Gene: U2AF1

7307
FP793|RN|RNU2AF1|U2AF35|U2AFBP
U2 small nuclear RNA auxiliary factor 1
protein-coding
21q22.3
Ensembl:ENSG00000160201 MIM:191317 Vega:OTTHUMG00000086836 UniprotKB:Q01081
NG_029455.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.278e-1 (AD)  7.531e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBXN10.93
RNF1810.923
RALY0.913
EIF3G0.913
RBM420.91
CHMP2A0.907
NELFE0.907
PFN10.906
PFDN20.905
KXD10.901

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.785
OR4F5-0.78
MTRNR2L6-0.152
MTRNR2L9-0.147
OR4F16-0.141
OR6S1-0.128
ZC3H11B-0.128
OR2T10-0.126
CHIA-0.115
HOXD4-0.111

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of U2AF1 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of U2AF1 mRNA21420995
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of U2AF1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of U2AF1 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of U2AF1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of U2AF1 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of U2AF1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of U2AF1 mRNA19770486
D004958EstradiolEstradiol affects the expression of U2AF1 mRNA23557687
D004958EstradiolEstradiol affects the expression of U2AF1 mRNA15598610
C006780bisphenol Abisphenol A affects the expression of U2AF1 mRNA23557687
C006780bisphenol Abisphenol A affects the expression of U2AF1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of U2AF1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of U2AF1 protein22941245
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of U2AF1 mRNA28472532
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of U2AF1 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of U2AF1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of U2AF1 mRNA]17585979
D003300CopperCopper results in increased expression of U2AF1 protein21146535
D016572CyclosporineCyclosporine results in increased expression of U2AF1 mRNA20106945
D003561CytarabineCytarabine results in decreased expression of U2AF1 mRNA21198554
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of U2AF1 mRNA"25908611
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of U2AF1 mRNA17361019|2126653
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of U2AF1 mRNA27638505
D004147DioxinsDioxins affects the expression of U2AF1 mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of U2AF1 protein23301498
D005485FlutamideFlutamide results in increased expression of U2AF1 mRNA24136188
D005897GlafenineGlafenine results in increased expression of U2AF1 mRNA24136188
D017313FenretinideFenretinide results in increased expression of U2AF1 mRNA28973697
D007545IsoproterenolIsoproterenol results in decreased expression of U2AF1 mRNA20003209
D007854LeadLead affects the expression of U2AF1 mRNA28903495
D007854LeadLead affects the splicing of U2AF1 mRNA28903495
D008727MethotrexateMethotrexate results in increased expression of U2AF1 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of U2AF1 mRNA26011545
D009151Mustard GasMustard Gas results in increased expression of U2AF1 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of U2AF1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of U2AF1 mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of U2AF1 mRNA24136188
C570897NSC668394NSC668394 results in increased expression of U2AF1 mRNA27137931
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of U2AF1 mRNA25729387
C006253pirinixic acidpirinixic acid results in increased expression of U2AF1 mRNA23811191
D012643SeleniumSelenium results in increased expression of U2AF1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of U2AF1 mRNA23806026
D018038Sodium SeleniteSodium Selenite results in increased expression of U2AF1 mRNA18175754
C009495titanium dioxidetitanium dioxide results in decreased expression of U2AF1 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of U2AF1 mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of U2AF1 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of U2AF1 mRNA"19682533
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of U2AF1 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of U2AF1 mRNA17292431
D014810Vitamin EVitamin E results in increased expression of U2AF1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI11551507  15652350  16189514  17353931  17577209  20696395  
21460037  21516116  21988832  22365833  23455924  23602568  
25416956  
GO:0030628pre-mRNA 3'-splice site binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000398mRNA splicing, via spliceosome-IBA21873635  
GO:0000398mRNA splicing, via spliceosome-IC9731529  11991638  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0006397mRNA processing-TAS1388271  
GO:0006405RNA export from nucleus-TAS-  
GO:0006406mRNA export from nucleus-TAS-  
GO:0008380RNA splicing-TAS1388271  
GO:0031124mRNA 3'-end processing-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005681spliceosomal complex-IBA21873635  
GO:0005681spliceosomal complex-IDA9731529  
GO:0015030Cajal body-TAS1388271  
GO:0016607nuclear speck-ISS-  
GO:0071013catalytic step 2 spliceosome-IDA11991638  
GO:0089701U2AF-IBA21873635  
GO:0089701U2AF-IDA1824937  2531895  
KEGG ID KEGG Term
hsa03040Spliceosome
hsa05131Shigellosis
Reactome ID Reactome Term Evidence
R-HSA-109688Cleavage of Growing Transcript in the Termination Region TAS
R-HSA-159236Transport of Mature mRNA derived from an Intron-Containing TranscriptTAS
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72187mRNA 3'-end processingTAS
R-HSA-72202Transport of Mature Transcript to CytoplasmTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-73856RNA Polymerase II Transcription TerminationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22980975Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. (2012 Sep 14)Imielinski MCell