Gene info: ID 727897

Gene: MUC5B

GENE ID: 727897

Synonyms: MG1|MUC-5B|MUC5|MUC9

Description: mucin 5B, oligomeric mucus/gel-forming

Gene type: protein-coding

Location: 11p15.5

dbXrefs: Ensembl:ENSG00000117983 MIM:600770 Vega:OTTHUMG00000166494 UniprotKB:Q9HC84

RefSeq: NG_031880.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 13

Sherlock p-value : 7.150e-1 (AD) 3.392e-1 (ND) (Frontal_Cortex)

Pascal p-value : 5.720e-1 (AD) 2.698e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PRSS21	0.407
GPR87	0.403
ZNF469	0.396
IGSF9B	0.385
GNRH2	0.381
BRS3	0.375
CTCFL	0.369
CAPN15	0.369
MAGEC2	0.368
VIL1	0.365

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TSPAN19	-0.242
TBC1D8B	-0.241
DACH1	-0.238
CCDC102B	-0.234
OTOL1	-0.229
FAM19A4	-0.227
CYB5R2	-0.226
TLL1	-0.217
MUSK	-0.217
EPM2A	-0.213

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
D001151	Arsenic	Arsenic results in increased expression of MUC5B mRNA	23221970
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MUC5B mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of MUC5B mRNA	19619570
C006780	bisphenol A	bisphenol A results in increased expression of MUC5B mRNA	23757601
C018475	butyraldehyde	butyraldehyde results in decreased expression of MUC5B mRNA	26079696
D002211	Capsaicin	Capsaicin results in increased secretion of MUC5B protein	21981454
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of MUC5B mRNA	19376846
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of MUC5B mRNA	24317228
C007262	deoxynivalenol	deoxynivalenol results in increased expression of and results in increased secretion of MUC5B protein	24496642
C007262	deoxynivalenol	deoxynivalenol results in increased expression of MUC5B mRNA	24496642
D015025	Zearalenone	Zearalenone results in increased expression of and results in increased secretion of MUC5B protein	24496642
D015025	Zearalenone	Zearalenone results in increased expression of MUC5B mRNA	24496642
C069837	fullerene C60	fullerene C60 results in increased expression of MUC5B mRNA	19167457
C056933	fumonisin B1	fumonisin B1 results in increased expression of and results in increased secretion of MUC5B protein	24496642
C056933	fumonisin B1	fumonisin B1 results in increased expression of MUC5B mRNA	24496642
D017313	Fenretinide	Fenretinide results in decreased expression of MUC5B mRNA	28973697
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MUC5B mRNA	26752646
C045463	leflunomide	leflunomide results in increased expression of MUC5B mRNA	28988120
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of MUC5B mRNA	22401849
C027793	mustard oil	mustard oil results in increased secretion of MUC5B protein	21981454
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of MUC5B mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MUC5B mRNA"	25554681
D009532	Nickel	[TBX21 gene mutant form results in increased susceptibility to Nickel analog] which results in increased expression of MUC5B mRNA	24499286
C038405	nivalenol	nivalenol results in increased expression of and results in increased secretion of MUC5B protein	24496642
C038405	nivalenol	nivalenol results in increased expression of MUC5B mRNA	24496642
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MUC5B mRNA	27935865
D052638	Particulate Matter	Particulate Matter results in decreased expression of MUC5B mRNA	22178795
D052638	Particulate Matter	[TBX21 gene mutant form results in increased susceptibility to Particulate Matter] which results in increased expression of MUC5B mRNA	24499286
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MUC5B mRNA	27935865
C009007	potassium persulfate	potassium persulfate results in increased expression of MUC5B protein	20815409
D011374	Progesterone	Progesterone results in increased expression of MUC5B mRNA	18070364
C005556	propionaldehyde	propionaldehyde results in decreased expression of MUC5B mRNA	26079696
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of MUC5B mRNA	25895662
C017947	sodium arsenite	sodium arsenite results in decreased expression of MUC5B mRNA	18812580
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of MUC5B protein	28918527
D053260	Soot	Soot results in increased expression of MUC5B mRNA	26551751
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MUC5B mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MUC5B mRNA	19619570
D013806	Theophylline	Theophylline results in decreased expression of MUC5B mRNA	16083514
C009495	titanium dioxide	titanium dioxide results in decreased expression of MUC5B mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of MUC5B mRNA	25788831
D014635	Valproic Acid	Valproic Acid results in increased methylation of MUC5B gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of MUC5B gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of MUC5B mRNA	19015723

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	1718282 12787366

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	-
GO:0016266	O-glycan processing	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	HDA	16502470
GO:0005796	Golgi lumen	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa04970	Salivary secretion

Reactome ID	Reactome Term	Evidence
R-HSA-1643685	Disease	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-3781865	Diseases of glycosylation	TAS
R-HSA-3906995	Diseases associated with O-glycosylation of proteins	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5083625	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	TAS
R-HSA-5083632	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	TAS
R-HSA-5083636	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	TAS
R-HSA-5173105	O-linked glycosylation	TAS
R-HSA-5621480	Dectin-2 family	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-913709	O-linked glycosylation of mucins	TAS
R-HSA-977068	Termination of O-glycan biosynthesis	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29053025	E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion. (2018 Feb 15)	Reidel B	Am J Respir Crit Care Med
28506611	Clinical and Genetic Associations of Objectively Identified Interstitial Changes in Smokers. (2017 Oct)	Ash SY	Chest
29066090	Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. (2017 Nov)	Allen RJ	Lancet Respir Med
15563701	Expression of ErbB receptors and mucins in the airways of long term current smokers. (2004 Dec)	O'Donnell RA	Thorax
23940607	The MUC5B variant is associated with idiopathic pulmonary fibrosis but not with systemic sclerosis interstitial lung disease in the European Caucasian population. (2013)	Borie R	PLoS One
22591690	Mucin5B expression by lung alveolar macrophages is increased in long-term smokers. (2012 Aug)	Sepper R	J Leukoc Biol
19723147	MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients. (2009 Sep)	Caramori G	Histopathology
26271244	Effect of inhaled corticosteroids on salival composition: a cross-sectional study in patients with bronchial asthma. (2015 Sep)	Navarrete BA	Clin Drug Investig
23783374	Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis. (2013 Dec)	Yang IV	Thorax
23692170	MUC5B promoter polymorphism and interstitial lung abnormalities. (2013 Jun 6)	Hunninghake GM	N Engl J Med
17035444	Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. (2006 Oct)	Innes AL	Chest
24454287	The epithelium in idiopathic pulmonary fibrosis: breaking the barrier. (2014 Jan 10)	Camelo A	Front Pharmacol
28620964	Does gene expression in laryngeal subsites differ between patients with laryngopharyngeal reflux and controls? (2018 Feb)	Wood JM	Clin Otolaryngol