Gene: ACOD1

730249
CAD|IRG1
aconitate decarboxylase 1
protein-coding
13q22.3
Ensembl:ENSG00000102794 MIM:615275 Vega:OTTHUMG00000017098 UniprotKB:A6NK06
NC_000013.11
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.475e-1 (AD)  5.500e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of ACOD1 mRNA17562736
D001151ArsenicArsenic results in decreased expression of ACOD1 mRNA19654921
D017639Asbestos, Amosite"Asbestos, Amosite results in decreased expression of ACOD1 mRNA"23917077
C547126AZM551248AZM551248 results in decreased expression of ACOD1 mRNA22323515
C006780bisphenol Abisphenol A results in decreased expression of ACOD1 mRNA26911702
C006780bisphenol Abisphenol A results in increased methylation of ACOD1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of ACOD1 mRNA25181051
C031180chrysenechrysene results in decreased expression of ACOD1 mRNA26377693
D003300CopperCopper deficiency results in increased expression of ACOD1 mRNA26033743
C029892cupric chloridecupric chloride results in decreased expression of ACOD1 mRNA24650576
D003520CyclophosphamideCyclophosphamide results in increased expression of ACOD1 mRNA15331540
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ACOD1 mRNA26924002
D019422Dietary SucroseDietary Sucrose results in increased expression of ACOD1 mRNA26033743
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of ACOD1 mRNA26924002
D004137DinitrochlorobenzeneDinitrochlorobenzene affects the expression of ACOD1 mRNA22302311
C029424hydrazinehydrazine results in decreased expression of ACOD1 mRNA15282401
C005229itaconic acidACOD1 protein results in increased chemical synthesis of itaconic acid26358042
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of ACOD1 mRNA]25890327|2658214
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of ACOD1 mRNA]25890327|2658214
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ACOD1 mRNA25890327|2658214
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ACOD1 protein26358042
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ACOD1 mRNA21641980
D015122MercaptopurineMercaptopurine results in increased expression of ACOD1 mRNA23358152
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ACOD1 mRNA26011545
C033069methyl salicylatemethyl salicylate affects the expression of ACOD1 mRNA22302311
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ACOD1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of ACOD1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ACOD1 mRNA"25554681
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of ACOD1 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of ACOD1 mRNA27935865
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of ACOD1 mRNA27935865
C014153pirimiphos methylpirimiphos methyl results in increased expression of ACOD1 mRNA27845199
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ACOD1 mRNA22698814
D011374ProgesteroneProgesterone affects the expression of ACOD115178747
D011374ProgesteroneProgesterone affects the expression of ACOD1 mRNA17251523
D011374ProgesteroneProgesterone results in increased expression of ACOD1 mRNA22238285
D012822Silicon DioxideSilicon Dioxide results in increased expression of ACOD1 mRNA19073995|2322117
D012834SilverSilver results in decreased expression of ACOD1 mRNA27131904
D053260SootSoot results in increased expression of ACOD1 mRNA22461453|2655175
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ACOD1 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ACOD1 mRNA26290441
D013792ThalidomideThalidomide results in decreased expression of ACOD1 mRNA28892372
C009495titanium dioxidetitanium dioxide results in increased expression of ACOD1 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ACOD1 mRNA20133372
C015559trimellitic anhydridetrimellitic anhydride affects the expression of ACOD1 mRNA22302311
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ACOD1 mRNA19042947
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of ACOD1 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00475472-methylcitrate dehydratase activity-IBA21873635  
GO:0047613aconitate decarboxylase activity-IBA21873635  
GO:0047613aconitate decarboxylase activity-IDA23610393  
GO ID GO Term Qualifier Evidence PubMed
GO:0002760positive regulation of antimicrobial humoral response-IDA23610393  
GO:0006952defense response-IBA21873635  
GO:0006952defense response-IDA23610393  
GO:0006954inflammatory response-IEA-  
GO:0007566embryo implantation-ISS-  
GO:0019679propionate metabolic process, methylcitrate cycle-IBA21873635  
GO:0032088negative regulation of NF-kappaB transcription factor activity-ISS-  
GO:0032480negative regulation of type I interferon production-ISS-  
GO:0034136negative regulation of toll-like receptor 2 signaling pathway-ISS-  
GO:0034144negative regulation of toll-like receptor 4 signaling pathway-ISS-  
GO:0035458cellular response to interferon-beta-ISS-  
GO:0045824negative regulation of innate immune response-ISS-  
GO:0050728negative regulation of inflammatory response-ISS-  
GO:0071219cellular response to molecule of bacterial origin-ISS-  
GO:0071222cellular response to lipopolysaccharide-IDA23609450  23610393  
GO:0071346cellular response to interferon-gamma-ISS-  
GO:0071347cellular response to interleukin-1-ISS-  
GO:0071356cellular response to tumor necrosis factor-ISS-  
GO:0071393cellular response to progesterone stimulus-ISS-  
GO:0072573tolerance induction to lipopolysaccharide-IDA23609450  
GO:2000379positive regulation of reactive oxygen species metabolic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal