Gene: TUFM

7284
COXPD4|EF-TuMT|EFTU|P43
Tu translation elongation factor, mitochondrial
protein-coding
16p11.2
Ensembl:ENSG00000178952 MIM:602389 Vega:OTTHUMG00000097039 UniprotKB:P49411
NG_008964.1
PubMed
0   ANCO-SNPs
ND
1   
2.672e-1 (AD)  2.956e-1 (ND)   (Frontal_Cortex)
9.712e-2 (AD)  4.658e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YIPF30.956
ECHS10.956
PUF600.949
TXN20.946
RNF1670.945
BCAP310.945
CTSD0.94
ENO10.939
PARK70.939
GAPDH0.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.873
OR4F29-0.844
KRT73-0.282
GADL1-0.263
KLRB1-0.262
DPPA4-0.255
C2orf83-0.255
PZP-0.254
MTRNR2L6-0.254
FER1L6-0.25

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of TUFM mRNA17562736
D000171AcroleinAcrolein results in increased metabolism of TUFM protein17570602
C039726artesunateTUFM mRNA results in decreased susceptibility to artesunate20144594
C547126AZM551248AZM551248 results in increased expression of TUFM mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TUFM protein17292933
C006780bisphenol Abisphenol A results in increased expression of TUFM mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TUFM gene28505145
C013418bromfenacoumbromfenacoum results in decreased expression of TUFM protein28903499
D002065BuspironeBuspirone results in decreased expression of TUFM mRNA24136188
C026105butylidenephthalidebutylidenephthalide results in increased expression of TUFM protein23770345
C584509C646 compoundC646 compound results in decreased expression of TUFM mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TUFM mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TUFM protein21699967
D002330CarmustineTUFM mRNA affects the susceptibility to Carmustine16365179
D002994ClofibrateClofibrate results in increased expression of TUFM protein16470657
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TUFM mRNA17602206
D016572CyclosporineCyclosporine results in decreased expression of TUFM mRNA20106945|2116390
D016572CyclosporineCyclosporine results in decreased expression of TUFM mRNA19770486
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TUFM mRNA17602206
C042080diisodecyl phthalatediisodecyl phthalate results in increased expression of TUFM mRNA25270620
D004298DopamineDopamine results in increased expression of TUFM protein24675778
D004317DoxorubicinDoxorubicin results in increased expression of TUFM protein16144979
D004317DoxorubicinDoxorubicin results in decreased expression of TUFM mRNA19915844
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TUFM protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TUFM mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TUFM mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUFM mRNA17942748
D005485FlutamideFlutamide results in increased expression of TUFM mRNA24136188
D005839GentamicinsGentamicins results in decreased expression of TUFM protein22061828
D005839GentamicinsGentamicins results in increased expression of TUFM mRNA22061828
D006046GoldGold analog results in decreased expression of and results in increased phosphorylation of TUFM protein24780912
C492448ICG 001ICG 001 results in decreased expression of TUFM mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TUFM mRNA25613284
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TUFM mRNA"24972896
D008148LovastatinLovastatin results in decreased expression of TUFM mRNA20493250
D008694MethamphetamineMethamphetamine results in decreased expression of TUFM protein19826936
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TUFM mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TUFM protein24675778
D052998MicrocystinsMicrocystins results in increased expression of TUFM protein22430071
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TUFM mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TUFM mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TUFM mRNA"25554681
C025256nonylphenolnonylphenol results in increased expression of TUFM protein19260726
C530734p-aminophenylarsine oxidep-aminophenylarsine oxide binds to TUFM protein22422341
D010261ParaoxonParaoxon results in increased expression of TUFM protein20931991
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of TUFM protein19954255
C006253pirinixic acidpirinixic acid results in increased expression of TUFM mRNA15375163|1830175
D010936Plant ExtractsPlant Extracts results in increased expression of TUFM mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TUFM mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TUFM mRNA22079256
C015586propiverinepropiverine binds to TUFM protein29273565
D011794QuercetinQuercetin results in decreased expression of TUFM protein19207037
D011794QuercetinQuercetin results in increased expression of TUFM protein17292933
C059514resveratrolresveratrol results in increased expression of TUFM protein25505154
C080703SK&F 83959SK&F 83959 affects the expression of TUFM protein25852303
D012969Sodium FluorideSodium Fluoride results in decreased expression of TUFM mRNA27862939
D018038Sodium SeleniteSodium Selenite results in increased expression of TUFM mRNA18175754
D012999SomanSoman results in increased expression of TUFM mRNA19281266
D013605T-2 ToxinT-2 Toxin affects the expression of TUFM protein26141394
C047246temozolomideTUFM mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TUFM mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUFM mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TUFM mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TUFM mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of TUFM protein"25852303
D014212TretinoinTretinoin results in decreased expression of TUFM mRNA16604517
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in increased expression of TUFM protein24685621
D014635Valproic AcidValproic Acid affects the expression of TUFM mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TUFM mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of TUFM mRNA17292431
D014859WarfarinWarfarin results in decreased expression of TUFM mRNA20493250
D015032ZincTUFM protein binds to Zinc14534351

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0003746translation elongation factor activity-IBA21873635  
GO:0003746translation elongation factor activity-IDA9332382  
GO:0003924GTPase activity-IEA-  
GO:0005515protein binding-IPI11741979  25416956  
GO:0005525GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006414translational elongation-IBA21873635  
GO:0006414translational elongation-IDA9332382  
GO:0045471response to ethanol-IEA-  
GO:0070125mitochondrial translational elongation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-HDA20833797  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA9332382  
GO:0016020membrane-HDA19946888  
GO:0042645mitochondrial nucleoid-IDA18063578  
GO:0043209myelin sheath-IEA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsIEA
R-HSA-5368287Mitochondrial translationIEA
R-HSA-5389840Mitochondrial translation elongationIEA
R-HSA-72766TranslationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26771213Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. (2016 Jul 1)Hobbs BDAm J Respir Crit Care Med