Gene: C7

730
-
complement C7
protein-coding
5p13.1
Ensembl:ENSG00000112936 MIM:217070 Vega:OTTHUMG00000150340 UniprotKB:P10643
NG_011692.1
PubMed
0   ANCO-SNPs
CD|ND|AD
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.972e-1 (AD)  8.035e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC16A120.837
CFI0.829
CFH0.825
TFPI0.824
MMRN10.819
TNFAIP80.814
STEAP40.812
MPZL20.8
SLC16A50.799
FBLIM10.798

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.541
KCNIP3-0.496
HAGHL-0.466
SPATA2L-0.463
CHRNA4-0.463
NEUROD6-0.453
C15orf59-0.452
KCNK4-0.451
SPEF1-0.45
FLRT1-0.445

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0122771,2-diamino-4-nitrobenzene"1,2-diamino-4-nitrobenzene results in decreased expression of C7 mRNA"17070881
C0353141-nitropropane1-nitropropane results in decreased expression of C7 mRNA17070881
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of C7 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of C7 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of C7 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of C7 mRNA"25510870
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of C7 mRNA"17070881
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of C7 mRNA"25510870
C0252352,6-diaminotoluene"2,6-diaminotoluene results in decreased expression of C7 mRNA"17070881
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of C7 mRNA"20406850
C0147062-nitro-4-phenylenediamine2-nitro-4-phenylenediamine results in decreased expression of C7 mRNA17070881
C0166172-nitropropane2-nitropropane results in increased expression of C7 mRNA17070881
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of C7 mRNA"25380136
C0286764-acetylaminofluorene4-acetylaminofluorene results in decreased expression of C7 mRNA17070881
D000082AcetaminophenAcetaminophen results in increased expression of C7 mRNA21420995
D020106AcrylamideAcrylamide results in decreased expression of C7 mRNA28959563
C025154alpha-cobratoxinalpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of C7 mRNA]16949557
C025154alpha-cobratoxinalpha-cobratoxin results in increased expression of C7 mRNA16949557
D000638AmiodaroneAmiodarone affects the expression of C7 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of C7 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of C7 mRNA24449571
D001151ArsenicArsenic affects the expression of C7 mRNA28793237
D001151Arsenic[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of C7 mRNA28793237
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of C7 mRNA27858113
D001553BenzbromaroneBenzbromarone affects the expression of C7 mRNA19483382
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of C7 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of C7 mRNA27858113
C006780bisphenol Abisphenol A results in decreased expression of C7 mRNA25181051
D002101Cacodylic Acid[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of C7 mRNA28793237
D019256Cadmium ChlorideCadmium Chloride results in increased expression of C7 mRNA17961207
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of C7 mRNA27858113
D002994ClofibrateClofibrate affects the expression of C7 mRNA19483382
D019327Copper SulfateCopper Sulfate results in decreased expression of C7 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of C7 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of C7 mRNA19264136
D003471CuprizoneCuprizone results in decreased expression of C7 mRNA26577399
D003976DiazinonDiazinon affects the expression of C7 mRNA22546817
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of C7 mRNA28962523
D004237DiuronDiuron results in decreased expression of C7 mRNA21551480|2515243
D005001EthionineEthionine affects the expression of C7 mRNA19483382
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of C7 mRNA17070881
C039281furanfuran results in increased expression of C7 mRNA26194646
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of C7 mRNA21179406
C016517indole-3-carbinolindole-3-carbinol affects the expression of C7 mRNA21396975
C051890irinotecanirinotecan results in increased expression of C7 mRNA20097248
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of C7 mRNA"19264136
D008464MecamylamineMecamylamine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]16949557
D008627Mercuric ChlorideMercuric Chloride affects the expression of C7 mRNA20353558
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of C7 mRNA17961207
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of C7 mRNA"26251327
D009151Mustard GasMustard Gas results in increased expression of C7 mRNA18988085
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of C7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of C7 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of C7 mRNA25380136
D009532NickelC7 protein binds to Nickel23896426
D009532NickelNickel results in decreased expression of C7 mRNA25583101
C022838nickel chloridenickel chloride affects the expression of C7 mRNA22546817
D009538Nicotinealpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of C7 mRNA]16949557
D009538NicotineMecamylamine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]16949557
D009538NicotineNicotine results in increased expression of C7 mRNA16949557
D009538NicotineTubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]16949557
D009853OmeprazoleOmeprazole affects the expression of C7 mRNA19483382
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of C7 mRNA"25510870
C006253pirinixic acidpirinixic acid affects the expression of C7 mRNA19483382
D011374ProgesteroneProgesterone results in decreased expression of C7 mRNA19690047
D011441PropylthiouracilPropylthiouracil affects the expression of C7 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in decreased expression of C7 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog affects the expression of C7 mRNA23806026
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of C7 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of C7 mRNA22431001
D053260SootSoot results in decreased expression of C7 mRNA26551751
D013853ThioacetamideThioacetamide affects the expression of C7 mRNA19483382
D014403TubocurarineTubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]16949557
D014403TubocurarineTubocurarine results in decreased expression of C7 mRNA16949557
C025643vinclozolinvinclozolin affects the expression of C7 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of C7 mRNA22570695
D015032ZincZinc deficiency results in decreased expression of C7 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006883cellular sodium ion homeostasis-IEA-  
GO:0006956complement activation-TAS3335508  
GO:0006957complement activation, alternative pathway-IEA-  
GO:0006958complement activation, classical pathway-IEA-  
GO:0019835cytolysis-IEA-  
GO:0030449regulation of complement activation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005579membrane attack complex-IDA22832194  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa05020Prion diseases
hsa05322Systemic lupus erythematosus
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-166665Terminal pathway of complementTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16947780Association of HLA-C3 and smoking with vasculitis in patients with rheumatoid arthritis. (2006 Sep)Turesson CArthritis Rheum
16804413Ethanol and the tobacco-specific carcinogen, NNK, contribute to signaling in immortalized human pancreatic duct epithelial cells. (2006 Jul)Askari MDPancreas
22791813Effects of chronic nicotine on the autocrine regulation of pancreatic cancer cells and pancreatic duct epithelial cells by stimulatory and inhibitory neurotransmitters. (2012 Sep)Al-Wadei MHCarcinogenesis
29251738NM23 proteins: innocent bystanders or local energy boosters for CFTR? (2018 Mar)Muimo RLab Invest
21689990Cervical spine bone mineral density as a function of vertebral level and anatomic location. (2011 Jul)Anderst WJSpine J
16018399[Subclavian steal carotid recovery syndrome--case report]. (2005)Dilic MMed Arh
16091975The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through beta-adrenergic transactivation of EGF receptors. (2005 Oct)Askari MDJ Cancer Res Clin Oncol
23271397Akt kinase mediates the prosurvival effect of smoking compounds in pancreatic ductal cells. (2013 May)Park CHPancreas
27165300Patient and aneurysm characteristics associated with rupture risk of multiple intracranial aneurysms in the anterior circulation system. (2016 Jul)Jiang HActa Neurochir (Wien)
24102987Regional anesthesia does not consistently block ischemic pain: two further cases and a review of the literature. (2014 Feb)Kucera TJPain Med
18098271GABA B receptor is a novel drug target for pancreatic cancer. (2008 Feb 15)Schuller HMCancer