Gene: TNFSF4

7292
CD134L|CD252|GP34|OX-40L|OX4OL|TNLG2B|TXGP1
TNF superfamily member 4
protein-coding
1q25.1
Ensembl:ENSG00000117586 MIM:603594 Vega:OTTHUMG00000034838 UniprotKB:P23510
NG_011477.1
PubMed|SNP Mapped
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.679e-1 (AD)  5.513e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10861599chr1:173176523TNFSF46.630e-9Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEK10.713
GPR75-ASB30.703
GALC0.693
ZNF518A0.688
MARC20.677
RAB300.671
ASPH0.671
DBT0.669
ACAP20.669
ETFDH0.668

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.365
OR4F29-0.329
NANOGNB-0.296
RERGL-0.289
GAL-0.281
KRT72-0.258
CD40LG-0.258
REM1-0.256
ITIH6-0.255
PTGDR2-0.254

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNFSF4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNFSF4 mRNA"27188386
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Particulate Matter results in increased expression of TNFSF4 mRNA]20974985
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of TNFSF4 mRNA]20974985
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TNFSF4 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TNFSF4 mRNA21641981
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TNFSF4 mRNA16483693
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of TNFSF4 mRNA17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of TNFSF4 mRNA17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNFSF4 mRNA20064835|2010694
C006780bisphenol Abisphenol A results in decreased expression of TNFSF4 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of TNFSF4 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of TNFSF4 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of TNFSF4 mRNA27178563
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TNFSF4 mRNA16997883
C018475butyraldehydebutyraldehyde results in decreased expression of TNFSF4 mRNA26079696
D002110CaffeineCaffeine results in increased expression of TNFSF4 mRNA18444173
D002220CarbamazepineCarbamazepine affects the expression of TNFSF4 mRNA25979313
C018021cobaltous chloridecobaltous chloride results in decreased expression of TNFSF4 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of TNFSF4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TNFSF4 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of TNFSF4 mRNA27989131
D003703DemecolcineDemecolcine results in increased expression of TNFSF4 mRNA23649840
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TNFSF4 mRNA16997883
D004075DiglyceridesTNFSF4 protein results in increased abundance of Diglycerides19416722
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TNFSF4 mRNA23649840
D005419FlavonoidsFlavonoids results in increased expression of TNFSF4 mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of TNFSF4 mRNA23649840
C069837fullerene C60fullerene C60 results in increased expression of TNFSF4 mRNA20471445
D019833GenisteinGenistein results in decreased expression of TNFSF4 mRNA18444173
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TNFSF4 mRNA18951874
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TNFSF4 mRNA16997883
D007530IsofluraneIsoflurane results in decreased expression of TNFSF4 mRNA16978161
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TNFSF4 mRNA24796395|2675264
D007657Ketone BodiesKetone Bodies results in decreased expression of TNFSF4 mRNA16807920
D007840LatexLatex analog results in increased expression of TNFSF4 mRNA24768652
C045463leflunomideleflunomide results in increased expression of TNFSF4 mRNA28988120
D008727MethotrexateMethotrexate results in increased expression of TNFSF4 mRNA17400583
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TNFSF4 mRNA23649840
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]19589242
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]]19589242
D015544Inositol 1,4,5-Trisphosphate"TNFSF4 protein results in increased abundance of Inositol 1,4,5-Trisphosphate"19416722
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TNFSF4 mRNA"24911292
D009532NickelNickel results in increased expression of TNFSF4 mRNA24768652
C014707nitrosobenzylmethylamine[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of TNFSF4 mRNA12517797
C558013NSC 689534NSC 689534 results in increased expression of TNFSF4 mRNA20971185
D010269ParaquatParaquat results in increased expression of TNFSF4 mRNA22938100
D052638Particulate MatterAcetylcysteine inhibits the reaction [Particulate Matter results in increased expression of TNFSF4 mRNA]20974985
D052638Particulate MatterParticulate Matter results in increased expression of TNFSF4 mRNA20974985
D052638Particulate MatterTSLP protein affects the reaction [Particulate Matter results in increased expression of TNFSF4 mRNA]20974985
D010424PentobarbitalPentobarbital results in decreased expression of TNFSF4 mRNA16978161
D010476PerfumePerfume results in increased expression of TNFSF4 mRNA24768652
D011441PropylthiouracilPropylthiouracil results in increased expression of TNFSF4 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of TNFSF4 mRNA21632981
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]19589242
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]]19589242
D019821SimvastatinSimvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]19589242
D019821SimvastatinSimvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]19589242
D019821SimvastatinSimvastatin results in decreased expression of TNFSF4 mRNA19589242
D019821SimvastatinSimvastatin results in decreased expression of TNFSF4 protein19589242
C017947sodium arsenitesodium arsenite affects the expression of TNFSF4 mRNA29319823
C017947sodium arsenitesodium arsenite results in increased expression of TNFSF4 mRNA20886546
D018038Sodium SeleniteSodium Selenite results in decreased expression of TNFSF4 mRNA18175754
D013619TacrineTacrine results in increased expression of TNFSF4 mRNA12832660
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of TNFSF4 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TNFSF4 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TNFSF4 mRNA18684927
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNFSF4 mRNA14718646|1597263
D019284ThapsigarginThapsigargin results in increased expression of TNFSF4 mRNA22378314
D014118Toxins, Biological"Toxins, Biological affects the expression of TNFSF4 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of TNFSF4 mRNA23724009
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of TNFSF4 mRNA23537331
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TNFSF4 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TNFSF4 mRNA29024780
D014415TunicamycinTunicamycin results in increased expression of TNFSF4 mRNA22378314
D014520UrethaneUrethane results in decreased expression of TNFSF4 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNFSF4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TNFSF4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TNFSF4 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of TNFSF4 mRNA17292431
D001335Vehicle EmissionsAcetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of TNFSF4 mRNA]20974985
D001335Vehicle EmissionsTSLP protein affects the reaction [Vehicle Emissions results in increased expression of TNFSF4 mRNA]20974985
D001335Vehicle EmissionsVehicle Emissions results in increased expression of TNFSF4 mRNA20974985
C025643vinclozolinvinclozolin results in increased expression of TNFSF4 mRNA18629315
D014750VincristineVincristine results in increased expression of TNFSF4 mRNA23649840
D015032Zinc[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of TNFSF4 mRNA12517797

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS7913952  
GO:0005125cytokine activity-IEA-  
GO:0005164tumor necrosis factor receptor binding-IEA-  
GO:0005515protein binding-IPI16905106  
GO:0032813tumor necrosis factor receptor superfamily binding-IBA21873635  
GO:0032813tumor necrosis factor receptor superfamily binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001819positive regulation of cytokine production-IBA21873635  
GO:0002215defense response to nematode-ISS-  
GO:0002526acute inflammatory response-ISS-  
GO:0002726positive regulation of T cell cytokine production-ISS-  
GO:0002819regulation of adaptive immune response-ISS-  
GO:0002830positive regulation of type 2 immune response-ISS-  
GO:0002891positive regulation of immunoglobulin mediated immune response-ISS-  
GO:0006954inflammatory response-IBA21873635  
GO:0006955immune response-IEA-  
GO:0007165signal transduction-TAS7913952  
GO:0008284positive regulation of cell proliferation-TAS7913952  
GO:0009615response to virus-ISS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0032689negative regulation of interferon-gamma production-ISS-  
GO:0032700negative regulation of interleukin-17 production-IDA18501882  
GO:0032729positive regulation of interferon-gamma production-IDA18501882  
GO:0032733positive regulation of interleukin-10 production-ISS-  
GO:0032735positive regulation of interleukin-12 production-ISS-  
GO:0032736positive regulation of interleukin-13 production-ISS-  
GO:0032753positive regulation of interleukin-4 production-IDA18501882  
GO:0032755positive regulation of interleukin-6 production-IDA20844189  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0035709memory T cell activation-ISS-  
GO:0035712T-helper 2 cell activation-ISS-  
GO:0035713response to nitrogen dioxide-ISS-  
GO:0042102positive regulation of T cell proliferation-IBA21873635  
GO:0043372positive regulation of CD4-positive, alpha-beta T cell differentiation-ISS-  
GO:0043382positive regulation of memory T cell differentiation-ISS-  
GO:0043433negative regulation of DNA-binding transcription factor activity-ISS-  
GO:0045590negative regulation of regulatory T cell differentiation-ISS-  
GO:0045626negative regulation of T-helper 1 cell differentiation-ISS-  
GO:0045630positive regulation of T-helper 2 cell differentiation-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0046641positive regulation of alpha-beta T cell proliferation-ISS-  
GO:0050727regulation of inflammatory response-ISS-  
GO:0050729positive regulation of inflammatory response-IDA20844189  
GO:0050871positive regulation of B cell activation-ISS-  
GO:0051024positive regulation of immunoglobulin secretion-ISS-  
GO:0071222cellular response to lipopolysaccharide-IDA20844189  
GO:0071380cellular response to prostaglandin E stimulus-IDA19029446  
GO:0071954chemokine (C-C motif) ligand 11 production-ISS-  
GO:1900281positive regulation of CD4-positive, alpha-beta T cell costimulation-ISS-  
GO:2000572positive regulation of interleukin-4-dependent isotype switching to IgE isotypes-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA17166734  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS18397322  
GO:0009986cell surface-IDA18397322  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5669034TNFs bind their physiological receptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28816579Application of the distance-based F test in an mGWAS investigating beta diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci. (2018 Jan 2)Ruhlemann MCGut Microbes
23184501TNFSF4 gene polymorphism rs3861950 but not rs3850641 is associated with the risk of cerebral infarction in a Chinese population. (2013 Oct)Feng JJ Thromb Thrombolysis