Gene info: ID 7295

Gene: TXN

GENE ID: 7295

Synonyms: TRDX|TRX|TRX1

Description: thioredoxin

Gene type: protein-coding

Location: 9q31.3

dbXrefs: Ensembl:ENSG00000136810 MIM:187700 Vega:OTTHUMG00000020480 UniprotKB:P10599

RefSeq: NC_000009.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.552e-2 (AD) 1.402e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MRPL20	0.95
PSMB4	0.946
LAMTOR5	0.945
SARNP	0.945
COX6C	0.942
SNRPD2	0.94
SUMO2	0.938
NDUFB6	0.937
ARPC3	0.937
SSBP1	0.936

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.831
OR4F29	-0.815
MTRNR2L6	-0.169
CCR8	-0.156
C8orf74	-0.155
DNAH11	-0.155
P2RY14	-0.148
MAGEA12	-0.147
MTRNR2L9	-0.146
FANCD2OS	-0.141

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB12695	Phenethyl Isothiocyanate	Small Molecule	2257-09-2	Investigational	Target

ID	Drug Name	Action	PubMed
C097949	1,25-dihydroxyvitamin D	"1,25-dihydroxyvitamin D affects the localization of TXN protein"	16061374
C015699	1,2-benzisothiazoline-3-one	"1,2-benzisothiazoline-3-one results in increased expression of TXN mRNA"	20491607
C478160	(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane	"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of and affects the localization of TXN protein"	28757135
C478160	(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane	"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of TXN mRNA"	28757135
C478160	(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane	"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of TXN protein"	28757135
C517232	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane analog results in increased expression of TXN mRNA"	24273086
C517232	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of TXN mRNA"	24273086
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TXN protein results in decreased susceptibility to Oxygen]	20812253
C055802	2-nonynoic acid methyl ester	2-nonynoic acid methyl ester results in increased expression of TXN mRNA	20491607
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of TXN mRNA	12958071
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TXN mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal affects the metabolism of TXN protein	17982132
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased activity of TXN protein	17982132
C065250	4-hydroxy-equilenin	4-hydroxy-equilenin results in increased expression of TXN mRNA	15135645
C032078	4-methylumbelliferyl acetate	4-methylumbelliferyl acetate results in increased activity of TXN protein	24103856
C477187	5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole	"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole results in decreased expression of TXN protein"	22745752
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TXN mRNA"	27188386
C114369	7,8-diacetoxy-4-methylcoumarin	"7,8-diacetoxy-4-methylcoumarin results in increased activity of TXN protein"	24103856
C114369	7,8-diacetoxy-4-methylcoumarin	"7,8-diacetoxy-4-methylcoumarin results in increased expression of TXN mRNA"	24103856
D000082	Acetaminophen	Acetaminophen affects the expression of TXN mRNA	25064622
D000082	Acetaminophen	Acetaminophen results in decreased expression of TXN mRNA	22230336\|2669055
D000082	Acetaminophen	Acetaminophen results in increased expression of TXN mRNA	17522070
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Acrolein results in increased oxidation of TXN protein]	18023956
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of TXN protein]	17959236
D000111	Acetylcysteine	Acetylcysteine results in decreased expression of TXN protein	17959236
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of TXN protein]	24157283
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]]	16449798
D000171	Acrolein	Acetylcysteine inhibits the reaction [Acrolein results in increased oxidation of TXN protein]	18023956
D000171	Acrolein	Acrolein affects the metabolism of TXN protein	17982132
D000171	Acrolein	Acrolein results in decreased activity of TXN protein	15388247\|1798213
D000171	Acrolein	Acrolein results in increased oxidation of TXN protein	18023956\|1913512
D000255	Adenosine Triphosphate	Adenosine Triphosphate results in increased expression of TXN protein	22129738
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of TXN protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of TXN gene	27153756
D000393	Air Pollutants	Air Pollutants results in increased expression of TXN mRNA	18079490
D000638	Amiodarone	Amiodarone affects the expression of TXN mRNA	25064622
C006632	arsenic trioxide	arsenic trioxide affects the expression of TXN mRNA	25873331
C006632	arsenic trioxide	arsenic trioxide results in increased expression of TXN mRNA	25258189
C006632	arsenic trioxide	arsenic trioxide results in increased oxidation of TXN protein	17640917\|2697547
C006632	arsenic trioxide	TXN protein results in decreased susceptibility to arsenic trioxide	20707922\|2259050
C006632	arsenic trioxide	Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of TXN protein]	24157283
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TXN protein	24157283
D001194	Asbestos	Asbestos results in increased expression of TXN protein	27032653
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of TXN mRNA"	24885895
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased oxidation of TXN protein"	24885895
D017638	Asbestos, Crocidolite	"[Asbestos, Crocidolite results in increased oxidation of TXN protein] inhibits the reaction [TXN protein binds to TXNIP protein]"	24885895
D017638	Asbestos, Crocidolite	"TXN mRNA inhibits the reaction [Asbestos, Crocidolite results in increased oxidation of TXN protein]"	24885895\|2488589
D017638	Asbestos, Crocidolite	"TXN protein affects the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]"	18403674
D001262	Atenolol	Atenolol results in increased expression of TXN mRNA	19915711
D001310	Auranofin	Auranofin results in increased oxidation of TXN protein	26975474
D001554	Benzene	TXN protein results in decreased susceptibility to Benzene	17157166
D001554	Benzene	[Benzene co-treated with TXN protein] results in decreased expression of AHR mRNA	17157166
D001554	Benzene	TXN protein inhibits the reaction [Benzene results in increased expression of CDKN1A mRNA]	17157166
C041512	benzo(b)fluorene	[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of TXN mRNA	22120849
D019817	Benzoic Acid	Benzoic Acid results in increased expression of TXN mRNA	20491607
D053119	Benzophenanthridines	[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of TXN mRNA	22120849
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TXN mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TXN mRNA	21632981
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TXN mRNA"	19150397
C526327	benzyl cinnamate	benzyl cinnamate results in increased expression of TXN mRNA	20491607
D004958	Estradiol	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of TXN mRNA	20823114
C006780	bisphenol A	bisphenol A results in decreased expression of TXN mRNA	20678512
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TXN mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of TXN mRNA	25181051
C013418	bromfenacoum	bromfenacoum results in decreased expression of TXN protein	28903499
D020122	tert-Butylhydroperoxide	TXN protein results in decreased susceptibility to tert-Butylhydroperoxide	10754530
D002101	Cacodylic Acid	[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of TXN mRNA	23192986
D002104	Cadmium	Cadmium results in increased expression of TXN protein	16440303
D002104	Cadmium	Cadmium results in increased expression of TXN mRNA	16624402
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TXN mRNA	19031917
D019256	Cadmium Chloride	Cadmium Chloride affects the localization of TXN protein	18261755\|2296109
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TXN mRNA	25596134\|2652539
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TXN protein	16440303
D019256	Cadmium Chloride	Cadmium Chloride results in increased oxidation of TXN protein	16337887
D019256	Cadmium Chloride	Cytochalasin D inhibits the reaction [Cadmium Chloride affects the localization of TXN protein]	22961094
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TXN mRNA	16624402
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TXN mRNA	17522070
C099555	CD 437	CD 437 results in decreased expression of TXN mRNA	12958071
C026690	cerous chloride	cerous chloride results in increased expression of TXN mRNA	28954213
D002635	Chenodeoxycholic Acid	[Chenodeoxycholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN mRNA	17724089
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in increased expression of TXN protein	17724089
C004656	chloroacetaldehyde	chloroacetaldehyde results in increased expression of TXN mRNA	25596134
D002725	Chloroform	Chloroform results in increased expression of TXN mRNA	17522070
D002726	Chlorogenic Acid	Chlorogenic Acid results in increased expression of TXN mRNA	20706672
D002746	Chlorpromazine	Chlorpromazine affects the expression of TXN mRNA	25064622
C074702	chromium hexavalent ion	chromium hexavalent ion inhibits the reaction [TXN protein binds to MAP3K5 protein]	19703554
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased oxidation of TXN protein	19703554\|2123724
C074702	chromium hexavalent ion	tris(2-carboxyethyl)phosphine inhibits the reaction [chromium hexavalent ion results in increased oxidation of TXN protein]	19703554
C059262	cidofovir	cidofovir results in increased expression of TXN mRNA	25596134
D004002	Clodronic Acid	Clodronic Acid results in increased expression of TXN mRNA	25596134
D002994	Clofibrate	Clofibrate results in increased expression of TXN mRNA	16081524
D002994	Clofibrate	Clofibrate results in decreased expression of TXN mRNA	17522070
C018021	cobaltous chloride	cobaltous chloride results in increased expression of TXN mRNA	24612858
D009249	NADP	TXN affects the reaction [PRDX4 protein modified form results in increased oxidation of NADP]	20381631
D003300	Copper	Copper results in increased expression of TXN mRNA	21616164
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TXN mRNA	19549813
D019327	Copper Sulfate	TXN protein inhibits the reaction [Copper Sulfate affects the reaction [Peroxynitrous Acid results in decreased activity of PRNP protein]]	14713301
C029892	cupric chloride	cupric chloride results in increased expression of TXN mRNA	17211630
D016572	Cyclosporine	Cyclosporine affects the expression of TXN mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in increased expression of TXN mRNA	20106945\|2559613
D015638	Cytochalasin D	Cytochalasin D inhibits the reaction [Cadmium Chloride affects the localization of TXN protein]	22961094
C010902	decabromobiphenyl ether	decabromobiphenyl ether analog results in increased expression of TXN mRNA	25222814
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TXN mRNA]	27941970
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TXN mRNA	28628672
D003958	Diamide	Diamide results in increased oxidation of TXN protein	26975474
C542282	dibutyldi(4-chlorobenzohydroxamato)tin(IV)	dibutyldi(4-chlorobenzohydroxamato)tin(IV) results in increased expression of TXN mRNA	22732634
C542282	dibutyldi(4-chlorobenzohydroxamato)tin(IV)	dibutyldi(4-chlorobenzohydroxamato)tin(IV) results in increased expression of TXN protein	22732634
D003994	Bucladesine	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of TXN mRNA	20823114
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of TXN mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of TXN mRNA	25450742\|2559613
D002945	Cisplatin	TXN protein results in decreased susceptibility to Cisplatin	10754530
D004008	Diclofenac	Diclofenac results in increased expression of TXN mRNA	19022234
C000944	dicrotophos	dicrotophos results in decreased expression of TXN mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of TXN mRNA	26924002
C014476	diethyl maleate	diethyl maleate results in decreased activity of TXN protein	15388247
C062856	dimethylarsine	[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of TXN mRNA	25873331
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of TXN mRNA	26924002
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene inhibits the reaction [Selegiline results in increased expression of TXN]	16099847
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene inhibits the reaction [TXN protein affects the susceptibility to Selegiline]	16099847
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased oxidation of TXN protein	26975474
C029402	diphenylcyclopropenone	diphenylcyclopropenone results in increased expression of TXN mRNA	20491607
D007980	Levodopa	Levodopa results in decreased activity of TXN protein	21815648
D004317	Doxorubicin	Doxorubicin results in increased oxidation of TXN protein	28818578
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TXN protein	23301498
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of TXN mRNA	20706672
C045651	epigallocatechin gallate	epigallocatechin gallate affects the expression of and affects the activity of TXN protein	25585349
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of TXN mRNA	25585349
D000431	Ethanol	[Zinc deficiency co-treated with Ethanol] results in increased expression of TXN protein	24155903
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of TXN mRNA	25064622
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of TXN mRNA	16174780
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate results in increased expression of TXN protein	15834431
D005411	Flame Retardants	Flame Retardants results in increased expression of TXN mRNA	19858236
D016650	Fluorescein-5-isothiocyanate	Fluorescein-5-isothiocyanate results in increased expression of TXN mRNA	20491607
D005557	Formaldehyde	Formaldehyde results in increased expression of TXN mRNA	20491607
D005648	Fuel Oils	Fuel Oils results in increased expression of TXN mRNA	20821661
D017965	gamma-Linolenic Acid	gamma-Linolenic Acid results in increased expression of TXN mRNA	20664735
D019833	Genistein	Genistein results in decreased expression of TXN mRNA	20706672
D005947	Glucose	Glucose deficiency results in increased secretion of TXN protein	24802182
D005947	Glucose	[CAT protein promotes the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]] inhibits the reaction [Glucose deficiency results in increased activity of and results in increased phosphorylation of MAPK8 protein]	14505347
C071834	glycidamide	glycidamide results in increased expression of TXN mRNA	17822822
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased oxidation of TXN protein	26975474
D006861	Hydrogen Peroxide	TXN protein results in decreased susceptibility to Hydrogen Peroxide	10754530\|1602401
C031927	hydroquinone	hydroquinone results in increased expression of TXN mRNA	15452088
C020755	hydroxycitronellal	hydroxycitronellal results in increased expression of TXN mRNA	20491607
D007069	Ifosfamide	Ifosfamide results in increased expression of TXN mRNA	25596134
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TXN mRNA	28628672
D007213	Indomethacin	TXN protein inhibits the reaction [Indomethacin results in decreased expression of AKT1 protein modified form]	17654042
D007213	Indomethacin	TXN protein inhibits the reaction [Indomethacin results in increased abundance of Reactive Oxygen Species]	17654042
D007213	Indomethacin	TXN protein inhibits the reaction [Indomethacin results in decreased expression of BIRC5 protein]	17654042
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TXN mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TXN mRNA	28628672
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of TXN mRNA	27392435
C410337	K 7174	K 7174 results in increased expression of TXN mRNA	24086573
C008261	lead acetate	lead acetate affects the expression of TXN mRNA	21147602
C018584	linalool	linalool results in increased expression of TXN mRNA	20491607
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of TXN protein	17959236
D008070	Lipopolysaccharides	Mercuric Chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of TXN protein]	17959236
D008095	Lithocholic Acid	[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN mRNA	17724089
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of TXN protein	17724089
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TXN mRNA	26378955
D008315	Malondialdehyde	TXN protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased abundance of Malondialdehyde]	16099847
C054474	manumycin	manumycin results in decreased expression of TXN	19409983
C054474	manumycin	TXN results in decreased susceptibility to manumycin	19409983
D008466	Mechlorethamine	Mechlorethamine results in decreased activity of TXN protein	26451472
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of TXN mRNA	20823114
D008627	Mercuric Chloride	Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of TXN protein]	17959236
D008627	Mercuric Chloride	Mercuric Chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of TXN protein]	17959236
D008627	Mercuric Chloride	Mercuric Chloride results in decreased activity of and affects the metabolism of TXN protein	18321861
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of TXN protein	17959236
D008627	Mercuric Chloride	Mercuric Chloride results in increased oxidation of TXN protein	16337887
D008627	Mercuric Chloride	sodium selenide inhibits the reaction [Mercuric Chloride results in decreased expression of TXN protein]	17959236
D008628	Mercury	Mercury binds to TXN protein	18321861
C543395	methylarsine	[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of TXN mRNA	25873331
D008751	Methylene Blue	Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA]	24556215
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TXN mRNA	23458150
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TXN mRNA	28001369
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased activity of TXN protein	21168431
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased activity of and affects the metabolism of TXN protein	18321861
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of TXN mRNA	26011545
D015655	1-Methyl-4-phenylpyridinium	TXN protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP12 protein]	24140863
D015655	1-Methyl-4-phenylpyridinium	TXN protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of DDIT3 protein]	24140863
D015655	1-Methyl-4-phenylpyridinium	TXN protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ERN1 protein]	24140863
D015655	1-Methyl-4-phenylpyridinium	TXN protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]	24140863
D015655	1-Methyl-4-phenylpyridinium	TXN protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TRAF2 protein]	24140863
D015655	1-Methyl-4-phenylpyridinium	TXN protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium	24140863
D015655	1-Methyl-4-phenylpyridinium	TXN protein affects the susceptibility to 1-Methyl-4-phenylpyridinium	16099847
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of TXN protein	24140863
D015655	1-Methyl-4-phenylpyridinium	TXN protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP12 protein]	24140863
D015655	1-Methyl-4-phenylpyridinium	TXN protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of DDIT3 protein]	24140863
D015655	1-Methyl-4-phenylpyridinium	TXN protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ERN1 protein]	24140863
D015655	1-Methyl-4-phenylpyridinium	TXN protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]	24140863
D015655	1-Methyl-4-phenylpyridinium	TXN protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TRAF2 protein]	24140863
D015655	1-Methyl-4-phenylpyridinium	TXN protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium	24140863
D015655	1-Methyl-4-phenylpyridinium	[Selegiline results in increased expression of TXN] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium	16099847
D015655	1-Methyl-4-phenylpyridinium	[[Selegiline results in increased expression of TXN] which results in increased expression of BCL2] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium	16099847
D015655	1-Methyl-4-phenylpyridinium	[[Selegiline results in increased expression of TXN] which results in increased expression of SOD2] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium	16099847
D015655	1-Methyl-4-phenylpyridinium	TXN protein affects the susceptibility to 1-Methyl-4-phenylpyridinium	16099847
D015655	1-Methyl-4-phenylpyridinium	TXN protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased abundance of Malondialdehyde]	16099847
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TXN protein"	24140863
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"TXN protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"	24140863
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"TXN protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased cleavage of CASP12 protein]"	24140863
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"TXN protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DDIT3 protein]"	24140863
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"TXN protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 protein]"	24140863
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"TXN protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPA5 protein]"	24140863
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"TXN protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TRAF2 protein]"	24140863
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"TXN protein results in decreased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"	24140863
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TXN protein"	24140863
C043243	methyl tert-butyl ether	methyl tert-butyl ether affects the expression of TXN mRNA	24128854
C063855	microcystin RR	microcystin RR results in decreased expression of TXN protein	19111056
D015735	Mifepristone	Mifepristone results in increased expression of TXN mRNA	19439560
C020300	monomethylarsonic acid	[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of TXN mRNA	23192986
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of TXN mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in increased expression of TXN mRNA	18988085
C064769	N-acetylsphingosine	N-acetylsphingosine results in decreased activity of TXN protein	18270325
C064769	N-acetylsphingosine	TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]	18270325
D009270	Naloxone	Naloxone results in increased expression of TXN mRNA	17522070
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of TXN protein"	22001959
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TXN protein"	22157353
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of TXN mRNA	17522070
D009532	Nickel	Nickel results in decreased expression of TXN mRNA	24084258
C022838	nickel chloride	nickel chloride results in increased expression of TXN mRNA	24612858
C014112	N-methyl-4-aminophenol	N-methyl-4-aminophenol results in increased expression of TXN mRNA	20491607
C010615	Nonidet P-40	Nonidet P-40 results in decreased expression of TXN mRNA	26552463
C464660	obeticholic acid	obeticholic acid results in decreased expression of TXN mRNA	27939613
D019319	Okadaic Acid	Okadaic Acid results in decreased expression of TXN protein	19397276
C485800	osajin	osajin results in increased expression of TXN mRNA	20706672
D010100	Oxygen	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TXN protein results in decreased susceptibility to Oxygen]	20812253
D010100	Oxygen	Oxygen deficiency results in decreased expression of TXN mRNA	25596134
D010100	Oxygen	TXN protein inhibits the reaction [Oxygen results in increased chemical synthesis of Reactive Oxygen Species]	20812253
D010100	Oxygen	TXN protein promotes the reaction [Oxygen results in increased activity of SOD2 protein]	20812253
D010100	Oxygen	TXN protein promotes the reaction [Oxygen results in increased phosphorylation of MAPK1 protein]	20812253
D010100	Oxygen	TXN protein promotes the reaction [Oxygen results in increased phosphorylation of MAPK3 protein]	20812253
D010100	Oxygen	TXN protein promotes the reaction [Oxygen results in increased phosphorylation of MAPK8 protein]	20812253
D010100	Oxygen	TXN protein promotes the reaction [Oxygen results in increased phosphorylation of MAPK9 protein]	20812253
D010100	Oxygen	TXN protein results in decreased susceptibility to Oxygen	20812253
D010100	Oxygen	U 0126 inhibits the reaction [TXN protein results in decreased susceptibility to Oxygen]	20812253
D010269	Paraquat	Paraquat affects the expression of TXN mRNA	25064622
D010269	Paraquat	TXN protein results in decreased susceptibility to Paraquat	10754530\|1602401
D052638	Particulate Matter	TXN protein promotes the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein]	16298680
D052638	Particulate Matter	TXN protein promotes the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein]	16298680
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of TXN mRNA	19858236
C033342	perillaldehyde	KEAP1 protein inhibits the reaction [perillaldehyde results in increased expression of TXN mRNA]	19123792
C033342	perillaldehyde	perillaldehyde promotes the reaction [NFE2L2 protein binds to TXN enhancer]	19123792
C033342	perillaldehyde	perillaldehyde results in increased expression of TXN mRNA	19123792
C033342	perillaldehyde	perillaldehyde results in increased expression of TXN protein	19123792
D030421	Peroxynitrous Acid	TXN protein inhibits the reaction [Copper Sulfate affects the reaction [Peroxynitrous Acid results in decreased activity of PRNP protein]]	14713301
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in increased expression of TXN mRNA	20442190
C058305	phenethyl isothiocyanate	TXN protein binds to phenethyl isothiocyanate	21838287
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TXN mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of TXN mRNA	26272509
D010695	Phlorhizin	Phlorhizin results in decreased expression of TXN mRNA	22538082
D010695	Phlorhizin	Phlorhizin results in increased expression of TXN mRNA	22538082
D010713	Phosphatidylcholines	[TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylcholines]	15313215
C483858	phosphatidylethanolamine	[TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to phosphatidylethanolamine]	15313215
D010718	Phosphatidylserines	[TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylserines]	15313215
D010936	Plant Extracts	Plant Extracts results in increased expression of TXN mRNA	19123792
C474837	pomiferin	pomiferin results in increased expression of TXN mRNA	20706672
D011429	Propolis	Propolis results in increased expression of TXN mRNA	20706672
C033607	puerarin	puerarin results in increased expression of TXN mRNA	20706672
C502851	quinocetone	quinocetone results in increased expression of TXN protein	27046791
D017382	Reactive Oxygen Species	TXN protein inhibits the reaction [Indomethacin results in increased abundance of Reactive Oxygen Species]	17654042
D017382	Reactive Oxygen Species	TXN protein inhibits the reaction [Oxygen results in increased chemical synthesis of Reactive Oxygen Species]	20812253
D017382	Reactive Oxygen Species	Reactive Oxygen Species affects the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]	16449798
C059514	resveratrol	resveratrol results in increased expression of TXN mRNA	20706672
C059514	resveratrol	resveratrol results in increased expression of TXN protein	16198371
C059514	resveratrol	resveratrol results in increased expression of TXN protein	16198371
C447880	retene	[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of TXN mRNA	22120849
D012254	Ribavirin	Ribavirin results in decreased expression of TXN protein	16198661
C529148	rosavin	rosavin results in increased expression of TXN mRNA	20706672
D012402	Rotenone	Acetylcysteine inhibits the reaction [Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]]	16449798
D012402	Rotenone	Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]	16449798
D020156	Salicylic Acid	Salicylic Acid results in increased expression of TXN mRNA	20491607
D012642	Selegiline	Dinitrochlorobenzene inhibits the reaction [Selegiline results in increased expression of TXN]	16099847
D012642	Selegiline	Dinitrochlorobenzene inhibits the reaction [TXN protein affects the susceptibility to Selegiline]	16099847
D012642	Selegiline	MYC protein affects the reaction [Selegiline results in increased expression of TXN]	16099847
D012642	Selegiline	Selegiline results in increased expression of TXN protein	16099847
D012642	Selegiline	TXN protein affects the susceptibility to Selegiline	16099847
D012642	Selegiline	Selegiline results in increased expression of TXN protein	16099847
D012642	Selegiline	TXN protein affects the susceptibility to Selegiline	16099847
D012642	Selegiline	[Selegiline results in increased expression of TXN] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium	16099847
D012642	Selegiline	[Selegiline results in increased expression of TXN] which results in increased expression of BCL2	16099847
D012642	Selegiline	[[Selegiline results in increased expression of TXN] which results in increased expression of BCL2] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium	16099847
D012642	Selegiline	[Selegiline results in increased expression of TXN] which results in increased expression of SOD2	16099847
D012642	Selegiline	[[Selegiline results in increased expression of TXN] which results in increased expression of SOD2] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium	16099847
C009277	sodium arsenate	sodium arsenate results in increased expression of TXN mRNA	23922661
C017947	sodium arsenite	[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of TXN mRNA	25873331
C017947	sodium arsenite	[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of TXN mRNA	23192986
C017947	sodium arsenite	sodium arsenite results in increased expression of TXN mRNA	12076508\|2128196
C017947	sodium arsenite	sodium arsenite results in increased expression of TXN protein	28512695
C017947	sodium arsenite	sodium arsenite results in increased oxidation of TXN protein	16337887
D012965	Sodium Chloride	Sodium Chloride results in increased expression of TXN mRNA	16115654
C028982	sodium chromate(VI)	sodium chromate(VI) results in increased oxidation of TXN protein	18328613\|1913512
C028982	sodium chromate(VI)	tris(2-carboxyethyl)phosphine inhibits the reaction [sodium chromate(VI) results in increased oxidation of TXN protein]	19135121
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased expression of TXN mRNA	20491607
C037341	sodium selenide	sodium selenide inhibits the reaction [Mercuric Chloride results in decreased expression of TXN protein]	17959236
C037341	sodium selenide	sodium selenide results in decreased expression of TXN protein	17959236
D018038	Sodium Selenite	"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of and affects the localization of TXN protein"	28757135
D018038	Sodium Selenite	"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of TXN mRNA"	28757135
D018038	Sodium Selenite	"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of TXN protein"	28757135
D013311	Streptozocin	TXN protein inhibits the reaction [Streptozocin results in increased secretion of ALB protein]	17360766
D010042	Ouabain	Ouabain affects the expression of TXN protein	17268060
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TXN mRNA	26378955
C016766	sulforafan	sulforafan results in increased expression of TXN mRNA	19123792\|2044219
C016766	sulforafan	sulforafan results in increased expression of TXN protein	25683455
D016559	Tacrolimus	Tacrolimus results in decreased expression of TXN mRNA	17085464
D013749	Tetrachlorodibenzodioxin	TXN protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR mRNA]	11462148
D013749	Tetrachlorodibenzodioxin	TXN protein results in decreased susceptibility to Tetrachlorodibenzodioxin	11462148
D013752	Tetracycline	Tetracycline affects the expression of TXN mRNA	25064622
D013752	Tetracycline	Tetracycline results in increased expression of TXN mRNA	17522070
C582340	tetradecabromodiphenoxybenzene	tetradecabromodiphenoxybenzene analog results in increased expression of TXN mRNA	25222814
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of TXN mRNA	24632381
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TXN mRNA	25613284
D013853	Thioacetamide	Thioacetamide affects the expression of TXN mRNA	25064622
C032628	tin protoporphyrin IX	tin protoporphyrin IX inhibits the reaction [TXN protein results in increased expression of VEGFA protein]	16198371
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of TXN mRNA	22363418
D014212	Tretinoin	Tretinoin results in decreased expression of TXN mRNA	21934132
C009549	triethyl phosphate	triethyl phosphate results in increased expression of TXN mRNA	24273086
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TXN mRNA"	24273086\|2524241
C541743	tris(2,3-dibromopropyl)isocyanurate	"tris(2,3-dibromopropyl)isocyanurate results in increased expression of TXN mRNA"	24273086
C080938	tris(2-carboxyethyl)phosphine	tris(2-carboxyethyl)phosphine inhibits the reaction [chromium hexavalent ion results in increased oxidation of TXN protein]	19703554
C080938	tris(2-carboxyethyl)phosphine	tris(2-carboxyethyl)phosphine inhibits the reaction [sodium chromate(VI) results in increased oxidation of TXN protein]	19135121
D014317	Tritolyl Phosphates	Tritolyl Phosphates results in increased expression of TXN mRNA	24273086
C057693	troglitazone	troglitazone results in increased expression of TXN mRNA	19022234
D014415	Tunicamycin	Tunicamycin results in decreased expression of TXN mRNA	22378314
C113580	U 0126	U 0126 inhibits the reaction [TXN protein results in decreased susceptibility to Oxygen]	20812253
D014527	Uric Acid	TXN protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]	18403674
D014635	Valproic Acid	Valproic Acid affects the expression of TXN mRNA	25064622
D001335	Vehicle Emissions	TXN protein promotes the reaction [Vehicle Emissions results in increased phosphorylation of AKT1 protein]	16298680
D001335	Vehicle Emissions	TXN protein promotes the reaction [Vehicle Emissions results in increased phosphorylation of AKT1 protein]	16298680
D014800	Vitallium	Vitallium analog results in increased expression of TXN mRNA	23825117
C111237	vorinostat	vorinostat results in decreased expression of TXN protein	20543569
C111237	vorinostat	vorinostat results in increased expression of TXN protein	17593366
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of TXN mRNA"	23246600
D015032	Zinc	[Zinc deficiency co-treated with Ethanol] results in increased expression of TXN protein	24155903
D015032	Zinc	Zinc deficiency results in increased expression of TXN protein	24155903
C023616	zinc chromate	zinc chromate results in increased oxidation of TXN protein	18328613

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22658674 22681889
GO:0005515	protein binding	-	IPI	10814541 11118054 15480426 15657067 17557078 17606900 19690162 19805025 20029029 21771788 21988832 24658140 24976139 25402766
GO:0015037	peptide disulfide oxidoreductase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006662	glycerol ether metabolic process	-	IEA	-
GO:0007165	signal transduction	-	TAS	10947064
GO:0007267	cell-cell signaling	-	TAS	10947064
GO:0008283	cell proliferation	-	TAS	3170595
GO:0009314	response to radiation	-	IDA	11118054
GO:0032148	activation of protein kinase B activity	-	IC	22492997
GO:0033138	positive regulation of peptidyl-serine phosphorylation	-	IGI	22492997
GO:0033158	regulation of protein import into nucleus, translocation	-	IDA	11118054
GO:0043388	positive regulation of DNA binding	-	IDA	11118054
GO:0046826	negative regulation of protein export from nucleus	-	IEA	-
GO:0051897	positive regulation of protein kinase B signaling	-	IC	22492997
GO:0055114	oxidation-reduction process	-	IDA	11118054
GO:0098869	cellular oxidant detoxification	-	IEA	-
GO:1903206	negative regulation of hydrogen peroxide-induced cell death	-	IGI	22492997

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867 20458337 23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-15869	Metabolism of nucleotides	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	TAS
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2559580	Oxidative Stress Induced Senescence	TAS
R-HSA-2559583	Cellular Senescence	TAS
R-HSA-3299685	Detoxification of Reactive Oxygen Species	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-499943	Interconversion of nucleotide di- and triphosphates	TAS
R-HSA-5628897	TP53 Regulates Metabolic Genes	TAS
R-HSA-5676934	Protein repair	TAS
R-HSA-622312	Inflammasomes	TAS
R-HSA-622312	Inflammasomes	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-844456	The NLRP3 inflammasome	TAS
R-HSA-844456	The NLRP3 inflammasome	IEA
R-HSA-8953897	Cellular responses to external stimuli	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29459183	Transcriptional differences between smokers and non-smokers and variance by obesity as a risk factor for human sensitivity to environmental exposures. (2018 Apr)	Nikodemova M	Environ Int
19860794	Age-related gray matter shrinkage in a treatment naive actively drinking alcohol-dependent sample. (2010 Jan)	Fein G	Alcohol Clin Exp Res
16737453	Normal performance on a simulated gambling task in treatment-naive alcohol-dependent individuals. (2006 Jun)	Fein G	Alcohol Clin Exp Res
18566111	Genetic variation and gene expression in antioxidant related enzymes and risk of COPD: a systematic review. (2008 Nov)	Bentley AR	Thorax