Gene: TYMS

7298
HST422|TMS|TS
thymidylate synthetase
protein-coding
18p11.32
Ensembl:ENSG00000176890 MIM:188350 Vega:OTTHUMG00000131473 UniprotKB:P04818
NG_028255.1
PubMed|SNP Mapped
ND|AD
17   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.337e-1 (AD)  2.422e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs502396chr18:659236 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHIP0.9
TRIM590.89
GJB10.888
SGK20.888
TMEM1440.88
EVI2A0.879
ENPP20.878
NIPAL40.878
FOLH10.876
TMEM1250.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WTIP-0.366
GPR153-0.331
CHRNA2-0.329
SLC29A4-0.327
CUX2-0.326
GRIN2D-0.306
SHISA8-0.305
CCDC85C-0.302
WNT7B-0.284
PAX2-0.282

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00293RaltitrexedSmall Molecule112887-68-0Approved|InvestigationalTarget
DB00322FloxuridineSmall Molecule50-91-9ApprovedTarget
DB00432TrifluridineSmall Molecule70-00-8Approved|InvestigationalTarget
DB00440TrimethoprimSmall Molecule738-70-5ApprovedTarget
DB00441GemcitabineSmall Molecule95058-81-4ApprovedTarget
DB00544FluorouracilSmall Molecule51-21-8ApprovedTarget
DB00642PemetrexedSmall Molecule137281-23-3Approved|InvestigationalTarget
DB01101CapecitabineSmall Molecule154361-50-9Approved|InvestigationalTarget
DB01643Thymidine-5'-PhosphateSmall Molecule365-07-1ExperimentalTarget
DB0354110-Propargyl-5,8-Dideazafolic AcidSmall MoleculeExperimentalTarget
DB038002'-deoxyuridylic acidSmall Molecule-ExperimentalTarget
DB04530S,S-(2-Hydroxyethyl)ThiocysteineSmall MoleculeExperimentalTarget
DB05116ThymectacinSmall Molecule232925-18-7InvestigationalTarget
DB05308ANX-510Small Molecule-InvestigationalTarget
DB05457OSI-7904LSmall Molecule-InvestigationalTarget
DB06813PralatrexateSmall Molecule146464-95-1Approved|InvestigationalTarget
DB075776-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINESmall MoleculeExperimentalTarget
DB08478N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamideSmall MoleculeExperimentalTarget
DB08479N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamideSmall MoleculeExperimentalTarget
DB087346,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINESmall MoleculeExperimentalTarget
DB09327Tegafur-uracilSmall Molecule74578-38-4Approved|InvestigationalTarget
DB00544FluorouracilSmall Molecule51-21-8ApprovedEnzyme
DB00563MethotrexateSmall Molecule59-05-2ApprovedEnzyme
ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of TYMS mRNA"22101062
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of TYMS mRNA"19167446
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TYMS mRNA"19167446
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TYMS mRNA"17547211|1903142
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TYMS mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TYMS mRNA"21346803
C0072672'-deoxyuridylic acid[Fluorouracil results in decreased activity of TYMS protein] which results in increased abundance of 2'-deoxyuridylic acid29258758
C0587062-desamino-2-methylaminopterin2-desamino-2-methylaminopterin analog binds to and results in decreased activity of TYMS protein1313737
C0194992-nitrofluorene2-nitrofluorene results in increased expression of TYMS mRNA14600272|1589037
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of TYMS mRNA]"11179685
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of TYMS mRNA16788091
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TYMS mRNA14600272|1589037
C0131235,10-methylenetetrahydrofolic acid"[Fluorodeoxyuridylate co-treated with 5,10-methylenetetrahydrofolic acid] binds to TYMS protein"15897250
C0303715,6,7,8-tetrahydrofolic acid"5,6,7,8-tetrahydrofolic acid results in increased activity of TYMS protein"187325
D000082AcetaminophenAcetaminophen results in decreased expression of TYMS mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of TYMS mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of TYMS mRNA17562736
C063261acetylleucyl-leucyl-norleucinalacetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]21444628
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TYMS protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TYMS mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TYMS mRNA14600272|1589037
C412373AG 1879AG 1879 results in decreased expression of TYMS mRNA18794807
C412373AG 1879AG 1879 results in decreased expression of TYMS protein18794807
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TYMS mRNA16483693
D000965AntimonyAntimony results in increased expression of TYMS mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in increased expression of TYMS mRNA17547211
D018501Antirheumatic AgentsTYMS gene polymorphism results in increased susceptibility to Antirheumatic Agents18322994
D018501Antirheumatic AgentsTYMS protein affects the susceptibility to Antirheumatic Agents18322994
C006632arsenic trioxidearsenic trioxide affects the activity of TYMS protein25335113
C006632arsenic trioxidearsenic trioxide affects the expression of TYMS mRNA20501625
C006632arsenic trioxidearsenic trioxide affects the expression of TYMS protein25335113
C006632arsenic trioxide[arsenic trioxide co-treated with Fluorouracil co-treated with Leucovorin] results in decreased expression of TYMS mRNA20501625
C006632arsenic trioxidearsenic trioxide results in decreased expression of TYMS mRNA20530422|2296340
C006632arsenic trioxidearsenic trioxide results in decreased expression of TYMS protein20530422|2469199
C006632arsenic trioxidearsenic trioxide results in increased expression of TYMS mRNA17547211
C006632arsenic trioxideTYMS protein results in decreased susceptibility to arsenic trioxide24691991
C015001arsenitearsenite results in decreased expression of TYMS mRNA18929588
D001280AtrazineAtrazine results in decreased expression of TYMS mRNA22378314
D001379AzathioprineAzathioprine results in decreased expression of TYMS mRNA22623647
D001397Azoxymethane[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TYMS mRNA17893519
C487081belinostatbelinostat results in decreased expression of TYMS mRNA19606018
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TYMS mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TYMS mRNA20064835|2180250
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TYMS mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TYMS mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of TYMS mRNA"20382639
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]21444628
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [trichostatin A results in decreased expression of TYMS protein]17172411
D004958Estradiol"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of TYMS mRNA]"11179685
D004958EstradiolEstradiol results in increased expression of TYMS mRNA11179685|1647417
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of TYMS mRNA]11179685
C044887beta-methylcholinebeta-methylcholine affects the expression of TYMS mRNA21179406
C504663BGC638BGC638 results in decreased activity of TYMS protein16357184
C504662BGC945BGC945 results in decreased activity of TYMS protein16357184
C504662BGC945BGC945 results in decreased activity of TYMS protein21879757
C053541bicalutamidebicalutamide results in decreased expression of TYMS protein17599054
C522781biflorinbiflorin affects the expression of TYMS mRNA27079618
C006780bisphenol Abisphenol A results in decreased expression of TYMS mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of TYMS mRNA16474171
C006780bisphenol Abisphenol A results in increased expression of TYMS mRNA29097150
D002087ButyratesButyrates results in decreased expression of TYMS mRNA20072153
D002104CadmiumCadmium results in increased expression of TYMS mRNA17547211
D002104CadmiumCadmium results in increased expression of TYMS protein14499349
D002104CadmiumCadmium results in decreased expression of TYMS mRNA24084258
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TYMS mRNA17547211
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TYMS mRNA18654764
D002110CaffeineCaffeine results in decreased expression of TYMS mRNA20864626
D002166CamptothecinCamptothecin results in increased expression of TYMS mRNA16568373
D000069287CapecitabineCapecitabine affects the expression of TYMS mRNA16438929
D000069287Capecitabine[TYMS enhancer polymorphism co-treated with VEGFA gene SNP] affects the susceptibility to [Capecitabine co-treated with oxaliplatin]21048041
D000069287CapecitabineTYMS protein results in decreased susceptibility to Capecitabine16734730
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TYMS mRNA17484886
C031662CB 3717CB 3717 analog results in decreased activity of TYMS protein8632414
C031662CB 3717CB 3717 results in decreased activity of TYMS protein3431591
D002509CephaloridineCephaloridine results in increased expression of TYMS mRNA18500788
C095424CF regimenCF regimen results in decreased expression of TYMS mRNA17638652
D002713ChlorineChlorine results in decreased expression of TYMS mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of TYMS mRNA18636392
D002857ChromiumChromium results in increased expression of TYMS mRNA17547211
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TYMS mRNA18654764
C018021cobaltous chloridecobaltous chloride results in decreased expression of TYMS mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of TYMS mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of TYMS mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of TYMS mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TYMS mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of TYMS mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of TYMS mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of TYMS mRNA21878529
D003513CycloheximideCycloheximide inhibits the reaction [trichostatin A results in decreased expression of TYMS mRNA]17172411
D016572CyclosporineCyclosporine results in decreased expression of TYMS mRNA20106945|2163298
C093628cyproconazolecyproconazole affects the expression of TYMS mRNA21621602
D003561CytarabineTYMS gene polymorphism affects the susceptibility to Cytarabine15713801
D003561CytarabineCytarabine results in increased activity of TYMS protein15816533
D003630DaunorubicinTYMS gene polymorphism affects the susceptibility to Daunorubicin15713801
D003634DDTDDT results in decreased expression of TYMS mRNA25014179
C014347decitabinedecitabine affects the expression of TYMS mRNA23300844
D013759DronabinolDronabinol results in decreased expression of TYMS mRNA17934890
D016264Dextran Sulfate[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TYMS mRNA17893519
D016190CarboplatinPCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Carboplatin]16685392
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TYMS mRNA17361019|2126653
D002945Cisplatinacetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]21444628
D002945Cisplatinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]21444628
D002945CisplatinCisplatin affects the expression of TYMS mRNA23300844
D002945Cisplatin[Cisplatin co-treated with Fluorouracil] results in decreased expression of TYMS mRNA15737843
D002945CisplatinCisplatin results in decreased degradation of TYMS protein21444628
D002945CisplatinCisplatin results in increased activity of TYMS protein16568373
D002945CisplatinCisplatin results in increased expression of TYMS mRNA16568373|2144462
D002945CisplatinCisplatin results in increased stability of TYMS mRNA21444628
D002945Cisplatin[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein21444628
D002945CisplatinPCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Cisplatin]16685392
D002945CisplatinTYMS gene polymorphism results in decreased susceptibility to [Fluorouracil co-treated with Cisplatin]16622263
D002945CisplatinTYMS gene polymorphism results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Cisplatin co-treated with Paclitaxel]16424979
D002945CisplatinTYMS protein results in decreased susceptibility to Cisplatin21444628
D002945CisplatinU 0126 inhibits the reaction [Cisplatin results in decreased degradation of TYMS protein]21444628
D004004DichlororibofuranosylbenzimidazoleDichlororibofuranosylbenzimidazole inhibits the reaction [Fluorouracil results in increased expression of TYMS protein]23056627
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in decreased expression of TYMS mRNA15784690
D004041Dietary FatsDietary Fats results in increased expression of TYMS mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of TYMS mRNA12807726
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TYMS mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TYMS mRNA15890375
D002117CalcitriolCalcitriol results in decreased expression of TYMS mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of TYMS mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TYMS mRNA"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TYMS mRNA14600272|1589037
C067311docetaxeldocetaxel inhibits the reaction [Fluorouracil results in increased activity of TYMS protein]16557585
C067311docetaxeldocetaxel inhibits the reaction [Fluorouracil results in increased expression of TYMS mRNA]16557585
C067311docetaxeldocetaxel results in decreased expression of TYMS protein16557585
C067311docetaxelFluorouracil promotes the reaction [docetaxel results in decreased expression of TYMS protein]16557585
C067311docetaxelTYMS promoter polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin co-treated with docetaxel]19074750
C025034doxifluridinedoxifluridine affects the expression of TYMS mRNA18630517
C025034doxifluridine[Paclitaxel co-treated with doxifluridine] affects the expression of TYMS mRNA18630517
C025034doxifluridineTYMS protein results in decreased susceptibility to doxifluridine16734730
D004317Doxorubicin[Doxorubicin co-treated with Paclitaxel] results in decreased expression of TYMS protein16168113
D004317DoxorubicinFluorouracil inhibits the reaction [[Doxorubicin co-treated with Paclitaxel] results in decreased expression of TYMS protein]16168113
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TYMS protein23301498
C034096ethoxyacetic acidethoxyacetic acid affects the expression of TYMS mRNA21621602
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TYMS mRNA23649840
D005047EtoposideTYMS gene polymorphism affects the susceptibility to Etoposide15713801
C435305FdUMP(10)FdUMP(10) results in decreased activity of TYMS protein15043163
C082360fipronilfipronil results in increased expression of TYMS mRNA23962444
D005467FloxuridineTYMS protein affects the susceptibility to Floxuridine10482907
D005467FloxuridineTYMS protein results in decreased susceptibility to Floxuridine15040806|1701858
D005467FloxuridineTYMS results in increased susceptibility to Floxuridine2537495
D005467FloxuridineFloxuridine results in decreased activity of TYMS protein15251465
D005468Fluorodeoxyuridylate"[Fluorodeoxyuridylate co-treated with 5,10-methylenetetrahydrofolic acid] binds to TYMS protein"15897250
D005472FluorouracilTYMS protein results in decreased susceptibility to Fluorouracil18612238
D005472FluorouracilFluorouracil binds to TYMS protein16619043
D005472Fluorouracilacetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]21444628
D005472Fluorouracil[arsenic trioxide co-treated with Fluorouracil co-treated with Leucovorin] results in decreased expression of TYMS mRNA20501625
D005472Fluorouracilbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]21444628
D005472Fluorouracil[Cisplatin co-treated with Fluorouracil] results in decreased expression of TYMS mRNA15737843
D005472FluorouracilDichlororibofuranosylbenzimidazole inhibits the reaction [Fluorouracil results in increased expression of TYMS protein]23056627
D005472Fluorouracildocetaxel inhibits the reaction [Fluorouracil results in increased activity of TYMS protein]16557585
D005472Fluorouracildocetaxel inhibits the reaction [Fluorouracil results in increased expression of TYMS mRNA]16557585
D005472FluorouracilFluorouracil affects the expression of TYMS mRNA18794807
D005472FluorouracilFluorouracil affects the expression of TYMS protein18794807
D005472Fluorouracil[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein21444628
D005472FluorouracilFluorouracil inhibits the reaction [[Doxorubicin co-treated with Paclitaxel] results in decreased expression of TYMS protein]16168113
D005472FluorouracilFluorouracil promotes the reaction [docetaxel results in decreased expression of TYMS protein]16557585
D005472FluorouracilFluorouracil promotes the reaction [geraniol results in decreased expression of TYMS mRNA]15374632
D005472FluorouracilFluorouracil results in decreased activity of TYMS protein12739060|1733989
D005472FluorouracilFluorouracil results in increased activity of TYMS protein16557585
D005472FluorouracilFluorouracil results in increased expression of TYMS mRNA15109396|1655758
D005472FluorouracilFluorouracil results in increased expression of TYMS protein15865071|1616811
D005472Fluorouracilgambogic acid inhibits the reaction [Fluorouracil results in increased expression of TYMS mRNA]19084572
D005472Fluorouracil[SU 9516 results in decreased expression of TYMS] which results in increased susceptibility to Fluorouracil18425338
D005472Fluorouracil[TP53 affects the expression of TYMS] which affects the susceptibility to Fluorouracil18600534
D005472Fluorouracil[trichostatin A results in decreased expression of TYMS protein] which results in increased susceptibility to Fluorouracil17172411
D005472FluorouracilTYMS 3' UTR mutant form results in decreased susceptibility to Fluorouracil16267625
D005472FluorouracilTYMS 3' UTR polymorphism affects the susceptibility to [Fluorouracil co-treated with oxaliplatin]15213713
D005472FluorouracilTYMS 5' UTR polymorphism results in decreased susceptibility to Fluorouracil16267625
D005472FluorouracilTYMS affects the susceptibility to Fluorouracil15067352
D005472FluorouracilTYMS gene polymorphism affects the susceptibility to Fluorouracil17016601|1866152
D005472FluorouracilTYMS gene polymorphism affects the susceptibility to [Fluorouracil co-treated with oxaliplatin]18448328
D005472FluorouracilTYMS gene polymorphism results in decreased susceptibility to Fluorouracil15446554
D005472FluorouracilTYMS gene polymorphism results in decreased susceptibility to [Fluorouracil co-treated with Cisplatin]16622263
D005472FluorouracilTYMS gene polymorphism results in increased susceptibility to Fluorouracil15735113|1850559
D005472FluorouracilTYMS gene polymorphism results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Cisplatin co-treated with Paclitaxel]16424979
D005472FluorouracilTYMS mRNA affects the susceptibility to Fluorouracil18507058|1898676
D005472FluorouracilTYMS mRNA affects the susceptibility to [irinotecan co-treated with Fluorouracil co-treated with Leucovorin]17454858
D005472FluorouracilTYMS mRNA results in decreased susceptibility to Fluorouracil15246190|1838387
D005472FluorouracilTYMS mRNA results in increased susceptibility to Fluorouracil15239142
D005472FluorouracilTYMS promoter polymorphism affects the susceptibility to Fluorouracil16596248
D005472FluorouracilTYMS promoter polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin co-treated with docetaxel]19074750
D005472FluorouracilTYMS protein affects the susceptibility to Fluorouracil10482907|1553873
D005472FluorouracilTYMS protein affects the susceptibility to Fluorouracil analog15608557
D005472FluorouracilTYMS protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin]18676755
D005472FluorouracilTYMS protein results in decreased susceptibility to Fluorouracil14970324|1589024
D005472FluorouracilTYMS protein results in increased susceptibility to Fluorouracil15446554|1577039
D005472FluorouracilTYMS results in decreased susceptibility to Fluorouracil7763285
D005472FluorouracilTYMS results in increased susceptibility to Fluorouracil2537495
D005472Fluorouracil[wogonin co-treated with Fluorouracil] results in increased expression of TYMS mRNA20570612
D005472FluorouracilFluorouracil results in decreased activity of TYMS protein29258758|9299594
D005472Fluorouracil[Fluorouracil results in decreased activity of TYMS protein] which results in decreased abundance of Thymidine Monophosphate29258758
D005472Fluorouracil[Fluorouracil results in decreased activity of TYMS protein] which results in increased abundance of 2'-deoxyuridylic acid29258758
D005472FluorouracilFluorouracil results in decreased expression of TYMS9050858
D005472FluorouracilLeucovorin promotes the reaction [Fluorouracil results in decreased expression of TYMS]9050858
D005472FluorouracilThymidine inhibits the reaction [Fluorouracil results in decreased expression of TYMS]9050858
D005472FluorouracilFluorouracil results in decreased activity of TYMS protein9299594
D005472FluorouracilFluorouracil results in decreased activity of TYMS19147506|1981694
D005472FluorouracilTYMS protein affects the metabolism of Fluorouracil16012767
D005472FluorouracilTYMS results in decreased susceptibility to Fluorouracil19023200
D005480FlurbiprofenFlurbiprofen results in increased expression of TYMS mRNA16949054
C061365flusilazoleflusilazole affects the expression of TYMS mRNA21621602
C410216Folfox protocolTYMS gene polymorphism results in increased susceptibility to Folfox protocol analog18505590
D005492Folic AcidFolic Acid affects the expression of TYMS mRNA17311948|1732036
D005492Folic AcidFolic Acid analog results in decreased activity of TYMS protein2909728
D005492Folic AcidFolic Acid deficiency results in increased expression of TYMS mRNA18623116
D005492Folic AcidFolic Acid results in increased expression of TYMS protein187325
D002955Leucovorin[arsenic trioxide co-treated with Fluorouracil co-treated with Leucovorin] results in decreased expression of TYMS mRNA20501625
D002955LeucovorinTYMS gene polymorphism results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Cisplatin co-treated with Paclitaxel]16424979
D002955LeucovorinTYMS mRNA affects the susceptibility to [irinotecan co-treated with Fluorouracil co-treated with Leucovorin]17454858
D002955LeucovorinTYMS promoter polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin co-treated with docetaxel]19074750
D002955LeucovorinTYMS protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin]18676755
D002955LeucovorinLeucovorin promotes the reaction [Fluorouracil results in decreased expression of TYMS]9050858
C074694FuMi protocolTYMS gene polymorphism affects the susceptibility to FuMi protocol18498133
C039281furanfuran results in increased expression of TYMS mRNA25539665|2619464
C052659gambogic acidgambogic acid inhibits the reaction [Fluorouracil results in increased expression of TYMS mRNA]19084572
C052659gambogic acidgambogic acid results in decreased expression of TYMS mRNA19084572
C419708gefitinibgefitinib results in decreased expression of TYMS mRNA18347146
C419708gefitinibgefitinib results in decreased expression of TYMS protein18347146
C419708gefitinibTYMS protein affects the susceptibility to [gefitinib co-treated with S 1 (combination)]18347146
D019833GenisteinGenistein results in increased expression of TYMS mRNA16474171
D005839GentamicinsGentamicins results in decreased expression of TYMS mRNA22061828
C007836geraniolFluorouracil promotes the reaction [geraniol results in decreased expression of TYMS mRNA]15374632
C007836geraniolgeraniol results in decreased expression of TYMS mRNA15374632
D017313FenretinideFenretinide results in increased expression of TYMS mRNA28973697
D007065IdoxuridineTYMS protein affects the uptake of Idoxuridine15001691
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TYMS mRNA25613284
C051890irinotecanTYMS mRNA affects the susceptibility to [irinotecan co-treated with Fluorouracil co-treated with Leucovorin]17454858
C561695(+)-JQ1 compound(+)-JQ1 compound analog binds to TYMS protein24972113
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TYMS mRNA23086925|2479639
C410337K 7174K 7174 results in decreased expression of TYMS mRNA24086573
D007649KetamineKetamine results in decreased expression of TYMS mRNA20080153
D007840LatexLatex analog results in increased expression of TYMS mRNA24768652
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TYMS mRNA18654764
D008070LipopolysaccharidesLipopolysaccharides affects the expression of TYMS mRNA28070326
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of TYMS mRNA]28070326
D008294MalathionMalathion results in decreased expression of TYMS mRNA16079077
D015122MercaptopurineTYMS gene polymorphism affects the susceptibility to Mercaptopurine15713801
D008628MercuryMercury results in increased expression of TYMS mRNA17547211
D008701MethapyrileneMethapyrilene results in increased expression of TYMS mRNA15890375
D008727MethotrexateMethotrexate results in decreased expression of TYMS mRNA23897011
D008727MethotrexateMethotrexate results in increased expression of TYMS mRNA23838799
D008727MethotrexateMethotrexate results in increased expression of TYMS protein22484375
D008727MethotrexateTYMS 3' UTR polymorphism affects the susceptibility to Methotrexate17410198
D008727MethotrexateTYMS 5' UTR polymorphism affects the susceptibility to Methotrexate17410198
D008727MethotrexateTYMS 5' UTR polymorphism results in decreased susceptibility to Methotrexate16267625
D008727MethotrexateTYMS gene polymorphism affects the susceptibility to Methotrexate15713801|2500718
D008727MethotrexateTYMS protein results in increased susceptibility to Methotrexate16267625
D008727MethotrexateTYMS results in increased susceptibility to Methotrexate2537495
D008727MethotrexateMethotrexate results in increased expression of TYMS protein22484375
D008727MethotrexateMethotrexate results in increased expression of TYMS protein187325
C013598methoxyacetic acidmethoxyacetic acid affects the expression of TYMS mRNA21621602
C013598methoxyacetic acidmethoxyacetic acid results in decreased expression of TYMS mRNA20864626
D008748MethylcholanthreneMethylcholanthrene results in increased expression of TYMS mRNA22100608
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TYMS mRNA20864626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TYMS mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TYMS mRNA22100608|2364984
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TYMS mRNA24810058
C008493methylselenic acidmethylselenic acid affects the expression of TYMS mRNA14617803
C008493methylselenic acidmethylselenic acid results in decreased expression of TYMS mRNA12517777
D016685MitomycinMitomycin results in increased expression of TYMS mRNA16568373
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of TYMS mRNA20864626
C047806monomethylpropionmonomethylpropion results in increased expression of TYMS mRNA22303338
D009532NickelNickel results in increased expression of TYMS mRNA25583101
C022838nickel chloridenickel chloride affects the expression of TYMS mRNA22110744
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of TYMS mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of TYMS mRNA19716841
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TYMS mRNA"12888634
C099178nolatrexednolatrexed results in decreased activity of TYMS protein17339891
C099178nolatrexedTYMS protein affects the susceptibility to nolatrexed17339891
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of TYMS mRNA20971185
C466913NU2058NU2058 results in decreased expression of TYMS protein17599054
C030110oxaliplatinoxaliplatin results in decreased expression of TYMS mRNA15057142
C030110oxaliplatinoxaliplatin results in decreased expression of TYMS protein15057142
C030110oxaliplatinTYMS 3' UTR polymorphism affects the susceptibility to [Fluorouracil co-treated with oxaliplatin]15213713
C030110oxaliplatin[TYMS enhancer polymorphism co-treated with VEGFA gene SNP] affects the susceptibility to [Capecitabine co-treated with oxaliplatin]21048041
C030110oxaliplatinTYMS gene polymorphism affects the susceptibility to [Fluorouracil co-treated with oxaliplatin]18448328
C030110oxaliplatinTYMS promoter polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin co-treated with docetaxel]19074750
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TYMS mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of TYMS mRNA25729387
C100692oxamflatinoxamflatin results in decreased expression of TYMS protein17172411
D010100OxygenOxygen deficiency results in decreased expression of TYMS mRNA24205000
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TYMS mRNA25658374
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of TYMS mRNA18636392
D017239Paclitaxel[Doxorubicin co-treated with Paclitaxel] results in decreased expression of TYMS protein16168113
D017239PaclitaxelFluorouracil inhibits the reaction [[Doxorubicin co-treated with Paclitaxel] results in decreased expression of TYMS protein]16168113
D017239PaclitaxelPaclitaxel affects the expression of TYMS mRNA18630517
D017239Paclitaxel[Paclitaxel co-treated with doxifluridine] affects the expression of TYMS mRNA18630517
D017239PaclitaxelPaclitaxel results in increased expression of TYMS mRNA16568373
D017239PaclitaxelTYMS gene polymorphism results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Cisplatin co-treated with Paclitaxel]16424979
C500026palbociclibpalbociclib results in decreased expression of TYMS mRNA22869556
C500026palbociclibpalbociclib results in decreased expression of TYMS protein20948315
D000068437PemetrexedPemetrexed results in decreased activity of TYMS protein17339891
D000068437PemetrexedTYMS affects the susceptibility to Pemetrexed21742432
D000068437PemetrexedTYMS protein affects the susceptibility to Pemetrexed17339891
D000068437PemetrexedTYMS protein inhibits the reaction [Pemetrexed results in increased expression of FAS protein]15161716
D000068437PemetrexedPemetrexed results in decreased activity of TYMS protein17465208
D010634PhenobarbitalPhenobarbital affects the expression of TYMS mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of TYMS mRNA23091169
D020113PhenolphthaleinPhenolphthalein results in decreased activity of TYMS protein21696158
C415326phenoxyacetic acidphenoxyacetic acid affects the expression of TYMS mRNA21621602
D048789PhytoestrogensPhytoestrogens results in increased expression of TYMS mRNA18310284
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of TYMS mRNA15890375
C006253pirinixic acidpirinixic acid results in increased expression of TYMS mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of TYMS mRNA15890375|1916217
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of TYMS mRNA]28070326
D010936Plant ExtractsPlant Extracts results in decreased expression of TYMS mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of TYMS mRNA16474171
D011192Potassium DichromatePotassium Dichromate results in increased expression of TYMS mRNA17547211
D011241PrednisoneTYMS gene polymorphism affects the susceptibility to Prednisone15713801
D011374ProgesteroneProgesterone results in decreased expression of TYMS mRNA21795739
D011374ProgesteroneProgesterone results in increased expression of TYMS mRNA18070364
D011624Pteroylpolyglutamic AcidsPteroylpolyglutamic Acids analog results in decreased activity of TYMS protein2909728
D011794QuercetinQuercetin results in decreased expression of TYMS protein16573383
D011794QuercetinQuercetin results in increased expression of TYMS mRNA21632981
D011794QuercetinQuercetin results in decreased expression of TYMS mRNA17103110
D011799QuinazolinesQuinazolines analog results in decreased activity of TYMS protein2909728
C068874raltitrexedraltitrexed results in decreased activity of TYMS protein17339891
C068874raltitrexedTYMS protein affects the susceptibility to raltitrexed10482907|1733989
C068874raltitrexedTYMS protein inhibits the reaction [raltitrexed results in increased expression of ANXA2 mRNA]15152939
C068874raltitrexedTYMS protein inhibits the reaction [raltitrexed results in increased expression of FAS protein]15161716
C068874raltitrexedTYMS protein inhibits the reaction [raltitrexed results in increased expression of SAT1 mRNA]15152939
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of TYMS mRNA19167446
C059514resveratrolresveratrol results in increased expression of TYMS mRNA19167446
D012402RotenoneRotenone results in decreased expression of TYMS mRNA24810058
C079198S 1 (combination)TYMS protein affects the susceptibility to [gefitinib co-treated with S 1 (combination)]18347146
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TYMS mRNA19073995
D019821SimvastatinSimvastatin results in decreased expression of TYMS mRNA17428261
D019821SimvastatinSimvastatin results in decreased expression of TYMS protein17428261
D020123SirolimusSirolimus results in decreased expression of TYMS20682991
D020123SirolimusSirolimus results in decreased expression of TYMS mRNA19764996
C016104sodium bichromatesodium bichromate affects the expression of TYMS mRNA22110744
C016104sodium bichromatesodium bichromate results in increased expression of TYMS mRNA25993096
D053260SootSoot results in increased expression of TYMS mRNA22461453
C030000stallimycinstallimycin analog results in decreased expression of and results in decreased activity of TYMS protein21814787
C030000stallimycinstallimycin results in decreased expression of TYMS mRNA21814787
C030000stallimycinstallimycin binds to TYMS mRNA21814787
C433985SU 9516SU 9516 results in decreased expression of TYMS18425338
C433985SU 9516[SU 9516 results in decreased expression of TYMS] which results in increased susceptibility to Fluorouracil18425338
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of TYMS mRNA"26680231
C112689TAC 101TAC 101 results in decreased expression of TYMS protein10225456
C112765tanespimycintanespimycin results in decreased expression of TYMS protein18830594
D005641TegafurTYMS promoter polymorphism affects the susceptibility to Tegafur16617381
C401859temsirolimustemsirolimus results in decreased expression of TYMS mRNA19764996
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of TYMS mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of TYMS mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of TYMS mRNA]11179685
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TYMS mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TYMS mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TYMS mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TYMS mRNA15667827
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TYMS mRNA22298810
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of TYMS mRNA19031421
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TYMS mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of TYMS mRNA22378314
D013853ThioacetamideThioacetamide results in increased expression of TYMS mRNA23411599
D013936ThymidineThymidine inhibits the reaction [Fluorouracil results in decreased expression of TYMS]9050858
D013938Thymidine Monophosphate[Fluorouracil results in decreased activity of TYMS protein] which results in decreased abundance of Thymidine Monophosphate29258758
C009495titanium dioxide[Vitallium analog binds to titanium dioxide] which results in decreased expression of TYMS mRNA23825117
C009495titanium dioxidetitanium dioxide results in increased expression of TYMS mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TYMS mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TYMS mRNA25729387
D019772TopotecanTopotecan results in decreased expression of TYMS mRNA25729387
D014212TretinoinTretinoin results in decreased expression of TYMS mRNA16249480|2193413
C012589trichostatin Abenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [trichostatin A results in decreased expression of TYMS protein]17172411
C012589trichostatin ACycloheximide inhibits the reaction [trichostatin A results in decreased expression of TYMS mRNA]17172411
C012589trichostatin Atrichostatin A results in decreased expression of TYMS mRNA17172411|1960601
C012589trichostatin Atrichostatin A results in decreased expression of TYMS protein17172411
C012589trichostatin A[trichostatin A results in decreased expression of TYMS protein] which results in increased susceptibility to Fluorouracil17172411
C012589trichostatin Atrichostatin A results in increased degradation of TYMS protein17172411
D014271TrifluridineTrifluridine results in decreased activity of TYMS19816940
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TYMS mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TYMS mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of TYMS mRNA19140230
C113580U 0126U 0126 inhibits the reaction [Cisplatin results in decreased degradation of TYMS protein]21444628
C113580U 0126U 0126 results in decreased expression of TYMS mRNA21444628
D014520UrethaneUrethane results in decreased expression of TYMS mRNA28818685
D014527Uric AcidNLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TYMS mRNA]23619996
D014527Uric AcidUric Acid results in decreased expression of TYMS mRNA23619996
D014635Valproic AcidValproic Acid results in decreased expression of TYMS mRNA28001369
D014750VincristineTYMS gene polymorphism affects the susceptibility to Vincristine15713801
D014800Vitallium[Vitallium analog binds to titanium dioxide] which results in decreased expression of TYMS mRNA23825117
D014800VitalliumVitallium analog results in decreased expression of TYMS mRNA23825117
D024483Vitamin K 3Vitamin K 3 affects the expression of TYMS mRNA20044591
C111237vorinostatvorinostat results in decreased expression of TYMS mRNA20072153
C111237vorinostatvorinostat results in decreased expression of TYMS protein17172411
C085514wogonin[wogonin co-treated with Fluorouracil] results in increased expression of TYMS mRNA20570612
C085514wogoninwogonin results in increased expression of TYMS mRNA20570612
C094299ZD 9331ZD 9331 results in decreased activity of TYMS protein15342418
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in decreased expression of TYMS mRNA15784690
D015032ZincZinc deficiency results in increased expression of TYMS mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-IEA-  
GO:0000900translation repressor activity, mRNA regulatory element binding-IDA1924359  
GO:0004799thymidylate synthase activity-IDA8845352  11278511  15093541  
GO:0004799thymidylate synthase activity-TAS1924359  
GO:0005542folic acid binding-IC15093541  
GO:0042803protein homodimerization activity-IEA-  
GO:0048037cofactor binding-IEA-  
GO:1990825sequence-specific mRNA binding-IDA1924359  
GO ID GO Term Qualifier Evidence PubMed
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle-TAS-  
GO:0006231dTMP biosynthetic process-IDA8845352  11278511  15093541  
GO:0006235dTTP biosynthetic process-IEA-  
GO:0007568aging-IEA-  
GO:0007623circadian rhythm-IEA-  
GO:0015949nucleobase-containing small molecule interconversion-TAS-  
GO:0017148negative regulation of translation-IDA1924359  
GO:0019088immortalization of host cell by virus-IEA-  
GO:0019860uracil metabolic process-IEA-  
GO:0032259methylation-IEA-  
GO:0032570response to progesterone-IEA-  
GO:0033189response to vitamin A-IEA-  
GO:0034097response to cytokine-IEA-  
GO:0035999tetrahydrofolate interconversion-IDA15093541  
GO:0045471response to ethanol-IEA-  
GO:0046078dUMP metabolic process-IEA-  
GO:0046683response to organophosphorus-IEP16079077  
GO:0048589developmental growth-IEA-  
GO:0051216cartilage development-IEA-  
GO:0051384response to glucocorticoid-IEA-  
GO:0051593response to folic acid-IEA-  
GO:0060574intestinal epithelial cell maturation-IEA-  
GO:0071897DNA biosynthetic process-IC15093541  
GO:0097421liver regeneration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA21876188  
GO:0005730nucleolus-IEA-  
GO:0005737cytoplasm-IDA21876188  
GO:0005739mitochondrion-IDA21876188  
GO:0005743mitochondrial inner membrane-IDA21876188  
GO:0005759mitochondrial matrix-IDA21876188  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00240Pyrimidine metabolism
hsa00670One carbon pool by folate
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-1640170Cell CycleTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-499943Interconversion of nucleotide di- and triphosphatesTAS
R-HSA-539107Activation of E2F1 target genes at G1/STAS
R-HSA-69205G1/S-Specific TranscriptionTAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24278388One-carbon metabolism pathway gene variants and risk of clear cell renal cell carcinoma in a Chinese population. (2013)Zhang LPLoS One
24994038Mutations of EGFR or KRAS and expression of chemotherapy-related genes based on small biopsy samples in stage IIIB and IV inoperable non-small cell lung cancer. (2014 Dec)Deng LLJ Cancer Res Clin Oncol
19837268Polymorphisms in one-carbon metabolism pathway genes and risk for bladder cancer in a Tunisian population. (2009 Nov)Rouissi KCancer Genet Cytogenet
25366782Associations between clinical characteristics and oncogene expression in patients with non-small cell lung cancer. (2014 Oct 31)Han YGenet Mol Res
15682292A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations. (2005 Apr)Kealey CHum Genet
24649266Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients. (2013 Sep)Han YMol Clin Oncol
22649255Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males. (2012 Jul)Wernimont SMJ Nutr
23372658Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer. (2013)Swartz MDPLoS One
19885596Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: a case-control study. (2009 Dec)Henriquez-Hernandez LAOncol Rep
23826176RPS19 and TYMS SNPs and Prevalent High Risk Human Papilloma Virus Infection in Nigerian Women. (2013)Famooto APLoS One
21339095Smoking and polymorphisms in folate metabolizing genes and their effects on the histological stage and grade for bladder tumors. (2011 Feb)Rouissi KBull Cancer
15579479Case-control analysis of thymidylate synthase polymorphisms and risk of lung cancer. (2005 Mar)Shi QCarcinogenesis
18635682Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (2008 Nov)Giusti BJ Med Genet
21254359Folate pathway and nonsyndromic cleft lip and palate. (2011 Jan)Blanton SHBirth Defects Res A Clin Mol Teratol
16580699A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers. (2006 Jul 25)Ishikawa HMutat Res
18336674Alcohol, cofactors and the genetics of hepatocellular carcinoma. (2008 Mar)Yu MCJ Gastroenterol Hepatol
20544798Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women. (2010 Aug)Summers CMBirth Defects Res A Clin Mol Teratol