Gene: CCR2

729230
CC-CKR-2|CCR-2|CCR2A|CCR2B|CD192|CKR2|CKR2A|CKR2B|CMKBR2|MCP-1-R
C-C motif chemokine receptor 2
protein-coding
3p21.31
Ensembl:ENSG00000121807 MIM:601267 Vega:OTTHUMG00000156466 UniprotKB:P41597
NG_021428.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
14   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.302e-1 (AD)  1.186e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LILRB20.753
TNFRSF10C0.726
NFE20.71
CD300E0.709
CD480.707
CST70.706
IL18RAP0.702
SH2D2A0.702
PARP150.701
CEACAM40.697

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.581
MARCH4-0.561
BCL11A-0.559
LRTM2-0.553
EXTL1-0.553
SVOP-0.55
CHRNA4-0.55
CDK5R2-0.547
KCNB2-0.544
HCN1-0.542

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05130INCB3284Small Molecule-InvestigationalTarget
DB05159CCX915Small Molecule-InvestigationalTarget
DB12520PlozalizumabBiotechDrug1610761-46-0InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CCR2 mRNA"18711122
C52473317-ethynyl-5-androstene-3, 7, 17-triol"17-ethynyl-5-androstene-3, 7, 17-triol results in decreased expression of CCR2"22384159
C4001841-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CCR2 mRNA16386258
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl affects the expression of CCR2 mRNA"21703328
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CCR2 mRNA"23146750
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein]26163174
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCR2 mRNA"23681119
C4574992-chloro-5-nitrobenzanilide[2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Simvastatin results in decreased expression of CCR2 mRNA]15781755
C4574992-chloro-5-nitrobenzanilide[2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Simvastatin results in decreased expression of CCR2 protein]15781755
C0306823-chlorophenol3-chlorophenol results in increased expression of CCR2 mRNA18486366
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [alitretinoin results in decreased expression of CCR2 mRNA]16712875
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole results in decreased expression of CCR2 mRNA16712875
C0297284-phenylenediamine4-phenylenediamine results in decreased expression of CCR2 mRNA19371601
D000079AcetaldehydeAcetaldehyde results in increased expression of CCR2 protein19036374
D000082AcetaminophenAcetaminophen results in increased expression of CCR2 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of CCR2 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of CCR2 mRNA22575169
D000082AcetaminophenAcetaminophen results in increased expression of CCR2 protein11981759
D000082AcetaminophenCCR2 protein affects the reaction [Acetaminophen results in increased expression of CCL7 protein]11981759
D000082AcetaminophenCCR2 protein affects the reaction [Acetaminophen results in increased expression of CXCL1 protein]11981759
D000082AcetaminophenCCR2 protein affects the reaction [Acetaminophen results in increased expression of TNF protein]11981759
D000082AcetaminophenCCR2 protein affects the susceptibility to Acetaminophen18713872
D000082AcetaminophenMST1R protein affects the reaction [Acetaminophen results in increased expression of CCR2 mRNA]22575169
D000082AcetaminophenAcetaminophen affects the expression of CCR2 mRNA20623750
D020106AcrylamideAcrylamide results in decreased expression of CCR2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CCR2 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of CCR2 mRNA"23195993
C103303alitretinoin4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [alitretinoin results in decreased expression of CCR2 mRNA]16712875
C103303alitretinoinalitretinoin results in decreased expression of CCR2 mRNA16712875
C103303alitretinoinalitretinoin results in decreased expression of CCR2 protein16712875
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CCR2 mRNA16483693
C018453ammonium hexachloroplatinateammonium hexachloroplatinate results in decreased expression of CCR2 mRNA19371601
D000666Amphotericin BAmphotericin B results in decreased expression of CCR2 mRNA20623750
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CCR2 mRNA24449571|2533912
D001151ArsenicArsenic affects the expression of CCR2 protein24675094
D001151ArsenicArsenic affects the methylation of CCR2 gene25304211
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of CCR2 mRNA19962721
D001151ArsenicArsenic results in decreased expression of CCR2 mRNA19962721
D001151ArsenicArsenic results in decreased expression of CCR2 mRNA19654921
D001194AsbestosAsbestos affects the expression of CCR2 mRNA17297452
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of CCR2 mRNA"24160326
C547126AZM551248AZM551248 results in decreased expression of CCR2 mRNA22323515
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of CCR2 mRNA18711122
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCR2 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CCR2 mRNA23735875
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CCR2 mRNA"18711122
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of CCR2 mRNA18711122
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of CCR2 mRNA"18711122
D004958EstradiolEstradiol results in increased expression of CCR2 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of CCR2 mRNA25181051
D001761BleomycinBleomycin results in increased expression of CCR2 mRNA29033951
D001761BleomycinCCR2 gene mutant form inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]14609568
D001761BleomycinCCR2 gene mutant form inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]14609568
D001761BleomycinCCR2 gene mutant form inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]14609568
D001761BleomycinCCR2 gene mutant form inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]14609568
D001761BleomycinCCR2 gene mutant form results in decreased susceptibility to Bleomycin14609568
C006794brevianamide Abrevianamide A results in increased expression of CCR2 mRNA19818335
C040048caffeic acid[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR2 mRNA16806235
C005563captaxcaptax results in increased expression of CCR2 mRNA20713136
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CCR2 mRNA22206755|2733941
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CCR2 protein22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of CCR2 mRNA]22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of CCR2 protein]22206755
D002392Catechin[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR2 mRNA16806235
D000068579CelecoxibCelecoxib results in decreased expression of CCR2 mRNA12902868
D002737ChloropreneChloroprene results in decreased expression of CCR2 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCR2 mRNA20938992
C000488cladosporincladosporin results in increased expression of CCR2 mRNA19818335
D003042CocaineCCR2 results in increased susceptibility to Cocaine20354174
D003042CocaineCocaine affects the expression of CCR2 mRNA20187946
D003436Croton OilCroton Oil results in increased expression of CCR2 mRNA19647056
D003474CurcuminCurcumin results in decreased expression of CCR2 mRNA18403477
C038459curdlancurdlan affects the expression of CCR2 mRNA19904525
D016572CyclosporineCyclosporine results in increased expression of CCR2 mRNA20106945
C014347decitabinedecitabine results in increased expression of CCR2 mRNA21856257
C007262deoxynivalenoldeoxynivalenol results in increased expression of CCR2 mRNA22968694
C041517dibenzo(a,l)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of CCR2 mRNA"18711122
D002945CisplatinCisplatin results in increased expression of CCR2 mRNA27594783
C027118didecyldimethylammoniumdidecyldimethylammonium results in increased expression of CCR2 mRNA19762220
D004041Dietary FatsDietary Fats results in decreased expression of CCR2 mRNA18042831
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of CCR2 mRNA21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CCR2 mRNA28085963
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CCR2 mRNA21041162
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of CCR2 mRNA17374397|1937160
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of CCR2 mRNA20713136
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of CCR2 mRNA19647056
D004139Dinitrofluorobenzene[CCL2 protein results in increased expression of CCR2 protein] which affects the susceptibility to Dinitrofluorobenzene21362464
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of CCR2 mRNA21362464
D004317Doxorubicin[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of CCR2 mRNA27181935
C046855epostaneepostane promotes the reaction [Dinoprost results in increased expression of CCR2 mRNA]21505051
D004917ErythromycinErythromycin results in increased expression of CCR2 mRNA27503388
D004917Erythromycin[Penicillin G co-treated with Erythromycin] results in increased expression of CCR2 mRNA27503388
D000431EthanolEthanol results in increased expression of CCR2 mRNA26014148
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CCR2 mRNA12538720|1588563
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CCR2 mRNA15834898
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CCR2 mRNA23649840
D005054EugenolEugenol results in decreased expression of CCR2 mRNA17374397
C012976flumequine"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCR2 mRNA"23681119
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of CCR2 mRNA19962721
D005459FluoridesFluorides results in decreased expression of CCR2 mRNA19962721
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCR2 mRNA20938992
D062610Fungal Polysaccharides[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of CCR2 mRNA27181935
C546771gardiquimodgardiquimod results in increased expression of CCR2 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CCR2 mRNA]28003376
D017313FenretinideFenretinide results in decreased expression of CCR2 mRNA28973697
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein] which results in increased expression of CCR2 mRNA"22206755
D007538IsoniazidIsoniazid results in decreased expression of CCR2 mRNA20623750
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CCR2 mRNA24435446
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CCR2 mRNA25982114
C008261lead acetatelead acetate results in increased expression of CCR2 mRNA22609695
C008261lead acetatelead acetate results in increased expression of CCR2 mRNA22641619
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in decreased expression of CCR2 mRNA"23090859
D019808LosartanLosartan results in decreased expression of CCR2 mRNA17922026
D008466MechlorethamineMechlorethamine results in increased expression of CCR2 mRNA26273949|2818490
D008466MechlorethamineMechlorethamine results in increased expression of CCR2 protein26273949
D008466MechlorethamineValproic Acid inhibits the reaction [Mechlorethamine results in increased expression of CCR2 mRNA]28184907
D008627Mercuric ChlorideCCR2 protein results in increased susceptibility to Mercuric Chloride12834626
D008627Mercuric ChlorideMercuric Chloride results in increased expression of CCR2 mRNA12834626
D008627Mercuric ChlorideMercuric Chloride results in increased expression of CCR2 protein12834626
D008628MercuryMercury results in decreased expression of CCR2 mRNA16823088
D008687MetforminMetformin inhibits the reaction [IL13 protein results in increased expression of CCR2 mRNA]26497364
D008694MethamphetamineCCR2 protein results in increased susceptibility to Methamphetamine20624155
D008694MethamphetamineMethamphetamine results in increased expression of CCR2 mRNA20624155
D008694MethamphetamineMethamphetamine results in increased methylation of CCR2 promoter20624155
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCR2 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of CCR2 mRNA24449571
D008767Methylmercury CompoundsCCR2 protein affects the susceptibility to Methylmercury Compounds21976372
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CCR2 mRNA23649840
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]]16321392
C523799MRK 003CCR2 results in increased susceptibility to MRK 00319903844
D009151Mustard GasMustard Gas results in increased expression of CCR2 mRNA18955075
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of CCR2 mRNA19818335
D009183MycotoxinsMycotoxins results in increased expression of CCR2 mRNA19818335
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CCR2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCR2 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of CCR2 mRNA19812364
C490266neoechinulin Aneoechinulin A results in increased expression of CCR2 mRNA19818335
D009532NickelNickel affects the expression of CCR2 mRNA14575637
D009532NickelNickel results in decreased expression of CCR2 mRNA23195993
D009532NickelNickel results in increased expression of CCR2 mRNA24768652|2558310
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of CCR2 mRNA]14575637
C029938nickel sulfatenickel sulfate results in decreased expression of CCR2 mRNA17374397
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CCR2 mRNA"12756304
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCR2 mRNA"19013360
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CCR2 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of CCR2 mRNA25729387
D010081OxazoloneOxazolone results in decreased expression of CCR2 mRNA17374397
D010081OxazoloneOxazolone results in increased expression of CCR2 mRNA19647056
D010126OzoneCCR2 gene mutant form results in decreased susceptibility to Ozone27837169
D000073878Palm OilPalm Oil results in decreased expression of CCR2 mRNA18042831
C084656paricalcitolparicalcitol results in increased expression of CCR2 mRNA25037058
D052638Particulate MatterCCR2 gene mutant form inhibits the reaction [Particulate Matter results in decreased expression of SLC2A2]24149114
D052638Particulate MatterCCR2 gene mutant form inhibits the reaction [Particulate Matter results in increased expression of ACACB mRNA]24149114
D052638Particulate MatterCCR2 gene mutant form inhibits the reaction [Particulate Matter results in increased expression of ADGRE1 mRNA]24149114
D052638Particulate MatterCCR2 gene mutant form inhibits the reaction [Particulate Matter results in increased expression of CD68 mRNA]24149114
D052638Particulate MatterCCR2 gene mutant form inhibits the reaction [Particulate Matter results in increased expression of FAS mRNA]24149114
D052638Particulate MatterCCR2 gene mutant form inhibits the reaction [Particulate Matter results in increased expression of SREBF1 mRNA]24149114
D052638Particulate MatterCCR2 protein results in increased susceptibility to Particulate Matter21906792|2414911
D052638Particulate MatterParticulate Matter results in increased expression of CCR2 mRNA21708214|2190679
C410127PCB 180PCB 180 affects the expression of CCR2 mRNA21703328
D010400Penicillin G[Penicillin G co-treated with Erythromycin] results in increased expression of CCR2 mRNA27503388
D010852PicrotoxinPicrotoxin results in increased expression of CCR2 mRNA15170462
D010862PilocarpinePilocarpine results in decreased expression of CCR2 mRNA19490431
D010862PilocarpinePilocarpine results in decreased expression of CCR2 protein19490431
D010862PilocarpinePilocarpine results in increased expression of CCR2 protein20034406
D010880PiperidinesPiperidines analog binds to and results in decreased activity of CCR2 protein10843593
D010880PiperidinesPiperidines analog inhibits the reaction [CCL2 protein binds to CCR2 protein]10770925
D010936Plant ExtractsPlant Extracts results in decreased expression of CCR2 mRNA12462994
D010972Platelet Activating FactorPlatelet Activating Factor results in increased expression of CCR2 mRNA16386258
C013221proanthocyanidinproanthocyanidin results in decreased expression of CCR2 mRNA12462994
D015237DinoprostDinoprost results in increased expression of CCR2 mRNA21505051
D015237Dinoprostepostane promotes the reaction [Dinoprost results in increased expression of CCR2 mRNA]21505051
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CCR2 mRNA]28003376
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein]26163174
C059514resveratrolresveratrol results in decreased expression of CCR2 mRNA17499741
C059514resveratrolresveratrol results in decreased expression of CCR2 protein17499741
C059514resveratrol[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR2 mRNA16806235
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of CCR2 mRNA21852083
C573791RS 102895RS 102895 inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein]26163174
C093642SB 203580SB 203580 inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein]26163174
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of CCR2 mRNA"16251409
D012822Silicon Dioxide2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein]26163174
D012822Silicon DioxideCCR2 promotes the reaction [Silicon Dioxide results in increased secretion of CCL2 protein]26163174
D012822Silicon Dioxidepyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein]26163174
D012822Silicon DioxideRS 102895 inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein]26163174
D012822Silicon DioxideSB 203580 inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein]26163174
D012822Silicon DioxideSilicon Dioxide results in increased expression of CCR2 mRNA26163174
D012822Silicon DioxideSilicon Dioxide results in increased expression of CCR2 protein26163174
D012822Silicon DioxideU 0126 inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein]26163174
D012822Silicon DioxideSilicon Dioxide results in increased expression of CCR2 mRNA21602193
D019821Simvastatin[2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Simvastatin results in decreased expression of CCR2 mRNA]15781755
D019821Simvastatin[2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Simvastatin results in decreased expression of CCR2 protein]15781755
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]]16321392
D019821SimvastatinSimvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]16321392
D019821SimvastatinSimvastatin results in decreased expression of CCR2 mRNA15781755|1678169
D019821SimvastatinSimvastatin results in decreased expression of CCR2 protein15781755
D019821SimvastatinSimvastatin results in decreased expression of CCR2 mRNA16414398
D019821SimvastatinSimvastatin results in decreased expression of CCR2 protein17449418
C017947sodium arsenitesodium arsenite results in increased expression of CCR2 mRNA21911445
C032706sodium chloratesodium chlorate inhibits the reaction [CCL2 protein results in increased activity of CCR2 protein]23408426
C032706sodium chloratesodium chlorate results in decreased sulfation of CCR2 protein23408426
D012969Sodium FluorideSodium Fluoride results in decreased expression of CCR2 mRNA27257137
D053260SootSoot results in decreased expression of CCR2 mRNA26551751
D013241SterigmatocystinSterigmatocystin results in increased expression of CCR2 mRNA19818335
C016766sulforafansulforafan results in decreased expression of CCR2 mRNA26833863
D013629TamoxifenTamoxifen results in decreased expression of CCR2 mRNA25123088
C084178telmisartantelmisartan results in decreased expression of CCR2 mRNA17922026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CCR2 protein21685244
D013893ThiramThiram results in decreased expression of CCR2 mRNA19371601
C009495titanium dioxidetitanium dioxide results in increased expression of CCR2 mRNA23557971
C402696TMC 120ATMC 120A results in increased expression of CCR2 mRNA19818335
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of CCR2 mRNA"19647056
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CCR2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CCR2 mRNA25729387
D014212TretinoinTretinoin results in increased expression of CCR2 mRNA19828696
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of CCR2 mRNA]14575637
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of CCR2 mRNA17982090
C001899triptolidetriptolide results in increased expression of CCR2 mRNA28962522
C113580U 0126U 0126 inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein]26163174
D014635Valproic AcidValproic Acid inhibits the reaction [Mechlorethamine results in increased expression of CCR2 mRNA]28184907
D001335Vehicle EmissionsCCR2 protein results in increased susceptibility to Vehicle Emissions21906792
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CCR2 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of CCR2 mRNA21906792
C025643vinclozolinvinclozolin results in increased expression of CCR2 mRNA23034163
D019287Zinc SulfateZinc Sulfate results in increased expression of CCR2 mRNA12756304
D015054ZymosanCCR2 protein affects the reaction [Zymosan results in increased expression of CCL2 protein]12845637
D015054ZymosanCCR2 protein affects the reaction [Zymosan results in increased expression of IFNG mRNA]12845637
D015054ZymosanCCR2 protein affects the reaction [Zymosan results in increased expression of IFNG protein]12845637

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004950chemokine receptor activity-TAS10623817  
GO:0005515protein binding-IPI23938203  
GO:0016493C-C chemokine receptor activity-IBA21873635  
GO:0016493C-C chemokine receptor activity-IEA-  
GO:0019956chemokine binding-IBA21873635  
GO:0019957C-C chemokine binding-IBA21873635  
GO:0031727CCR2 chemokine receptor binding-IDA15995708  
GO:0035715chemokine (C-C motif) ligand 2 binding-IBA21873635  
GO:0035715chemokine (C-C motif) ligand 2 binding-IEA-  
GO:0035716chemokine (C-C motif) ligand 12 binding-IBA21873635  
GO:0035716chemokine (C-C motif) ligand 12 binding-IEA-  
GO:0035717chemokine (C-C motif) ligand 7 binding-IBA21873635  
GO:0035717chemokine (C-C motif) ligand 7 binding-IEA-  
GO:0042803protein homodimerization activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001974blood vessel remodeling-ISS-  
GO:0002407dendritic cell chemotaxis-TAS16621978  
GO:0002548monocyte chemotaxis-IEA-  
GO:0002827positive regulation of T-helper 1 type immune response-ISS-  
GO:0002829negative regulation of type 2 immune response-ISS-  
GO:0006874cellular calcium ion homeostasis-ISS-  
GO:0006935chemotaxis-IBA21873635  
GO:0006935chemotaxis-TAS10623817  
GO:0006954inflammatory response-IBA21873635  
GO:0006954inflammatory response-IEA-  
GO:0006955immune response-IBA21873635  
GO:0006955immune response-TAS10751368  
GO:0006959humoral immune response-IEA-  
GO:0006968cellular defense response-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007194negative regulation of adenylate cyclase activity-TAS8995400  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-TAS9548499  
GO:0007259JAK-STAT cascade-TAS9670957  
GO:0009611response to wounding-TAS8146186  
GO:0010574regulation of vascular endothelial growth factor production-ISS-  
GO:0010820positive regulation of T cell chemotaxis-ISS-  
GO:0016032viral process-IEA-  
GO:0016525negative regulation of angiogenesis-ISS-  
GO:0019221cytokine-mediated signaling pathway-IDA15995708  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0019233sensory perception of pain-IEA-  
GO:0019722calcium-mediated signaling-IBA21873635  
GO:0019725cellular homeostasis-ISS-  
GO:0030097hemopoiesis-IEA-  
GO:0032729positive regulation of interferon-gamma production-ISS-  
GO:0032743positive regulation of interleukin-2 production-ISS-  
GO:0035705T-helper 17 cell chemotaxis-ISS-  
GO:0042535positive regulation of tumor necrosis factor biosynthetic process-ISS-  
GO:0043310negative regulation of eosinophil degranulation-ISS-  
GO:0046641positive regulation of alpha-beta T cell proliferation-ISS-  
GO:0048873homeostasis of number of cells within a tissue-IEA-  
GO:0050729positive regulation of inflammatory response-ISS-  
GO:0050870positive regulation of T cell activation-ISS-  
GO:0060326cell chemotaxis-IBA21873635  
GO:0061756leukocyte adhesion to vascular endothelial cell-IEA-  
GO:0070098chemokine-mediated signaling pathway-ISS-  
GO:0090026positive regulation of monocyte chemotaxis-IDA18587271  
GO:0090026positive regulation of monocyte chemotaxis-ISS-  
GO:0090265positive regulation of immune complex clearance by monocytes and macrophages-ISS-  
GO:0097350neutrophil clearance-IEA-  
GO:1903238positive regulation of leukocyte tethering or rolling-IEA-  
GO:2000439positive regulation of monocyte extravasation-ISS-  
GO:2000451positive regulation of CD8-positive, alpha-beta T cell extravasation-ISS-  
GO:2000464positive regulation of astrocyte chemotaxis-IDA12271471  
GO:2000473positive regulation of hematopoietic stem cell migration-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA15995708  
GO:0005829cytosol-ISS-  
GO:0005886plasma membrane-IDA15995708  18587271  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8146186  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0009897external side of plasma membrane-IEA-  
GO:0016021integral component of membrane-TAS8530354  
GO:0030425dendrite-ISS-  
GO:0043025neuronal cell body-ISS-  
GO:0043204perikaryon-ISS-  
GO:0048471perinuclear region of cytoplasm-ISS-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1461957Beta defensinsTAS
R-HSA-1461973DefensinsTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-6783783Interleukin-10 signalingTAS
R-HSA-6803157Antimicrobial peptidesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19506371Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosis. (2009)Nyquist PACerebrovasc Dis
17917677Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI family heart study follow-up examination. (2007 Dec)Bielinski SJGenes Immun
10727989Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD. (2000 Apr)de Boer WIJ Pathol
20354174Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. (2010 Jun 10)Yao HBlood
16055130Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US women. (2006 May)Pai JKAtherosclerosis
25397464Relationship between innate immunity, soluble markers and metabolic-clinical parameters in HIV+ patients ART treated with HIV-RNA<50 cp/mL. (2014)Dentone CJ Int AIDS Soc
23090289Expression of monocyte chemoattractant protein-1 and CC chemokine receptor 2 in non-small cell lung cancer and its significance. (2013 Mar)Zhang XWCancer Immunol Immunother
20887155Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers. (2010 Dec)Edmiston JSBiomarkers
21264360Combined association of CCR2-V64I and MCP-1-2518A/G polymorphisms with generalised aggressive periodontitis in Chinese. (2010)Zhu XLChin J Dent Res
22097713[Expression of mRNA for MCP-1 and CCR2 in cerebral tissue of rats with acute alcoholism]. (2011 Aug)Xu CYZhongguo Ying Yong Sheng Li Xue Za Zhi
25716997Buprenorphine decreases the CCL2-mediated chemotactic response of monocytes. (2015 Apr 1)Carvallo LJ Immunol
26591766[Interaction of polymorphisms of monocyte chemoattractant protein-1 receptor CCR2 gene 190A/G, nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox gene C242T and cigarette smoking increases the risk of nonalcoholic fatty liver disease]. (2015 Sep)Zhang CWei Sheng Yan Jiu
12962514Therapy for chronic obstructive pulmonary disease in the 21st century. (2003)Donnelly LEDrugs
16207551Additive effects of the chemokine receptor 2, vitamin D receptor, interleukin-6 polymorphisms and cardiovascular risk factors on the prevalence of myocardial infarction in patients below 65 years. (2005 Oct 20)Ortlepp JRInt J Cardiol