Gene: SFTPA2

729238
COLEC5|PSAP|PSP-A|PSPA|SFTP1|SFTPA2B|SP-2A|SP-A|SPA2|SPAII
surfactant protein A2
protein-coding
10q22.3
Ensembl:ENSG00000185303 MIM:178642 Vega:OTTHUMG00000018566 UniprotKB:Q8IWL1
NG_013046.1
PubMed
0   ANCO-SNPs
ND
1   
3.121e-1 (AD)  NA (ND)   (Frontal_Cortex)
1.738e-1 (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFTPA10.883
SFTPB0.878
SLC34A20.692
SCGB1A10.638
SCGB3A20.614
CXCL170.609
TPO0.609
KRT70.604
CSRP30.587
C4BPA0.58

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES6-0.32
FAM69C-0.316
HES5-0.298
HDAC11-0.295
C1orf53-0.293
HHATL-0.289
ENHO-0.287
HOMER3-0.287
C16orf74-0.285
HAGHL-0.283

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000255Adenosine TriphosphateOzone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]15065867
D000255Adenosine TriphosphateOzone inhibits the reaction [SFTPA2 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]15065867
D000255Adenosine Triphosphate[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]15065867
D000255Adenosine TriphosphateSFTPA2 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]15065867
D001280AtrazineAtrazine results in increased expression of SFTPA2 mRNA22378314
D001761Bleomycin[Bleomycin co-treated with SFTPA2 protein polymorphism] results in increased expression of CXCL8 protein14617519
D001761Bleomycin[Bleomycin co-treated with SFTPA2 protein polymorphism] results in increased expression of TNF protein14617519
D001761BleomycinBleomycin promotes the reaction [[SFTPA1 protein binds to SFTPA2 protein] which results in increased expression of TNF protein]14617519
D001761Bleomycincalfactant inhibits the reaction [Bleomycin promotes the reaction [[SFTPA1 protein binds to SFTPA2 protein] which results in increased expression of TNF protein]]14617519
D001761BleomycinOzone inhibits the reaction [[Bleomycin co-treated with SFTPA2 protein polymorphism] results in increased expression of TNF protein]14617519
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SFTPA2 mRNA16997883
C117342calfactantcalfactant inhibits the reaction [Bleomycin promotes the reaction [[SFTPA1 protein binds to SFTPA2 protein] which results in increased expression of TNF protein]]14617519
C117342calfactantcalfactant inhibits the reaction [[SFTPA1 protein binds to SFTPA2 protein] which results in increased expression of TNF protein]14617519
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SFTPA2 mRNA16997883
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SFTPA2 mRNA16997883
D010126OzoneOzone inhibits the reaction [[Bleomycin co-treated with SFTPA2 protein polymorphism] results in increased expression of TNF protein]14617519
D010126OzoneOzone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]15065867
D010126OzoneOzone inhibits the reaction [SFTPA2 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]15065867
D010126OzoneOzone inhibits the reaction [SFTPA2 protein polymorphism results in increased expression of TNF protein]14617519
D010126OzoneOzone promotes the reaction [SFTPA2 protein polymorphism binds to SFTPA2 protein polymorphism]15065867
D010126OzoneOzone results in increased oxidation of SFTPA2 protein polymorphism14617519|1506586
D010126OzoneSFTPA2 protein affects the susceptibility to Ozone11781168
D010126OzoneSFTPA2 protein promotes the reaction [Ozone results in increased expression of CXCL8 protein]11781168
D010126OzoneSFTPA2 protein promotes the reaction [Ozone results in increased expression of TNF protein]11781168
D010713PhosphatidylcholinesOzone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]15065867
D010713PhosphatidylcholinesOzone inhibits the reaction [SFTPA2 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]15065867
D010713Phosphatidylcholines[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]15065867
D010713PhosphatidylcholinesSFTPA2 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]15065867
D010936Plant ExtractsPlant Extracts results in decreased expression of SFTPA2 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SFTPA2 mRNA21296121
D014635Valproic AcidValproic Acid results in increased methylation of SFTPA2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased expression of SFTPA2 protein mutant form19181744

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001530lipopolysaccharide binding-IBA21873635  
GO:0030246carbohydrate binding-IEA-  
GO:0048029monosaccharide binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002224toll-like receptor signaling pathway-TAS-  
GO:0007585respiratory gaseous exchange-IEA-  
GO:0032502developmental process-IBA21873635  
GO:0043129surfactant homeostasis-IBA21873635  
GO:0044267cellular protein metabolic process-TAS-  
GO:0050766positive regulation of phagocytosis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005581collagen trimer-IEA-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IEA-  
GO:0005771multivesicular body-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005791rough endoplasmic reticulum-IBA21873635  
GO:0042599lamellar body-TAS-  
GO:0045334clathrin-coated endocytic vesicle-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-1643685DiseaseTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-391160Signal regulatory protein family interactionsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-5683826Surfactant metabolismTAS
R-HSA-5686938Regulation of TLR by endogenous ligandTAS
R-HSA-5687613Diseases associated with surfactant metabolismTAS
R-HSA-5687868Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)TAS
R-HSA-5688849Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)TAS
R-HSA-5688890Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301408Pulmonary Fibrosis, Familial (1993)Talbert JL-