Gene info: ID 7316

Gene: UBC

GENE ID: 7316

Synonyms: HMG20

Description: ubiquitin C

Gene type: protein-coding

Location: 12q24.31

dbXrefs: Ensembl:ENSG00000150991 MIM:191340 Vega:OTTHUMG00000044421 UniprotKB:P0CG48

RefSeq: NG_027722.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 11

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.456e-1 (AD) 5.729e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HSP90AB1	0.891
PCBP2	0.89
HSPA9	0.889
NUCB1	0.887
UBB	0.884
EIF3I	0.88
EIF1	0.874
OSER1	0.874
RAB7A	0.873
HSP90B1	0.873

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.799
OR4F5	-0.788
LYZL2	-0.203
KLRB1	-0.202
FCRL1	-0.196
FCRL2	-0.187
KLRF1	-0.187
FCRL3	-0.185
XCL2	-0.185
KRT73	-0.179

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB04464	N-Formylmethionine	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of UBC mRNA	28329830
C015802	2,6-dichloro-4-nitrophenol	"2,6-dichloro-4-nitrophenol results in increased expression of UBC mRNA"	11227219
C012796	2-butenal	2-butenal results in increased expression of UBC mRNA	20471460
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of UBC mRNA"	20206263
C054649	3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol	"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased expression of UBC mRNA"	12734338
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of UBC mRNA"	18648102
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of UBC mRNA"	19561079
C011865	5-hydroxymethylcytosine	[Chloranil results in increased abundance of 5-hydroxymethylcytosine] which results in increased expression of UBC mRNA	24214992
D000082	Acetaminophen	Acetaminophen affects the expression of UBC mRNA	25064622
D000082	Acetaminophen	Acetaminophen affects the expression of UBC mRNA	15606129
D000082	Acetaminophen	Acetaminophen results in increased expression of UBC mRNA	11264010
D000082	Acetaminophen	Acetaminophen results in increased expression of UBC protein	21329376
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of UBC mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of UBC mRNA]	17585979
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of UBC gene	27153756
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in increased expression of UBC mRNA	16940010
D000616	Aminoglutethimide	Aminoglutethimide results in increased expression of UBC protein	26102013
D000638	Amiodarone	Amiodarone affects the expression of UBC mRNA	25064622
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of UBC mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of UBC protein	19364129
C406592	azaspiracid	azaspiracid results in increased expression of UBC mRNA	28939011
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of UBC mRNA	19737606
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of UBC mRNA	19770486\|2012785
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of UBC mRNA	22300585
D004958	Estradiol	Estradiol results in increased expression of UBC mRNA	20106945
C044887	beta-methylcholine	beta-methylcholine affects the expression of UBC mRNA	21179406
C006780	bisphenol A	bisphenol A results in decreased expression of UBC mRNA	23798566
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in increased expression of UBC mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of UBC mRNA	25181051
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of UBC mRNA	15878706
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of UBC mRNA	26558471
D019256	Cadmium Chloride	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of UBC mRNA	19840844
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of UBC mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of UBC mRNA	19010381
C037123	cadmium sulfate	cadmium sulfate results in increased expression of UBC mRNA	21783983
C037123	cadmium sulfate	cadmium sulfate affects the reaction [MTF1 affects the expression of UBC mRNA]	16221973
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBC mRNA"	20230807
D002110	Caffeine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBC mRNA]"	20230807
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of UBC mRNA	15963342
D002703	Chloranil	[Chloranil results in increased abundance of 5-hydroxymethylcytosine] which results in increased expression of UBC mRNA	24214992
D002703	Chloranil	Chloranil results in increased expression of UBC mRNA	24214992
C100187	chloropicrin	chloropicrin results in decreased expression of UBC mRNA	26352163
D002738	Chloroquine	Chloroquine results in increased expression of UBC mRNA	19296457
D002746	Chlorpromazine	Chlorpromazine affects the expression of UBC mRNA	25064622
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of UBC mRNA	18668222
C022990	chromic chloride	chromic chloride promotes the reaction [INS1 protein results in decreased expression of UBC mRNA]	20013160
C022990	chromic chloride	chromic chloride results in decreased expression of UBC mRNA	20013160
D002922	Ciguatoxins	Ciguatoxins affects the expression of UBC mRNA	18353800
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of UBC mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of UBC mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of UBC mRNA]	17585979
C018021	cobaltous chloride	cobaltous chloride results in increased expression of UBC mRNA	17553155\|1932097
D019327	Copper Sulfate	Copper Sulfate results in increased expression of UBC mRNA	19549813
C029892	cupric chloride	cupric chloride results in increased expression of UBC mRNA	17211630
D003474	Curcumin	Curcumin results in increased expression of UBC mRNA	16101141
D016572	Cyclosporine	Cyclosporine affects the expression of UBC mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in increased expression of UBC mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased methylation of UBC promoter	27989131
D013759	Dronabinol	Dronabinol results in decreased expression of UBC mRNA	11015613
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of UBC mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in increased expression of UBC mRNA	21041162
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of UBC mRNA	17379624
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of UBC mRNA	28962523
D004008	Diclofenac	Diclofenac affects the expression of UBC mRNA	26934552
D004041	Dietary Fats	Dietary Fats results in decreased expression of UBC mRNA	18042831
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of UBC mRNA	17942915
D004052	Diethylnitrosamine	MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of UBC mRNA]	17942915
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of UBC mRNA	21041162
C051904	dinophysistoxin 1	dinophysistoxin 1 results in increased expression of UBC mRNA	28939011
D004317	Doxorubicin	Doxorubicin results in increased expression of UBC mRNA	22016648
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of UBC mRNA"	23811387
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of UBC mRNA	25064622
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of UBC mRNA	17555576\|1794274
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBC mRNA	17942748
D005419	Flavonoids	Flavonoids results in decreased expression of UBC mRNA	18035473
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of UBC mRNA	28329830
C061365	flusilazole	flusilazole affects the expression of UBC mRNA	21195148
D005485	Flutamide	Flutamide results in increased expression of UBC mRNA	24793618
C039281	furan	furan results in decreased expression of UBC mRNA	26194646
C409722	hexaconazole	hexaconazole affects the expression of UBC mRNA	21195148
D007545	Isoproterenol	Isoproterenol results in decreased expression of UBC mRNA	20003209
C060282	lariciresinol	lariciresinol results in increased expression of UBC protein	27417256
C008261	lead acetate	lead acetate results in decreased expression of UBC mRNA	21829687
C045463	leflunomide	leflunomide results in decreased expression of UBC mRNA	28988120
D001556	Lindane	Lindane results in increased expression of UBC mRNA	18804290
D008344	Maneb	[Paraquat co-treated with Maneb] results in increased expression of UBC mRNA	18386188
D008694	Methamphetamine	Methamphetamine results in increased expression of UBC mRNA	24042092
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of UBC mRNA	26558463
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of UBC mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of UBC mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of UBC mRNA	19840844
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBC mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBC mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBC mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBC mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBC mRNA]"	20230807
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of UBC mRNA"	25620056
D009285	Naphthoquinones	Naphthoquinones results in increased expression of UBC mRNA	23811387
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of UBC mRNA	19812364
C017557	nickel subsulfide	nickel subsulfide results in increased expression of UBC mRNA	12760830
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBC mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBC mRNA]"	20230807
D009569	Nitric Oxide	Nitric Oxide deficiency results in increased expression of UBC mRNA	15878706
D016627	Oxidopamine	Oxidopamine results in increased expression of UBC mRNA	12486162
D019319	Okadaic Acid	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of UBC mRNA	19840844
D000073878	Palm Oil	Palm Oil results in decreased expression of UBC mRNA	18042831
D010269	Paraquat	Paraquat affects the expression of UBC mRNA	25064622
D010269	Paraquat	[Paraquat co-treated with Maneb] results in increased expression of UBC mRNA	18386188
D010269	Paraquat	Paraquat results in increased expression of UBC mRNA	12595580
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of UBC mRNA	18593933
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of UBC mRNA	18804290
D010634	Phenobarbital	Phenobarbital affects the expression of UBC mRNA	23091169
D010695	Phlorhizin	Phlorhizin results in decreased expression of UBC mRNA	22538082
C030614	picolinic acid	picolinic acid promotes the reaction [INS1 protein results in decreased expression of UBC mRNA]	20013160
C030614	picolinic acid	picolinic acid results in decreased expression of UBC mRNA	20013160
D011748	Pyrogallol	Pyrogallol results in increased expression of UBC mRNA	20362636
D011794	Quercetin	Quercetin results in decreased expression of UBC mRNA	19496084
D012524	Sarin	Sarin results in increased expression of UBC protein	25842371
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of UBC mRNA	19073995
D012834	Silver	Silver results in increased expression of UBC mRNA	26014281
C017947	sodium arsenite	sodium arsenite results in increased expression of UBC mRNA	12760830\|2088654
C017947	sodium arsenite	sodium arsenite results in increased stability of UBC mRNA	25493608
C016104	sodium bichromate	sodium bichromate results in increased expression of UBC mRNA	12760830
D012460	Sulfasalazine	Sulfasalazine results in increased expression of UBC mRNA	22016648
D013629	Tamoxifen	Tamoxifen affects the expression of UBC mRNA	17555576\|2093736
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in increased expression of UBC mRNA	26496021
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of UBC mRNA	24680724
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBC mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of UBC mRNA	16466705\|1846511
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of UBC mRNA	28973375
D013752	Tetracycline	Tetracycline affects the expression of UBC mRNA	25064622
D013755	Tetradecanoylphorbol Acetate	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of UBC mRNA	19840844
D013853	Thioacetamide	Thioacetamide affects the expression of UBC mRNA	25064622
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of UBC mRNA	28065790
D014050	Toluene	Toluene affects the expression of UBC mRNA	21827849
D014118	Toxins, Biological	"Toxins, Biological affects the expression of UBC mRNA"	19682533
C032910	triadimefon	triadimefon affects the expression of UBC mRNA	21195148
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of UBC mRNA	12163651
D017974	Uranium Compounds	Uranium Compounds results in decreased expression of UBC mRNA	19654044
D014520	Urethane	Urethane results in increased expression of UBC mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of UBC mRNA	25064622
D014635	Valproic Acid	Valproic Acid results in decreased methylation of UBC gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of UBC mRNA	17292431
C025643	vinclozolin	vinclozolin results in decreased expression of UBC mRNA	23034163
D014750	Vincristine	Vincristine results in decreased expression of UBC mRNA	23649840
D014801	Vitamin A	Vitamin A deficiency results in increased expression of UBC mRNA	12163651
D024483	Vitamin K 3	Vitamin K 3 affects the expression of UBC mRNA	20044591
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of UBC mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IPI	21185309
GO:0003723	RNA binding	-	HDA	22681889
GO:0005515	protein binding	-	IPI	8570649 8702753 9488668 11584278 11689694 11916981 11988742 12207904 12230472 12354939 12750381 12857745 14559776 16256071 16424905 16482222 16763556 16810318 16845370 16874300 16874301 16936636 16996503 17006543 17028573 17067581 17070805 17110928 17139261 17159902 17170702 17183367 17255943 17268548 17290220 17304240 17318174 17318178 17320083 17363902 17363905 17568776 17703191 17948050 18239685 18309296 18388957 18539148 18539162 18566587 18566590 18680311 19026640 19098711 19111546 19111555 19131971 19153604 19166840 19233177 19262565 19285159 19322197 19322201 19373254 19376117 19407811 19427866 19536131 19619542 19680224 19763089 19779455 19796170 19798103 19820695 19909340 20006610 20059542 20150893 20395957 20491914 20495530 20601937 20936779 21150319 21900206 22795130
GO:0031386	protein tag	-	IBA	21873635
GO:0031625	ubiquitin protein ligase binding	-	IBA	21873635
GO:0070628	proteasome binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	TAS	-
GO:0000187	activation of MAPK activity	-	TAS	-
GO:0000209	protein polyubiquitination	-	TAS	-
GO:0000715	nucleotide-excision repair, DNA damage recognition	-	TAS	-
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	-	TAS	-
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	-
GO:0006294	nucleotide-excision repair, preincision complex assembly	-	TAS	-
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	-
GO:0006297	nucleotide-excision repair, DNA gap filling	-	TAS	-
GO:0006625	protein targeting to peroxisome	-	TAS	-
GO:0007179	transforming growth factor beta receptor signaling pathway	-	TAS	-
GO:0007249	I-kappaB kinase/NF-kappaB signaling	-	TAS	-
GO:0007254	JNK cascade	-	TAS	-
GO:0016055	Wnt signaling pathway	-	TAS	-
GO:0016197	endosomal transport	-	TAS	-
GO:0016567	protein ubiquitination	-	IBA	21873635
GO:0016567	protein ubiquitination	-	TAS	-
GO:0016579	protein deubiquitination	-	TAS	-
GO:0019058	viral life cycle	-	TAS	-
GO:0019068	virion assembly	-	TAS	-
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0019941	modification-dependent protein catabolic process	-	IBA	21873635
GO:0019985	translesion synthesis	-	TAS	-
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	-	TAS	-
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	-
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	-
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	-	TAS	-
GO:0036297	interstrand cross-link repair	-	TAS	-
GO:0042276	error-prone translesion synthesis	-	TAS	-
GO:0042769	DNA damage response, detection of DNA damage	-	TAS	-
GO:0043065	positive regulation of apoptotic process	-	TAS	-
GO:0043066	negative regulation of apoptotic process	-	TAS	-
GO:0043488	regulation of mRNA stability	-	TAS	-
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	TAS	-
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	TAS	-
GO:0051403	stress-activated MAPK cascade	-	TAS	-
GO:0055085	transmembrane transport	-	TAS	-
GO:0061024	membrane organization	-	TAS	-
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	-
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	-	TAS	-
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	-
GO:0070911	global genome nucleotide-excision repair	-	TAS	-
GO:0070987	error-free translesion synthesis	-	TAS	-
GO:0075733	intracellular transport of virus	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	HDA	16502470
GO:0005634	nucleus	-	HDA	21630459
GO:0005634	nucleus	-	IBA	21873635
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005741	mitochondrial outer membrane	-	TAS	-
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0010008	endosome membrane	-	TAS	-
GO:0030666	endocytic vesicle membrane	-	TAS	-
GO:0031982	vesicle	-	HDA	19190083
GO:0043209	myelin sheath	-	IEA	-
GO:0043657	host cell	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa03320	PPAR signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	IEA
R-HSA-110312	Translesion synthesis by REV1	TAS
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	TAS
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	TAS
R-HSA-110320	Translesion Synthesis by POLH	TAS
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	TAS
R-HSA-1169091	Activation of NF-kappaB in B cells	TAS
R-HSA-1169408	ISG15 antiviral mechanism	TAS
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	TAS
R-HSA-1227986	Signaling by ERBB2	TAS
R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen	TAS
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	TAS
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	TAS
R-HSA-1236394	Signaling by ERBB4	TAS
R-HSA-1236974	ER-Phagosome pathway	IEA
R-HSA-1236975	Antigen processing-Cross presentation	IEA
R-HSA-1253288	Downregulation of ERBB4 signaling	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-1295596	Spry regulation of FGF signaling	TAS
R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-157118	Signaling by NOTCH	IEA
R-HSA-157118	Signaling by NOTCH	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162587	HIV Life Cycle	TAS
R-HSA-162588	Budding and maturation of HIV virion	TAS
R-HSA-162599	Late Phase of HIV Life Cycle	TAS
R-HSA-162906	HIV Infection	TAS
R-HSA-162909	Host Interactions of HIV factors	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1643685	Disease	TAS
R-HSA-1643713	Signaling by EGFR in Cancer	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168638	NOD1/2 Signaling Pathway	TAS
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-168927	TICAM1, RIP1-mediated IKK complex recruitment	TAS
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	TAS
R-HSA-169911	Regulation of Apoptosis	IEA
R-HSA-170834	Signaling by TGF-beta Receptor Complex	TAS
R-HSA-170834	Signaling by TGF-beta Receptor Complex	IEA
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	TAS
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	TAS
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	TAS
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	TAS
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	TAS
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	TAS
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	TAS
R-HSA-174490	Membrane binding and targetting of GAG proteins	TAS
R-HSA-174495	Synthesis And Processing Of GAG, GAGPOL Polyproteins	TAS
R-HSA-175474	Assembly Of The HIV Virion	TAS
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	TAS
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	TAS
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	TAS
R-HSA-177929	Signaling by EGFR	TAS
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	TAS
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	TAS
R-HSA-180534	Vpu mediated degradation of CD4	TAS
R-HSA-180585	Vif-mediated degradation of APOBEC3G	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-182971	EGFR downregulation	TAS
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	TAS
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	TAS
R-HSA-190236	Signaling by FGFR	TAS
R-HSA-193639	p75NTR signals via NF-kB	TAS
R-HSA-193704	p75 NTR receptor-mediated signalling	TAS
R-HSA-195253	Degradation of beta-catenin by the destruction complex	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-1980143	Signaling by NOTCH1	IEA
R-HSA-1980143	Signaling by NOTCH1	TAS
R-HSA-1980145	Signaling by NOTCH2	IEA
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-202403	TCR signaling	TAS
R-HSA-202424	Downstream TCR signaling	TAS
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	TAS
R-HSA-205043	NRIF signals cell death from the nucleus	TAS
R-HSA-209543	p75NTR recruits signalling complexes	TAS
R-HSA-209560	NF-kB is activated and signals survival	TAS
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	IEA
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	IEA
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	IEA
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	IEA
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	TAS
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	IEA
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	TAS
R-HSA-2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	TAS
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	TAS
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	IEA
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	TAS
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	IEA
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	IEA
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	TAS
R-HSA-2262749	Cellular response to hypoxia	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2467813	Separation of Sister Chromatids	TAS
R-HSA-2555396	Mitotic Metaphase and Anaphase	TAS
R-HSA-2559580	Oxidative Stress Induced Senescence	TAS
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	TAS
R-HSA-2559583	Cellular Senescence	TAS
R-HSA-2559585	Oncogene Induced Senescence	TAS
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	TAS
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	TAS
R-HSA-2644603	Signaling by NOTCH1 in Cancer	TAS
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	TAS
R-HSA-2672351	Stimuli-sensing channels	TAS
R-HSA-2691230	Signaling by NOTCH1 HD Domain Mutants in Cancer	TAS
R-HSA-2691232	Constitutive Signaling by NOTCH1 HD Domain Mutants	TAS
R-HSA-2871837	FCERI mediated NF-kB activation	TAS
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	TAS
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	TAS
R-HSA-2979096	NOTCH2 Activation and Transmission of Signal to the Nucleus	IEA
R-HSA-3134975	Regulation of innate immune responses to cytosolic DNA	TAS
R-HSA-3229121	Glycogen storage diseases	TAS
R-HSA-3322077	Glycogen synthesis	TAS
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-376176	Signaling by ROBO receptors	TAS
R-HSA-376176	Signaling by ROBO receptors	IEA
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	TAS
R-HSA-3785653	Myoclonic epilepsy of Lafora	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-382556	ABC-family proteins mediated transport	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-392499	Metabolism of proteins	IEA
R-HSA-400253	Circadian Clock	IEA
R-HSA-4086400	PCP/CE pathway	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	TAS
R-HSA-446203	Asparagine N-linked glycosylation	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-448424	Interleukin-17 signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450294	MAP kinase activation	TAS
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	TAS
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	TAS
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	TAS
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	TAS
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-453276	Regulation of mitotic cell cycle	TAS
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-4608870	Asymmetric localization of PCP proteins	TAS
R-HSA-4641257	Degradation of AXIN	TAS
R-HSA-4641258	Degradation of DVL	TAS
R-HSA-4641263	Regulation of FZD by ubiquitination	TAS
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	TAS
R-HSA-5205647	Mitophagy	TAS
R-HSA-5205685	Pink/Parkin Mediated Mitophagy	TAS
R-HSA-5213460	RIPK1-mediated regulated necrosis	TAS
R-HSA-5218859	Regulated Necrosis	TAS
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	TAS
R-HSA-5357801	Programmed Cell Death	IEA
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-5357905	Regulation of TNFR1 signaling	TAS
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	TAS
R-HSA-5358346	Hedgehog ligand biogenesis	TAS
R-HSA-5358351	Signaling by Hedgehog	TAS
R-HSA-5358351	Signaling by Hedgehog	IEA
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	TAS
R-HSA-5387390	Hh mutants abrogate ligand secretion	TAS
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	TAS
R-HSA-5607764	CLEC7A (Dectin-1) signaling	TAS
R-HSA-5610780	Degradation of GLI1 by the proteasome	TAS
R-HSA-5610783	Degradation of GLI2 by the proteasome	IEA
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	TAS
R-HSA-5610787	Hedgehog 'off' state	TAS
R-HSA-5610787	Hedgehog 'off' state	IEA
R-HSA-5619084	ABC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-5632684	Hedgehog 'on' state	TAS
R-HSA-5632684	Hedgehog 'on' state	IEA
R-HSA-5633007	Regulation of TP53 Activity	TAS
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5654726	Negative regulation of FGFR1 signaling	TAS
R-HSA-5654727	Negative regulation of FGFR2 signaling	TAS
R-HSA-5654732	Negative regulation of FGFR3 signaling	TAS
R-HSA-5654733	Negative regulation of FGFR4 signaling	TAS
R-HSA-5654736	Signaling by FGFR1	TAS
R-HSA-5654738	Signaling by FGFR2	TAS
R-HSA-5654741	Signaling by FGFR3	TAS
R-HSA-5654743	Signaling by FGFR4	TAS
R-HSA-5655862	Translesion synthesis by POLK	TAS
R-HSA-5656121	Translesion synthesis by POLI	TAS
R-HSA-5656169	Termination of translesion DNA synthesis	TAS
R-HSA-5658442	Regulation of RAS by GAPs	TAS
R-HSA-5663084	Diseases of carbohydrate metabolism	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	TAS
R-HSA-5668914	Diseases of metabolism	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5675221	Negative regulation of MAPK pathway	TAS
R-HSA-5675482	Regulation of necroptotic cell death	TAS
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	TAS
R-HSA-5678895	Defective CFTR causes cystic fibrosis	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684264	MAP3K8 (TPL2)-dependent MAPK1/3 activation	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-5685942	HDR through Homologous Recombination (HRR)	TAS
R-HSA-5687128	MAPK6/MAPK4 signaling	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5688426	Deubiquitination	IEA
R-HSA-5689603	UCH proteinases	TAS
R-HSA-5689603	UCH proteinases	IEA
R-HSA-5689877	Josephin domain DUBs	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-5689896	Ovarian tumor domain proteases	TAS
R-HSA-5689901	Metalloprotease DUBs	TAS
R-HSA-5693532	DNA Double-Strand Break Repair	TAS
R-HSA-5693538	Homology Directed Repair	TAS
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	TAS
R-HSA-5693567	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	TAS
R-HSA-5693606	DNA Double Strand Break Response	TAS
R-HSA-5693607	Processing of DNA double-strand break ends	TAS
R-HSA-5696394	DNA Damage Recognition in GG-NER	TAS
R-HSA-5696395	Formation of Incision Complex in GG-NER	TAS
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	TAS
R-HSA-5696398	Nucleotide Excision Repair	TAS
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	TAS
R-HSA-5696400	Dual Incision in GG-NER	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-597592	Post-translational protein modification	IEA
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	TAS
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	TAS
R-HSA-6782135	Dual incision in TC-NER	TAS
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	TAS
R-HSA-6783310	Fanconi Anemia Pathway	TAS
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	TAS
R-HSA-6804757	Regulation of TP53 Degradation	TAS
R-HSA-6804760	Regulation of TP53 Activity through Methylation	TAS
R-HSA-6806003	Regulation of TP53 Expression and Degradation	TAS
R-HSA-6806834	Signaling by MET	TAS
R-HSA-6807004	Negative regulation of MET activity	TAS
R-HSA-6807070	PTEN Regulation	TAS
R-HSA-68827	CDT1 association with the CDC6:ORC:origin complex	TAS
R-HSA-68867	Assembly of the pre-replicative complex	TAS
R-HSA-68874	M/G1 Transition	TAS
R-HSA-68882	Mitotic Anaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-68949	Orc1 removal from chromatin	TAS
R-HSA-69002	DNA Replication Pre-Initiation	TAS
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	TAS
R-HSA-69052	Switching of origins to a post-replicative state	TAS
R-HSA-69202	Cyclin E associated events during G1/S transition	TAS
R-HSA-69206	G1/S Transition	TAS
R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1	TAS
R-HSA-69231	Cyclin D associated events in G1	TAS
R-HSA-69236	G1 Phase	TAS
R-HSA-69239	Synthesis of DNA	TAS
R-HSA-69242	S Phase	TAS
R-HSA-69275	G2/M Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69306	DNA Replication	TAS
R-HSA-69481	G2/M Checkpoints	TAS
R-HSA-69541	Stabilization of p53	TAS
R-HSA-69563	p53-Dependent G1 DNA Damage Response	TAS
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	TAS
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	TAS
R-HSA-69610	p53-Independent DNA Damage Response	TAS
R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	TAS
R-HSA-69615	G1/S DNA Damage Checkpoints	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	TAS
R-HSA-71387	Metabolism of carbohydrates	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-73887	Death Receptor Signalling	TAS
R-HSA-73893	DNA Damage Bypass	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	TAS
R-HSA-75893	TNF signaling	TAS
R-HSA-8848021	Signaling by PTK6	TAS
R-HSA-8849469	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	TAS
R-HSA-8852135	Protein ubiquitination	TAS
R-HSA-8852135	Protein ubiquitination	IEA
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	TAS
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	TAS
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	TAS
R-HSA-8856828	Clathrin-mediated endocytosis	TAS
R-HSA-8863795	Downregulation of ERBB2 signaling	TAS
R-HSA-8866652	Synthesis of active ubiquitin: roles of E1 and E2 enzymes	TAS
R-HSA-8866652	Synthesis of active ubiquitin: roles of E1 and E2 enzymes	IEA
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	TAS
R-HSA-8875360	InlB-mediated entry of Listeria monocytogenes into host cell	TAS
R-HSA-8876384	Listeria monocytogenes entry into host cells	TAS
R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	TAS
R-HSA-8878159	Transcriptional regulation by RUNX3	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	TAS
R-HSA-8939902	Regulation of RUNX2 expression and activity	TAS
R-HSA-8939902	Regulation of RUNX2 expression and activity	IEA
R-HSA-8941858	Regulation of RUNX3 expression and activity	TAS
R-HSA-8948747	Regulation of PTEN localization	TAS
R-HSA-8948751	Regulation of PTEN stability and activity	TAS
R-HSA-8951664	Neddylation	TAS
R-HSA-8953854	Metabolism of RNA	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-8982491	Glycogen metabolism	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9006936	Signaling by TGF-beta family members	TAS
R-HSA-9006936	Signaling by TGF-beta family members	IEA
R-HSA-901032	ER Quality Control Compartment (ERQC)	TAS
R-HSA-901042	Calnexin/calreticulin cycle	TAS
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	TAS
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	IEA
R-HSA-9012852	Signaling by NOTCH3	IEA
R-HSA-9012852	Signaling by NOTCH3	TAS
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	IEA
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	TAS
R-HSA-9013973	TICAM1-dependent activation of IRF3/IRF7	TAS
R-HSA-9014325	TICAM1,TRAF6-dependent induction of TAK1 complex	TAS
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-9033241	Peroxisomal protein import	IEA
R-HSA-9033241	Peroxisomal protein import	TAS
R-HSA-912631	Regulation of signaling by CBL	TAS
R-HSA-913531	Interferon Signaling	TAS
R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)	TAS
R-HSA-917937	Iron uptake and transport	TAS
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	TAS
R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	TAS
R-HSA-937039	IRAK1 recruits IKK complex	TAS
R-HSA-937041	IKK complex recruitment mediated by RIP1	TAS
R-HSA-937042	IRAK2 mediated activation of TAK1 complex	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-937072	TRAF6-mediated induction of TAK1 complex within TLR4 complex	TAS
R-HSA-975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975144	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS
R-HSA-977225	Amyloid fiber formation	TAS
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	IEA
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS
R-HSA-983712	Ion channel transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28386678	Identification of novel potential genetic predictors of urothelial bladder carcinoma susceptibility in Pakistani population. (2017 Oct)	Ali SHB	Fam Cancer
23284801	Distinct SNP combinations confer susceptibility to urinary bladder cancer in smokers and non-smokers. (2012)	Schwender H	PLoS One
22532026	Rs11892031[A] on chromosome 2q37 in an intronic region of the UGT1A locus is associated with urinary bladder cancer risk. (2012 Sep)	Selinski S	Arch Toxicol
21892705	Urinary bladder cancer risk in relation to a single nucleotide polymorphism (rs2854744) in the insulin-like growth factor-binding protein-3 (IGFBP3) gene. (2012 Feb)	Selinski S	Arch Toxicol
17530260	Epidemiology of urinary bladder cancer: from tumor development to patient's death. (2007 Jun)	Murta-Nascimento C	World J Urol
19237018	Interleukin-10 G-1082A and C-819T polymorphisms as possible molecular markers of urothelial bladder cancer. (2009 Feb)	Ahirwar D	Arch Med Res
29139108	A 3' untranslated region polymorphism rs2304277 in the DNA repair pathway gene OGG1 is a novel risk modulator for urothelial bladder carcinoma. (2018 Mar)	Ahmed T	Ann Hum Genet
19815090	Do DNA repair genes OGG1, XRCC3 and XRCC7 have an impact on susceptibility to bladder cancer in the North Indian population? (2009 Nov-Dec)	Gangwar R	Mutat Res
23108201	Plasma 25-hydroxyvitamin D(3) and bladder cancer risk according to tumor stage and FGFR3 status: a mechanism-based epidemiological study. (2012 Dec 19)	Amaral AF	J Natl Cancer Inst
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