Gene: C8B

732
C82
complement C8 beta chain
protein-coding
1p32.2
Ensembl:ENSG00000021852 MIM:120960 Vega:OTTHUMG00000008305 UniprotKB:P07358
NG_007285.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.737e-1 (AD)  2.082e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs856843chr1:56961578 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs605648chr1:56929578 (GRCh38.p7)T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPN20.734
OTOR0.724
OR7C20.711
MUC170.705
PLA2G2E0.669
DEFB1150.666
CNGA20.659
C18orf630.643
OPN1MW20.633
UGT2B40.632

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MDH1B-0.248
MYH15-0.241
HYKK-0.228
MGAT4C-0.219
LRTOMT-0.212
LRRC34-0.208
ANKRD45-0.206
RPS6KA5-0.206
GPR75-0.204
HMGB3-0.204

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of C8B mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of C8B mRNA"25614096
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of C8B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of C8B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of C8B mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of C8B mRNA"25510870
C0415944-nonylphenol4-nonylphenol results in increased expression of C8B mRNA15792627
D000082AcetaminophenAcetaminophen results in decreased expression of C8B mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of C8B mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of C8B protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of C8B mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of C8B gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of C8B mRNA19770486
D000638AmiodaroneAmiodarone results in decreased expression of C8B mRNA24535564
D000638AmiodaroneAmiodarone affects the expression of C8B mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of C8B mRNA16483693
D001553BenzbromaroneBenzbromarone affects the expression of C8B mRNA19483382
C006780bisphenol Abisphenol A results in increased expression of C8B mRNA24534842
C006780bisphenol Abisphenol A affects the expression of C8B mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of C8B mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of C8B mRNA24794047
D019256Cadmium ChlorideCadmium Chloride affects the expression of C8B mRNA22110744
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of C8B mRNA27339419
D000068579CelecoxibCelecoxib results in increased expression of C8B mRNA28201806
D002994ClofibrateClofibrate affects the expression of C8B mRNA19483382
C018021cobaltous chloridecobaltous chloride results in decreased expression of C8B mRNA24386269
D003300CopperC8B protein binds to Copper23896426
D019327Copper SulfateCopper Sulfate results in decreased expression of C8B mRNA19549813
D016572CyclosporineCyclosporine affects the expression of C8B mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of C8B mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased expression of C8B mRNA21632981
D016572CyclosporineCyclosporine results in decreased expression of C8B mRNA19770486
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of C8B mRNA28962523
D004026DieldrinDieldrin results in increased expression of C8B mRNA20438755
D004041Dietary FatsDietary Fats results in decreased expression of C8B mRNA22609946
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of C8B mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of C8B mRNA]19850644
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of C8B mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of C8B mRNA28943392
D000431EthanolEthanol results in increased expression of C8B mRNA15353170
D005001EthionineEthionine affects the expression of C8B mRNA19483382
C024565ethylene dichlorideethylene dichloride results in decreased expression of C8B mRNA28189721
D005485FlutamideFlutamide results in decreased expression of C8B mRNA24136188
C039281furanfuran results in decreased expression of C8B mRNA25539665
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of C8B mRNA22467014
D017313FenretinideFenretinide results in decreased expression of C8B mRNA28973697
D017313FenretinideFenretinide results in increased expression of C8B mRNA28973697
D007213IndomethacinIndomethacin results in increased expression of C8B mRNA28201806
C410337K 7174K 7174 results in decreased expression of C8B mRNA24086573
D007657Ketone BodiesKetone Bodies results in decreased expression of C8B mRNA16807920
D008627Mercuric ChlorideMercuric Chloride affects the expression of C8B mRNA20353558
D008727MethotrexateMethotrexate affects the expression of C8B mRNA18502557
C051752nefazodonenefazodone results in decreased expression of C8B mRNA24136188
D009532NickelC8B protein binds to Nickel23896426
C022838nickel chloridenickel chloride affects the expression of C8B mRNA22110744
C012655nimesulidenimesulide results in decreased expression of C8B mRNA24136188
D009853OmeprazoleOmeprazole affects the expression of C8B mRNA19483382
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of C8B mRNA"25510870
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of C8B mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of C8B mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of C8B mRNA20936131
C076994perfluorooctane sulfonic acidPPARA protein promotes the reaction [perfluorooctane sulfonic acid results in decreased expression of C8B mRNA]20936131
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of C8B mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of C8B mRNA18467677|2093613
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of C8B mRNA]18467677
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of C8B mRNA19162173
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of C8B mRNA]17950772
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of C8B mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of C8B mRNA17950772|1846767
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of C8B mRNA]17950772|1846767
C006253pirinixic acidpirinixic acid affects the expression of C8B mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of C8B mRNA19162173
D011441PropylthiouracilPropylthiouracil affects the expression of C8B mRNA19483382
D011441PropylthiouracilPropylthiouracil results in increased expression of C8B mRNA24780913
D011794QuercetinQuercetin results in decreased expression of C8B mRNA21632981
C089730rosiglitazonerosiglitazone results in decreased expression of C8B mRNA25572481
D012406RoxarsoneRoxarsone results in increased expression of C8B protein21652273
C016104sodium bichromatesodium bichromate results in decreased expression of C8B mRNA24612858
C016104sodium bichromatesodium bichromate affects the expression of C8B mRNA22110744
D012969Sodium FluorideSodium Fluoride results in decreased expression of C8B mRNA27862939
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of C8B mRNA22467014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of C8B mRNA21570461|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to C8B promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of C8B mRNA21215274
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of C8B mRNA28943392
D013853ThioacetamideThioacetamide affects the expression of C8B mRNA19483382
D013853ThioacetamideThioacetamide results in decreased expression of C8B mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of C8B mRNA23131501
D014241TrichloroethyleneTrichloroethylene results in decreased expression of C8B mRNA25549359
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of C8B mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of C8B mRNA25572481
D014635Valproic AcidValproic Acid results in decreased expression of C8B mRNA29154799
D014635Valproic AcidValproic Acid results in decreased expression of C8B mRNA24535564
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of C8B gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of C8B mRNA"23246600
D015032ZincC8B protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0044877protein-containing complex binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-TAS8098723  
GO:0006956complement activation-TAS8098723  
GO:0006957complement activation, alternative pathway-IEA-  
GO:0006958complement activation, classical pathway-IEA-  
GO:0019835cytolysis-IEA-  
GO:0030449regulation of complement activation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005579membrane attack complex-IDA22832194  
GO:0016020membrane-TAS2820472  
GO:0070062extracellular exosome-HDA23533145  
GO:1903561extracellular vesicle-HDA24769233  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa05020Prion diseases
hsa05146Amoebiasis
hsa05322Systemic lupus erythematosus
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-166665Terminal pathway of complementTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal