Gene info: ID 7298

Gene: TYMS

GENE ID: 7298

Synonyms: HST422|TMS|TS

Description: thymidylate synthetase

Gene type: protein-coding

Location: 18p11.32

dbXrefs: Ensembl:ENSG00000176890 MIM:188350 Vega:OTTHUMG00000131473 UniprotKB:P04818

RefSeq: NG_028255.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 17

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.337e-1 (AD) 2.422e-2 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs502396	chr18:659236 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HHIP	0.9
TRIM59	0.89
GJB1	0.888
SGK2	0.888
TMEM144	0.88
EVI2A	0.879
ENPP2	0.878
NIPAL4	0.878
FOLH1	0.876
TMEM125	0.876

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
WTIP	-0.366
GPR153	-0.331
CHRNA2	-0.329
SLC29A4	-0.327
CUX2	-0.326
GRIN2D	-0.306
SHISA8	-0.305
CCDC85C	-0.302
WNT7B	-0.284
PAX2	-0.282

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00293	Raltitrexed	Small Molecule	112887-68-0	Approved\|Investigational	Target
DB00322	Floxuridine	Small Molecule	50-91-9	Approved	Target
DB00432	Trifluridine	Small Molecule	70-00-8	Approved\|Investigational	Target
DB00440	Trimethoprim	Small Molecule	738-70-5	Approved	Target
DB00441	Gemcitabine	Small Molecule	95058-81-4	Approved	Target
DB00544	Fluorouracil	Small Molecule	51-21-8	Approved	Target
DB00642	Pemetrexed	Small Molecule	137281-23-3	Approved\|Investigational	Target
DB01101	Capecitabine	Small Molecule	154361-50-9	Approved\|Investigational	Target
DB01643	Thymidine-5'-Phosphate	Small Molecule	365-07-1	Experimental	Target
DB03541	10-Propargyl-5,8-Dideazafolic Acid	Small Molecule		Experimental	Target
DB03800	2'-deoxyuridylic acid	Small Molecule	-	Experimental	Target
DB04530	S,S-(2-Hydroxyethyl)Thiocysteine	Small Molecule		Experimental	Target
DB05116	Thymectacin	Small Molecule	232925-18-7	Investigational	Target
DB05308	ANX-510	Small Molecule	-	Investigational	Target
DB05457	OSI-7904L	Small Molecule	-	Investigational	Target
DB06813	Pralatrexate	Small Molecule	146464-95-1	Approved\|Investigational	Target
DB07577	6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE	Small Molecule		Experimental	Target
DB08478	N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide	Small Molecule		Experimental	Target
DB08479	N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide	Small Molecule		Experimental	Target
DB08734	6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE	Small Molecule		Experimental	Target
DB09327	Tegafur-uracil	Small Molecule	74578-38-4	Approved\|Investigational	Target
DB00544	Fluorouracil	Small Molecule	51-21-8	Approved	Enzyme
DB00563	Methotrexate	Small Molecule	59-05-2	Approved	Enzyme

ID	Drug Name	Action	PubMed
C495626	14-deoxy-11,12-didehydroandrographolide	"14-deoxy-11,12-didehydroandrographolide results in decreased expression of TYMS mRNA"	22101062
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of TYMS mRNA"	19167446
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TYMS mRNA"	19167446
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TYMS mRNA"	17547211\|1903142
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of TYMS mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of TYMS mRNA"	21346803
C007267	2'-deoxyuridylic acid	[Fluorouracil results in decreased activity of TYMS protein] which results in increased abundance of 2'-deoxyuridylic acid	29258758
C058706	2-desamino-2-methylaminopterin	2-desamino-2-methylaminopterin analog binds to and results in decreased activity of TYMS protein	1313737
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of TYMS mRNA	14600272\|1589037
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of TYMS mRNA]"	11179685
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of TYMS mRNA	16788091
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TYMS mRNA	14600272\|1589037
C013123	5,10-methylenetetrahydrofolic acid	"[Fluorodeoxyuridylate co-treated with 5,10-methylenetetrahydrofolic acid] binds to TYMS protein"	15897250
C030371	5,6,7,8-tetrahydrofolic acid	"5,6,7,8-tetrahydrofolic acid results in increased activity of TYMS protein"	187325
D000082	Acetaminophen	Acetaminophen results in decreased expression of TYMS mRNA	21420995
D000082	Acetaminophen	Acetaminophen results in increased expression of TYMS mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of TYMS mRNA	17562736
C063261	acetylleucyl-leucyl-norleucinal	acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]	21444628
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of TYMS protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TYMS mRNA	22100608\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TYMS mRNA	14600272\|1589037
C412373	AG 1879	AG 1879 results in decreased expression of TYMS mRNA	18794807
C412373	AG 1879	AG 1879 results in decreased expression of TYMS protein	18794807
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TYMS mRNA	16483693
D000965	Antimony	Antimony results in increased expression of TYMS mRNA	17547211
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in increased expression of TYMS mRNA	17547211
D018501	Antirheumatic Agents	TYMS gene polymorphism results in increased susceptibility to Antirheumatic Agents	18322994
D018501	Antirheumatic Agents	TYMS protein affects the susceptibility to Antirheumatic Agents	18322994
C006632	arsenic trioxide	arsenic trioxide affects the activity of TYMS protein	25335113
C006632	arsenic trioxide	arsenic trioxide affects the expression of TYMS mRNA	20501625
C006632	arsenic trioxide	arsenic trioxide affects the expression of TYMS protein	25335113
C006632	arsenic trioxide	[arsenic trioxide co-treated with Fluorouracil co-treated with Leucovorin] results in decreased expression of TYMS mRNA	20501625
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TYMS mRNA	20530422\|2296340
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TYMS protein	20530422\|2469199
C006632	arsenic trioxide	arsenic trioxide results in increased expression of TYMS mRNA	17547211
C006632	arsenic trioxide	TYMS protein results in decreased susceptibility to arsenic trioxide	24691991
C015001	arsenite	arsenite results in decreased expression of TYMS mRNA	18929588
D001280	Atrazine	Atrazine results in decreased expression of TYMS mRNA	22378314
D001379	Azathioprine	Azathioprine results in decreased expression of TYMS mRNA	22623647
D001397	Azoxymethane	[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TYMS mRNA	17893519
C487081	belinostat	belinostat results in decreased expression of TYMS mRNA	19606018
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TYMS mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TYMS mRNA	20064835\|2180250
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TYMS mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TYMS mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of TYMS mRNA"	20382639
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]	21444628
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [trichostatin A results in decreased expression of TYMS protein]	17172411
D004958	Estradiol	"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of TYMS mRNA]"	11179685
D004958	Estradiol	Estradiol results in increased expression of TYMS mRNA	11179685\|1647417
D004958	Estradiol	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of TYMS mRNA]	11179685
C044887	beta-methylcholine	beta-methylcholine affects the expression of TYMS mRNA	21179406
C504663	BGC638	BGC638 results in decreased activity of TYMS protein	16357184
C504662	BGC945	BGC945 results in decreased activity of TYMS protein	16357184
C504662	BGC945	BGC945 results in decreased activity of TYMS protein	21879757
C053541	bicalutamide	bicalutamide results in decreased expression of TYMS protein	17599054
C522781	biflorin	biflorin affects the expression of TYMS mRNA	27079618
C006780	bisphenol A	bisphenol A results in decreased expression of TYMS mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of TYMS mRNA	16474171
C006780	bisphenol A	bisphenol A results in increased expression of TYMS mRNA	29097150
D002087	Butyrates	Butyrates results in decreased expression of TYMS mRNA	20072153
D002104	Cadmium	Cadmium results in increased expression of TYMS mRNA	17547211
D002104	Cadmium	Cadmium results in increased expression of TYMS protein	14499349
D002104	Cadmium	Cadmium results in decreased expression of TYMS mRNA	24084258
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TYMS mRNA	17547211
C037123	cadmium sulfate	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TYMS mRNA	18654764
D002110	Caffeine	Caffeine results in decreased expression of TYMS mRNA	20864626
D002166	Camptothecin	Camptothecin results in increased expression of TYMS mRNA	16568373
D000069287	Capecitabine	Capecitabine affects the expression of TYMS mRNA	16438929
D000069287	Capecitabine	[TYMS enhancer polymorphism co-treated with VEGFA gene SNP] affects the susceptibility to [Capecitabine co-treated with oxaliplatin]	21048041
D000069287	Capecitabine	TYMS protein results in decreased susceptibility to Capecitabine	16734730
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of TYMS mRNA	17484886
C031662	CB 3717	CB 3717 analog results in decreased activity of TYMS protein	8632414
C031662	CB 3717	CB 3717 results in decreased activity of TYMS protein	3431591
D002509	Cephaloridine	Cephaloridine results in increased expression of TYMS mRNA	18500788
C095424	CF regimen	CF regimen results in decreased expression of TYMS mRNA	17638652
D002713	Chlorine	Chlorine results in decreased expression of TYMS mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of TYMS mRNA	18636392
D002857	Chromium	Chromium results in increased expression of TYMS mRNA	17547211
C018021	cobaltous chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TYMS mRNA	18654764
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TYMS mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TYMS mRNA	24386269
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of TYMS mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of TYMS mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TYMS mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of TYMS mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of TYMS mRNA	19167446
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in decreased expression of TYMS mRNA	21878529
D003513	Cycloheximide	Cycloheximide inhibits the reaction [trichostatin A results in decreased expression of TYMS mRNA]	17172411
D016572	Cyclosporine	Cyclosporine results in decreased expression of TYMS mRNA	20106945\|2163298
C093628	cyproconazole	cyproconazole affects the expression of TYMS mRNA	21621602
D003561	Cytarabine	TYMS gene polymorphism affects the susceptibility to Cytarabine	15713801
D003561	Cytarabine	Cytarabine results in increased activity of TYMS protein	15816533
D003630	Daunorubicin	TYMS gene polymorphism affects the susceptibility to Daunorubicin	15713801
D003634	DDT	DDT results in decreased expression of TYMS mRNA	25014179
C014347	decitabine	decitabine affects the expression of TYMS mRNA	23300844
D013759	Dronabinol	Dronabinol results in decreased expression of TYMS mRNA	17934890
D016264	Dextran Sulfate	[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TYMS mRNA	17893519
D016190	Carboplatin	PCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Carboplatin]	16685392
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of TYMS mRNA	17361019\|2126653
D002945	Cisplatin	acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]	21444628
D002945	Cisplatin	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]	21444628
D002945	Cisplatin	Cisplatin affects the expression of TYMS mRNA	23300844
D002945	Cisplatin	[Cisplatin co-treated with Fluorouracil] results in decreased expression of TYMS mRNA	15737843
D002945	Cisplatin	Cisplatin results in decreased degradation of TYMS protein	21444628
D002945	Cisplatin	Cisplatin results in increased activity of TYMS protein	16568373
D002945	Cisplatin	Cisplatin results in increased expression of TYMS mRNA	16568373\|2144462
D002945	Cisplatin	Cisplatin results in increased stability of TYMS mRNA	21444628
D002945	Cisplatin	[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein	21444628
D002945	Cisplatin	PCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Cisplatin]	16685392
D002945	Cisplatin	TYMS gene polymorphism results in decreased susceptibility to [Fluorouracil co-treated with Cisplatin]	16622263
D002945	Cisplatin	TYMS gene polymorphism results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Cisplatin co-treated with Paclitaxel]	16424979
D002945	Cisplatin	TYMS protein results in decreased susceptibility to Cisplatin	21444628
D002945	Cisplatin	U 0126 inhibits the reaction [Cisplatin results in decreased degradation of TYMS protein]	21444628
D004004	Dichlororibofuranosylbenzimidazole	Dichlororibofuranosylbenzimidazole inhibits the reaction [Fluorouracil results in increased expression of TYMS protein]	23056627
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine] results in decreased expression of TYMS mRNA	15784690
D004041	Dietary Fats	Dietary Fats results in increased expression of TYMS mRNA	25016146
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of TYMS mRNA	12807726
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TYMS mRNA	18164116
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of TYMS mRNA	15890375
D002117	Calcitriol	Calcitriol results in decreased expression of TYMS mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of TYMS mRNA	21592394
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TYMS mRNA"	22485181
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of TYMS mRNA	14600272\|1589037
C067311	docetaxel	docetaxel inhibits the reaction [Fluorouracil results in increased activity of TYMS protein]	16557585
C067311	docetaxel	docetaxel inhibits the reaction [Fluorouracil results in increased expression of TYMS mRNA]	16557585
C067311	docetaxel	docetaxel results in decreased expression of TYMS protein	16557585
C067311	docetaxel	Fluorouracil promotes the reaction [docetaxel results in decreased expression of TYMS protein]	16557585
C067311	docetaxel	TYMS promoter polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin co-treated with docetaxel]	19074750
C025034	doxifluridine	doxifluridine affects the expression of TYMS mRNA	18630517
C025034	doxifluridine	[Paclitaxel co-treated with doxifluridine] affects the expression of TYMS mRNA	18630517
C025034	doxifluridine	TYMS protein results in decreased susceptibility to doxifluridine	16734730
D004317	Doxorubicin	[Doxorubicin co-treated with Paclitaxel] results in decreased expression of TYMS protein	16168113
D004317	Doxorubicin	Fluorouracil inhibits the reaction [[Doxorubicin co-treated with Paclitaxel] results in decreased expression of TYMS protein]	16168113
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TYMS protein	23301498
C034096	ethoxyacetic acid	ethoxyacetic acid affects the expression of TYMS mRNA	21621602
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of TYMS mRNA	23649840
D005047	Etoposide	TYMS gene polymorphism affects the susceptibility to Etoposide	15713801
C435305	FdUMP(10)	FdUMP(10) results in decreased activity of TYMS protein	15043163
C082360	fipronil	fipronil results in increased expression of TYMS mRNA	23962444
D005467	Floxuridine	TYMS protein affects the susceptibility to Floxuridine	10482907
D005467	Floxuridine	TYMS protein results in decreased susceptibility to Floxuridine	15040806\|1701858
D005467	Floxuridine	TYMS results in increased susceptibility to Floxuridine	2537495
D005467	Floxuridine	Floxuridine results in decreased activity of TYMS protein	15251465
D005468	Fluorodeoxyuridylate	"[Fluorodeoxyuridylate co-treated with 5,10-methylenetetrahydrofolic acid] binds to TYMS protein"	15897250
D005472	Fluorouracil	TYMS protein results in decreased susceptibility to Fluorouracil	18612238
D005472	Fluorouracil	Fluorouracil binds to TYMS protein	16619043
D005472	Fluorouracil	acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]	21444628
D005472	Fluorouracil	[arsenic trioxide co-treated with Fluorouracil co-treated with Leucovorin] results in decreased expression of TYMS mRNA	20501625
D005472	Fluorouracil	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]	21444628
D005472	Fluorouracil	[Cisplatin co-treated with Fluorouracil] results in decreased expression of TYMS mRNA	15737843
D005472	Fluorouracil	Dichlororibofuranosylbenzimidazole inhibits the reaction [Fluorouracil results in increased expression of TYMS protein]	23056627
D005472	Fluorouracil	docetaxel inhibits the reaction [Fluorouracil results in increased activity of TYMS protein]	16557585
D005472	Fluorouracil	docetaxel inhibits the reaction [Fluorouracil results in increased expression of TYMS mRNA]	16557585
D005472	Fluorouracil	Fluorouracil affects the expression of TYMS mRNA	18794807
D005472	Fluorouracil	Fluorouracil affects the expression of TYMS protein	18794807
D005472	Fluorouracil	[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein	21444628
D005472	Fluorouracil	Fluorouracil inhibits the reaction [[Doxorubicin co-treated with Paclitaxel] results in decreased expression of TYMS protein]	16168113
D005472	Fluorouracil	Fluorouracil promotes the reaction [docetaxel results in decreased expression of TYMS protein]	16557585
D005472	Fluorouracil	Fluorouracil promotes the reaction [geraniol results in decreased expression of TYMS mRNA]	15374632
D005472	Fluorouracil	Fluorouracil results in decreased activity of TYMS protein	12739060\|1733989
D005472	Fluorouracil	Fluorouracil results in increased activity of TYMS protein	16557585
D005472	Fluorouracil	Fluorouracil results in increased expression of TYMS mRNA	15109396\|1655758
D005472	Fluorouracil	Fluorouracil results in increased expression of TYMS protein	15865071\|1616811
D005472	Fluorouracil	gambogic acid inhibits the reaction [Fluorouracil results in increased expression of TYMS mRNA]	19084572
D005472	Fluorouracil	[SU 9516 results in decreased expression of TYMS] which results in increased susceptibility to Fluorouracil	18425338
D005472	Fluorouracil	[TP53 affects the expression of TYMS] which affects the susceptibility to Fluorouracil	18600534
D005472	Fluorouracil	[trichostatin A results in decreased expression of TYMS protein] which results in increased susceptibility to Fluorouracil	17172411
D005472	Fluorouracil	TYMS 3' UTR mutant form results in decreased susceptibility to Fluorouracil	16267625
D005472	Fluorouracil	TYMS 3' UTR polymorphism affects the susceptibility to [Fluorouracil co-treated with oxaliplatin]	15213713
D005472	Fluorouracil	TYMS 5' UTR polymorphism results in decreased susceptibility to Fluorouracil	16267625
D005472	Fluorouracil	TYMS affects the susceptibility to Fluorouracil	15067352
D005472	Fluorouracil	TYMS gene polymorphism affects the susceptibility to Fluorouracil	17016601\|1866152
D005472	Fluorouracil	TYMS gene polymorphism affects the susceptibility to [Fluorouracil co-treated with oxaliplatin]	18448328
D005472	Fluorouracil	TYMS gene polymorphism results in decreased susceptibility to Fluorouracil	15446554
D005472	Fluorouracil	TYMS gene polymorphism results in decreased susceptibility to [Fluorouracil co-treated with Cisplatin]	16622263
D005472	Fluorouracil	TYMS gene polymorphism results in increased susceptibility to Fluorouracil	15735113\|1850559
D005472	Fluorouracil	TYMS gene polymorphism results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Cisplatin co-treated with Paclitaxel]	16424979
D005472	Fluorouracil	TYMS mRNA affects the susceptibility to Fluorouracil	18507058\|1898676
D005472	Fluorouracil	TYMS mRNA affects the susceptibility to [irinotecan co-treated with Fluorouracil co-treated with Leucovorin]	17454858
D005472	Fluorouracil	TYMS mRNA results in decreased susceptibility to Fluorouracil	15246190\|1838387
D005472	Fluorouracil	TYMS mRNA results in increased susceptibility to Fluorouracil	15239142
D005472	Fluorouracil	TYMS promoter polymorphism affects the susceptibility to Fluorouracil	16596248
D005472	Fluorouracil	TYMS promoter polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin co-treated with docetaxel]	19074750
D005472	Fluorouracil	TYMS protein affects the susceptibility to Fluorouracil	10482907\|1553873
D005472	Fluorouracil	TYMS protein affects the susceptibility to Fluorouracil analog	15608557
D005472	Fluorouracil	TYMS protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin]	18676755
D005472	Fluorouracil	TYMS protein results in decreased susceptibility to Fluorouracil	14970324\|1589024
D005472	Fluorouracil	TYMS protein results in increased susceptibility to Fluorouracil	15446554\|1577039
D005472	Fluorouracil	TYMS results in decreased susceptibility to Fluorouracil	7763285
D005472	Fluorouracil	TYMS results in increased susceptibility to Fluorouracil	2537495
D005472	Fluorouracil	[wogonin co-treated with Fluorouracil] results in increased expression of TYMS mRNA	20570612
D005472	Fluorouracil	Fluorouracil results in decreased activity of TYMS protein	29258758\|9299594
D005472	Fluorouracil	[Fluorouracil results in decreased activity of TYMS protein] which results in decreased abundance of Thymidine Monophosphate	29258758
D005472	Fluorouracil	[Fluorouracil results in decreased activity of TYMS protein] which results in increased abundance of 2'-deoxyuridylic acid	29258758
D005472	Fluorouracil	Fluorouracil results in decreased expression of TYMS	9050858
D005472	Fluorouracil	Leucovorin promotes the reaction [Fluorouracil results in decreased expression of TYMS]	9050858
D005472	Fluorouracil	Thymidine inhibits the reaction [Fluorouracil results in decreased expression of TYMS]	9050858
D005472	Fluorouracil	Fluorouracil results in decreased activity of TYMS protein	9299594
D005472	Fluorouracil	Fluorouracil results in decreased activity of TYMS	19147506\|1981694
D005472	Fluorouracil	TYMS protein affects the metabolism of Fluorouracil	16012767
D005472	Fluorouracil	TYMS results in decreased susceptibility to Fluorouracil	19023200
D005480	Flurbiprofen	Flurbiprofen results in increased expression of TYMS mRNA	16949054
C061365	flusilazole	flusilazole affects the expression of TYMS mRNA	21621602
C410216	Folfox protocol	TYMS gene polymorphism results in increased susceptibility to Folfox protocol analog	18505590
D005492	Folic Acid	Folic Acid affects the expression of TYMS mRNA	17311948\|1732036
D005492	Folic Acid	Folic Acid analog results in decreased activity of TYMS protein	2909728
D005492	Folic Acid	Folic Acid deficiency results in increased expression of TYMS mRNA	18623116
D005492	Folic Acid	Folic Acid results in increased expression of TYMS protein	187325
D002955	Leucovorin	[arsenic trioxide co-treated with Fluorouracil co-treated with Leucovorin] results in decreased expression of TYMS mRNA	20501625
D002955	Leucovorin	TYMS gene polymorphism results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Cisplatin co-treated with Paclitaxel]	16424979
D002955	Leucovorin	TYMS mRNA affects the susceptibility to [irinotecan co-treated with Fluorouracil co-treated with Leucovorin]	17454858
D002955	Leucovorin	TYMS promoter polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin co-treated with docetaxel]	19074750
D002955	Leucovorin	TYMS protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin]	18676755
D002955	Leucovorin	Leucovorin promotes the reaction [Fluorouracil results in decreased expression of TYMS]	9050858
C074694	FuMi protocol	TYMS gene polymorphism affects the susceptibility to FuMi protocol	18498133
C039281	furan	furan results in increased expression of TYMS mRNA	25539665\|2619464
C052659	gambogic acid	gambogic acid inhibits the reaction [Fluorouracil results in increased expression of TYMS mRNA]	19084572
C052659	gambogic acid	gambogic acid results in decreased expression of TYMS mRNA	19084572
C419708	gefitinib	gefitinib results in decreased expression of TYMS mRNA	18347146
C419708	gefitinib	gefitinib results in decreased expression of TYMS protein	18347146
C419708	gefitinib	TYMS protein affects the susceptibility to [gefitinib co-treated with S 1 (combination)]	18347146
D019833	Genistein	Genistein results in increased expression of TYMS mRNA	16474171
D005839	Gentamicins	Gentamicins results in decreased expression of TYMS mRNA	22061828
C007836	geraniol	Fluorouracil promotes the reaction [geraniol results in decreased expression of TYMS mRNA]	15374632
C007836	geraniol	geraniol results in decreased expression of TYMS mRNA	15374632
D017313	Fenretinide	Fenretinide results in increased expression of TYMS mRNA	28973697
D007065	Idoxuridine	TYMS protein affects the uptake of Idoxuridine	15001691
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TYMS mRNA	25613284
C051890	irinotecan	TYMS mRNA affects the susceptibility to [irinotecan co-treated with Fluorouracil co-treated with Leucovorin]	17454858
C561695	(+)-JQ1 compound	(+)-JQ1 compound analog binds to TYMS protein	24972113
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TYMS mRNA	23086925\|2479639
C410337	K 7174	K 7174 results in decreased expression of TYMS mRNA	24086573
D007649	Ketamine	Ketamine results in decreased expression of TYMS mRNA	20080153
D007840	Latex	Latex analog results in increased expression of TYMS mRNA	24768652
C029891	lead chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TYMS mRNA	18654764
D008070	Lipopolysaccharides	Lipopolysaccharides affects the expression of TYMS mRNA	28070326
D008070	Lipopolysaccharides	Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of TYMS mRNA]	28070326
D008294	Malathion	Malathion results in decreased expression of TYMS mRNA	16079077
D015122	Mercaptopurine	TYMS gene polymorphism affects the susceptibility to Mercaptopurine	15713801
D008628	Mercury	Mercury results in increased expression of TYMS mRNA	17547211
D008701	Methapyrilene	Methapyrilene results in increased expression of TYMS mRNA	15890375
D008727	Methotrexate	Methotrexate results in decreased expression of TYMS mRNA	23897011
D008727	Methotrexate	Methotrexate results in increased expression of TYMS mRNA	23838799
D008727	Methotrexate	Methotrexate results in increased expression of TYMS protein	22484375
D008727	Methotrexate	TYMS 3' UTR polymorphism affects the susceptibility to Methotrexate	17410198
D008727	Methotrexate	TYMS 5' UTR polymorphism affects the susceptibility to Methotrexate	17410198
D008727	Methotrexate	TYMS 5' UTR polymorphism results in decreased susceptibility to Methotrexate	16267625
D008727	Methotrexate	TYMS gene polymorphism affects the susceptibility to Methotrexate	15713801\|2500718
D008727	Methotrexate	TYMS protein results in increased susceptibility to Methotrexate	16267625
D008727	Methotrexate	TYMS results in increased susceptibility to Methotrexate	2537495
D008727	Methotrexate	Methotrexate results in increased expression of TYMS protein	22484375
D008727	Methotrexate	Methotrexate results in increased expression of TYMS protein	187325
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of TYMS mRNA	21621602
C013598	methoxyacetic acid	methoxyacetic acid results in decreased expression of TYMS mRNA	20864626
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of TYMS mRNA	22100608
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TYMS mRNA	20864626
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of TYMS mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of TYMS mRNA	22100608\|2364984
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of TYMS mRNA	24810058
C008493	methylselenic acid	methylselenic acid affects the expression of TYMS mRNA	14617803
C008493	methylselenic acid	methylselenic acid results in decreased expression of TYMS mRNA	12517777
D016685	Mitomycin	Mitomycin results in increased expression of TYMS mRNA	16568373
C028577	monobutyl phthalate	monobutyl phthalate results in decreased expression of TYMS mRNA	20864626
C047806	monomethylpropion	monomethylpropion results in increased expression of TYMS mRNA	22303338
D009532	Nickel	Nickel results in increased expression of TYMS mRNA	25583101
C022838	nickel chloride	nickel chloride affects the expression of TYMS mRNA	22110744
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of TYMS mRNA	17616710
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of TYMS mRNA	19716841
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TYMS mRNA"	12888634
C099178	nolatrexed	nolatrexed results in decreased activity of TYMS protein	17339891
C099178	nolatrexed	TYMS protein affects the susceptibility to nolatrexed	17339891
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of TYMS mRNA	20971185
C466913	NU2058	NU2058 results in decreased expression of TYMS protein	17599054
C030110	oxaliplatin	oxaliplatin results in decreased expression of TYMS mRNA	15057142
C030110	oxaliplatin	oxaliplatin results in decreased expression of TYMS protein	15057142
C030110	oxaliplatin	TYMS 3' UTR polymorphism affects the susceptibility to [Fluorouracil co-treated with oxaliplatin]	15213713
C030110	oxaliplatin	[TYMS enhancer polymorphism co-treated with VEGFA gene SNP] affects the susceptibility to [Capecitabine co-treated with oxaliplatin]	21048041
C030110	oxaliplatin	TYMS gene polymorphism affects the susceptibility to [Fluorouracil co-treated with oxaliplatin]	18448328
C030110	oxaliplatin	TYMS promoter polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin co-treated with docetaxel]	19074750
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of TYMS mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of TYMS mRNA	25729387
C100692	oxamflatin	oxamflatin results in decreased expression of TYMS protein	17172411
D010100	Oxygen	Oxygen deficiency results in decreased expression of TYMS mRNA	24205000
D010126	Ozone	[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TYMS mRNA	25658374
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of TYMS mRNA	18636392
D017239	Paclitaxel	[Doxorubicin co-treated with Paclitaxel] results in decreased expression of TYMS protein	16168113
D017239	Paclitaxel	Fluorouracil inhibits the reaction [[Doxorubicin co-treated with Paclitaxel] results in decreased expression of TYMS protein]	16168113
D017239	Paclitaxel	Paclitaxel affects the expression of TYMS mRNA	18630517
D017239	Paclitaxel	[Paclitaxel co-treated with doxifluridine] affects the expression of TYMS mRNA	18630517
D017239	Paclitaxel	Paclitaxel results in increased expression of TYMS mRNA	16568373
D017239	Paclitaxel	TYMS gene polymorphism results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Cisplatin co-treated with Paclitaxel]	16424979
C500026	palbociclib	palbociclib results in decreased expression of TYMS mRNA	22869556
C500026	palbociclib	palbociclib results in decreased expression of TYMS protein	20948315
D000068437	Pemetrexed	Pemetrexed results in decreased activity of TYMS protein	17339891
D000068437	Pemetrexed	TYMS affects the susceptibility to Pemetrexed	21742432
D000068437	Pemetrexed	TYMS protein affects the susceptibility to Pemetrexed	17339891
D000068437	Pemetrexed	TYMS protein inhibits the reaction [Pemetrexed results in increased expression of FAS protein]	15161716
D000068437	Pemetrexed	Pemetrexed results in decreased activity of TYMS protein	17465208
D010634	Phenobarbital	Phenobarbital affects the expression of TYMS mRNA	19159669
D010634	Phenobarbital	Phenobarbital affects the expression of TYMS mRNA	23091169
D020113	Phenolphthalein	Phenolphthalein results in decreased activity of TYMS protein	21696158
C415326	phenoxyacetic acid	phenoxyacetic acid affects the expression of TYMS mRNA	21621602
D048789	Phytoestrogens	Phytoestrogens results in increased expression of TYMS mRNA	18310284
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of TYMS mRNA	15890375
C006253	pirinixic acid	pirinixic acid results in increased expression of TYMS mRNA	23811191
C006253	pirinixic acid	pirinixic acid results in increased expression of TYMS mRNA	15890375\|1916217
D010936	Plant Extracts	Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of TYMS mRNA]	28070326
D010936	Plant Extracts	Plant Extracts results in decreased expression of TYMS mRNA	23557933
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in increased expression of TYMS mRNA	16474171
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of TYMS mRNA	17547211
D011241	Prednisone	TYMS gene polymorphism affects the susceptibility to Prednisone	15713801
D011374	Progesterone	Progesterone results in decreased expression of TYMS mRNA	21795739
D011374	Progesterone	Progesterone results in increased expression of TYMS mRNA	18070364
D011624	Pteroylpolyglutamic Acids	Pteroylpolyglutamic Acids analog results in decreased activity of TYMS protein	2909728
D011794	Quercetin	Quercetin results in decreased expression of TYMS protein	16573383
D011794	Quercetin	Quercetin results in increased expression of TYMS mRNA	21632981
D011794	Quercetin	Quercetin results in decreased expression of TYMS mRNA	17103110
D011799	Quinazolines	Quinazolines analog results in decreased activity of TYMS protein	2909728
C068874	raltitrexed	raltitrexed results in decreased activity of TYMS protein	17339891
C068874	raltitrexed	TYMS protein affects the susceptibility to raltitrexed	10482907\|1733989
C068874	raltitrexed	TYMS protein inhibits the reaction [raltitrexed results in increased expression of ANXA2 mRNA]	15152939
C068874	raltitrexed	TYMS protein inhibits the reaction [raltitrexed results in increased expression of FAS protein]	15161716
C068874	raltitrexed	TYMS protein inhibits the reaction [raltitrexed results in increased expression of SAT1 mRNA]	15152939
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of TYMS mRNA	19167446
C059514	resveratrol	resveratrol results in increased expression of TYMS mRNA	19167446
D012402	Rotenone	Rotenone results in decreased expression of TYMS mRNA	24810058
C079198	S 1 (combination)	TYMS protein affects the susceptibility to [gefitinib co-treated with S 1 (combination)]	18347146
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of TYMS mRNA	19073995
D019821	Simvastatin	Simvastatin results in decreased expression of TYMS mRNA	17428261
D019821	Simvastatin	Simvastatin results in decreased expression of TYMS protein	17428261
D020123	Sirolimus	Sirolimus results in decreased expression of TYMS	20682991
D020123	Sirolimus	Sirolimus results in decreased expression of TYMS mRNA	19764996
C016104	sodium bichromate	sodium bichromate affects the expression of TYMS mRNA	22110744
C016104	sodium bichromate	sodium bichromate results in increased expression of TYMS mRNA	25993096
D053260	Soot	Soot results in increased expression of TYMS mRNA	22461453
C030000	stallimycin	stallimycin analog results in decreased expression of and results in decreased activity of TYMS protein	21814787
C030000	stallimycin	stallimycin results in decreased expression of TYMS mRNA	21814787
C030000	stallimycin	stallimycin binds to TYMS mRNA	21814787
C433985	SU 9516	SU 9516 results in decreased expression of TYMS	18425338
C433985	SU 9516	[SU 9516 results in decreased expression of TYMS] which results in increased susceptibility to Fluorouracil	18425338
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of TYMS mRNA"	26680231
C112689	TAC 101	TAC 101 results in decreased expression of TYMS protein	10225456
C112765	tanespimycin	tanespimycin results in decreased expression of TYMS protein	18830594
D005641	Tegafur	TYMS promoter polymorphism affects the susceptibility to Tegafur	16617381
C401859	temsirolimus	temsirolimus results in decreased expression of TYMS mRNA	19764996
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of TYMS mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of TYMS mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of TYMS mRNA]	11179685
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TYMS mRNA	21802500
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TYMS mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TYMS mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TYMS mRNA	15667827
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TYMS mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of TYMS mRNA	19031421
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TYMS mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in decreased expression of TYMS mRNA	22378314
D013853	Thioacetamide	Thioacetamide results in increased expression of TYMS mRNA	23411599
D013936	Thymidine	Thymidine inhibits the reaction [Fluorouracil results in decreased expression of TYMS]	9050858
D013938	Thymidine Monophosphate	[Fluorouracil results in decreased activity of TYMS protein] which results in decreased abundance of Thymidine Monophosphate	29258758
C009495	titanium dioxide	[Vitallium analog binds to titanium dioxide] which results in decreased expression of TYMS mRNA	23825117
C009495	titanium dioxide	titanium dioxide results in increased expression of TYMS mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of TYMS mRNA	28065790
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of TYMS mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of TYMS mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of TYMS mRNA	16249480\|2193413
C012589	trichostatin A	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [trichostatin A results in decreased expression of TYMS protein]	17172411
C012589	trichostatin A	Cycloheximide inhibits the reaction [trichostatin A results in decreased expression of TYMS mRNA]	17172411
C012589	trichostatin A	trichostatin A results in decreased expression of TYMS mRNA	17172411\|1960601
C012589	trichostatin A	trichostatin A results in decreased expression of TYMS protein	17172411
C012589	trichostatin A	[trichostatin A results in decreased expression of TYMS protein] which results in increased susceptibility to Fluorouracil	17172411
C012589	trichostatin A	trichostatin A results in increased degradation of TYMS protein	17172411
D014271	Trifluridine	Trifluridine results in decreased activity of TYMS	19816940
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of TYMS mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TYMS mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of TYMS mRNA	19140230
C113580	U 0126	U 0126 inhibits the reaction [Cisplatin results in decreased degradation of TYMS protein]	21444628
C113580	U 0126	U 0126 results in decreased expression of TYMS mRNA	21444628
D014520	Urethane	Urethane results in decreased expression of TYMS mRNA	28818685
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TYMS mRNA]	23619996
D014527	Uric Acid	Uric Acid results in decreased expression of TYMS mRNA	23619996
D014635	Valproic Acid	Valproic Acid results in decreased expression of TYMS mRNA	28001369
D014750	Vincristine	TYMS gene polymorphism affects the susceptibility to Vincristine	15713801
D014800	Vitallium	[Vitallium analog binds to titanium dioxide] which results in decreased expression of TYMS mRNA	23825117
D014800	Vitallium	Vitallium analog results in decreased expression of TYMS mRNA	23825117
D024483	Vitamin K 3	Vitamin K 3 affects the expression of TYMS mRNA	20044591
C111237	vorinostat	vorinostat results in decreased expression of TYMS mRNA	20072153
C111237	vorinostat	vorinostat results in decreased expression of TYMS protein	17172411
C085514	wogonin	[wogonin co-treated with Fluorouracil] results in increased expression of TYMS mRNA	20570612
C085514	wogonin	wogonin results in increased expression of TYMS mRNA	20570612
C094299	ZD 9331	ZD 9331 results in decreased activity of TYMS protein	15342418
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine] results in decreased expression of TYMS mRNA	15784690
D015032	Zinc	Zinc deficiency results in increased expression of TYMS mRNA	22171008

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000166	nucleotide binding	-	IEA	-
GO:0000900	translation repressor activity, mRNA regulatory element binding	-	IDA	1924359
GO:0004799	thymidylate synthase activity	-	IDA	8845352 11278511 15093541
GO:0004799	thymidylate synthase activity	-	TAS	1924359
GO:0005542	folic acid binding	-	IC	15093541
GO:0042803	protein homodimerization activity	-	IEA	-
GO:0048037	cofactor binding	-	IEA	-
GO:1990825	sequence-specific mRNA binding	-	IDA	1924359

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	-	TAS	-
GO:0006231	dTMP biosynthetic process	-	IDA	8845352 11278511 15093541
GO:0006235	dTTP biosynthetic process	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0007623	circadian rhythm	-	IEA	-
GO:0015949	nucleobase-containing small molecule interconversion	-	TAS	-
GO:0017148	negative regulation of translation	-	IDA	1924359
GO:0019088	immortalization of host cell by virus	-	IEA	-
GO:0019860	uracil metabolic process	-	IEA	-
GO:0032259	methylation	-	IEA	-
GO:0032570	response to progesterone	-	IEA	-
GO:0033189	response to vitamin A	-	IEA	-
GO:0034097	response to cytokine	-	IEA	-
GO:0035999	tetrahydrofolate interconversion	-	IDA	15093541
GO:0045471	response to ethanol	-	IEA	-
GO:0046078	dUMP metabolic process	-	IEA	-
GO:0046683	response to organophosphorus	-	IEP	16079077
GO:0048589	developmental growth	-	IEA	-
GO:0051216	cartilage development	-	IEA	-
GO:0051384	response to glucocorticoid	-	IEA	-
GO:0051593	response to folic acid	-	IEA	-
GO:0060574	intestinal epithelial cell maturation	-	IEA	-
GO:0071897	DNA biosynthetic process	-	IC	15093541
GO:0097421	liver regeneration	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	21876188
GO:0005730	nucleolus	-	IEA	-
GO:0005737	cytoplasm	-	IDA	21876188
GO:0005739	mitochondrion	-	IDA	21876188
GO:0005743	mitochondrial inner membrane	-	IDA	21876188
GO:0005759	mitochondrial matrix	-	IDA	21876188
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa00240	Pyrimidine metabolism
hsa00670	One carbon pool by folate
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-15869	Metabolism of nucleotides	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-499943	Interconversion of nucleotide di- and triphosphates	TAS
R-HSA-539107	Activation of E2F1 target genes at G1/S	TAS
R-HSA-69205	G1/S-Specific Transcription	TAS
R-HSA-69206	G1/S Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24278388	One-carbon metabolism pathway gene variants and risk of clear cell renal cell carcinoma in a Chinese population. (2013)	Zhang L	PLoS One
24994038	Mutations of EGFR or KRAS and expression of chemotherapy-related genes based on small biopsy samples in stage IIIB and IV inoperable non-small cell lung cancer. (2014 Dec)	Deng LL	J Cancer Res Clin Oncol
19837268	Polymorphisms in one-carbon metabolism pathway genes and risk for bladder cancer in a Tunisian population. (2009 Nov)	Rouissi K	Cancer Genet Cytogenet
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