Gene info: ID 7301

Gene: TYRO3

GENE ID: 7301

Synonyms: BYK|Dtk|Etk-2|RSE|Rek|Sky|Tif

Description: TYRO3 protein tyrosine kinase

Gene type: protein-coding

Location: 15q15.1

dbXrefs: Ensembl:ENSG00000092445 MIM:600341 Vega:OTTHUMG00000130341 UniprotKB:Q06418

RefSeq: NG_033013.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.967e-2 (AD) 7.967e-3 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg17082634	chr15:41850503	TYRO3		6.200e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATG9A	0.949
CLSTN1	0.948
CORO2B	0.945
ZER1	0.942
MAPT	0.941
WIPI2	0.938
FAIM2	0.938
ATP6V0A1	0.937
RUSC2	0.935
NUDCD3	0.935

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.65
OR4F29	-0.606
TFPI2	-0.479
KCNJ15	-0.439
SIX1	-0.428
IL18RAP	-0.426
EBF1	-0.425
KLRB1	-0.413
C9orf135	-0.408
CEACAM3	-0.405

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TYRO3 mRNA	19933214
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TYRO3 mRNA"	27291303
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TYRO3 mRNA"	23196670
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TYRO3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TYRO3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TYRO3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TYRO3 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of TYRO3 mRNA	29067470
D000244	Adenosine Diphosphate	TYRO3 protein results in increased susceptibility to Adenosine Diphosphate	15733062
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TYRO3 mRNA	22100608
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TYRO3 mRNA	16483693
D001280	Atrazine	Atrazine results in increased expression of TYRO3 mRNA	22378314
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of TYRO3 mRNA	26377693
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TYRO3 mRNA	18164116
C006780	bisphenol A	bisphenol A results in decreased expression of TYRO3 mRNA	23557687
C006780	bisphenol A	bisphenol A results in decreased expression of TYRO3 mRNA	25181051
D001966	Bromine	Bromine results in decreased expression of TYRO3 mRNA	18790026
D002220	Carbamazepine	Carbamazepine affects the expression of TYRO3 mRNA	25979313
D060729	Coal Ash	Coal Ash results in increased expression of TYRO3 mRNA	19000753
D016572	Cyclosporine	Cyclosporine results in increased expression of TYRO3 mRNA	20106945
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of TYRO3 mRNA	23640034
D013759	Dronabinol	Dronabinol results in decreased expression of TYRO3 mRNA	18454173
D003907	Dexamethasone	Dexamethasone results in decreased expression of TYRO3 mRNA	12782123
D002945	Cisplatin	Cisplatin results in decreased expression of TYRO3 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of TYRO3 mRNA	27594783
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TYRO3 mRNA	18164116
D004221	Disulfiram	Disulfiram results in decreased expression of TYRO3 mRNA	20530235
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of TYRO3 mRNA	12628509
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TYRO3 mRNA	17606305\|2022741
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TYRO3 mRNA	23550701
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in increased expression of TYRO3 mRNA	21782745
C010176	halofuginone	halofuginone results in increased expression of TYRO3 mRNA	17180598
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of TYRO3 mRNA	20044591
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of TYRO3 protein	17337753
C561695	(+)-JQ1 compound	(+)-JQ1 compound affects the expression of TYRO3 mRNA	24297863
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TYRO3 mRNA	21889194\|2379244
D001556	Lindane	Lindane affects the expression of TYRO3 mRNA	17785943
D008727	Methotrexate	Methotrexate affects the expression of TYRO3 mRNA	18502557
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in increased expression of TYRO3 mRNA	21782745
D008731	Methoxychlor	Methoxychlor results in increased expression of TYRO3 mRNA	21782745
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TYRO3 mRNA"	20188158
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of TYRO3 mRNA	29191790
D009151	Mustard Gas	Mustard Gas results in decreased expression of TYRO3 mRNA	18988085
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of TYRO3 mRNA"	25554681
D009281	Naphthalenes	Naphthalenes results in decreased expression of TYRO3 protein	17337753
D009532	Nickel	Nickel affects the expression of TYRO3 mRNA	14575637
D009532	Nickel	trichostatin A inhibits the reaction [Nickel affects the expression of TYRO3 mRNA]	14575637
C029938	nickel sulfate	nickel sulfate results in decreased expression of TYRO3 mRNA	16166746
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of TYRO3 mRNA	25729387
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of TYRO3 mRNA	18692542
C006253	pirinixic acid	pirinixic acid results in increased expression of TYRO3 mRNA	19162173
D011374	Progesterone	Progesterone results in decreased expression of TYRO3 mRNA	20726854
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of TYRO3 mRNA	24780913
C010313	pseudocumene	pseudocumene results in decreased expression of TYRO3 protein	17337753
C009166	retinol acetate	retinol acetate results in increased expression of TYRO3 mRNA	16772331
C017947	sodium arsenite	sodium arsenite affects the methylation of TYRO3 gene	28589171
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of TYRO3 mRNA	18175754
C061133	tamibarotene	tamibarotene results in decreased expression of TYRO3 mRNA	15498508
C501413	tesaglitazar	tesaglitazar results in increased expression of TYRO3 mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TYRO3 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TYRO3 mRNA	19933214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TYRO3 mRNA	22298810
D013893	Thiram	Thiram results in decreased expression of TYRO3 mRNA	20530235
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased methylation of TYRO3 gene	28576685
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of TYRO3 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of TYRO3 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of TYRO3 mRNA	15498508\|2193413
D014212	Tretinoin	Tretinoin results in decreased expression of TYRO3 mRNA	20488242
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TYRO3 mRNA"	27188386
C012589	trichostatin A	trichostatin A inhibits the reaction [Nickel affects the expression of TYRO3 mRNA]	14575637
C012589	trichostatin A	trichostatin A results in decreased expression of TYRO3 mRNA	26272509
C022884	undecane	undecane results in decreased expression of TYRO3 protein	17337753
D014635	Valproic Acid	Valproic Acid affects the expression of TYRO3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased methylation of TYRO3 gene	29154799
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TYRO3 mRNA"	27188386
C111237	vorinostat	vorinostat results in decreased expression of TYRO3 mRNA	26272509
D014859	Warfarin	Warfarin results in decreased expression of TYRO3 mRNA	18772604

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001618	virus receptor activity	-	IEA	-
GO:0004709	MAP kinase kinase kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IDA	7537495
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IBA	21873635
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	NAS	7511603
GO:0004888	transmembrane signaling receptor activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	7634325 21516116 25416956
GO:0005524	ATP binding	-	IEA	-
GO:0017147	Wnt-protein binding	-	IBA	21873635
GO:0031434	mitogen-activated protein kinase kinase binding	-	IBA	21873635
GO:0043548	phosphatidylinositol 3-kinase binding	-	IPI	10627473
GO:0046982	protein heterodimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001779	natural killer cell differentiation	-	IEA	-
GO:0007155	cell adhesion	-	NAS	8108112
GO:0007165	signal transduction	-	NAS	7511603
GO:0007218	neuropeptide signaling pathway	-	IEA	-
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0007283	spermatogenesis	-	ISS	-
GO:0009968	negative regulation of signal transduction	-	IBA	21873635
GO:0014065	phosphatidylinositol 3-kinase signaling	-	NAS	10627473
GO:0016055	Wnt signaling pathway	-	IBA	21873635
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	-
GO:0021885	forebrain cell migration	-	ISS	-
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030168	platelet activation	-	ISS	-
GO:0032940	secretion by cell	-	ISS	-
GO:0033674	positive regulation of kinase activity	-	IBA	21873635
GO:0034122	negative regulation of toll-like receptor signaling pathway	-	ISS	-
GO:0034446	substrate adhesion-dependent cell spreading	-	ISS	-
GO:0042698	ovulation cycle	-	ISS	-
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043277	apoptotic cell clearance	-	ISS	-
GO:0043410	positive regulation of MAPK cascade	-	IBA	21873635
GO:0043491	protein kinase B signaling	-	ISS	-
GO:0043524	negative regulation of neuron apoptotic process	-	ISS	-
GO:0045824	negative regulation of innate immune response	-	ISS	-
GO:0046718	viral entry into host cell	-	IEA	-
GO:0046777	protein autophosphorylation	-	IDA	7511603 7537495
GO:0050728	negative regulation of inflammatory response	-	ISS	-
GO:0051250	negative regulation of lymphocyte activation	-	IEA	-
GO:0060068	vagina development	-	IEA	-
GO:0070050	neuron cellular homeostasis	-	ISS	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:0070527	platelet aggregation	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	ISS	-
GO:0005635	nuclear envelope	-	ISS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005789	endoplasmic reticulum membrane	-	ISS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	NAS	7511603
GO:0009986	cell surface	-	IDA	7511603
GO:0043235	receptor complex	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27100677	Clinical, Pathological, and Molecular Features of Lung Adenocarcinomas with AXL Expression. (2016)	Sato K	PLoS One
29315717	Impact of cigarette-smoking on sperm DNA methylation and its effect on sperm parameters. (2018 Jan 9)	Alkhaled Y	Andrologia