Gene: GGT2

728441
GGT|GGT 2
gamma-glutamyltransferase 2
protein-coding
22q11.21
Ensembl:ENSG00000133475 MIM:137181 Vega:OTTHUMG00000150617 UniprotKB:P36268
NC_000022.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TERT0.492
OBSCN0.485
SLC22A250.485
ATG9B0.442
KCNH40.435
FAM90A10.427
DCDC2B0.427
C14orf1800.425
NPAP10.424
PTPRQ0.423

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LY96-0.263
ANXA1-0.256
CD44-0.251
HLA-DPA1-0.248
GAS2L3-0.242
RARRES3-0.239
EVI2B-0.233
FCGR3A-0.232
IL18-0.23
TMEM236-0.229

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [KRAS protein mutant form results in increased expression of GGT2 mRNA]22269385
D006861Hydrogen PeroxideGGT2 protein affects the reaction [KRAS protein mutant form results in decreased susceptibility to Hydrogen Peroxide]22269385
D006861Hydrogen Peroxide[KRAS protein results in increased activity of GGT2 protein] which results in decreased susceptibility to Hydrogen Peroxide22269385
D014212TretinoinTretinoin results in increased expression of GGT2 mRNA16054129
C088658zoledronic acidzoledronic acid results in decreased expression of GGT2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0036374glutathione hydrolase activityNOTIDA23682772  
GO ID GO Term Qualifier Evidence PubMed
GO:0006751glutathione catabolic process-IEA-  
GO:0031638zymogen activationNOTIDA23682772  
GO:1901750leukotriene D4 biosynthetic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA23682772  
GO:0048471perinuclear region of cytoplasm-IDA23682772  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23688726Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function. (2013 Oct)Tang WFree Radic Biol Med