Gene: UBE2D3

7323
E2(17)KB3|UBC4/5|UBCH5C
ubiquitin conjugating enzyme E2 D3
protein-coding
4q24
Ensembl:ENSG00000109332 MIM:602963 Vega:OTTHUMG00000131119 UniprotKB:P61077
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.681e-1 (AD)  5.398e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06670463chr4:103749966UBE2D31.900e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMED20.953
CCT6A0.948
RSRC20.944
AKIRIN10.942
CAP10.941
EIF2S10.941
SNX30.94
MMADHC0.939
CRK0.938
TAF70.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.804
OR4F29-0.773
TCL1A-0.178
C16orf97-0.165
TNFRSF13B-0.157
NXNL1-0.157
HES5-0.155
OR6C74-0.146
HMHB1-0.146
KRTAP19-1-0.145

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of UBE2D3 mRNA"21354444
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of UBE2D3 mRNA"21346803
C0179063-dinitrobenzene3-dinitrobenzene affects the expression of UBE2D3 mRNA16988215
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of UBE2D3 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UBE2D3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UBE2D3 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of UBE2D3 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UBE2D3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UBE2D3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of UBE2D3 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of UBE2D3 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of UBE2D3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of UBE2D3 mRNA]17585979
D000117AcetylglucosamineAcetylglucosamine results in increased expression of UBE2D3 mRNA18047607
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of UBE2D3 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of UBE2D3 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UBE2D3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of UBE2D3 mRNA24449571
D001280AtrazineAtrazine results in increased expression of UBE2D3 mRNA18522720
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of UBE2D3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UBE2D3 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UBE2D3 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UBE2D3 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of UBE2D3 mRNA"20382639
C044887beta-methylcholinebeta-methylcholine affects the expression of UBE2D3 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of UBE2D3 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of UBE2D3 mRNA25181051
D002101Cacodylic AcidCacodylic Acid results in increased expression of UBE2D3 mRNA17720352
D002104CadmiumCadmium results in increased expression of UBE2D3 mRNA23369406
D002104CadmiumCadmium results in decreased expression of UBE2D3 mRNA21467746
D002104CadmiumCadmium results in decreased expression of UBE2D324212999
D002104CadmiumCadmium results in decreased expression of UBE2D3 mRNA21467746
D002104CadmiumCadmium results in decreased expression of UBE2D3 mRNA23095357
D019256Cadmium ChlorideCadmium Chloride results in increased expression of UBE2D3 mRNA21457566
C459604candoxincandoxin results in increased expression of UBE2D3 mRNA16309724
C054133casticincasticin results in decreased expression of UBE2D3 mRNA28444820
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of UBE2D3 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of UBE2D3 mRNA]17585979
D019327Copper SulfateCopper Sulfate results in increased expression of UBE2D3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of UBE2D3 mRNA19770486
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of UBE2D3 mRNA]27941970
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of UBE2D3 mRNA"25908611
D004041Dietary FatsDietary Fats results in increased expression of UBE2D3 mRNA19030233
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of UBE2D3 mRNA28939011
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UBE2D3 mRNA17555576|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBE2D3 mRNA17942748
D005485FlutamideFlutamide results in increased expression of UBE2D3 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of UBE2D3 mRNA20655997
D019833GenisteinGenistein results in increased expression of UBE2D3 mRNA17341692
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of UBE2D3 mRNA19376150
C544151jinfukangjinfukang results in decreased expression of UBE2D3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UBE2D3 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of UBE2D3 mRNA24796395
C410337K 7174K 7174 results in increased expression of UBE2D3 mRNA24086573
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of UBE2D3 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of UBE2D3 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of UBE2D3 mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of UBE2D3 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of UBE2D3 mRNA17616710
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of UBE2D3 mRNA19074003
D016627OxidopamineOxidopamine results in increased expression of UBE2D3 mRNA12486162
D019319Okadaic AcidOkadaic Acid results in increased expression of UBE2D3 mRNA28939011
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of UBE2D3 mRNA18593933
D010634PhenobarbitalPhenobarbital results in decreased expression of UBE2D3 mRNA19363144
D010634PhenobarbitalPhenobarbital results in increased expression of UBE2D3 mRNA19363144
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UBE2D3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of UBE2D3 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of UBE2D3 mRNA21061450
D010862PilocarpinePilocarpine results in increased expression of UBE2D3 mRNA17971868
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of UBE2D3 mRNA22714537
C059514resveratrolresveratrol results in decreased expression of UBE2D3 mRNA17804521
D012402RotenoneRotenone results in decreased expression of UBE2D3 mRNA23186747
D012402RotenoneRotenone results in increased expression of UBE2D3 mRNA19013527
D012999SomanSoman results in increased expression of UBE2D3 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of UBE2D3 mRNA17555576
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of UBE2D3 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UBE2D3 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBE2D3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UBE2D3 mRNA17942748
D013806TheophyllineTheophylline affects the expression of UBE2D3 mRNA16988215
C009495titanium dioxidetitanium dioxide results in increased expression of UBE2D3 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of UBE2D3 mRNA28065790
D014241TrichloroethyleneTrichloroethylene results in increased expression of UBE2D3 mRNA19448997
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UBE2D3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of UBE2D3 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of UBE2D3 mRNA"26179874
C022884undecaneundecane results in decreased expression of UBE2D3 protein17337753
D014635Valproic AcidValproic Acid results in decreased expression of UBE2D3 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of UBE2D3 gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of UBE2D3 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-IDA14765125  16522193  20061386  20347421  21532592  
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0005515protein binding-IPI14667819  16189514  17353931  18313049  18515077  19549727  
19690564  20133640  22124327  24211586  24446487  25416956  
26752685  
GO:0005524ATP binding-IEA-  
GO:0031625ubiquitin protein ligase binding-IBA21873635  
GO:0061631ubiquitin conjugating enzyme activity-IBA21873635  
GO:0061631ubiquitin conjugating enzyme activity-IDA10230407  20017557  20061386  21068390  21685362  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS-  
GO:0000209protein polyubiquitination-IDA14765125  16522193  
GO:0006281DNA repair-IEA-  
GO:0006464cellular protein modification process-TAS8090726  
GO:0006511ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0006511ubiquitin-dependent protein catabolic process-TAS8530467  
GO:0006513protein monoubiquitination-IDA20347421  
GO:0006625protein targeting to peroxisome-TAS-  
GO:0006915apoptotic process-IEA-  
GO:0016567protein ubiquitination-IDA9990509  21532592  
GO:0016567protein ubiquitination-TAS-  
GO:0030509BMP signaling pathway-TAS-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IDA20347421  
GO:0051865protein autoubiquitination-IDA21068390  
GO:0070936protein K48-linked ubiquitination-IBA21873635  
GO:0070936protein K48-linked ubiquitination-IDA20061386  
GO:0070979protein K11-linked ubiquitination-IBA21873635  
GO:0070979protein K11-linked ubiquitination-IDA20061386  
GO:1903955positive regulation of protein targeting to mitochondrion-HMP24270810  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complex-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0010008endosome membrane-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
hsa04141Protein processing in endoplasmic reticulum
Reactome ID Reactome Term Evidence
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-168927TICAM1, RIP1-mediated IKK complex recruitment TAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaIEA
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-201451Signaling by BMPTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerTAS
R-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activityTAS
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8852135Protein ubiquitinationTAS
R-HSA-8866654E3 ubiquitin ligases ubiquitinate target proteinsTAS
R-HSA-8951664NeddylationTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS
R-HSA-9033241Peroxisomal protein importTAS
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingIEA
R-HSA-937041IKK complex recruitment mediated by RIP1TAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27164557Genetic Relationship between Schizophrenia and Nicotine Dependence. (2016 May 10)Chen JSci Rep