Gene: GTF2H2C

728340
GTF2H2C_2
GTF2H2 family member C
protein-coding
5q13.2
Ensembl:ENSG00000183474 Vega:OTTHUMG00000162365 UniprotKB:Q6P1K8
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.813e-1 (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POLK0.669
UBA60.655
SEC24A0.643
INTS20.64
GART0.64
PBRM10.636
FUBP10.632
KIAA05860.631
HCFC20.628
SPTLC10.626

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.325
OR4F29-0.287
RSPO1-0.242
LCN1-0.235
GRHL2-0.222
TNP2-0.221
OR4F16-0.208
RERGL-0.194
MTRNR2L6-0.192
RBBP8NL-0.183

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GTF2H2C gene27153756
D001151ArsenicArsenic affects the methylation of GTF2H2C gene25304211
C028559bathocuproine sulfonate[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of GTF2H2C mRNA15477007
C006780bisphenol Abisphenol A results in decreased expression of GTF2H2C mRNA29275510
C020972pyrrolidine dithiocarbamic acid[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of GTF2H2C mRNA15477007

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006289nucleotide-excision repair-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000439core TFIIH complex-IEA-  
GO:0005675holo TFIIH complex-IBA21873635  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25482056Fetal lung and placental methylation is associated with in utero nicotine exposure. (2014 Nov)Chhabra DEpigenetics