Gene: TYK2

7297
IMD35|JTK1
tyrosine kinase 2
protein-coding
19p13.2
Ensembl:ENSG00000105397 MIM:176941 Vega:OTTHUMG00000166373 UniprotKB:P29597
NG_007872.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.147e-1 (AD)  4.835e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRCH40.915
TRABD0.903
CCNL20.898
SRRM20.896
AKT20.895
CLK20.893
METTL170.891
WDR60.889
ZSWIM80.887
NDOR10.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.648
OR4F29-0.617
HMX2-0.192
FOXB1-0.192
NTS-0.186
GSDMC-0.184
LHX5-0.183
OTP-0.183
C22orf42-0.182
SIM1-0.182

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB047162-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONESmall MoleculeExperimentalTarget
DB08895TofacitinibSmall Molecule477600-75-2Approved|InvestigationalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TYK2 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of TYK2 protein"19632255
C5550214-acetylantroquinonol B4-acetylantroquinonol B results in decreased expression of TYK2 protein26235807
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of TYK2 protein modified form]29031523
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased phosphorylation of TYK2 protein]29031523
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside results in increased phosphorylation of TYK2 protein29031523
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranosideSOCS3 protein inhibits the reaction [6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of TYK2 protein modified form]]29031523
D000082AcetaminophenAcetaminophen affects the expression of TYK2 mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of TYK2 mRNA22230336
C482289Ageladine AAgeladine A analog results in decreased activity of TYK2 protein21413800
C482289Ageladine AAgeladine A results in decreased activity of TYK2 protein21413800
D000638AmiodaroneAmiodarone affects the expression of TYK2 mRNA25064622
C006632arsenic trioxide[arsenic trioxide co-treated with decitabine] results in decreased expression of TYK2 mRNA24762999
C006632arsenic trioxidearsenic trioxide results in decreased expression of TYK2 mRNA24762999
D001241AspirinAspirin results in decreased expression of TYK2 mRNA15928584
D004958EstradiolEstradiol results in increased expression of TYK2 mRNA18709148
C584509C646 compoundC646 compound results in increased expression of TYK2 mRNA26191083
D002746ChlorpromazineChlorpromazine affects the expression of TYK2 mRNA25064622
D002994ClofibrateClofibrate results in decreased expression of TYK2 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of TYK2 mRNA19320972
D003042CocaineTYK2 gene SNP affects the susceptibility to Cocaine18438686
D016572CyclosporineCyclosporine affects the expression of TYK2 mRNA25064622
C014347decitabine[arsenic trioxide co-treated with decitabine] results in decreased expression of TYK2 mRNA24762999
C014347decitabinedecitabine results in decreased expression of TYK2 mRNA24762999
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased expression of TYK2 mRNA18709148
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TYK2 mRNA]27941970
C058064dinitrophenyl-human serum albumin conjugatedinitrophenyl-human serum albumin conjugate results in increased activity of TYK2 protein26621445
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TYK2 mRNA25064622
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TYK2 mRNA17942748
C492448ICG 001ICG 001 results in increased expression of TYK2 mRNA26191083
C554043interferon alfa-2a6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of TYK2 protein modified form]29031523
C554043interferon alfa-2a6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased phosphorylation of TYK2 protein]29031523
C554043interferon alfa-2ainterferon alfa-2a results in increased expression of TYK2 protein modified form29031523
C554043interferon alfa-2ainterferon alfa-2a results in increased phosphorylation of TYK2 protein29031523
C554043interferon alfa-2aSOCS3 protein inhibits the reaction [6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of TYK2 protein modified form]]29031523
C554043interferon alfa-2aSOCS3 protein inhibits the reaction [interferon alfa-2a results in increased expression of TYK2 protein modified form]29031523
C440499lipopolysaccharide, Escherichia coli O111 B4"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased phosphorylation of TYK2 protein"20060843
C440499lipopolysaccharide, Escherichia coli O111 B4"Quercetin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased phosphorylation of TYK2 protein]"20060843
D008727MethotrexateTYK2 protein affects the susceptibility to Methotrexate16217747
D008767Methylmercury Compounds[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of TYK2 mRNA20020106
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TYK2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TYK2 mRNA"15585362
C464660obeticholic acidobeticholic acid results in decreased expression of TYK2 mRNA27939613
C507134ON 01910ON 01910 results in decreased phosphorylation of TYK2 protein25472472
D010269ParaquatParaquat affects the expression of TYK2 mRNA25064622
D010416PentachlorophenolPentachlorophenol results in increased expression of TYK2 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TYK2 mRNA18709148
D011078Polychlorinated Biphenyls[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of TYK2 mRNA20020106
C545373ponatinibponatinib results in decreased activity of TYK2 protein19878872
D011794Quercetin"Quercetin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased phosphorylation of TYK2 protein]"20060843
C017947sodium arsenitesodium arsenite results in decreased expression of TYK2 mRNA12760830
D013654TaurineTaurine results in decreased expression of TYK2 mRNA16579726
C004648testosterone enanthatetestosterone enanthate results in increased expression of TYK2 mRNA25603467
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TYK2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TYK2 mRNA17942748
D013752TetracyclineTetracycline affects the expression of TYK2 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of TYK2 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of TYK2 mRNA25064622
D024483Vitamin K 3Vitamin K 3 affects the expression of TYK2 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-EXP1386289  8232552  
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0004715non-membrane spanning protein tyrosine kinase activity-TAS-  
GO:0005131growth hormone receptor binding-IPI10502458  
GO:0005515protein binding-IPI10523853  21516116  22939624  24704786  25416956  26175413  
GO:0005524ATP binding-IEA-  
GO:0031702type 1 angiotensin receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-TAS2216457  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0035556intracellular signal transduction-IEA-  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO:0038155interleukin-23-mediated signaling pathway-TAS-  
GO:0060337type I interferon signaling pathway-TAS-  
GO:0070106interleukin-27-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10502458  
GO:0005737cytoplasm-IDA10502458  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04380Osteoclast differentiation
hsa04630Jak-STAT signaling pathway
hsa05145Toxoplasmosis
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1059683Interleukin-6 signalingTAS
R-HSA-1059683Interleukin-6 signalingIEA
R-HSA-110056MAPK3 (ERK1) activationTAS
R-HSA-112409RAF-independent MAPK1/3 activationTAS
R-HSA-112411MAPK1 (ERK2) activationTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-447115Interleukin-12 family signalingIEA
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-449836Other interleukin signalingTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6783589Interleukin-6 family signalingTAS
R-HSA-6783589Interleukin-6 family signalingIEA
R-HSA-6783783Interleukin-10 signalingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-6788467IL-6-type cytokine receptor ligand interactionsTAS
R-HSA-8854691Interleukin-20 family signalingTAS
R-HSA-8984722Interleukin-35 SignallingTAS
R-HSA-9020591Interleukin-12 signalingIEA
R-HSA-9020591Interleukin-12 signalingTAS
R-HSA-9020933Interleukin-23 signalingIEA
R-HSA-9020933Interleukin-23 signalingTAS
R-HSA-9020956Interleukin-27 signalingIEA
R-HSA-9020956Interleukin-27 signalingTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-909733Interferon alpha/beta signalingIEA
R-HSA-912694Regulation of IFNA signalingIEA
R-HSA-912694Regulation of IFNA signalingTAS
R-HSA-913531Interferon SignalingTAS
R-HSA-913531Interferon SignalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25104439Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study. (2014 Aug)Slattery MLBreast Cancer Res Treat
22121102JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. (2013 Feb)Slattery MLMol Carcinog