Gene: UBA52

7311
CEP52|HUBCEP52|L40|RPL40
ubiquitin A-52 residue ribosomal protein fusion product 1
protein-coding
19p13.11
Ensembl:ENSG00000221983 MIM:191321 Vega:OTTHUMG00000183110 UniprotKB:P62987
NG_023288.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.273e-1 (AD)  1.371e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPL7A0.967
RPL60.952
RPL30.951
RPL40.949
RPL80.949
RPL170.948
RPL50.947
PFDN50.943
RPL270.943
RPL36AL0.942

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.877
OR4F5-0.84
FANCD2OS-0.124
OR13C3-0.123
PRDM14-0.118
CCR8-0.116
TAS2R41-0.112
NPHS2-0.111
MROH9-0.108
C8orf74-0.108

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of UBA52 mRNA"19162173
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of UBA52 mRNA"20206263
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of UBA52 mRNA12958071
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of UBA52 mRNA"18648102
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of UBA52 mRNA19038236
D000638AmiodaroneAmiodarone affects the expression of UBA52 mRNA18355885|1948338
D000639AmitriptylineAmitriptyline affects the expression of UBA52 mRNA18355885
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UBA52 mRNA16483693
D001151ArsenicArsenic affects the methylation of UBA52 gene25304211
D001553BenzbromaroneBenzbromarone affects the expression of UBA52 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UBA52 mRNA23892563
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UBA52 protein23892563
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UBA52 mRNA15034205|2389256
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UBA52 protein23892563
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UBA52 mRNA22300585
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of UBA52 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of UBA52 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of UBA52 mRNA27104808
C006780bisphenol Abisphenol A affects the expression of UBA52 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of UBA52 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of UBA52 mRNA25181051
C034939cadmium sulfide[cadmium telluride co-treated with cadmium sulfide] results in increased expression of UBA52 mRNA20596552
C028337cadmium telluride[cadmium telluride co-treated with cadmium sulfide] results in increased expression of UBA52 mRNA20596552
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of UBA52 mRNA15963342
C099555CD 437CD 437 results in decreased expression of UBA52 mRNA12958071
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of UBA52 mRNA18804290
C100187chloropicrinchloropicrin affects the expression of UBA52 mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of UBA52 mRNA28472532
D002994ClofibrateClofibrate affects the expression of UBA52 mRNA19483382
D002997ClomipramineClomipramine affects the expression of UBA52 mRNA18355885
D003024ClozapineClozapine results in increased expression of UBA52 mRNA14647396
C018021cobaltous chloridecobaltous chloride results in increased expression of UBA52 mRNA17553155
D003300CopperCopper results in decreased expression of UBA52 mRNA18522721
D003300CopperCopper results in increased expression of UBA52 mRNA16629173
D003300CopperCopper affects the expression of UBA52 mRNA23825565
C017180decamethrindecamethrin results in increased expression of UBA52 mRNA23892563
C017180decamethrindecamethrin results in increased expression of UBA52 protein23892563
C017180decamethrindecamethrin results in increased expression of UBA52 mRNA23892563
C017180decamethrindecamethrin results in increased expression of UBA52 protein23892563
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of UBA52 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of UBA52 mRNA17379624
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of UBA52 mRNA28939011
D005001EthionineEthionine affects the expression of UBA52 mRNA19483382
D005419FlavonoidsFlavonoids results in decreased expression of UBA52 mRNA18035473
D005485FlutamideFlutamide results in increased expression of UBA52 mRNA21126777
D005485FlutamideFlutamide results in increased expression of UBA52 mRNA24136188
C039281furanfuran results in increased methylation of UBA52 gene22079235
D006220HaloperidolHaloperidol results in increased expression of UBA52 mRNA14647396
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of UBA52 mRNA17183730
D007099ImipramineImipramine affects the expression of UBA52 mRNA18355885
D007213IndomethacinIndomethacin results in increased expression of UBA52 mRNA28201806
D007654KetoconazoleKetoconazole affects the expression of UBA52 mRNA18355885
D001556LindaneLindane results in increased expression of UBA52 mRNA18804290
D008748MethylcholanthreneMethylcholanthrene results in increased expression of UBA52 mRNA18804290
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of UBA52 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of UBA52 protein24675778
D009853OmeprazoleOmeprazole affects the expression of UBA52 mRNA19483382
C009897O,O-diisopropyl-S-benzylthiophosphate"O,O-diisopropyl-S-benzylthiophosphate results in increased expression of UBA52 mRNA"18983944
D010416PentachlorophenolPentachlorophenol results in decreased expression of UBA52 mRNA24642059
D026023PermethrinPermethrin results in decreased expression of UBA52 protein26631339
C006253pirinixic acidpirinixic acid affects the expression of UBA52 mRNA19483382
D011192Potassium DichromatePotassium Dichromate results in decreased expression of UBA52 protein23718831
D011441PropylthiouracilPropylthiouracil affects the expression of UBA52 mRNA19483382
D012643SeleniumSelenium results in decreased expression of UBA52 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of UBA52 mRNA18685790
D018038Sodium SeleniteSodium Selenite results in increased expression of UBA52 mRNA18175754
D012999SomanSoman results in decreased expression of UBA52 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UBA52 mRNA15034205|1946511
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UBA52 protein16548065
D013853ThioacetamideThioacetamide affects the expression of UBA52 mRNA19483382
C009495titanium dioxidetitanium dioxide results in increased expression of UBA52 mRNA23131501
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of UBA52 mRNA17183730
D001335Vehicle EmissionsVehicle Emissions affects the methylation of UBA52 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of UBA52 mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of UBA52 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003735structural constituent of ribosome-IEA-  
GO:0005515protein binding-IPI15147878  15936278  21900206  
GO:0031386protein tag-IBA21873635  
GO:0031625ubiquitin protein ligase binding-IBA21873635  
GO:0070628proteasome binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS-  
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-TAS-  
GO:0000187activation of MAPK activity-TAS-  
GO:0000209protein polyubiquitination-TAS-  
GO:0000715nucleotide-excision repair, DNA damage recognition-TAS-  
GO:0002755MyD88-dependent toll-like receptor signaling pathway-TAS-  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006294nucleotide-excision repair, preincision complex assembly-TAS-  
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TAS-  
GO:0006297nucleotide-excision repair, DNA gap filling-TAS-  
GO:0006413translational initiation-TAS-  
GO:0006464cellular protein modification process-TAS2581967  
GO:0006614SRP-dependent cotranslational protein targeting to membrane-TAS-  
GO:0006625protein targeting to peroxisome-TAS-  
GO:0007179transforming growth factor beta receptor signaling pathway-TAS-  
GO:0007249I-kappaB kinase/NF-kappaB signaling-TAS-  
GO:0007254JNK cascade-TAS-  
GO:0016055Wnt signaling pathway-TAS-  
GO:0016197endosomal transport-TAS-  
GO:0016567protein ubiquitination-IBA21873635  
GO:0016567protein ubiquitination-TAS-  
GO:0016579protein deubiquitination-TAS-  
GO:0019058viral life cycle-TAS-  
GO:0019068virion assembly-TAS-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0019941modification-dependent protein catabolic process-IBA21873635  
GO:0019985translesion synthesis-TAS-  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-TAS-  
GO:0031145anaphase-promoting complex-dependent catabolic process-TAS-  
GO:0033683nucleotide-excision repair, DNA incision-TAS-  
GO:0035666TRIF-dependent toll-like receptor signaling pathway-TAS-  
GO:0036297interstrand cross-link repair-TAS-  
GO:0042276error-prone translesion synthesis-TAS-  
GO:0042769DNA damage response, detection of DNA damage-TAS-  
GO:0043065positive regulation of apoptotic process-TAS-  
GO:0043066negative regulation of apoptotic process-TAS-  
GO:0043488regulation of mRNA stability-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-TAS-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-TAS-  
GO:0051403stress-activated MAPK cascade-TAS-  
GO:0055085transmembrane transport-TAS-  
GO:0061024membrane organization-TAS-  
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia-TAS-  
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway-TAS-  
GO:0070498interleukin-1-mediated signaling pathway-TAS-  
GO:0070911global genome nucleotide-excision repair-TAS-  
GO:0070987error-free translesion synthesis-TAS-  
GO:0075733intracellular transport of virus-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA16502470  
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005840ribosome-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0010008endosome membrane-TAS-  
GO:0015935small ribosomal subunit-IBA21873635  
GO:0022627cytosolic small ribosomal subunit-IBA21873635  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0031982vesicle-HDA19190083  
GO:0043657host cell-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa03010Ribosome
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisIEA
R-HSA-110312Translesion synthesis by REV1TAS
R-HSA-110313Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateTAS
R-HSA-110314Recognition of DNA damage by PCNA-containing replication complexTAS
R-HSA-110320Translesion Synthesis by POLHTAS
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1169091Activation of NF-kappaB in B cellsTAS
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1227986Signaling by ERBB2TAS
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaTAS
R-HSA-1236382Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsTAS
R-HSA-1236394Signaling by ERBB4TAS
R-HSA-1236974ER-Phagosome pathwayIEA
R-HSA-1236975Antigen processing-Cross presentationIEA
R-HSA-1253288Downregulation of ERBB4 signalingTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-1295596Spry regulation of FGF signalingTAS
R-HSA-1358803Downregulation of ERBB2:ERBB3 signalingTAS
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expressionTAS
R-HSA-156842Eukaryotic Translation ElongationIEA
R-HSA-156902Peptide chain elongationIEA
R-HSA-157118Signaling by NOTCHIEA
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162587HIV Life CycleTAS
R-HSA-162588Budding and maturation of HIV virionTAS
R-HSA-162599Late Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionTAS
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-1643713Signaling by EGFR in CancerTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168254Influenza InfectionTAS
R-HSA-168255Influenza Life CycleTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168273Influenza Viral RNA Transcription and ReplicationTAS
R-HSA-168638NOD1/2 Signaling PathwayTAS
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-168927TICAM1, RIP1-mediated IKK complex recruitment TAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-169911Regulation of ApoptosisIEA
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexIEA
R-HSA-174048APC/C:Cdc20 mediated degradation of Cyclin BTAS
R-HSA-174084Autodegradation of Cdh1 by Cdh1:APC/CTAS
R-HSA-174113SCF-beta-TrCP mediated degradation of Emi1TAS
R-HSA-174143APC/C-mediated degradation of cell cycle proteinsTAS
R-HSA-174154APC/C:Cdc20 mediated degradation of SecurinTAS
R-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1TAS
R-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin ATAS
R-HSA-174490Membrane binding and targetting of GAG proteinsTAS
R-HSA-174495Synthesis And Processing Of GAG, GAGPOL PolyproteinsTAS
R-HSA-175474Assembly Of The HIV VirionTAS
R-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseTAS
R-HSA-176409APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-177929Signaling by EGFRTAS
R-HSA-179409APC-Cdc20 mediated degradation of Nek2ATAS
R-HSA-179419APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointTAS
R-HSA-1799339SRP-dependent cotranslational protein targeting to membraneIEA
R-HSA-1799339SRP-dependent cotranslational protein targeting to membraneTAS
R-HSA-180534Vpu mediated degradation of CD4TAS
R-HSA-180585Vif-mediated degradation of APOBEC3GTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-182971EGFR downregulationTAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-187577SCF(Skp2)-mediated degradation of p27/p21TAS
R-HSA-190236Signaling by FGFRTAS
R-HSA-192823Viral mRNA TranslationTAS
R-HSA-193639p75NTR signals via NF-kBTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-195253Degradation of beta-catenin by the destruction complexTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1980143Signaling by NOTCH1TAS
R-HSA-1980145Signaling by NOTCH2IEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADETAS
R-HSA-205043NRIF signals cell death from the nucleusTAS
R-HSA-209543p75NTR recruits signalling complexesTAS
R-HSA-209560NF-kB is activated and signals survivalTAS
R-HSA-211733Regulation of activated PAK-2p34 by proteasome mediated degradationIEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusIEA
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-2173788Downregulation of TGF-beta receptor signalingIEA
R-HSA-2173788Downregulation of TGF-beta receptor signalingTAS
R-HSA-2173789TGF-beta receptor signaling activates SMADsIEA
R-HSA-2173789TGF-beta receptor signaling activates SMADsTAS
R-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)TAS
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerTAS
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerIEA
R-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activityTAS
R-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activityIEA
R-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionIEA
R-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionTAS
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-2408557Selenocysteine synthesisIEA
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)TAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559585Oncogene Induced SenescenceTAS
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-2691230Signaling by NOTCH1 HD Domain Mutants in CancerTAS
R-HSA-2691232Constitutive Signaling by NOTCH1 HD Domain MutantsTAS
R-HSA-2871837FCERI mediated NF-kB activationTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-2979096NOTCH2 Activation and Transmission of Signal to the NucleusIEA
R-HSA-3134975Regulation of innate immune responses to cytosolic DNATAS
R-HSA-3229121Glycogen storage diseasesTAS
R-HSA-3322077Glycogen synthesisTAS
R-HSA-349425Autodegradation of the E3 ubiquitin ligase COP1TAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-3769402Deactivation of the beta-catenin transactivating complexTAS
R-HSA-3785653Myoclonic epilepsy of LaforaTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-400253Circadian ClockIEA
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-445989TAK1 activates NFkB by phosphorylation and activation of IKKs complexTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-448424Interleukin-17 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450294MAP kinase activationTAS
R-HSA-450302activated TAK1 mediates p38 MAPK activationTAS
R-HSA-450321JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1TAS
R-HSA-450408AUF1 (hnRNP D0) binds and destabilizes mRNATAS
R-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elementsTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-453276Regulation of mitotic cell cycleTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-4608870Asymmetric localization of PCP proteinsTAS
R-HSA-4641257Degradation of AXINTAS
R-HSA-4641258Degradation of DVLTAS
R-HSA-4641263Regulation of FZD by ubiquitinationTAS
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-5205647MitophagyTAS
R-HSA-5205685Pink/Parkin Mediated MitophagyTAS
R-HSA-5213460RIPK1-mediated regulated necrosisTAS
R-HSA-5218859Regulated NecrosisTAS
R-HSA-532668N-glycan trimming in the ER and Calnexin/Calreticulin cycleTAS
R-HSA-5357801Programmed Cell DeathIEA
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5357905Regulation of TNFR1 signalingTAS
R-HSA-5357956TNFR1-induced NFkappaB signaling pathwayTAS
R-HSA-5358346Hedgehog ligand biogenesisTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5358351Signaling by HedgehogIEA
R-HSA-5362768Hh mutants that don't undergo autocatalytic processing are degraded by ERADTAS
R-HSA-5387390Hh mutants abrogate ligand secretionTAS
R-HSA-5607761Dectin-1 mediated noncanonical NF-kB signalingTAS
R-HSA-5607764CLEC7A (Dectin-1) signalingTAS
R-HSA-5610780Degradation of GLI1 by the proteasomeTAS
R-HSA-5610783Degradation of GLI2 by the proteasomeIEA
R-HSA-5610785GLI3 is processed to GLI3R by the proteasomeTAS
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-5610787Hedgehog 'off' stateIEA
R-HSA-5619084ABC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5632684Hedgehog 'on' stateIEA
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5637815Signaling by Ligand-Responsive EGFR Variants in CancerTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5654726Negative regulation of FGFR1 signalingTAS
R-HSA-5654727Negative regulation of FGFR2 signalingTAS
R-HSA-5654732Negative regulation of FGFR3 signalingTAS
R-HSA-5654733Negative regulation of FGFR4 signalingTAS
R-HSA-5654736Signaling by FGFR1TAS
R-HSA-5654738Signaling by FGFR2TAS
R-HSA-5654741Signaling by FGFR3TAS
R-HSA-5654743Signaling by FGFR4TAS
R-HSA-5655862Translesion synthesis by POLKTAS
R-HSA-5656121Translesion synthesis by POLITAS
R-HSA-5656169Termination of translesion DNA synthesisTAS
R-HSA-5658442Regulation of RAS by GAPsTAS
R-HSA-5663084Diseases of carbohydrate metabolismTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5675221Negative regulation of MAPK pathwayTAS
R-HSA-5675482Regulation of necroptotic cell deathTAS
R-HSA-5676590NIK-->noncanonical NF-kB signalingTAS
R-HSA-5678895Defective CFTR causes cystic fibrosisTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684264MAP3K8 (TPL2)-dependent MAPK1/3 activationTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5688426DeubiquitinationIEA
R-HSA-5689603UCH proteinasesTAS
R-HSA-5689603UCH proteinasesIEA
R-HSA-5689877Josephin domain DUBsTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-5689896Ovarian tumor domain proteasesTAS
R-HSA-5689901Metalloprotease DUBsTAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5696394DNA Damage Recognition in GG-NERTAS
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696397Gap-filling DNA repair synthesis and ligation in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-5696400Dual Incision in GG-NERTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-597592Post-translational protein modificationIEA
R-HSA-6781823Formation of TC-NER Pre-Incision ComplexTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782135Dual incision in TC-NERTAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-6783310Fanconi Anemia PathwayTAS
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-6804757Regulation of TP53 DegradationTAS
R-HSA-6804760Regulation of TP53 Activity through MethylationTAS
R-HSA-6806003Regulation of TP53 Expression and DegradationTAS
R-HSA-6806834Signaling by METTAS
R-HSA-6807004Negative regulation of MET activityTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-68827CDT1 association with the CDC6:ORC:origin complexTAS
R-HSA-68867Assembly of the pre-replicative complexTAS
R-HSA-68874M/G1 TransitionTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-68949Orc1 removal from chromatinTAS
R-HSA-69002DNA Replication Pre-InitiationTAS
R-HSA-69017CDK-mediated phosphorylation and removal of Cdc6TAS
R-HSA-69052Switching of origins to a post-replicative stateTAS
R-HSA-69202Cyclin E associated events during G1/S transition TAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69229Ubiquitin-dependent degradation of Cyclin D1TAS
R-HSA-69231Cyclin D associated events in G1TAS
R-HSA-69236G1 PhaseTAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69541Stabilization of p53TAS
R-HSA-69563p53-Dependent G1 DNA Damage ResponseTAS
R-HSA-69580p53-Dependent G1/S DNA damage checkpointTAS
R-HSA-69601Ubiquitin Mediated Degradation of Phosphorylated Cdc25ATAS
R-HSA-69610p53-Independent DNA Damage ResponseTAS
R-HSA-69613p53-Independent G1/S DNA damage checkpointTAS
R-HSA-69615G1/S DNA Damage CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-69656Cyclin A:Cdk2-associated events at S phase entryTAS
R-HSA-71291Metabolism of amino acids and derivativesIEA
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-72312rRNA processingTAS
R-HSA-72613Eukaryotic Translation InitiationTAS
R-HSA-72689Formation of a pool of free 40S subunitsTAS
R-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunitTAS
R-HSA-72737Cap-dependent Translation InitiationTAS
R-HSA-72764Eukaryotic Translation TerminationIEA
R-HSA-72766TranslationTAS
R-HSA-72766TranslationIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73887Death Receptor SignallingTAS
R-HSA-73893DNA Damage BypassTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-75815Ubiquitin-dependent degradation of Cyclin DTAS
R-HSA-75893TNF signalingTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849469PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1TAS
R-HSA-8852135Protein ubiquitinationTAS
R-HSA-8852135Protein ubiquitinationIEA
R-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointTAS
R-HSA-8854050FBXL7 down-regulates AURKA during mitotic entry and in early mitosisTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-8863795Downregulation of ERBB2 signalingTAS
R-HSA-8866652Synthesis of active ubiquitin: roles of E1 and E2 enzymesTAS
R-HSA-8866652Synthesis of active ubiquitin: roles of E1 and E2 enzymesIEA
R-HSA-8866654E3 ubiquitin ligases ubiquitinate target proteinsTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8875360InlB-mediated entry of Listeria monocytogenes into host cellTAS
R-HSA-8876384Listeria monocytogenes entry into host cellsTAS
R-HSA-8876493InlA-mediated entry of Listeria monocytogenes into host cellsTAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8878166Transcriptional regulation by RUNX2TAS
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsTAS
R-HSA-8939902Regulation of RUNX2 expression and activityTAS
R-HSA-8939902Regulation of RUNX2 expression and activityIEA
R-HSA-8941858Regulation of RUNX3 expression and activityTAS
R-HSA-8948747Regulation of PTEN localizationTAS
R-HSA-8948751Regulation of PTEN stability and activityTAS
R-HSA-8951664NeddylationTAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8982491Glycogen metabolismTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS
R-HSA-9006936Signaling by TGF-beta family membersIEA
R-HSA-901032ER Quality Control Compartment (ERQC)TAS
R-HSA-901042Calnexin/calreticulin cycleTAS
R-HSA-9010553Regulation of expression of SLITs and ROBOsTAS
R-HSA-9010553Regulation of expression of SLITs and ROBOsIEA
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusIEA
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusTAS
R-HSA-9013973TICAM1-dependent activation of IRF3/IRF7TAS
R-HSA-9014325TICAM1,TRAF6-dependent induction of TAK1 complexTAS
R-HSA-9020702Interleukin-1 signalingTAS
R-HSA-9033241Peroxisomal protein importIEA
R-HSA-9033241Peroxisomal protein importTAS
R-HSA-912631Regulation of signaling by CBLTAS
R-HSA-913531Interferon SignalingTAS
R-HSA-917729Endosomal Sorting Complex Required For Transport (ESCRT)TAS
R-HSA-917937Iron uptake and transportTAS
R-HSA-927802Nonsense-Mediated Decay (NMD)TAS
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingTAS
R-HSA-936964Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonTAS
R-HSA-937039IRAK1 recruits IKK complexTAS
R-HSA-937041IKK complex recruitment mediated by RIP1TAS
R-HSA-937042IRAK2 mediated activation of TAK1 complexTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-937072TRAF6-mediated induction of TAK1 complex within TLR4 complexTAS
R-HSA-975110TRAF6 mediated IRF7 activation in TLR7/8 or 9 signalingTAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975144IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975163IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulationTAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS
R-HSA-975956Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)TAS
R-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)TAS
R-HSA-977225Amyloid fiber formationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationIEA
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19038236Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (2009 Feb 12)Prokopczyk BChem Biol Interact