Gene: TWIST1

7291
ACS3|BPES2|BPES3|CRS|CRS1|CSO|SCS|SWCOS|TWIST|bHLHa38
twist family bHLH transcription factor 1
protein-coding
7p21.1
Ensembl:ENSG00000122691 MIM:601622 Vega:OTTHUMG00000090821 UniprotKB:Q15672
NG_008114.2
PubMed
0   ANCO-SNPs
ND
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.824e-1 (AD)  7.183e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLA2G4A0.566
CALHM20.553
SLC38A110.54
SLC6A200.54
FAM162B0.531
ARHGAP100.522
STAT60.522
BTN3A30.521
MGST20.518
LRCH10.516

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOX3-0.373
DIAPH3-0.326
SLC25A48-0.317
NTSR2-0.31
PDE11A-0.309
ZFHX4-AS1-0.304
HSD17B6-0.291
GPAM-0.289
PON1-0.289
MEGF10-0.288

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TWIST1 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
C0555064-(diethylamino)benzaldehyde4-(diethylamino)benzaldehyde results in decreased expression of TWIST1 protein16316642
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TWIST1 mRNA21167638
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TWIST1 mRNA17585979
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of TWIST1 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TWIST1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TWIST1 mRNA28965971
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TWIST1 gene27153756
C526957alisol B 23-acetatealisol B 23-acetate inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]28578904
C526957alisol B 23-acetatealisol B 23-acetate inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]28578904
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TWIST1 mRNA16483693
D001151ArsenicTWIST1 protein results in decreased susceptibility to Arsenic19806464
C015001arsenitearsenite results in increased methylation of TWIST1 promoter23974009
C487081belinostatbelinostat results in increased expression of TWIST1 protein23671600
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TWIST1 mRNA24847786
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TWIST1 protein24847786
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TWIST1 mRNA22610609
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TWIST1 mRNA21839799
D004958EstradiolEstradiol results in decreased expression of TWIST1 mRNA18692832
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of TWIST1 mRNA17404688|1869283
C006780bisphenol Abisphenol A results in decreased expression of TWIST1 mRNA22576693|2636321
C006780bisphenol Abisphenol A results in increased methylation of TWIST1 gene22576693
C006780bisphenol Abisphenol A affects the methylation of TWIST1 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of TWIST1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride affects the expression of TWIST1 mRNA23828170
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TWIST1 mRNA20478370
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TWIST1 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of TWIST1 protein23518002
C018021cobaltous chloridecobaltous chloride results in increased expression of and affects the localization of TWIST1 protein26174737
C018021cobaltous chloridetetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of TWIST1 protein]26174737
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TWIST1 mRNA"19167446
C551994crizotinibTWIST1 protein results in decreased susceptibility to crizotinib22155737
D003907DexamethasoneDexamethasone results in increased expression of TWIST1 mRNA25047013
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of TWIST1 protein27566995
C042577diallyl trisulfideLDHA protein inhibits the reaction [diallyl trisulfide results in decreased expression of TWIST1 protein]27566995
D002945CisplatinCisplatin results in decreased expression of TWIST1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TWIST1 mRNA21618587
D002945CisplatinU 0126 inhibits the reaction [Cisplatin results in increased expression of TWIST1 mRNA]21618587
D004041Dietary FatsDietary Fats results in decreased expression of TWIST1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of TWIST1 mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of TWIST1 mRNA26485663
C024629dimethyl phthalatedimethyl phthalate affects the expression of TWIST1 mRNA26924002
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of TWIST1 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of TWIST1 mRNA21233418
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of TWIST1 gene16724327
D015025ZearalenoneZearalenone results in decreased expression of TWIST1 mRNA28965971
D018120FinasterideFinasteride inhibits the reaction [Testosterone results in increased expression of TWIST1 mRNA]27866977
D005480FlurbiprofenFlurbiprofen results in decreased expression of TWIST1 mRNA16949054
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TWIST1 gene20938992
D004397FonofosFonofos results in increased methylation of TWIST1 promoter22847954
D017313FenretinideFenretinide results in decreased expression of TWIST1 mRNA28973697
C492448ICG 001ICG 001 inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]28578904
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]28578904
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]28578904
C042720mercuric bromidemercuric bromide results in increased expression of TWIST1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TWIST1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TWIST1 mRNA28001369
D008770Methylnitrosourea[Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA25164625
D008770MethylnitrosoureaQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA]25164625
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TWIST1 mRNA26924002
C523799MRK 003TWIST1 results in increased susceptibility to MRK 00319903844
C119536nickel acetatenickel acetate affects the expression of TWIST1 mRNA23828170
D009538NicotineNicotine results in increased expression of TWIST1 mRNA23219715
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TWIST1 mRNA25729387
D010100OxygenCA9 mutant form inhibits the reaction [[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of TWIST1 mRNA]26305601
D010100Oxygen[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of TWIST1 mRNA26305601
C102487pachymic acidpachymic acid analog inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]28578904
C102487pachymic acidpachymic acid analog inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]28578904
D000073878Palm OilPalm Oil results in decreased expression of TWIST1 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of TWIST1 mRNA26272509
D010278ParathionParathion results in increased methylation of TWIST1 promoter22847954
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of TWIST1 mRNA22790973
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TWIST1 mRNA26272509
C029217phenyl-N-tert-butylnitronephenyl-N-tert-butylnitrone inhibits the reaction [Thalidomide results in decreased expression of TWIST1 mRNA]12242718
C006253pirinixic acidpirinixic acid results in increased expression of TWIST1 mRNA20813756
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of TWIST1 mRNA17404688|1869283
D011374ProgesteroneProgesterone results in decreased expression of TWIST1 mRNA17404688|1869283
D011441PropylthiouracilPropylthiouracil results in increased expression of TWIST1 mRNA24780913
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein]27060453
C587274Qing Ye DanQing Ye Dan inhibits the reaction [Testosterone results in increased expression of TWIST1 mRNA]27866977
D011794QuercetinQuercetin results in decreased expression of TWIST1 protein22422628
D011794QuercetinQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA]25164625
C059514resveratrolresveratrol results in increased expression of TWIST1 mRNA25866375
C093642SB 203580SB 203580 inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein]27060453
C017947sodium arseniteEPAS1 mutant form inhibits the reaction [sodium arsenite results in increased expression of TWIST1 protein]22662215
C017947sodium arsenitesodium arsenite promotes the reaction [EPAS1 protein binds to TWIST1 promoter]22662215
C017947sodium arsenitesodium arsenite results in increased expression of TWIST1 mRNA22662215
C017947sodium arsenitesodium arsenite results in increased expression of TWIST1 protein22662215
C471405sorafenibsorafenib results in decreased expression of TWIST1 mRNA21360571
C013270swertiamarinswertiamarin inhibits the reaction [Testosterone results in increased expression of TWIST1 mRNA]27866977
C012568terbufosterbufos results in increased methylation of TWIST1 promoter22847954
D013739TestosteroneFinasteride inhibits the reaction [Testosterone results in increased expression of TWIST1 mRNA]27866977
D013739Testosterone[Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA25164625
D013739TestosteroneQing Ye Dan inhibits the reaction [Testosterone results in increased expression of TWIST1 mRNA]27866977
D013739TestosteroneQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA]25164625
D013739Testosteroneswertiamarin inhibits the reaction [Testosterone results in increased expression of TWIST1 mRNA]27866977
D013739TestosteroneTestosterone results in increased expression of TWIST1 mRNA27866977
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TWIST1 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of TWIST1 mRNA]22749964
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TWIST1 mRNA21167638
C034269tetraethylenepentaminetetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of TWIST1 protein]26174737
C034269tetraethylenepentaminetetraethylenepentamine results in decreased expression of TWIST1 protein26174737
D013792Thalidomidephenyl-N-tert-butylnitrone inhibits the reaction [Thalidomide results in decreased expression of TWIST1 mRNA]12242718
D013792ThalidomideThalidomide results in decreased expression of TWIST1 mRNA12242718|1471333
C003466thymoquinonepyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein]27060453
C003466thymoquinoneSB 203580 inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein]27060453
C003466thymoquinonethymoquinone results in decreased expression of TWIST1 protein27060453
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TWIST1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of TWIST1 protein16316642
D014212TretinoinTretinoin results in increased expression of TWIST1 mRNA21934132|2372400
C011559tributyltinTetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of TWIST1 mRNA]22749964
C011559tributyltintributyltin results in decreased expression of TWIST1 mRNA22749964
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of TWIST1 mRNA24935251|2627250
C113580U 0126U 0126 inhibits the reaction [Cisplatin results in increased expression of TWIST1 mRNA]21618587
C022884undecaneundecane results in increased expression of TWIST1 protein17337753
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TWIST1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of TWIST1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of TWIST1 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TWIST1 gene25560391
C111237vorinostatvorinostat results in increased expression of TWIST1 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IDA17332325  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0005515protein binding-IPI18504427  18598946  21983900  22975381  24525235  25402006  
25609649  25893917  
GO:0008134transcription factor binding-IPI15545268  
GO:0019904protein domain specific binding-IEA-  
GO:0042803protein homodimerization activity-IEA-  
GO:0043425bHLH transcription factor binding-IPI10749989  
GO:0046982protein heterodimerization activity-IEA-  
GO:0070888E-box binding-IDA17332325  20804746  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP17690110  
GO:0001503ossification-TAS11001584  
GO:0001649osteoblast differentiation-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0001764neuron migration-IEA-  
GO:0001843neural tube closure-IEA-  
GO:0003180aortic valve morphogenesis-IMP20804746  
GO:0003183mitral valve morphogenesis-IEA-  
GO:0003203endocardial cushion morphogenesis-IEA-  
GO:0003253cardiac neural crest cell migration involved in outflow tract morphogenesis-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007517muscle organ development-IEA-  
GO:0010628positive regulation of gene expression-IMP17003487  
GO:0010718positive regulation of epithelial to mesenchymal transition-IMP18297062  
GO:0014067negative regulation of phosphatidylinositol 3-kinase signaling-IMP17003487  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030500regulation of bone mineralization-IMP19597909  
GO:0032000positive regulation of fatty acid beta-oxidation-IMP20007935  
GO:0032720negative regulation of tumor necrosis factor production-IEA-  
GO:0032760positive regulation of tumor necrosis factor production-IMP20007935  
GO:0033128negative regulation of histone phosphorylation-IMP17690110  
GO:0035067negative regulation of histone acetylation-IEA-  
GO:0035115embryonic forelimb morphogenesis-IEA-  
GO:0035116embryonic hindlimb morphogenesis-IEA-  
GO:0035359negative regulation of peroxisome proliferator activated receptor signaling pathway-IEA-  
GO:0042473outer ear morphogenesis-TAS11001584  
GO:0042476odontogenesis-IEA-  
GO:0042733embryonic digit morphogenesis-TAS11001584  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043433negative regulation of DNA-binding transcription factor activity-IEA-  
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator-IMP17690110  
GO:0045668negative regulation of osteoblast differentiation-IMP16888803  
GO:0045766positive regulation of angiogenesis-NAS17987801  
GO:0045892negative regulation of transcription, DNA-templated-IDA25981568  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA17332325  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP12270142  
GO:0048511rhythmic process-IEA-  
GO:0048642negative regulation of skeletal muscle tissue development-IEA-  
GO:0048701embryonic cranial skeleton morphogenesis-IMP8988166  8988167  
GO:0050679positive regulation of epithelial cell proliferation-IEA-  
GO:0060021roof of mouth development-IEA-  
GO:0060363cranial suture morphogenesis-TAS11001584  
GO:0060900embryonic camera-type eye formation-IMP17070479  
GO:0061029eyelid development in camera-type eye-IMP17070479  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO:0071456cellular response to hypoxia-IMP18297062  
GO:0071639positive regulation of monocyte chemotactic protein-1 production-IMP20007935  
GO:2000144positive regulation of DNA-templated transcription, initiation-IDA17332325  
GO:2000147positive regulation of cell motility-IMP17332325  
GO:2000147positive regulation of cell motility-NAS17332324  
GO:2000276negative regulation of oxidative phosphorylation uncoupler activity-IEA-  
GO:2000679positive regulation of transcription regulatory region DNA binding-IMP12270142  
GO:2000773negative regulation of cellular senescence-IMP17690110  
GO:2000778positive regulation of interleukin-6 secretion-IMP20007935  
GO:2000780negative regulation of double-strand break repair-IMP17690110  
GO:2000793cell proliferation involved in heart valve development-IMP20804746  
GO:2000802positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10749989  15545268  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8878166Transcriptional regulation by RUNX2TAS
R-HSA-8939902Regulation of RUNX2 expression and activityIEA
R-HSA-8939902Regulation of RUNX2 expression and activityTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26081431Fibroblast-epithelial cell interactions drive epithelial-mesenchymal transition differently in cells from normal and COPD patients. (2015 Jun 18)Nishioka MRespir Res
28106542Urinary NID2 and TWIST1 methylation to augment conventional urine cytology for the detection of bladder cancer. (2017)Fantony JJCancer Biomark
24354880Effects of a functional variant c.353T>C in snai1 on risk of two contextual diseases. Chronic obstructive pulmonary disease and lung cancer. (2014 Jan 15)Yang LAm J Respir Crit Care Med
18549475Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma. (2008 Jun 12)Blons HBMC Med Genomics
26671626Sources of polycyclic aromatic hydrocarbons are associated with gene-specific promoter methylation in women with breast cancer. (2016 Feb)White AJEnviron Res
26027762Multi-institutional external validation of urinary TWIST1 and NID2 methylation as a diagnostic test for bladder cancer. (2015 Sep)Fantony JJUrol Oncol
23613408Expression of transcription factor Twist1 in bladder urothelial carcinoma and its clinical significance. (2013 Jan-Mar)Tang XJ BUON
29634978Clinical implication of programmed death-ligand 1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition. (2018 Apr 7)Kwon MJHum Pathol