Gene info: ID 7280

Gene: TUBB2A

GENE ID: 7280

Synonyms: CDCBM5|TUBB|TUBB2

Description: tubulin beta 2A class IIa

Gene type: protein-coding

Location: 6p25.2

dbXrefs: Ensembl:ENSG00000137267 MIM:615101 Vega:OTTHUMG00000014135 UniprotKB:Q13885

RefSeq: NG_042223.1

Retrived from: PubMed|SNP Mapped

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.530e-1 (AD) 7.895e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATP6V0D1	0.957
FARSA	0.952
RNF187	0.95
CRMP1	0.95
OTUB1	0.947
TUBG1	0.947
MDH2	0.946
HK1	0.944
ATP6AP1	0.944
AP2S1	0.944

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.673
OR4F29	-0.628
RAI14	-0.4
REST	-0.398
CXCR2	-0.392
EBF1	-0.387
IL18RAP	-0.385
KCNJ15	-0.379
ASB4	-0.378
TFPI2	-0.376

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB05147	CYT997	Small Molecule	-	Investigational	Target
DB12695	Phenethyl Isothiocyanate	Small Molecule	2257-09-2	Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in decreased expression of TUBB2A mRNA"	26377693
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TUBB2A mRNA"	22698814
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of TUBB2A mRNA"	19095052
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TUBB2A mRNA"	20056577
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TUBB2A mRNA"	19167446
C440850	2,4,3',5'-tetramethoxystilbene	"2,4,3',5'-tetramethoxystilbene results in decreased expression of TUBB2A mRNA"	20490654
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of TUBB2A mRNA"	20206263
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of TUBB2A protein	26194647
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased oxidation of TUBB2A protein	25716674
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TUBB2A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TUBB2A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TUBB2A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TUBB2A mRNA"	27188386
C029370	4-toluidine	4-toluidine results in decreased expression of TUBB2A mRNA	27638505
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TUBB2A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TUBB2A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TUBB2A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TUBB2A mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of TUBB2A mRNA	15606129\|1756273
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of TUBB2A mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TUBB2A mRNA]	17585979
C430898	AGN 194204	AGN 194204 results in decreased expression of TUBB2A mRNA	15302862
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of TUBB2A mRNA"	22863853
D000068180	Aripiprazole	Aripiprazole results in decreased expression of TUBB2A mRNA	17868501
D001151	Arsenic	TUBB2A mRNA results in increased susceptibility to Arsenic	17976673
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of TUBB2A mRNA"	25351596
D001280	Atrazine	Atrazine results in decreased expression of TUBB2A mRNA	25929836
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of TUBB2A mRNA	26377693
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of TUBB2A mRNA	26377693
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of TUBB2A mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TUBB2A mRNA	22316170\|2623829
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TUBB2A mRNA"	19150397
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of TUBB2A mRNA	20660070
D004958	Estradiol	Estradiol promotes the reaction [TUBB2A protein binds to ESR1 protein]	27156127
C006780	bisphenol A	bisphenol A results in decreased expression of TUBB2A mRNA	29275510
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TUBB2A mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of TUBB2A mRNA	26063408
C006780	bisphenol A	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TUBB2A promoter	23359474
C006780	bisphenol A	bisphenol A results in decreased expression of TUBB2A mRNA	25181051
D001761	Bleomycin	Bleomycin results in decreased expression of TUBB2A protein	25933445
D000069286	Bortezomib	Bortezomib results in increased expression of TUBB2A mRNA	20977926
D001973	Bromodeoxyuridine	[Bromodeoxyuridine co-treated with furan] results in increased expression of TUBB2A mRNA	24910943
D002065	Buspirone	Buspirone results in decreased expression of TUBB2A mRNA	24136188
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of TUBB2A mRNA	14729362
C018475	butyraldehyde	butyraldehyde results in increased expression of TUBB2A mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of TUBB2A mRNA	24376830
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of TUBB2A mRNA	22110744
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TUBB2A mRNA	17084009\|2733941
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TUBB2A mRNA	20938992
D002922	Ciguatoxins	Ciguatoxins affects the expression of TUBB2A mRNA	18353800
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of TUBB2A mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of TUBB2A mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TUBB2A mRNA]	17585979
C018021	cobaltous chloride	cobaltous chloride results in increased expression of TUBB2A mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TUBB2A mRNA	21139344
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of TUBB2A mRNA	24690739
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TUBB2A mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TUBB2A mRNA"	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of TUBB2A mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased expression of TUBB2A mRNA	25562108
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of TUBB2A mRNA	23640034
C014347	decitabine	[decitabine co-treated with vorinostat] affects the expression of TUBB2A mRNA	17330099
D003907	Dexamethasone	Dexamethasone results in increased expression of TUBB2A mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TUBB2A mRNA	28628672
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBB2A mRNA	16054899
D003993	Dibutyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TUBB2A promoter	23359474
D002945	Cisplatin	Cisplatin promotes the reaction [jinfukang results in decreased expression of TUBB2A mRNA]	27392435
D002945	Cisplatin	jinfukang promotes the reaction [Cisplatin results in decreased expression of TUBB2A mRNA]	27392435
D002945	Cisplatin	TUBB2A protein affects the susceptibility to Cisplatin	16217747
D004041	Dietary Fats	Dietary Fats results in increased expression of TUBB2A mRNA	18042831\|1845759
D004051	Diethylhexyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TUBB2A promoter	23359474
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TUBB2A mRNA	24535843
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of TUBB2A mRNA	24690739
D004237	Diuron	Diuron results in decreased expression of TUBB2A mRNA	25152437
C118739	entinostat	entinostat results in increased expression of TUBB2A mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TUBB2A mRNA"	27188386
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUBB2A mRNA	17942748
D005485	Flutamide	Flutamide results in increased expression of TUBB2A mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TUBB2A mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of TUBB2A mRNA	23649840
C056933	fumonisin B1	fumonisin B1 results in increased expression of TUBB2A mRNA	16221962
C039281	furan	[Bromodeoxyuridine co-treated with furan] results in increased expression of TUBB2A mRNA	24910943
C039281	furan	furan results in increased expression of TUBB2A mRNA	24183702\|2491094
C039281	furan	furan results in decreased expression of TUBB2A mRNA	26194646
D005947	Glucose	Glucose results in increased expression of TUBB2A mRNA	17178593
D017313	Fenretinide	Fenretinide results in decreased expression of TUBB2A mRNA	28973697
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TUBB2A mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TUBB2A mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBB2A mRNA	16054899
D007545	Isoproterenol	Isoproterenol results in decreased expression of TUBB2A mRNA	20003209
C544151	jinfukang	Cisplatin promotes the reaction [jinfukang results in decreased expression of TUBB2A mRNA]	27392435
C544151	jinfukang	jinfukang promotes the reaction [Cisplatin results in decreased expression of TUBB2A mRNA]	27392435
C410337	K 7174	K 7174 results in increased expression of TUBB2A mRNA	24086573
D007854	Lead	Lead affects the expression of TUBB2A mRNA	28903495
D008694	Methamphetamine	Methamphetamine results in decreased expression of TUBB2A protein	19826936
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TUBB2A mRNA	20938992
D008727	Methotrexate	Methotrexate results in decreased expression of TUBB2A mRNA	24449571
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of TUBB2A protein	27012723
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TUBB2A mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TUBB2A mRNA"	27188386
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of TUBB2A mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of TUBB2A mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TUBB2A mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TUBB2A mRNA"	25554681\|2562005
C051752	nefazodone	nefazodone results in decreased expression of TUBB2A mRNA	24136188
C012655	nimesulide	nimesulide results in decreased expression of TUBB2A mRNA	24136188
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in decreased expression of TUBB2A protein	19716841
C025256	nonylphenol	nonylphenol results in decreased expression of TUBB2A mRNA	22982499
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of TUBB2A mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in decreased expression of TUBB2A protein	25937538
D000073878	Palm Oil	Palm Oil results in increased expression of TUBB2A mRNA	18042831
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TUBB2A mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of TUBB2A mRNA	26272509
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of TUBB2A protein	19954255
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of TUBB2A protein	19954255
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of TUBB2A protein	26879310
C058305	phenethyl isothiocyanate	TUBB2A protein binds to phenethyl isothiocyanate	21838287
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TUBB2A mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of TUBB2A mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of TUBB2A mRNA	19270015
D010634	Phenobarbital	Phenobarbital results in increased expression of TUBB2A mRNA	19482888
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TUBB2A mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of TUBB2A mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TUBB2A mRNA	19710929
C006253	pirinixic acid	pirinixic acid affects the expression of TUBB2A mRNA	20059764
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in increased expression of TUBB2A mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in increased expression of TUBB2A mRNA	15302862\|1622196
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid affects the expression of TUBB2A mRNA]	20059764
D011374	Progesterone	Progesterone results in decreased expression of TUBB2A mRNA	23018184
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of TUBB2A mRNA	20660070
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in increased expression of TUBB2A mRNA]	17556502
D011374	Progesterone	Progesterone results in increased expression of TUBB2A mRNA	17556502
C045950	propiconazole	propiconazole results in increased expression of TUBB2A mRNA	21278054
C089730	rosiglitazone	rosiglitazone results in decreased expression of TUBB2A mRNA	25572481
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBB2A mRNA	16054899
D012402	Rotenone	Rotenone affects the expression of TUBB2A mRNA	21893155
D012402	Rotenone	TRP53 affects the reaction [Rotenone affects the expression of TUBB2A mRNA]	21893155
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of TUBB2A mRNA	25351596
C080703	SK&F 83959	SK&F 83959 results in decreased expression of TUBB2A protein	25852303
C017947	sodium arsenite	sodium arsenite affects the expression of TUBB2A mRNA	29319823
C017947	sodium arsenite	sodium arsenite affects the methylation of TUBB2A gene	28589171
C017947	sodium arsenite	sodium arsenite results in increased expression of TUBB2A mRNA	28595984
C016104	sodium bichromate	sodium bichromate affects the expression of TUBB2A mRNA	22110744
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of TUBB2A protein	27548804\|2891852
D012999	Soman	Soman results in decreased expression of TUBB2A mRNA	19281266
D013629	Tamoxifen	Tamoxifen affects the expression of TUBB2A mRNA	20937368
C030141	taurine-ursodeoxycholate conjugate	taurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of TUBB2A mRNA]	21079772
C010792	testosterone undecanoate	testosterone undecanoate results in increased expression of TUBB2A mRNA	19074003
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TUBB2A mRNA	20106945
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TUBB2A mRNA	21570461\|2892240
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUBB2A mRNA	17942748
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of TUBB2A mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TUBB2A mRNA	26290441
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TUBB2A mRNA	21215274
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of TUBB2A mRNA	28973375
D013849	Thimerosal	Thimerosal results in decreased expression of TUBB2A mRNA	27188386
C009495	titanium dioxide	titanium dioxide results in increased expression of TUBB2A mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased metabolism of TUBB2A protein	23396223
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of TUBB2A mRNA	28111298
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of TUBB2A mRNA	25729387
C012589	trichostatin A	trichostatin A results in increased expression of TUBB2A mRNA	28542535
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of TUBB2A mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TUBB2A mRNA"	26179874
C080163	trovafloxacin	trovafloxacin results in decreased expression of TUBB2A mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of TUBB2A mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of TUBB2A mRNA	23179753\|2493525
D014635	Valproic Acid	Valproic Acid results in increased methylation of TUBB2A gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of TUBB2A mRNA	17963808
C111237	vorinostat	[decitabine co-treated with vorinostat] affects the expression of TUBB2A mRNA	17330099
C111237	vorinostat	vorinostat results in decreased expression of TUBB2A mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003924	GTPase activity	-	IEA	-
GO:0005200	structural constituent of cytoskeleton	-	IBA	21873635
GO:0005200	structural constituent of cytoskeleton	-	IEA	-
GO:0005515	protein binding	-	IPI	21044950
GO:0005525	GTP binding	-	IBA	21873635
GO:0005525	GTP binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000226	microtubule cytoskeleton organization	-	IBA	21873635
GO:0000278	mitotic cell cycle	-	IBA	21873635
GO:0007010	cytoskeleton organization	-	IEA	-
GO:0007017	microtubule-based process	-	IBA	21873635
GO:0007017	microtubule-based process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	HDA	21630459
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	IEA	-
GO:0005874	microtubule	-	IBA	21873635
GO:0005874	microtubule	-	IDA	21525035
GO:0070062	extracellular exosome	-	HDA	19056867
GO:1903561	extracellular vesicle	-	HDA	24769233

KEGG ID	KEGG Term
hsa04145	Phagosome
hsa04540	Gap junction
hsa05130	Pathogenic Escherichia coli infection

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	IEA
R-HSA-157858	Gap junction trafficking and regulation	IEA
R-HSA-157858	Gap junction trafficking and regulation	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-168256	Immune System	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-190828	Gap junction trafficking	IEA
R-HSA-190828	Gap junction trafficking	TAS
R-HSA-190840	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	TAS
R-HSA-190861	Gap junction assembly	IEA
R-HSA-190861	Gap junction assembly	TAS
R-HSA-190872	Transport of connexons to the plasma membrane	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-199977	ER to Golgi Anterograde Transport	TAS
R-HSA-199991	Membrane Trafficking	IEA
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-2132295	MHC class II antigen presentation	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2467813	Separation of Sister Chromatids	TAS
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	TAS
R-HSA-2555396	Mitotic Metaphase and Anaphase	TAS
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)	TAS
R-HSA-373760	L1CAM interactions	TAS
R-HSA-373760	L1CAM interactions	IEA
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	TAS
R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	IEA
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	IEA
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	IEA
R-HSA-389977	Post-chaperonin tubulin folding pathway	IEA
R-HSA-390466	Chaperonin-mediated protein folding	IEA
R-HSA-391251	Protein folding	IEA
R-HSA-392499	Metabolism of proteins	IEA
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-437239	Recycling pathway of L1	TAS
R-HSA-437239	Recycling pathway of L1	IEA
R-HSA-446203	Asparagine N-linked glycosylation	TAS
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-5358351	Signaling by Hedgehog	TAS
R-HSA-5610787	Hedgehog 'off' state	TAS
R-HSA-5617833	Cilium Assembly	TAS
R-HSA-5620924	Intraflagellar transport	TAS
R-HSA-5626467	RHO GTPases activate IQGAPs	TAS
R-HSA-5653656	Vesicle-mediated transport	IEA
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5663220	RHO GTPases Activate Formins	TAS
R-HSA-597592	Post-translational protein modification	IEA
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6807878	COPI-mediated anterograde transport	TAS
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	TAS
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	TAS
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	TAS
R-HSA-68877	Mitotic Prometaphase	TAS
R-HSA-68882	Mitotic Anaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-69275	G2/M Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	TAS
R-HSA-8856688	Golgi-to-ER retrograde transport	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-8955332	Carboxyterminal post-translational modifications of tubulin	IEA
R-HSA-8955332	Carboxyterminal post-translational modifications of tubulin	TAS
R-HSA-948021	Transport to the Golgi and subsequent modification	TAS
R-HSA-983189	Kinesins	TAS
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal