Gene info: ID 7299

Gene: TYR

GENE ID: 7299

Description: tyrosinase

Gene type: protein-coding

Location: 11q14.3

dbXrefs: Ensembl:ENSG00000077498 MIM:606933 Vega:OTTHUMG00000167294 UniprotKB:P14679

RefSeq: NG_008748.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 36

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.618e-1 (AD) 5.153e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR10J5	0.367
OR2G3	0.339
SERPINB5	0.334
SERPINB7	0.313
PNLIPRP3	0.302
OR52E8	0.294
LAD1	0.29
DCAF8L2	0.29
C17orf112	0.289
OVCH2	0.289

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
VCX3B	-0.28
ABHD1	-0.247
RIBC1	-0.213
LCAT	-0.21
ENTPD2	-0.204
TEKT3	-0.204
PROK1	-0.202
TST	-0.199
LRTM1	-0.197
KLKB1	-0.196

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target
DB00548	Azelaic Acid	Small Molecule	123-99-9	Approved	Target
DB00600	Monobenzone	Small Molecule	103-16-2	Approved	Target
DB01055	Mimosine	Small Molecule	500-44-7	Approved	Target
DB09526	Hydroquinone	Small Molecule	123-31-9	Approved\|Investigational	Target
DB06778	Cupric sulfate	Small Molecule	7758-98-7	Approved	Enzyme
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Enzyme

ID	Drug Name	Action	PubMed
C084012	1,1-diethyl-2-hydroxy-2-nitrosohydrazine	"1,1-diethyl-2-hydroxy-2-nitrosohydrazine results in increased activity of TYR protein"	10748137
C050642	1,2-dihydroxynaphthalene	"TYR protein results in increased oxidation of 1,2-dihydroxynaphthalene"	17224140
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TYR mRNA"	25614096
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cannabidiol results in increased activity of TYR protein]	28601556
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cannabidiol results in increased expression of TYR mRNA]	28601556
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of TYR protein]"	21816215
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of TYR protein]"	21816215
C000995	3,4-dihydroxyphenylpropionic acid	"TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid"	20685355
C000995	3,4-dihydroxyphenylpropionic acid	"[TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid] which results in decreased abundance of Glutathione"	20685355
C094702	3-hydroxyanisole	TYR protein results in increased oxidation of 3-hydroxyanisole	19944085
C032948	3-hydroxybenzoic acid	TYR protein results in increased oxidation of 3-hydroxybenzoic acid	19944085
C011276	3-hydroxybenzyl alcohol	TYR protein results in increased oxidation of 3-hydroxybenzyl alcohol	19944085
C047368	3-methylquercetin	3-methylquercetin results in increased expression of TYR protein	24853321
C035253	3-phenylpropionic acid	TYR protein results in increased oxidation of 3-phenylpropionic acid	20685355
C035253	3-phenylpropionic acid	[TYR protein results in increased oxidation of 3-phenylpropionic acid] which results in decreased abundance of Glutathione	20685355
C523393	4-(6-hydroxy-2-naphthyl)-1,3-benzenediol	"4-(6-hydroxy-2-naphthyl)-1,3-benzenediol results in decreased activity of TYR protein"	17827726
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of TYR mRNA	23489423
C031335	4-hydroxyacetophenone	TYR protein results in increased oxidation of 4-hydroxyacetophenone	19944085
C038193	4-hydroxybenzoic acid	TYR protein results in increased oxidation of 4-hydroxybenzoic acid	19944085
C018966	4-hydroxybenzyl alcohol	TYR protein results in increased oxidation of 4-hydroxybenzyl alcohol	19944085
C016276	8-bromocyclic GMP	8-bromocyclic GMP results in increased activity of TYR protein	10748137
C031390	9-cis-retinal	9-cis-retinal results in increased expression of TYR mRNA	23489423
C031390	9-cis-retinal	ALDH1A1 mutant form inhibits the reaction [9-cis-retinal results in increased expression of TYR mRNA]	23489423
C038699	acetophenone	TYR protein results in increased oxidation of acetophenone	19944085
C477954	afzelin	afzelin results in increased expression of and results in increased activity of TYR protein	27287415
C477954	afzelin	afzelin results in increased expression of TYR mRNA	27287415
D000393	Air Pollutants	Air Pollutants analog results in increased expression of TYR mRNA	21757418
C103303	alitretinoin	alitretinoin results in increased expression of TYR mRNA	23489423
C103303	alitretinoin	alitretinoin results in increased expression of TYR protein	23489423
C011164	amentoflavone	amentoflavone analog results in decreased activity of TYR protein	17473463
D000583	Amikacin	Amikacin results in decreased activity of TYR protein	23416261
C060998	anisole	TYR protein results in increased oxidation of anisole	19944085
D047310	Apigenin	Apigenin results in increased expression of TYR mRNA	21071833
D001104	Arbutin	Arbutin results in decreased activity of TYR protein	22705713
D001104	Arbutin	Arbutin results in decreased expression of TYR mRNA	21071833
C030610	argemone oil	"[[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with argemone oil] results in decreased activity of TYR protein"	20691676
C030610	argemone oil	"[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with argemone oil]] results in decreased activity of TYR protein"	20691676
C047721	artemisic acid	artemisic acid results in decreased expression of TYR mRNA	23063590
D001205	Ascorbic Acid	ethylenediamine inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid]	20685355
D001205	Ascorbic Acid	Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid]	20685355
D001205	Ascorbic Acid	[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid	20685355
C010038	azelaic acid	azelaic acid results in decreased expression of TYR protein	20804622
C010038	azelaic acid	[Taurine co-treated with azelaic acid] results in decreased activity of TYR protein	20804622
C010038	azelaic acid	[Taurine co-treated with azelaic acid] results in decreased expression of TYR protein	20804622
C028559	bathocuproine sulfonate	bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]	11092760
C028559	bathocuproine sulfonate	cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]]	11092760
D001549	Benzamides	Benzamides results in decreased activity of TYR protein	16513349
D019817	Benzoic Acid	Benzoic Acid analog results in decreased activity of TYR protein	20476840
D019817	Benzoic Acid	TYR protein results in increased oxidation of Benzoic Acid	19944085
C013409	benzoyl chloride	benzoyl chloride analog results in decreased activity of TYR protein	20476840
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Fenofibrate results in decreased expression of TYR protein]	23872139
D004958	Estradiol	Estradiol inhibits the reaction [imidazole results in increased expression of TYR protein]	3127403
C008157	beta-ionone	beta-ionone results in increased expression of TYR mRNA	27226631
C008157	beta-ionone	beta-ionone results in increased expression of TYR protein	27226631
C004541	biochanin A	biochanin A results in increased expression of TYR mRNA	21071833
C006780	bisphenol A	TYR protein modified form results in increased degradation of bisphenol A	21125313
C492482	bisphenol B	TYR protein modified form results in increased degradation of bisphenol B	21125313
D057886	Bleaching Agents	Bleaching Agents results in decreased expression of TYR mRNA	21071833
D019256	Cadmium Chloride	Cadmium Chloride results in increased activity of TYR protein	16372273
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TYR protein	22941245
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TYR mRNA	23741332
C040048	caffeic acid	TYR protein results in increased oxidation of caffeic acid	20685355
C040048	caffeic acid	[TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione	20685355
C055494	caffeic acid phenethyl ester	ethylenediamine inhibits the reaction [TYR protein results in increased oxidation of caffeic acid phenethyl ester]	20685355
C055494	caffeic acid phenethyl ester	ethylenediamine inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid]	20685355
C055494	caffeic acid phenethyl ester	ethylenediamine inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD]	20685355
C055494	caffeic acid phenethyl ester	Glutathione inhibits the reaction [TYR protein results in increased oxidation of caffeic acid phenethyl ester]	20685355
C055494	caffeic acid phenethyl ester	Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid]	20685355
C055494	caffeic acid phenethyl ester	Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD]	20685355
C055494	caffeic acid phenethyl ester	TYR protein affects the susceptibility to caffeic acid phenethyl ester	20685355
C055494	caffeic acid phenethyl ester	[TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Glutathione	20685355
C055494	caffeic acid phenethyl ester	[TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Reactive Oxygen Species	20685355
C055494	caffeic acid phenethyl ester	TYR protein results in increased metabolism of and results in increased susceptibility to caffeic acid phenethyl ester	21458432
C055494	caffeic acid phenethyl ester	TYR protein results in increased oxidation of caffeic acid phenethyl ester	20685355
C055494	caffeic acid phenethyl ester	[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid	20685355
C055494	caffeic acid phenethyl ester	[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD	20685355
C055494	caffeic acid phenethyl ester	TYR protein results in increased activity of caffeic acid phenethyl ester	20685355
C055494	caffeic acid phenethyl ester	[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in decreased abundance of Glutathione	20685355
D002185	Cannabidiol	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cannabidiol results in increased activity of TYR protein]	28601556
D002185	Cannabidiol	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cannabidiol results in increased expression of TYR mRNA]	28601556
D002185	Cannabidiol	Cannabidiol results in increased expression of and results in increased activity of TYR protein	28601556
D002185	Cannabidiol	Cannabidiol results in increased expression of TYR mRNA	28601556
D002185	Cannabidiol	SB 203580 inhibits the reaction [Cannabidiol results in increased activity of TYR protein]	28601556
D002185	Cannabidiol	SB 203580 inhibits the reaction [Cannabidiol results in increased expression of TYR mRNA]	28601556
C032761	carbamothioic acid, S,S'-(2-(dimethylamino)-1,3-propanediyl) ester	"carbamothioic acid, S,S'-(2-(dimethylamino)-1,3-propanediyl) ester results in decreased activity of TYR protein"	19923012
C032761	carbamothioic acid, S,S'-(2-(dimethylamino)-1,3-propanediyl) ester	"carbamothioic acid, S,S'-(2-(dimethylamino)-1,3-propanediyl) ester results in increased expression of TYR mRNA"	19923012
C068623	carnosol	carnosol results in decreased expression of TYR mRNA	21071833
C068623	carnosol	carnosol results in decreased expression of TYR protein	21071833
C002511	chaetocin	chaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased activity of TYR protein]	26748310
C002511	chaetocin	chaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of and results in increased activity of TYR protein]	26748310
C002511	chaetocin	chaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of TYR mRNA]	26748310
D002726	Chlorogenic Acid	TYR protein results in increased oxidation of Chlorogenic Acid	20685355
D002726	Chlorogenic Acid	[TYR protein results in increased oxidation of Chlorogenic Acid] which results in decreased abundance of Glutathione	20685355
D002746	Chlorpromazine	Chlorpromazine results in increased expression of TYR protein	25449126
C043561	chrysin	chrysin results in increased expression of TYR mRNA	21071833
C029010	cinnamic acid	TYR protein results in increased oxidation of cinnamic acid	20685355
C029010	cinnamic acid	[TYR protein results in increased oxidation of cinnamic acid] which results in decreased abundance of Glutathione	20685355
D009243	NAD	ethylenediamine inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD]	20685355
D009243	NAD	Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD]	20685355
D009243	NAD	[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD	20685355
D005576	Colforsin	Colforsin results in increased activity of TYR protein	17460731
D005576	Colforsin	Colforsin results in increased expression of and results in increased activity of TYR protein	28601556
D005576	Colforsin	Colforsin results in increased expression of TYR mRNA	23700242\|2860155
D005576	Colforsin	Particulate Matter inhibits the reaction [Colforsin results in increased expression of TYR mRNA]	23700242
D005576	Colforsin	[resveratrol co-treated with Colforsin] results in decreased activity of TYR protein	17460731
D005576	Colforsin	[Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYR mRNA]	23700242
D003300	Copper	[CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]	23053666
D003300	Copper	[CLDN4 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]	23053666
D003300	Copper	[Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYR mRNA]	23700242
D003300	Copper	Copper inhibits the reaction [[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of TYR protein]	12177073
D003300	Copper	[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of TYR protein	12177073
D003300	Copper	TYR protein binds to Copper	11781109
C029892	cupric chloride	cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]]	11092760
D003484	Cyanamide	Cyanamide results in decreased expression of TYR mRNA	23489423
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Quercetin results in increased activity of TYR protein]	14717847
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Quercetin results in increased activity of TYR protein]	14717847
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]	15278367
C004742	daidzein	daidzein results in increased expression of TYR mRNA	21071833
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of TYR mRNA	24317228
D004008	Diclofenac	Diclofenac results in decreased expression of TYR protein	21079976
D004026	Dieldrin	Dieldrin results in decreased expression of TYR mRNA	28385952
C472036	dihydromyricetin	dihydromyricetin results in decreased expression of and results in decreased activity of TYR protein	27586645
D004112	Dimercaprol	Dimercaprol results in decreased activity of TYR protein	16928136
D015127	9,10-Dimethyl-1,2-benzanthracene	"[[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with argemone oil] results in decreased activity of TYR protein"	20691676
D015127	9,10-Dimethyl-1,2-benzanthracene	"[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with argemone oil]] results in decreased activity of TYR protein"	20691676
D015127	9,10-Dimethyl-1,2-benzanthracene	"[[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of TYR protein"	20691676
D015127	9,10-Dimethyl-1,2-benzanthracene	"[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of TYR protein"	20691676
D015127	9,10-Dimethyl-1,2-benzanthracene	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in decreased activity of TYR protein"	20691676
D007980	Levodopa	[CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]	23053666
D007980	Levodopa	[CLDN4 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]	23053666
D007980	Levodopa	TYR protein results in increased oxidation of Levodopa	23053666
D007980	Levodopa	[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins	23053666
D007980	Levodopa	TYR protein binds to Levodopa	11781109
D007980	Levodopa	TYR protein results in increased chemical synthesis of and results in increased oxidation of Levodopa	11781109
C001123	dopachrome	[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome	26586997
C001123	dopachrome	Quercetin analog inhibits the reaction [[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome]	26586997
D004298	Dopamine	TYR protein affects the metabolism of Dopamine	8131222
D004365	Drugs, Chinese Herbal	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of TYR protein]"	21816215
D004365	Drugs, Chinese Herbal	"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of TYR protein]"	21816215
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased expression of TYR mRNA"	21816215
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased expression of TYR protein"	21816215
D004642	Emodin	Emodin results in decreased activity of TYR protein	26972667
D004855	Equilenin	TYR protein results in increased oxidation of Equilenin	22290292
D004964	Estriol	Estriol inhibits the reaction [imidazole results in increased expression of TYR protein]	3127403
C031234	ethylenediamine	ethylenediamine inhibits the reaction [TYR protein results in increased oxidation of caffeic acid phenethyl ester]	20685355
C031234	ethylenediamine	ethylenediamine inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid]	20685355
C031234	ethylenediamine	ethylenediamine inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD]	20685355
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of TYR gene	16180137\|1717435
C012313	ethyl-p-hydroxybenzoate	TYR protein affects the susceptibility to ethyl-p-hydroxybenzoate	19944085
C012313	ethyl-p-hydroxybenzoate	TYR protein results in increased oxidation of ethyl-p-hydroxybenzoate	19944085
C041835	ethyl salicylate	TYR protein results in increased oxidation of ethyl salicylate	19944085
D005054	Eugenol	TYR protein results in increased oxidation of Eugenol	8620581
D011345	Fenofibrate	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Fenofibrate results in decreased expression of TYR protein]	23872139
D011345	Fenofibrate	[Fenofibrate results in decreased chemical synthesis of Melanins] which results in decreased expression of TYR	23872139
D011345	Fenofibrate	Fenofibrate results in decreased expression of and results in decreased activity of TYR protein	23872139
D011345	Fenofibrate	Fenofibrate results in decreased expression of TYR mRNA	23872139
C004999	ferulic acid	TYR protein results in increased oxidation of ferulic acid	20685355
C004999	ferulic acid	[TYR protein results in increased oxidation of ferulic acid] which results in decreased abundance of Glutathione	20685355
C037032	galangin	galangin results in increased expression of TYR mRNA	21071833
D019833	Genistein	Genistein results in increased expression of TYR mRNA	21071833
D005978	Glutathione	Glutathione inhibits the reaction [TYR protein results in increased oxidation of caffeic acid phenethyl ester]	20685355
D005978	Glutathione	Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid]	20685355
D005978	Glutathione	Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD]	20685355
D005978	Glutathione	[TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Glutathione	20685355
D005978	Glutathione	"[TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid] which results in decreased abundance of Glutathione"	20685355
D005978	Glutathione	[TYR protein results in increased oxidation of 3-phenylpropionic acid] which results in decreased abundance of Glutathione	20685355
D005978	Glutathione	[TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione	20685355
D005978	Glutathione	[TYR protein results in increased oxidation of Chlorogenic Acid] which results in decreased abundance of Glutathione	20685355
D005978	Glutathione	[TYR protein results in increased oxidation of cinnamic acid] which results in decreased abundance of Glutathione	20685355
D005978	Glutathione	[TYR protein results in increased oxidation of ferulic acid] which results in decreased abundance of Glutathione	20685355
D005978	Glutathione	[TYR protein results in increased oxidation of trans-3-(4'-hydroxyphenyl)-2-propenoic acid] which results in decreased abundance of Glutathione	20685355
D005978	Glutathione	[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in decreased abundance of Glutathione	20685355
D006046	Gold	Gold analog results in decreased expression of TYR mRNA	23549158
D006139	Guaiacol	TYR protein results in increased oxidation of Guaiacol	19944085
C001652	homoharringtonine	homoharringtonine results in increased expression of TYR mRNA	21071833
D006861	Hydrogen Peroxide	CAT protein inhibits the reaction [TYR protein results in increased abundance of Hydrogen Peroxide]	15885091
D006861	Hydrogen Peroxide	resveratrol inhibits the reaction [TYR protein results in increased abundance of Hydrogen Peroxide]	15885091
D006861	Hydrogen Peroxide	TYR protein results in increased abundance of Hydrogen Peroxide	15885091
C029899	imidazole	Estradiol inhibits the reaction [imidazole results in increased expression of TYR protein]	3127403
C029899	imidazole	Estriol inhibits the reaction [imidazole results in increased expression of TYR protein]	3127403
C029899	imidazole	imidazole results in increased expression of TYR protein	3127403
D015056	1-Methyl-3-isobutylxanthine	1-Methyl-3-isobutylxanthine results in increased expression of and results in increased activity of TYR protein	26748310
D015056	1-Methyl-3-isobutylxanthine	1-Methyl-3-isobutylxanthine results in increased expression of TYR mRNA	26748310
D015056	1-Methyl-3-isobutylxanthine	chaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased activity of TYR protein]	26748310
D015056	1-Methyl-3-isobutylxanthine	chaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of and results in increased activity of TYR protein]	26748310
D015056	1-Methyl-3-isobutylxanthine	chaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of TYR mRNA]	26748310
D007550	Isothiuronium	Isothiuronium analog results in decreased expression of TYR mRNA	8043013
C119620	kenpaullone	kenpaullone results in increased expression of TYR mRNA	21071833
C011890	kojic acid	kojic acid results in decreased activity of TYR protein	27586645
C011890	kojic acid	kojic acid analog results in decreased activity of TYR protein	20476840
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of TYR protein"	25149594
C440499	lipopolysaccharide, Escherichia coli O111 B4	"S-methylisothiopseudouronium inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of TYR protein]"	25149594
D047311	Luteolin	Luteolin results in increased expression of TYR mRNA	21071833
D047311	Luteolin	TYR protein results in increased metabolism of Luteolin	26279214
C504960	LY2066948	TYR protein results in increased oxidation of LY2066948	22290292
D008528	Mefenamic Acid	Mefenamic Acid results in decreased expression of TYR mRNA	21079976
D008528	Mefenamic Acid	Mefenamic Acid results in decreased expression of TYR protein	21079976
D008543	Melanins	[CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]	23053666
D008543	Melanins	[CLDN4 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]	23053666
D008543	Melanins	[Tetrachlorodibenzodioxin results in increased activity of TYR protein] which results in increased abundance of Melanins	20973933
D008543	Melanins	[TYR protein co-treated with ATP7A protein] results in increased abundance of Melanins	11092760
D008543	Melanins	[TYR protein results in decreased expression of and results in decreased activity of PLD1 protein] which results in decreased abundance of Melanins	14615486
D008543	Melanins	[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins	23053666
D008543	Melanins	[Fenofibrate results in decreased chemical synthesis of Melanins] which results in decreased expression of TYR	23872139
C009760	mequinol	TYR protein results in increased oxidation of mequinol	19944085
C538691	methyl 3, 5-O-dicaffeoylquinate	"methyl 3, 5-O-dicaffeoylquinate results in decreased activity of TYR protein"	22705713
C538691	methyl 3, 5-O-dicaffeoylquinate	"methyl 3, 5-O-dicaffeoylquinate results in decreased expression of TYR mRNA"	22705713
D008750	Methyldopa	TYR protein affects the metabolism of Methyldopa	8131222
D008770	Methylnitrosourea	Methylnitrosourea results in increased mutagenesis of TYR gene	17174358
D008898	Mimosine	Mimosine analog results in decreased activity of TYR protein	20476840
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [scoparone results in increased expression of TYR protein]	17049123
C012655	nimesulide	nimesulide results in decreased expression of TYR mRNA	21079976
C012655	nimesulide	nimesulide results in decreased expression of TYR protein	21079976
D009853	Omeprazole	Omeprazole affects the N-linked glycosylation of and results in increased degradation of TYR protein	25337692
D009853	Omeprazole	Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]	25337692
D009853	Omeprazole	Omeprazole results in decreased expression of TYR protein	25337692
D052638	Particulate Matter	Particulate Matter inhibits the reaction [Colforsin results in increased expression of TYR mRNA]	23700242
D010636	Phenols	TYR protein results in increased oxidation of Phenols	19944085
D010656	Phenylephrine	Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]	15278367
D010656	Phenylephrine	Phenylephrine results in increased activity of TYR protein	15278367
D010656	Phenylephrine	Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]	15278367
D010670	Phenylthiourea	Phenylthiourea results in decreased expression of TYR protein	26051519
C018362	pheomelanin	TYR gene mutant form results in decreased abundance of pheomelanin	11277491
D010693	Phloretin	Phloretin results in decreased activity of TYR protein	24613711
C000603415	phloretin isonicotinyl hydrazone	phloretin isonicotinyl hydrazone results in decreased activity of TYR protein	24613711
C121565	pifithrin	pifithrin results in decreased expression of TYR mRNA	19098008
C121565	pifithrin	pifithrin results in decreased expression of TYR protein	19098008
D010936	Plant Extracts	Plant Extracts results in decreased activity of TYR protein	17473463
D010936	Plant Extracts	Plant Extracts results in decreased expression of TYR mRNA	19288216\|2355793
D010936	Plant Extracts	Plant Extracts results in decreased activity of TYR protein	24380755
D059808	Polyphenols	Polyphenols results in decreased expression of TYR mRNA	16293270
D011224	Prazosin	Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]	15278367
C034912	puag-haad	puag-haad results in decreased activity of TYR protein	11864987
C071226	pyrrole-2,3,5-tricarboxylic acid	"TYR gene mutant form results in decreased abundance of pyrrole-2,3,5-tricarboxylic acid"	9548375
D011794	Quercetin	Cycloheximide inhibits the reaction [Quercetin results in increased activity of TYR protein]	14717847
D011794	Quercetin	Dactinomycin inhibits the reaction [Quercetin results in increased activity of TYR protein]	14717847
D011794	Quercetin	Quercetin affects the activity of TYR protein	21290442
D011794	Quercetin	Quercetin affects the expression of TYR protein	21290442
D011794	Quercetin	Quercetin affects the expression of TYR protein modified form	21290442
D011794	Quercetin	Quercetin results in increased activity of TYR protein	14717847
D011794	Quercetin	TYR protein results in increased metabolism of Quercetin	18001220
D011794	Quercetin	TYR protein results in increased susceptibility to Quercetin	18001220
D011794	Quercetin	Quercetin affects the activity of TYR protein	21290442
D011794	Quercetin	Quercetin affects the expression of TYR protein	21290442
D011794	Quercetin	Quercetin affects the expression of TYR protein modified form	21290442
D011794	Quercetin	Quercetin analog inhibits the reaction [[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome]	26586997
D011794	Quercetin	Quercetin analog inhibits the reaction [POMC protein modified form results in increased expression of and results in increased activity of TYR protein]	26586997
D011794	Quercetin	Quercetin inhibits the reaction [POMC protein results in increased expression of and results in increased activity of TYR protein]	21290442
D011794	Quercetin	Quercetin results in increased expression of TYR protein	24318284
D011794	Quercetin	Quercetin results in decreased activity of TYR protein	24613711
D017382	Reactive Oxygen Species	[TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Reactive Oxygen Species	20685355
C059514	resveratrol	resveratrol affects the localization of TYR protein modified form	17460731
C059514	resveratrol	[resveratrol co-treated with Colforsin] results in decreased activity of TYR protein	17460731
C059514	resveratrol	resveratrol results in decreased activity of TYR protein	17460731
C059514	resveratrol	resveratrol results in decreased expression of TYR protein	17460731
C059514	resveratrol	resveratrol results in increased expression of TYR mRNA	21071833
C059514	resveratrol	resveratrol inhibits the reaction [TYR protein results in increased abundance of Hydrogen Peroxide]	15885091
C085746	rottlerin	rottlerin results in decreased expression of TYR mRNA	21071833
C085746	rottlerin	rottlerin results in decreased expression of TYR protein	21071833
C018381	salvin	salvin results in decreased expression of TYR mRNA	21071833
C005705	sanguinarine	"[[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of TYR protein"	20691676
C005705	sanguinarine	"[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of TYR protein"	20691676
C093642	SB 203580	SB 203580 inhibits the reaction [Cannabidiol results in increased activity of TYR protein]	28601556
C093642	SB 203580	SB 203580 inhibits the reaction [Cannabidiol results in increased expression of TYR mRNA]	28601556
C018145	scoparone	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [scoparone results in increased expression of TYR protein]	17049123
C018145	scoparone	scoparone results in increased expression of and results in increased activity of TYR protein	17049123
C018145	scoparone	scoparone results in increased expression of TYR mRNA	17049123
D012834	Silver	Silver analog results in decreased expression of TYR mRNA	22727896
C027744	S-methylisothiopseudouronium	"S-methylisothiopseudouronium inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of TYR protein]"	25149594
D013267	Stilbenes	Stilbenes analog results in decreased expression of TYR mRNA	29042215
C016766	sulforafan	sulforafan results in decreased expression of TYR mRNA	21071833
D013481	Superoxides	TYR protein results in increased abundance of Superoxides	15885091
C049412	sweroside	sweroside results in decreased expression of TYR protein	26051519
C049412	sweroside	sweroside results in decreased expression of TYR protein	26051519
D014284	Triiodothyronine	Triiodothyronine results in increased expression of TYR mRNA	22281776
D013654	Taurine	[Taurine co-treated with azelaic acid] results in decreased activity of TYR protein	20804622
D013654	Taurine	[Taurine co-treated with azelaic acid] results in decreased expression of TYR protein	20804622
D013654	Taurine	Taurine results in decreased expression of TYR protein	20804622
D013739	Testosterone	Testosterone results in decreased expression of TYR protein	18336327
C041181	tetrachlorodian	TYR protein modified form results in increased degradation of tetrachlorodian	21125313
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of TYR protein]	20973933
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TYR mRNA]	20973933
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased activity of TYR protein	20973933
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin results in increased activity of TYR protein] which results in increased abundance of Melanins	20973933
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TYR mRNA	20973933
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TYR mRNA	21570461
D013755	Tetradecanoylphorbol Acetate	"[[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with argemone oil] results in decreased activity of TYR protein"	20691676
D013755	Tetradecanoylphorbol Acetate	"[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with argemone oil]] results in decreased activity of TYR protein"	20691676
D013755	Tetradecanoylphorbol Acetate	"[[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of TYR protein"	20691676
D013755	Tetradecanoylphorbol Acetate	"[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of TYR protein"	20691676
D013755	Tetradecanoylphorbol Acetate	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in decreased activity of TYR protein"	20691676
C077197	theaflavin digallate	theaflavin digallate results in decreased expression of TYR mRNA	21071833
D013806	Theophylline	Theophylline results in increased expression of TYR mRNA	21071833
D014050	Toluene	TYR protein results in increased oxidation of Toluene	19944085
C495469	trans-3-(4'-hydroxyphenyl)-2-propenoic acid	TYR protein results in increased oxidation of trans-3-(4'-hydroxyphenyl)-2-propenoic acid	20685355
C495469	trans-3-(4'-hydroxyphenyl)-2-propenoic acid	[TYR protein results in increased oxidation of trans-3-(4'-hydroxyphenyl)-2-propenoic acid] which results in decreased abundance of Glutathione	20685355
D014212	Tretinoin	Tretinoin results in increased expression of TYR mRNA	11851873
D014635	Valproic Acid	Valproic Acid results in increased expression of TYR mRNA	27188386
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of TYR gene	25560391
C551177	vemurafenib	vemurafenib results in increased expression of TYR mRNA	26640592
C551177	vemurafenib	vemurafenib results in increased expression of TYR protein	26640592
D015032	Zinc	[Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYR mRNA]	23700242

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004497	monooxygenase activity	-	TAS	-
GO:0004503	monophenol monooxygenase activity	-	IBA	21873635
GO:0004503	monophenol monooxygenase activity	-	IDA	11092760
GO:0005507	copper ion binding	-	IMP	11092760
GO:0005515	protein binding	-	IPI	16162817
GO:0042803	protein homodimerization activity	-	ISS	-
GO:0046982	protein heterodimerization activity	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006583	melanin biosynthetic process from tyrosine	-	TAS	7704033
GO:0006726	eye pigment biosynthetic process	-	TAS	7704033
GO:0007601	visual perception	-	TAS	7704033
GO:0008283	cell proliferation	-	IEA	-
GO:0009411	response to UV	-	IBA	21873635
GO:0009411	response to UV	-	IEA	-
GO:0033280	response to vitamin D	-	IBA	21873635
GO:0033280	response to vitamin D	-	IEA	-
GO:0042438	melanin biosynthetic process	-	IBA	21873635
GO:0042438	melanin biosynthetic process	-	IDA	8126111
GO:0042438	melanin biosynthetic process	-	TAS	-
GO:0043473	pigmentation	-	IBA	21873635
GO:0048538	thymus development	-	IEA	-
GO:0051591	response to cAMP	-	IEA	-
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005737	cytoplasm	-	IDA	11092760
GO:0005764	lysosome	-	TAS	11092760
GO:0005798	Golgi-associated vesicle	-	TAS	10823941
GO:0005829	cytosol	-	IEA	-
GO:0016021	integral component of membrane	-	IEA	-
GO:0033162	melanosome membrane	-	TAS	-
GO:0042470	melanosome	COLOCALIZES_WITH	IBA	21873635
GO:0042470	melanosome	colocalizes_with	IDA	1145200
GO:0042470	melanosome	-	ISS	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-
GO:0048471	perinuclear region of cytoplasm	-	IDA	11092760

KEGG ID	KEGG Term
hsa00350	Tyrosine metabolism
hsa00740	Riboflavin metabolism
hsa01100	Metabolic pathways
hsa04916	Melanogenesis

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-5662702	Melanin biosynthesis	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
9096372	Inflammation and NO(X)-induced nitration: assay for 3-nitrotyrosine by HPLC with electrochemical detection. (1997 Apr 1)	Shigenaga MK	Proc Natl Acad Sci U S A
14968555	[Genetic risk factors for ischemic cerebrovascular disease--analysis on fifteen candidate prothrombotic gene polymorphisms in the Japanese population]. (2004 Jan)	Ishii K	Rinsho Byori
22214283	Engineering endomorphin drugs: state of the art. (2012 Jan)	Lazarus LH	Expert Opin Ther Pat
14988221	Epoxide hydrolase polymorphisms, cigarette smoking and risk of colorectal adenoma in the Nurses' Health Study and the Health Professionals Follow-up Study. (2004 Jul)	Tranah GJ	Carcinogenesis
11543766	Peptide derived from insulin with regulatory activity of dopamine transporter. (2001 Sep)	Liu Z	Neuropharmacology
10029200	Characterization of adducts of ethanol metabolites with cytochrome c. (1999 Jan)	Anni H	Alcohol Clin Exp Res
19596360	Arginine vasopressin gene expression changes within the nucleus accumbens during environment elicited cocaine-conditioned response in rats. (2010 Jan)	Rodriguez-Borrero E	Neuropharmacology
27626030	Blood Levels of Monoamine Precursors and Smoking in Patients with Schizophrenia. (2016)	Mathai AJ	Front Public Health
14764579	Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 induction by cigarette smoke. (2004 Apr 23)	Mercer BA	J Biol Chem
12141066	Microsomal epoxide hydrolase polymorphisms and lung cancer risk: a quantitative review. (2002 May-Jun)	Lee WJ	Biomarkers
26843839	Complement factor H polymorphism rs1061170 and the effect of cigarette smoking on the risk of lung cancer. (2015)	Ezzeldin N	Contemp Oncol (Pozn)
26801172	Metabolomics of Neurotransmitters and Related Metabolites in Post-Mortem Tissue from the Dorsal and Ventral Striatum of Alcoholic Human Brain. (2016 Feb)	Kashem MA	Neurochem Res
25745440	Genetic relationship between serum pregnancy-associated plasma protein-A gene polymorphism and ischemic cerebrovascular disease in a Northern Han Chinese population. (2012 Mar 5)	Wang H	Neural Regen Res
11281420	Overestimated frequency of a possible emphysema-susceptibility allele when microsomal epoxide hydrolase is genotyped by the conventional polymerase chain reaction-based method. (2001)	Keicho N	J Hum Genet
26210390	Alcohol binding in the C1 (C1A+C1B) domain of protein kinase C epsilon. (2015 Nov)	Pany S	Biochim Biophys Acta
27541571	Analysis of Chlorination, Nitration, and Nitrosylation of Tyrosine and Oxidation of Methionine and Cysteine in Hemoglobin from Type 2 Diabetes Mellitus Patients by Nanoflow Liquid Chromatography Tandem Mass Spectrometry. (2016 Sep 20)	Chen HJ	Anal Chem
12670526	Associations between genetic polymorphisms of Phase I and II metabolizing enzymes, p53 and susceptibility to esophageal adenocarcinoma. (2003)	Casson AG	Cancer Detect Prev
24667898	Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity. (2015)	Kim A	Brain Struct Funct
11718039	[The role of beta-catenin in the repair of the damaged airway epithelium in smoking mice]. (2001 Aug)	Li W	Zhonghua Jie He He Hu Xi Za Zhi
2843746	Smoking-related alterations in epidermal growth factor and insulin receptors in human placenta. (1988 Sep)	Wang SL	Mol Pharmacol
17526865	Passive smoking, metabolic gene polymorphisms, and infant birth weight in a prospective cohort study of Chinese women. (2007 Aug 1)	Wu T	Am J Epidemiol
25921801	Eye color: A potential indicator of alcohol dependence risk in European Americans. (2015 Jul)	Sulovari A	Am J Med Genet B Neuropsychiatr Genet
17548691	Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race. (2007 Jun)	Nock NL	Cancer Epidemiol Biomarkers Prev
14669306	Epoxide hydrolase Tyr113His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China. (2003 Dec)	Zhang JH	World J Gastroenterol
10635992	Influence of GSTM1, GSTT1, GSTP1, and EPHX gene polymorphisms on DNA adduct level and HPRT mutant frequency in coke-oven workers. (1999 Dec 17)	Viezzer C	Mutat Res
11489754	Epoxide hydrolase Tyr113His polymorphism is associated with elevated risk of colorectal polyps in the presence of smoking and high meat intake. (2001 Aug)	Ulrich CM	Cancer Epidemiol Biomarkers Prev
9068125	Regional binding to corticotropin releasing factor receptors in brain of rats exposed to chronic cocaine and cocaine withdrawal. (1997 Mar)	Ambrosio E	Synapse
25732140	Protracted abstinence from chronic ethanol exposure alters the structure of neurons and expression of oligodendrocytes and myelin in the medial prefrontal cortex. (2015 May 7)	Navarro AI	Neuroscience
8090802	Effects induced by BC 264, a selective agonist of CCK-B receptors, on morphine-dependent rats. (1994 Jun)	Maldonado R	Pharmacol Biochem Behav
22103900	Microsomal epoxide hydrolase polymorphisms, cigarette smoking and prostate cancer risk in the Slovak population. (2012)	Sivonova MK	Neoplasma
11849215	Genetic polymorphisms in microsomal epoxide hydrolase and susceptibility to adult acute myeloid leukaemia with defined cytogenetic abnormalities. (2002 Mar)	Lebailly P	Br J Haematol
20357116	Shared mechanisms for opioid tolerance and a transition to chronic pain. (2010 Mar 31)	Joseph EK	J Neurosci
28818835	Src-dependent phosphorylation of mu-opioid receptor at Tyr(336) modulates opiate withdrawal. (2017 Nov)	Zhang L	EMBO Mol Med
15668489	Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma. (2005 Jan)	Huang WY	Cancer Epidemiol Biomarkers Prev
23860305	Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. (2013 Oct)	Largent-Milnes TM	J Pharmacol Exp Ther
224245	[On the physiology and pharmacology of endorphins (author's transl)]. (1979 Jul 15)	Kuschinsky K	Klin Wochenschr