-0.312
FOXK1-0.306

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
DB00255DiethylstilbestrolSmall Molecule56-53-1Approved|InvestigationalCarrier
DB00279LiothyronineSmall Molecule6893-02-3ApprovedCarrier
DB00451LevothyroxineSmall Molecule51-48-9ApprovedCarrier
DB00586DiclofenacSmall Molecule15307-86-5ApprovedCarrier
DB00861DiflunisalSmall Molecule22494-42-4Approved|InvestigationalCarrier
DB01093Dimethyl sulfoxideSmall Molecule67-68-5ApprovedCarrier
DB01583LiotrixSmall Molecule8065-29-0ApprovedCarrier
DB01645GenisteinSmall Molecule446-72-0InvestigationalCarrier
DB017513,3',5,5'-Tetraiodothyroacetic AcidSmall MoleculeExperimentalCarrier
DB018386,4'-Dihydroxy-3-Methyl-3',5'-DibromoflavoneSmall MoleculeExperimentalCarrier
DB02179O-Trifluoromethylphenyl Anthranilic AcidSmall MoleculeExperimentalCarrier
DB02266Flufenamic AcidSmall Molecule530-78-9ExperimentalCarrier
DB024172,4,6-TribromophenolSmall Molecule118-79-6ExperimentalCarrier
DB02698N-(M-Trifluoromethylphenyl) Phenoxazine-4,6-Dicarboxylic AcidSmall MoleculeExperimentalCarrier
DB02709ResveratrolSmall Molecule501-36-0Approved|Experimental|InvestigationalCarrier
DB03167PentabromophenolSmall MoleculeExperimentalCarrier
DB032393',5'-Dinitro-N-Acetyl-L-ThyronineSmall MoleculeExperimentalCarrier
DB033463,5,3',5'-Tetrachloro-Biphenyl-4,4'-DiolSmall MoleculeExperimentalCarrier
DB03682Dibenzofuran-4,6-Dicarboxylic AcidSmall MoleculeExperimentalCarrier
DB044741-Anilino-8-Naphthalene SulfonateSmall MoleculeExperimentalCarrier
DB046742-HYDROXY-3,5-DIIODOBENZOIC ACIDSmall Molecule-ExperimentalCarrier
DB047562-[(3,5-Dichloro-4-trioxidanylphenyl)amino]benzoic acidSmall Molecule-ExperimentalCarrier
DB05235NRP409Small Molecule-InvestigationalCarrier
DB05352Fx-1006ASmall Molecule-InvestigationalCarrier
DB068853-[({(1E)-[2-(trifluoromethyl)phenyl]methylidene}amino)oxy]propanoic acidSmall MoleculeExperimentalCarrier
DB069072-(2,6-DICHLOROPHENYL)-1,3-BENZOXAZOLE-6-CARBOXYLIC ACIDSmall MoleculeExperimentalCarrier
DB069352',6'-DIFLUOROBIPHENYL-4-CARBOXYLIC ACIDSmall MoleculeExperimentalCarrier
DB070472',4'-DICHLORO-4-HYDROXY-1,1'-BIPHENYL-3-CARBOXYLIC ACIDSmall MoleculeExperimentalCarrier
DB071765-aminonaphthalene-1-sulfonic acidSmall MoleculeExperimentalCarrier
DB07201(2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acidSmall MoleculeExperimentalCarrier
DB072403-[(9H-fluoren-9-ylideneamino)oxy]propanoic acidSmall MoleculeExperimentalCarrier
DB072823-({[(1Z)-(2-methoxyphenyl)methylidene]amino}oxy)propanoic acidSmall MoleculeExperimentalCarrier
DB07693N-(3,5-dibromo-4-hydroxyphenyl)-2,6-dimethylbenzamideSmall MoleculeExperimentalCarrier
DB076942,5-dichloro-N-(3,5-dibromo-4-hydroxyphenyl)benzamideSmall MoleculeExperimentalCarrier
DB07695N-(3,5-dibromo-4-hydroxyphenyl)-4-hydroxy-3,5-dimethylbenzamideSmall MoleculeExperimentalCarrier
DB077533',5'-DIFLUOROBIPHENYL-4-CARBOXYLIC ACIDSmall MoleculeExperimentalCarrier
DB077753',5'-DIBROMO-2',4,4',6'-TETRAHYDROXY AURONESmall MoleculeExperimentalCarrier
DB07962METHYL N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINATESmall MoleculeExperimentalCarrier
DB07963N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINESmall MoleculeExperimentalCarrier
DB081002,6-dimethyl-4-[(E)-2-phenylethenyl]phenolSmall MoleculeExperimentalCarrier
DB081012,6-dibromo-4-[(E)-2-phenylethenyl]phenolSmall MoleculeExperimentalCarrier
DB081023,5-dibromobiphenyl-4-olSmall MoleculeExperimentalCarrier
DB081032,6-dibromo-4-phenoxyphenolSmall MoleculeExperimentalCarrier
DB08104N-(3,5-dibromo-4-hydroxyphenyl)benzamideSmall MoleculeExperimentalCarrier
DB082054-(1,3-BENZOXAZOL-2-YL)-2,6-DIMETHYLPHENOLSmall MoleculeExperimentalCarrier
DB082064-(1,3-BENZOXAZOL-2-YL)-2,6-DIBROMOPHENOLSmall MoleculeExperimentalCarrier
DB082072-(3,5-DIMETHYLPHENYL)-1,3-BENZOXAZOLESmall MoleculeExperimentalCarrier
ID Drug Name Action PubMed
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane affects the expression of TTR mRNA"24375616
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of TTR mRNA"15302862
C0271321-anilino-8-naphthalenesulfonate1-anilino-8-naphthalenesulfonate binds to TTR protein23584369
C0271321-anilino-8-naphthalenesulfonate"3,3'-dichlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]"23584369
C0271321-anilino-8-naphthalenesulfonate"3,4-dichlorinated biphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]"23584369
C0271321-anilino-8-naphthalenesulfonate4-chlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]23584369
C0271321-anilino-8-naphthalenesulfonateThyroxine inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]23584369
C5411312,2',3,3',4,4',5-heptachlorobiphenyl"2,2',3,3',4,4',5-heptachlorobiphenyl binds to TTR protein"21357386
C5411312,2',3,3',4,4',5-heptachlorobiphenyl"2,2',3,3',4,4',5-heptachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]"21357386
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl binds to TTR protein"21357386
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]"21357386
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTR mRNA"25510870
C5558592,2',4,4',5,6'-hexabromodiphenyl ether"2,2',4,4',5,6'-hexabromodiphenyl ether analog binds to TTR protein"20804816
C4776942,2',4,4',5-brominated diphenyl ether"2,2',4,4',5-brominated diphenyl ether inhibits the reaction [Triiodothyronine binds to TTR protein]"17553549
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TTR mRNA"22100034
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TTR mRNA"25544063
C5112952,2',4,4'-tetrabromodiphenyl ether"[perchlorate co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in decreased expression of TTR mRNA"24177579
C5112952,2',4,4'-tetrabromodiphenyl ether"[perchlorate co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in decreased expression of TTR protein"24177579
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog binds to TTR protein"20804816
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog inhibits the reaction [Thyroxine binds to TTR protein]"16601080
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine binds to TTR protein]"16601080
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog binds to TTR protein"19033396
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether analog binds to TTR protein] inhibits the reaction [Thyroxine binds to TTR protein]"19033396
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether analog binds to TTR protein] inhibits the reaction [Triiodothyronine binds to TTR protein]"19033396
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether binds to TTR protein"19033396
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether binds to TTR protein] inhibits the reaction [Thyroxine binds to TTR protein]"19033396
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether binds to TTR protein] inhibits the reaction [Triiodothyronine binds to TTR protein]"19033396
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog binds to TTR protein"19033396
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether analog binds to TTR protein] inhibits the reaction [Thyroxine binds to TTR protein]"19033396
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether analog binds to TTR protein] inhibits the reaction [Triiodothyronine binds to TTR protein]"19033396
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether binds to TTR protein"19033396
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether binds to TTR protein] inhibits the reaction [Thyroxine binds to TTR protein]"19033396
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether binds to TTR protein] inhibits the reaction [Triiodothyronine binds to TTR protein]"19033396
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TTR mRNA"17964624
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether binds to TTR protein"18161906
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine binds to TTR protein]"18161906
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether metabolite binds to TTR protein"18161906
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to TTR protein]"18161906
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Triiodothyronine binds to TTR protein]"17553549
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [Triiodothyronine binds to TTR protein]"17553549
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]"22859314
C5726252,2',4,5'-tetrabromodiphenyl ether"2,2',4,5'-tetrabromodiphenyl ether inhibits the reaction [Triiodothyronine binds to TTR protein]"17553549
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TTR mRNA"19114083
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in decreased expression of TTR mRNA"24713691
C0445782,3,5,6-tetrachlorohydroquinone"2,3,5,6-tetrachlorohydroquinone binds to TTR protein"2043046
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of TTR mRNA"24713691
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTR mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl binds to TTR protein"21357386
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]"21357386
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTR mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of TTR protein"24878560
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTR mRNA"25510870
C0045542,4,6-tribromophenol"2,4,6-tribromophenol binds to TTR protein"10869457
C0668592,4,6-triiodophenol"2,4,6-triiodophenol inhibits the reaction [Triiodothyronine binds to TTR protein]"15590892
C0139302,4-dibromophenol"2,4-dibromophenol binds to TTR protein"10869457
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTR mRNA"25510870
C5611572'-hydroxy-2,3',4,5'-tetrabromodipheyl ether"2'-hydroxy-2,3',4,5'-tetrabromodipheyl ether binds to TTR protein"20804816
C0912382-isopropylphenol2-isopropylphenol inhibits the reaction [Triiodothyronine binds to TTR protein]15590892
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of TTR mRNA"20206263
C0354062-tert-butylphenol2-tert-butylphenol inhibits the reaction [Triiodothyronine binds to TTR protein]15590892
C0299063,3'-dichlorobiphenyl"3,3'-dichlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]"23584369
C5346793,3'-dichlorobisphenol A"3,3'-dichlorobisphenol A inhibits the reaction [Triiodothyronine binds to TTR protein]"15590892
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl metabolite inhibits the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]"22859314
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TTR"20965207
C5815813,4-dichlorinated biphenyl"3,4-dichlorinated biphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]"23584369
C0857943,5-dibromo-2-(2,4-dibromophenoxy)phenol"3,5-dibromo-2-(2,4-dibromophenoxy)phenol analog binds to TTR protein"20804816
C0299043,5-dichlorobiphenyl"3,5-dichlorobiphenyl metabolite inhibits the reaction [Thyroxine binds to TTR protein]"16478101
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTR mRNA"27188386
C0069834-chlorobiphenyl4-chlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]23584369
C0415944-nonylphenol4-nonylphenol inhibits the reaction [Triiodothyronine binds to TTR protein]13129501
C0415944-nonylphenol4-nonylphenol analog inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
C0415944-nonylphenol4-nonylphenol inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
C0415944-nonylphenol4-nonylphenol analog inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
C0415944-nonylphenol4-nonylphenol inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
C0415944-nonylphenol4-nonylphenol analog inhibits the reaction [Triiodothyronine binds to TTR protein]15590892
C0415944-nonylphenol4-nonylphenol inhibits the reaction [Triiodothyronine binds to TTR protein]15590892
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTR mRNA"27188386
C5805996-OH-BDE-476-OH-BDE-47 results in decreased expression of TTR mRNA23110413
C5155948-anilino-1-naphthalenesulfonic acid"2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]"22859314
C5155948-anilino-1-naphthalenesulfonic acid"3,4,3',4'-tetrachlorobiphenyl metabolite inhibits the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]"22859314
C5155948-anilino-1-naphthalenesulfonic acid8-anilino-1-naphthalenesulfonic acid binds to TTR protein22859314
C5155948-anilino-1-naphthalenesulfonic acidArachidonic Acid affects the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]22859314
C5155948-anilino-1-naphthalenesulfonic acidlauric acid inhibits the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]22859314
C5155948-anilino-1-naphthalenesulfonic acidLinoleic Acid affects the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]22859314
C5155948-anilino-1-naphthalenesulfonic acidMyristic Acid inhibits the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]22859314
C5155948-anilino-1-naphthalenesulfonic acidOleic Acid affects the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]22859314
C5155948-anilino-1-naphthalenesulfonic acidPalmitic Acid affects the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]22859314
C5155948-anilino-1-naphthalenesulfonic acidThyroxine inhibits the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]22859314
D000082AcetaminophenAcetaminophen results in decreased expression of TTR mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of TTR mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of TTR mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TTR mRNA]17585979
D000082AcetaminophenAcetaminophen affects the expression of TTR protein16687475
D000082AcetaminophenAcetaminophen results in decreased expression of TTR mRNA17522070
C043377acetochloracetochlor results in decreased expression of TTR mRNA26397822
D000143AcidsAcids results in decreased folding of TTR protein15469931
D000143AcidsDiethylstilbestrol inhibits the reaction [Acids results in decreased folding of TTR protein]15469931
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TTR protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TTR gene27153756
C103303alitretinoinalitretinoin results in decreased expression of TTR mRNA16648578
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TTR mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of TTR mRNA"22863853
D016718Arachidonic AcidArachidonic Acid affects the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]22859314
D001151ArsenicArsenic affects the methylation of TTR gene25304211
C041512benzo(b)fluorene[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in decreased expression of TTR mRNA22120849
D053119Benzophenanthridines[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in decreased expression of TTR mRNA22120849
D053119BenzophenanthridinesBenzophenanthridines analog results in decreased expression of TTR mRNA22120849
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TTR mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TTR mRNA22228805|2719552
D004958EstradiolEstradiol results in increased expression of TTR mRNA17522070|2006800
C095105bexarotenebexarotene results in decreased expression of TTR mRNA16648578
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of TTR mRNA26894911
C006780bisphenol Abisphenol A inhibits the reaction [Triiodothyronine binds to TTR protein]13129501
C006780bisphenol Abisphenol A analog inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
C006780bisphenol Abisphenol A inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
C006780bisphenol Abisphenol A binds to TTR protein21517007
C006780bisphenol Abisphenol A inhibits the reaction [Thyroxine binds to TTR protein]16478101
C006780bisphenol Abisphenol A analog inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
C006780bisphenol Abisphenol A inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
C006780bisphenol A[bisphenol A co-treated with Genistein] results in decreased methylation of TTR gene28505145
C006780bisphenol Abisphenol A results in decreased expression of TTR mRNA25181051
C006780bisphenol Abisphenol A results in decreased methylation of TTR gene28505145
C006780bisphenol A[Fructose co-treated with bisphenol A] results in increased expression of TTR protein26930160
C006780bisphenol Abisphenol A analog inhibits the reaction [Triiodothyronine binds to TTR protein]15590892
C006780bisphenol Abisphenol A inhibits the reaction [Triiodothyronine binds to TTR protein]15590892
C032036bromobenzenebromobenzene metabolite binds to TTR protein12018992
C006826bromoxynilbromoxynil binds to TTR protein2043046
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of TTR mRNA12082028
C027561butylbenzyl phthalatebutylbenzyl phthalate inhibits the reaction [Triiodothyronine binds to TTR protein]13129501
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TTR mRNA18804290
D002104CadmiumTTR protein binds to Cadmium23896426
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TTR mRNA17582521
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TTR mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TTR mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TTR mRNA17522070
C084597chlorcyclizinechlorcyclizine results in increased expression of TTR mRNA21058326
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of TTR mRNA16720020
D002725ChloroformChloroform results in decreased expression of TTR mRNA17522070
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of TTR mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TTR mRNA]17585979
D002994ClofibrateClofibrate results in decreased expression of TTR mRNA1280124|12851107
D002994ClofibrateClofibrate results in decreased expression of TTR mRNA16896063
D003024ClozapineClozapine results in decreased expression of TTR mRNA17266109
D003024ClozapineClozapine results in increased expression of TTR mRNA15927202
D003024ClozapineClozapine results in increased expression of TTR protein15927202
C018021cobaltous chloridecobaltous chloride results in decreased expression of TTR mRNA24386269
D003300CopperCopper affects the reaction [TTR protein mutant form binds to TTR protein mutant form]17630783
D003300CopperTTR protein binds to Copper23896426
D003300CopperCopper deficiency results in increased expression of TTR protein18993053
D019327Copper SulfateCopper Sulfate results in decreased expression of TTR mRNA19549813
D003471CuprizoneCuprizone results in increased expression of TTR mRNA26577399
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of TTR mRNA17654400
D016572CyclosporineCyclosporine results in decreased expression of TTR mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased secretion of TTR protein21354196
D003634DDTDDT results in decreased expression of TTR mRNA19797855
C010902decabromobiphenyl etherdecabromobiphenyl ether analog results in decreased expression of TTR mRNA25222814
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of TTR mRNA21901812
D003907DexamethasoneDexamethasone results in decreased expression of TTR mRNA17522070
D003976DiazinonDiazinon results in decreased expression of TTR mRNA29108742
C558403dibromodiphenyl etherdibromodiphenyl ether analog binds to TTR protein20804816
D002945CisplatinCisplatin results in increased secretion of TTR protein28885000
D003633Dichlorodiphenyl Dichloroethylene"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of TTR protein"24878560
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in decreased expression of TTR protein21512963
D004008DiclofenacDiclofenac results in increased expression of TTR protein23506792
D004010DicofolDicofol inhibits the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
D004010DicofolDicofol promotes the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
D004010DicofolDicofol binds to TTR protein2043046
D004041Dietary FatsDietary Fats results in increased expression of TTR mRNA18457598|2501614
D004054DiethylstilbestrolDiethylstilbestrol inhibits the reaction [Triiodothyronine binds to TTR protein]13129501
D004054DiethylstilbestrolDiethylstilbestrol binds to TTR protein12581883
D004054DiethylstilbestrolDiethylstilbestrol inhibits the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
D004054DiethylstilbestrolDiethylstilbestrol inhibits the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
D004054DiethylstilbestrolDiethylstilbestrol binds to TTR protein15469931
D004054DiethylstilbestrolDiethylstilbestrol inhibits the reaction [Acids results in decreased folding of TTR protein]15469931
D004054DiethylstilbestrolDiethylstilbestrol inhibits the reaction [Thyroxine binds to TTR protein]15469931
D004061DiflunisalDiflunisal binds to TTR protein mutant form17701470
D004061Diflunisal[Diflunisal binds to TTR protein mutant form] which results in decreased susceptibility to Urea17701470
D004061DiflunisalDiflunisal promotes the reaction [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein]18326041
D004077DigoxinABCB1 gene mutant form affects the reaction [Digoxin affects the expression of TTR mRNA]25419811
D004237DiuronDiuron results in increased expression of TTR mRNA25152437
C084101doramectinABCB1 gene mutant form affects the reaction [doramectin affects the expression of TTR mRNA]25419811
D004317DoxorubicinDoxorubicin results in increased secretion of TTR protein28885000
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of TTR mRNA17522070
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TTR mRNA12082028
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TTR mRNA17157075|2355070
D005411Flame RetardantsFlame Retardants results in decreased expression of TTR mRNA19945756
D005411Flame RetardantsFlame Retardants results in decreased expression of TTR mRNA18482827
D005411Flame RetardantsFlame Retardants results in increased expression of TTR mRNA21901812
D005411Flame RetardantsFlame Retardants inhibits the reaction [Thyroxine binds to TTR protein]18161906
D005411Flame RetardantsFlame Retardants results in decreased expression of TTR mRNA18983098
D005411Flame RetardantsFlame Retardants inhibits the reaction [Triiodothyronine binds to TTR protein]17553549
D0150732-AcetylaminofluoreneTRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of TTR mRNA]17317680
D005473FluoxetineFluoxetine results in increased expression of TTR mRNA17105902
D005485FlutamideFlutamide results in increased expression of TTR mRNA24793618
D004397FonofosFonofos results in increased methylation of TTR promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of TTR mRNA17285311
D005632Fructose[Fructose co-treated with bisphenol A] results in increased expression of TTR protein26930160
C056933fumonisin B1fumonisin B1 results in decreased expression of TTR mRNA16221962
C039281furanfuran binds to TTR protein22240984
C039281furanfuran results in increased methylation of TTR gene22079235
D019833Genistein[bisphenol A co-treated with Genistein] results in decreased methylation of TTR gene28505145
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of TTR mRNA22634610
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers analog inhibits the reaction [Thyroxine binds to TTR protein]16601080
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers metabolite binds to TTR protein10869457
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers inhibits the reaction [Triiodothyronine binds to TTR protein]17553549
D006540HerbicidesHerbicides inhibits the reaction [Triiodothyronine binds to TTR protein]17553549
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of TTR mRNA18791181
D006581HexachlorobenzeneHexachlorobenzene binds to TTR protein2043046
C527454hexachlorocyclopentadienyl-dibromocyclooctanehexachlorocyclopentadienyl-dibromocyclooctane results in decreased expression of TTR mRNA21893176
C409722hexaconazolehexaconazole results in increased expression of TTR mRNA23685399
D017313FenretinideFenretinide analog inhibits the reaction [Vitamin A promotes the reaction [RBP4 protein binds to TTR protein]]21591606
D017313Fenretinide[Fenretinide binds to RBP4 protein] inhibits the reaction [RBP4 protein binds to TTR protein]21591606
C029424hydrazinehydrazine results in decreased expression of TTR protein15370871
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in increased expression of TTR mRNA"18077114
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TTR mRNA20044591
C008161ioxynilioxynil inhibits the reaction [Triiodothyronine binds to TTR protein]13129501
C008161ioxynilioxynil binds to TTR protein12581883
C008161ioxynilioxynil inhibits the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
C008161ioxynilioxynil inhibits the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
D007545IsoproterenolIsoproterenol results in increased expression of TTR mRNA20003209
D007559IvermectinABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of TTR mRNA]25419811
C410337K 7174K 7174 results in decreased expression of TTR mRNA24086573
C030358lauric acidlauric acid inhibits the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]22859314
D007854LeadLead results in decreased expression of TTR mRNA25703175
D007854Leadtitanium dioxide promotes the reaction [Lead results in decreased expression of TTR mRNA]25703175
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of TTR mRNA19136613
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TTR mRNA12057914
D008294MalathionMalathion inhibits the reaction [Triiodothyronine binds to TTR protein]13129501
C042720mercuric bromidemercuric bromide results in increased expression of TTR mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTR mRNA"27188386
D008727MethotrexateMethotrexate results in decreased expression of TTR mRNA15120968
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of TTR mRNA18077114
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TTR mRNA"20188158
C027837milbemycinABCB1 gene mutant form affects the reaction [milbemycin affects the expression of TTR mRNA]25419811
D009020MorphineMorphine deficiency affects the reaction [Morphine results in decreased expression of TTR protein]23056601
D009020MorphineMorphine results in decreased expression of TTR protein23056601
D019814Myristic AcidMyristic Acid inhibits the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]22859314
C031721naphthalenenaphthalene metabolite binds to TTR protein16206326
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of TTR mRNA17522070
D009532NickelTTR protein binds to Nickel23896426
C022838nickel chloridenickel chloride affects the expression of TTR mRNA22110744
D009570NitrilesNitriles inhibits the reaction [Triiodothyronine binds to TTR protein]17553549
C007350nitrofennitrofen results in decreased expression of TTR protein22015466
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of TTR protein19716841
D019787Linoleic AcidLinoleic Acid affects the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]22859314
D019301Oleic AcidOleic Acid affects the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]22859314
C076029olanzapineolanzapine results in increased expression of TTR mRNA15927202
D019308Palmitic AcidPalmitic Acid affects the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]22859314
D010269ParaquatParaquat results in decreased expression of TTR mRNA21371552
D010278ParathionParathion results in increased methylation of TTR promoter22847954
D052638Particulate MatterParticulate Matter results in increased expression of TTR protein17520064
C410127PCB 180PCB 180 binds to TTR protein21357386
C410127PCB 180PCB 180 inhibits the reaction [Thyroxine binds to TTR protein]21357386
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TTR mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of TTR mRNA19945756|2203983
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of TTR mRNA18482827|1879118
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog binds to TTR protein20804816
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of TTR mRNA18983098
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of TTR mRNA18978342
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of TTR protein19954255
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of TTR protein19954255
C098189pentabromophenolpentabromophenol binds to TTR protein10869457
D010416PentachlorophenolPentachlorophenol inhibits the reaction [Triiodothyronine binds to TTR protein]13129501
D010416PentachlorophenolPentachlorophenol binds to TTR protein12581883
D010416PentachlorophenolPentachlorophenol inhibits the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
D010416PentachlorophenolPentachlorophenol inhibits the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
C494474perchlorate"[perchlorate co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in decreased expression of TTR mRNA"24177579
C494474perchlorate"[perchlorate co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in decreased expression of TTR protein"24177579
C539348perfluorobutanesulfonic acidperfluorobutanesulfonic acid affects the reaction [Thyroxine binds to TTR protein]27528273
C033094perfluorobutyric acidperfluorobutyric acid affects the reaction [Thyroxine binds to TTR protein]27528273
C036567perfluorodecanoic acidperfluorodecanoic acid affects the reaction [Thyroxine binds to TTR protein]27528273
C522391perfluorododecanoic acidperfluorododecanoic acid affects the reaction [Thyroxine binds to TTR protein]27528273
C000610525perfluoroheptanoic acidperfluoroheptanoic acid affects the reaction [Thyroxine binds to TTR protein]27528273
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of TTR mRNA21212296
C479228perfluorohexanoic acidperfluorohexanoic acid affects the reaction [Thyroxine binds to TTR protein]27528273
C101815perfluoro-n-heptanoic acidperfluoro-n-heptanoic acid results in increased expression of TTR mRNA21212296
C584865perfluorononanoic acidperfluorononanoic acid affects the reaction [Thyroxine binds to TTR protein]27528273
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TTR mRNA19703701
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the reaction [Thyroxine binds to TTR protein]27528273
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of TTR mRNA20136073
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of TTR mRNA19924978
C023036perfluorooctanoic acidperfluorooctanoic acid affects the reaction [Thyroxine binds to TTR protein]27528273
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TTR mRNA18804290
C586085perfluoroundecanoic acidperfluoroundecanoic acid affects the reaction [Thyroxine binds to TTR protein]27528273
D026023PermethrinPermethrin results in decreased expression of TTR protein26631339
D010622PhencyclidinePhencyclidine results in decreased expression of TTR mRNA17266109
D010634PhenobarbitalPhenobarbital results in increased expression of TTR mRNA12082028
D010636PhenolsPhenols inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
D010636PhenolsPhenols inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTR mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TTR mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of TTR mRNA21061450
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of TTR mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of TTR mRNA15302862|1622196
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of TTR mRNA]20059764
C006253pirinixic acidpirinixic acid affects the expression of TTR protein16099942
D010936Plant ExtractsPlant Extracts results in decreased expression of TTR mRNA23557933
D011075Polybrominated BiphenylsPolybrominated Biphenyls analog binds to TTR protein10869457
D011075Polybrominated BiphenylsPolybrominated Biphenyls inhibits the reaction [Triiodothyronine binds to TTR protein]16627555
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog binds to TTR protein10631123
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog inhibits the reaction [Thyroxine binds to TTR protein]10631123
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls binds to TTR protein10631123
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls binds to TTR protein19033396
D011078Polychlorinated Biphenyls[Polychlorinated Biphenyls binds to TTR protein] inhibits the reaction [Thyroxine binds to TTR protein]19033396
D011078Polychlorinated Biphenyls[Polychlorinated Biphenyls binds to TTR protein] inhibits the reaction [Triiodothyronine binds to TTR protein]19033396
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls binds to TTR protein19033396
D011078Polychlorinated Biphenyls[Polychlorinated Biphenyls binds to TTR protein] inhibits the reaction [Thyroxine binds to TTR protein]19033396
D011078Polychlorinated Biphenyls[Polychlorinated Biphenyls binds to TTR protein] inhibits the reaction [Triiodothyronine binds to TTR protein]19033396
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls metabolite binds to TTR protein15254343
D011374ProgesteroneNCOA2 protein affects the reaction [Progesterone results in increased expression of TTR mRNA]17556502
D011374ProgesteroneProgesterone results in increased expression of TTR mRNA17556502
C005556propionaldehydepropionaldehyde results in decreased expression of TTR mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of TTR mRNA24780913
D011441PropylthiouracilPropylthiouracil results in increased expression of TTR mRNA18077114
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of TTR protein19264907
D011794QuercetinQuercetin results in decreased expression of TTR mRNA21632981
D015125OxyquinolineOxyquinoline results in increased expression of TTR mRNA21632981
C447880retene[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in decreased expression of TTR mRNA22120849
D012822Silicon DioxideSilicon Dioxide analog affects the expression of TTR mRNA25895662
D012834SilverSilver results in decreased expression of TTR mRNA26014281
C017947sodium arsenitesodium arsenite results in increased expression of TTR mRNA12760830
C017947sodium arsenitesodium arsenite affects the expression of TTR mRNA17450228
C016104sodium bichromatesodium bichromate affects the expression of TTR mRNA22110744
D013311StreptozocinStreptozocin results in decreased expression of TTR protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in decreased expression of TTR protein]19634143
D014284TriiodothyronineTriiodothyronine binds to TTR protein12649043
D014284Triiodothyronine"Water Pollutants, Chemical inhibits the reaction [Triiodothyronine binds to TTR protein]"12649043
D014284Triiodothyronine4-nonylphenol inhibits the reaction [Triiodothyronine binds to TTR protein]13129501
D014284Triiodothyroninebisphenol A inhibits the reaction [Triiodothyronine binds to TTR protein]13129501
D014284Triiodothyroninebutylbenzyl phthalate inhibits the reaction [Triiodothyronine binds to TTR protein]13129501
D014284TriiodothyronineDiethylstilbestrol inhibits the reaction [Triiodothyronine binds to TTR protein]13129501
D014284Triiodothyronineioxynil inhibits the reaction [Triiodothyronine binds to TTR protein]13129501
D014284TriiodothyronineMalathion inhibits the reaction [Triiodothyronine binds to TTR protein]13129501
D014284TriiodothyroninePentachlorophenol inhibits the reaction [Triiodothyronine binds to TTR protein]13129501
D014284TriiodothyronineTriiodothyronine binds to TTR protein13129501
D014284Triiodothyronine4-nonylphenol analog inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
D014284Triiodothyronine4-nonylphenol inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
D014284Triiodothyroninebisphenol A analog inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
D014284Triiodothyroninebisphenol A inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
D014284TriiodothyronineDiethylstilbestrol inhibits the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
D014284Triiodothyronineioxynil inhibits the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
D014284TriiodothyroninePentachlorophenol inhibits the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
D014284TriiodothyroninePhenols inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
D014284TriiodothyronineTriiodothyronine binds to TTR protein12649043
D014284TriiodothyronineTriiodothyronine results in decreased expression of TTR mRNA21212296
D014284Triiodothyronine"Water Pollutants, Chemical inhibits the reaction [Triiodothyronine binds to TTR protein]"12649043
D014284TriiodothyronineTriiodothyronine binds to TTR protein20804816|2151700
D014284Triiodothyronine"[2,2',4,4'-tetrabromodiphenyl ether analog binds to TTR protein] inhibits the reaction [Triiodothyronine binds to TTR protein]"19033396
D014284Triiodothyronine"[2,2',4,4'-tetrabromodiphenyl ether binds to TTR protein] inhibits the reaction [Triiodothyronine binds to TTR protein]"19033396
D014284Triiodothyronine[Polychlorinated Biphenyls binds to TTR protein] inhibits the reaction [Triiodothyronine binds to TTR protein]19033396
D014284TriiodothyronineTriiodothyronine binds to TTR protein19033396
D014284TriiodothyronineTriiodothyronine results in decreased expression of TTR mRNA18983098
D014284Triiodothyronine"[2,2',4,4'-tetrabromodiphenyl ether analog binds to TTR protein] inhibits the reaction [Triiodothyronine binds to TTR protein]"19033396
D014284Triiodothyronine"[2,2',4,4'-tetrabromodiphenyl ether binds to TTR protein] inhibits the reaction [Triiodothyronine binds to TTR protein]"19033396
D014284Triiodothyronine[Polychlorinated Biphenyls binds to TTR protein] inhibits the reaction [Triiodothyronine binds to TTR protein]19033396
D014284TriiodothyronineTriiodothyronine binds to TTR protein19033396
D014284Triiodothyronine4-nonylphenol analog inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
D014284Triiodothyronine4-nonylphenol inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
D014284Triiodothyroninebisphenol A analog inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
D014284Triiodothyroninebisphenol A inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
D014284TriiodothyronineDicofol inhibits the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
D014284TriiodothyronineDicofol promotes the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
D014284TriiodothyronineDiethylstilbestrol inhibits the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
D014284Triiodothyronineioxynil inhibits the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
D014284TriiodothyroninePentachlorophenol inhibits the reaction [Triiodothyronine metabolite binds to TTR protein]12581883
D014284TriiodothyroninePhenols inhibits the reaction [Triiodothyronine binds to TTR protein]12649043
D014284TriiodothyronineTriiodothyronine binds to TTR protein12649043
D014284Triiodothyronine"Water Pollutants, Chemical inhibits the reaction [Triiodothyronine binds to TTR protein]"12649043
D014284Triiodothyronine"2,2',4,4',5-brominated diphenyl ether inhibits the reaction [Triiodothyronine binds to TTR protein]"17553549
D014284Triiodothyronine"2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Triiodothyronine binds to TTR protein]"17553549
D014284Triiodothyronine"2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [Triiodothyronine binds to TTR protein]"17553549
D014284Triiodothyronine"2,2',4,5'-tetrabromodiphenyl ether inhibits the reaction [Triiodothyronine binds to TTR protein]"17553549
D014284TriiodothyronineFlame Retardants inhibits the reaction [Triiodothyronine binds to TTR protein]17553549
D014284TriiodothyronineHalogenated Diphenyl Ethers inhibits the reaction [Triiodothyronine binds to TTR protein]17553549
D014284TriiodothyronineHerbicides inhibits the reaction [Triiodothyronine binds to TTR protein]17553549
D014284TriiodothyronineNitriles inhibits the reaction [Triiodothyronine binds to TTR protein]17553549
D014284Triiodothyroninetetrabromobisphenol A inhibits the reaction [Triiodothyronine binds to TTR protein]17553549
D014284TriiodothyronineThyroxine inhibits the reaction [Triiodothyronine binds to TTR protein]17553549
D014284TriiodothyronineTriiodothyronine binds to TTR protein17553549
D014284Triiodothyronine"2,4,6-triiodophenol inhibits the reaction [Triiodothyronine binds to TTR protein]"15590892
D014284Triiodothyronine2-isopropylphenol inhibits the reaction [Triiodothyronine binds to TTR protein]15590892
D014284Triiodothyronine2-tert-butylphenol inhibits the reaction [Triiodothyronine binds to TTR protein]15590892
D014284Triiodothyronine"3,3'-dichlorobisphenol A inhibits the reaction [Triiodothyronine binds to TTR protein]"15590892
D014284Triiodothyronine4-nonylphenol analog inhibits the reaction [Triiodothyronine binds to TTR protein]15590892
D014284Triiodothyronine4-nonylphenol inhibits the reaction [Triiodothyronine binds to TTR protein]15590892
D014284Triiodothyroninebisphenol A analog inhibits the reaction [Triiodothyronine binds to TTR protein]15590892
D014284Triiodothyroninebisphenol A inhibits the reaction [Triiodothyronine binds to TTR protein]15590892
D014284TriiodothyroninePolybrominated Biphenyls inhibits the reaction [Triiodothyronine binds to TTR protein]16627555
D014284Triiodothyroninetetrachlorodian inhibits the reaction [Triiodothyronine binds to TTR protein]15590892
D014284TriiodothyronineTriiodothyronine binds to TTR protein16627555
C547076tafamidistafamidis promotes the reaction [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein]25595224
C061133tamibarotenetamibarotene results in increased expression of TTR mRNA20138974
C087114tebuconazoletebuconazole results in increased expression of TTR mRNA23685399
C012568terbufosterbufos results in increased methylation of TTR promoter22847954
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of TTR mRNA22100034|2554406
C020806tetrabromobisphenol Atetrabromobisphenol A binds to TTR protein10869457
C020806tetrabromobisphenol Atetrabromobisphenol A inhibits the reaction [Thyroxine binds to TTR protein]16478101|1660108
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of TTR mRNA26988606
C020806tetrabromobisphenol Atetrabromobisphenol A inhibits the reaction [Triiodothyronine binds to TTR protein]17553549
C041181tetrachlorodiantetrachlorodian binds to TTR protein10869457
C041181tetrachlorodiantetrachlorodian inhibits the reaction [Thyroxine binds to TTR protein]16478101
C041181tetrachlorodiantetrachlorodian inhibits the reaction [Triiodothyronine binds to TTR protein]15590892
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TTR mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TTR mRNA24713691
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TTR mRNA15644576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TTR protein15822908
D013752TetracyclineTetracycline results in decreased expression of TTR mRNA17522070
D013974Thyroxine"2,2',3,3',4,4',5-heptachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]"21357386
D013974Thyroxine"2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]"21357386
D013974Thyroxine"2,2',4,4'-tetrabromodiphenyl ether analog inhibits the reaction [Thyroxine binds to TTR protein]"16601080
D013974Thyroxine"2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine binds to TTR protein]"16601080
D013974Thyroxine"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]"21357386
D013974Thyroxine"3,5-dichlorobiphenyl metabolite inhibits the reaction [Thyroxine binds to TTR protein]"16478101
D013974Thyroxinebisphenol A inhibits the reaction [Thyroxine binds to TTR protein]16478101
D013974ThyroxineFlame Retardants inhibits the reaction [Thyroxine binds to TTR protein]18161906
D013974ThyroxineHalogenated Diphenyl Ethers analog inhibits the reaction [Thyroxine binds to TTR protein]16601080
D013974ThyroxinePCB 180 inhibits the reaction [Thyroxine binds to TTR protein]21357386
D013974Thyroxineperfluorobutanesulfonic acid affects the reaction [Thyroxine binds to TTR protein]27528273
D013974Thyroxineperfluorobutyric acid affects the reaction [Thyroxine binds to TTR protein]27528273
D013974Thyroxineperfluorodecanoic acid affects the reaction [Thyroxine binds to TTR protein]27528273
D013974Thyroxineperfluorododecanoic acid affects the reaction [Thyroxine binds to TTR protein]27528273
D013974Thyroxineperfluoroheptanoic acid affects the reaction [Thyroxine binds to TTR protein]27528273
D013974Thyroxineperfluorohexanoic acid affects the reaction [Thyroxine binds to TTR protein]27528273
D013974Thyroxineperfluorononanoic acid affects the reaction [Thyroxine binds to TTR protein]27528273
D013974Thyroxineperfluorooctane sulfonic acid affects the reaction [Thyroxine binds to TTR protein]27528273
D013974Thyroxineperfluorooctanoic acid affects the reaction [Thyroxine binds to TTR protein]27528273
D013974Thyroxineperfluoroundecanoic acid affects the reaction [Thyroxine binds to TTR protein]27528273
D013974ThyroxinePolychlorinated Biphenyls analog inhibits the reaction [Thyroxine binds to TTR protein]10631123
D013974Thyroxinetetrabromobisphenol A inhibits the reaction [Thyroxine binds to TTR protein]16478101|1660108
D013974Thyroxinetetrachlorodian inhibits the reaction [Thyroxine binds to TTR protein]16478101
D013974ThyroxineThyroxine binds to TTR protein10631123|1086945
D013974ThyroxineThyroxine inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]23584369
D013974Thyroxine"[2,2',4,4'-tetrabromodiphenyl ether analog binds to TTR protein] inhibits the reaction [Thyroxine binds to TTR protein]"19033396
D013974Thyroxine"[2,2',4,4'-tetrabromodiphenyl ether binds to TTR protein] inhibits the reaction [Thyroxine binds to TTR protein]"19033396
D013974Thyroxine[Polychlorinated Biphenyls binds to TTR protein] inhibits the reaction [Thyroxine binds to TTR protein]19033396
D013974ThyroxineThyroxine binds to TTR protein19033396
D013974Thyroxine"[2,2',4,4'-tetrabromodiphenyl ether analog binds to TTR protein] inhibits the reaction [Thyroxine binds to TTR protein]"19033396
D013974Thyroxine"[2,2',4,4'-tetrabromodiphenyl ether binds to TTR protein] inhibits the reaction [Thyroxine binds to TTR protein]"19033396
D013974Thyroxine[Polychlorinated Biphenyls binds to TTR protein] inhibits the reaction [Thyroxine binds to TTR protein]19033396
D013974ThyroxineThyroxine binds to TTR protein19033396
D013974Thyroxine"2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine binds to TTR protein]"18161906
D013974Thyroxine"2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to TTR protein]"18161906
D013974ThyroxineThyroxine inhibits the reaction [Triiodothyronine binds to TTR protein]17553549
D013974ThyroxineDiethylstilbestrol inhibits the reaction [Thyroxine binds to TTR protein]15469931
D013974ThyroxineThyroxine binds to TTR protein21357386|2358436
D013974ThyroxineThyroxine inhibits the reaction [8-anilino-1-naphthalenesulfonic acid binds to TTR protein]22859314
D013974ThyroxineTTR protein results in increased transport of Thyroxine23584369
C009495titanium dioxidetitanium dioxide promotes the reaction [Lead results in decreased expression of TTR mRNA]25703175
C423915TO-901317TO-901317 results in decreased expression of TTR mRNA15302862
C072782tri-(2-chloroisopropyl)phosphatetri-(2-chloroisopropyl)phosphate results in decreased expression of TTR mRNA22268003
C533760tribromodiphenyl ether 28tribromodiphenyl ether 28 analog binds to TTR protein20804816
D014241TrichloroethyleneTrichloroethylene results in decreased expression of TTR mRNA26745549
D014266TrientineTrientine inhibits the reaction [Streptozocin results in decreased expression of TTR protein]19634143
C009549triethyl phosphatetriethyl phosphate results in decreased expression of TTR mRNA24998971
C005445triphenyl phosphatetriphenyl phosphate results in increased expression of TTR mRNA25646720
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TTR mRNA"26179874
D014508Urea[Diflunisal binds to TTR protein mutant form] which results in decreased susceptibility to Urea17701470
D014635Valproic AcidValproic Acid results in decreased expression of TTR mRNA27188386
D014635Valproic AcidValproic Acid results in decreased methylation of TTR gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of TTR mRNA24896083
D014640VancomycinVancomycin results in increased expression of TTR mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TTR gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of TTR protein17520064
D014801Vitamin AFenretinide analog inhibits the reaction [Vitamin A promotes the reaction [RBP4 protein binds to TTR protein]]21591606
D014801Vitamin AVitamin A promotes the reaction [RBP4 protein binds to TTR protein]21591606
D014874Water Pollutants, Chemical"Water Pollutants, Chemical inhibits the reaction [Triiodothyronine binds to TTR protein]"12649043
D014874Water Pollutants, Chemical"Water Pollutants, Chemical inhibits the reaction [Triiodothyronine binds to TTR protein]"12649043
D014874Water Pollutants, Chemical"Water Pollutants, Chemical inhibits the reaction [Triiodothyronine binds to TTR protein]"12649043
D015032ZincTTR protein binds to Zinc23896426
D015032ZincZinc affects the reaction [TTR protein mutant form binds to TTR protein mutant form]17630783
D015032ZincZinc deficiency results in increased expression of TTR mRNA7854157

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005179hormone activity-IEA-  
GO:0005515protein binding-IPI986177  16716307  20646067  25416956  
GO:0042802identical protein binding-IPI19861125  21422279  21740906  21777382  23792159  23850452  
GO:0046982protein heterodimerization activity-IEA-  
GO:0070324thyroid hormone binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0006144purine nucleobase metabolic process-IBA21873635  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0042572retinol metabolic process-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0070327thyroid hormone transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IBA21873635  
GO:0032991protein-containing complex-IEA-  
GO:0035578azurophil granule lumen-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-2453864Retinoid cycle disease eventsTAS
R-HSA-2453902The canonical retinoid cycle in rods (twilight vision)TAS
R-HSA-2474795Diseases associated with visual transductionTAS
R-HSA-3000171Non-integrin membrane-ECM interactionsTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-975634Retinoid metabolism and transportTAS
R-HSA-977225Amyloid fiber formationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28434967Cysteinylated transthyretin as a discriminator of cardiovascular risk in patients with diabetes mellitus. (2017 Jul)Wakabayashi IClin Chim Acta
27091638Sources of variation of transthyretin in healthy subjects in East and Southeast Asia: Clinical and experimental evidence for the effect of alcohol on transthyretin metabolism. (2016 Jul 1)Jono HClin Chim Acta
23547084Associations between cigarette smoking status and colon cancer prognosis among participants in North Central Cancer Treatment Group Phase III Trial N0147. (2013 Jun 1)Phipps AIJ Clin Oncol
10662821Nicotine enhances the biosynthesis and secretion of transthyretin from the choroid plexus in rats: implications for beta-amyloid formation. (2000 Feb 15)Li MDJ Neurosci
20832065Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness. (2010 Dec)Bobbert TAtherosclerosis
21111029Changes in the expression of transthyretin and protein kinase Cgamma genes in the prefrontal cortex in response to naltrexone. (2011 Jan 25)Yu JNeurosci Lett
28720541Biological sources of variation of serum adiponectin among healthy individuals in comparison with related nutritional and inflammatory markers. (2017 Sep)Shimizu YClin Chim Acta