Gene info: ID 7334

Gene: UBE2N

GENE ID: 7334

Synonyms: HEL-S-71|UBC13|UBCHBEN; UBC13|UbcH-ben|UbcH13

Description: ubiquitin conjugating enzyme E2 N

Gene type: protein-coding

Location: 12q22

dbXrefs: Ensembl:ENSG00000177889 MIM:603679 Vega:OTTHUMG00000170156 UniprotKB:P61088

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.361e-1 (AD) 5.905e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NDFIP1	0.979
MEAF6	0.976
RAB2A	0.976
YWHAZ	0.974
ATP6AP2	0.973
UBE2V2	0.972
ISCA1	0.972
VDAC1	0.97
ARL1	0.97
NECAP1	0.969

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.66
OR4F29	-0.611
CSAG1	-0.416
MTRNR2L6	-0.361
MTRNR2L10	-0.359
MTRNR2L9	-0.356
MAGEA12	-0.354
VNN3	-0.322
CXCR2	-0.321
CNN2	-0.321

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of UBE2N mRNA"	18084045
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of UBE2N mRNA"	21346803
C017906	3-dinitrobenzene	3-dinitrobenzene results in decreased expression of UBE2N mRNA	24140754
D000082	Acetaminophen	Acetaminophen affects the expression of UBE2N mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of UBE2N mRNA	19770486
D000638	Amiodarone	Amiodarone affects the expression of UBE2N mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of UBE2N mRNA	16483693
D001151	Arsenic	Arsenic results in increased methylation of UBE2N gene	24525453
D001280	Atrazine	Atrazine results in decreased expression of UBE2N mRNA	22378314
D001553	Benzbromarone	Benzbromarone affects the expression of UBE2N mRNA	19483382
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of UBE2N mRNA	20064835
D001564	Benzo(a)pyrene	[Soot co-treated with Benzo(a)pyrene] results in increased expression of UBE2N protein modified form	24464499
C006780	bisphenol A	bisphenol A results in decreased expression of UBE2N mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of UBE2N mRNA	26063408
C006780	bisphenol A	bisphenol A affects the expression of UBE2N mRNA	25181051
D002104	Cadmium	Cadmium results in decreased expression of UBE2N mRNA	24067728
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of UBE2N protein	24527689
C099555	CD 437	CD 437 results in decreased expression of UBE2N mRNA	12958071
C007020	chlorophyllin	chlorophyllin analog results in decreased expression of UBE2N protein	22852132
C100187	chloropicrin	chloropicrin results in decreased expression of UBE2N mRNA	28476498
D002994	Clofibrate	Clofibrate affects the expression of UBE2N mRNA	19483382
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of UBE2N mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased expression of UBE2N protein	24386269
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of UBE2N mRNA	19549813
D003375	Coumestrol	Coumestrol results in increased expression of UBE2N mRNA	19167446
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in increased expression of UBE2N mRNA	21878529
D016572	Cyclosporine	Cyclosporine results in decreased expression of UBE2N mRNA	25562108
D002945	Cisplatin	Cisplatin affects the reaction [Piroxicam results in decreased expression of UBE2N mRNA]	21858171
D002945	Cisplatin	Cisplatin results in decreased expression of UBE2N mRNA	27594783
D000431	Ethanol	Ethanol results in increased expression of UBE2N mRNA	15513904
D000431	Ethanol	Ethanol results in decreased expression of UBE2N protein	23702218
D005001	Ethionine	Ethionine affects the expression of UBE2N mRNA	19483382
D005485	Flutamide	Flutamide results in increased expression of UBE2N mRNA	24136188
C056933	fumonisin B1	fumonisin B1 results in increased expression of UBE2N mRNA	16221962
D005897	Glafenine	Glafenine results in increased expression of UBE2N mRNA	24136188
D006046	Gold	Gold results in decreased expression of UBE2N mRNA	25523186
C492448	ICG 001	ICG 001 results in increased expression of UBE2N mRNA	26191083
C544151	jinfukang	jinfukang results in decreased expression of UBE2N mRNA	27392435
C410337	K 7174	K 7174 results in decreased expression of UBE2N mRNA	24086573
D008345	Manganese	Manganese results in decreased expression of UBE2N mRNA	18284614
D008628	Mercury	Mercury results in decreased expression of UBE2N mRNA	16823088
D008694	Methamphetamine	Methamphetamine affects the expression of UBE2N protein	17904249
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of UBE2N mRNA	23103053
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of UBE2N mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of UBE2N mRNA	23649840
C028577	monobutyl phthalate	monobutyl phthalate results in increased expression of UBE2N mRNA	29162477
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of UBE2N mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of UBE2N mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of UBE2N mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of UBE2N mRNA"	25554681
C051752	nefazodone	nefazodone results in increased expression of UBE2N mRNA	24136188
C012655	nimesulide	nimesulide results in increased expression of UBE2N mRNA	24136188
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of UBE2N mRNA	17616710
D009853	Omeprazole	Omeprazole affects the expression of UBE2N mRNA	19483382
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in decreased expression of UBE2N protein	19854247
D010695	Phlorhizin	Phlorhizin results in decreased expression of UBE2N mRNA	22538082
C006253	pirinixic acid	pirinixic acid results in increased expression of UBE2N mRNA	16221962\|1830175
C006253	pirinixic acid	pirinixic acid affects the expression of UBE2N mRNA	19483382
D010894	Piroxicam	Cisplatin affects the reaction [Piroxicam results in decreased expression of UBE2N mRNA]	21858171
D010894	Piroxicam	Piroxicam results in decreased expression of UBE2N mRNA	21858171
D011441	Propylthiouracil	Propylthiouracil affects the expression of UBE2N mRNA	19483382
D012402	Rotenone	Rotenone results in increased expression of UBE2N mRNA	18191903
D012402	Rotenone	Rotenone results in decreased expression of UBE2N mRNA	23186747
C017947	sodium arsenite	sodium arsenite results in increased expression of UBE2N mRNA	28595984
C017947	sodium arsenite	TP53 protein affects the reaction [sodium arsenite results in increased expression of UBE2N mRNA]	16966095
D053260	Soot	[Soot co-treated with Benzo(a)pyrene] results in increased expression of UBE2N protein modified form	24464499
D013605	T-2 Toxin	T-2 Toxin affects the expression of UBE2N protein	26141394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of UBE2N mRNA	21570461
D019284	Thapsigargin	Thapsigargin results in decreased expression of UBE2N mRNA	22378314
D013853	Thioacetamide	Thioacetamide affects the expression of UBE2N mRNA	19483382
D014212	Tretinoin	Tretinoin results in decreased expression of UBE2N mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of UBE2N mRNA	24977338
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of UBE2N gene	27618143
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of UBE2N mRNA"	26179874
D014415	Tunicamycin	Tunicamycin results in decreased expression of UBE2N mRNA	22378314
D014635	Valproic Acid	Valproic Acid affects the expression of UBE2N mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of UBE2N mRNA	23179753
C025643	vinclozolin	vinclozolin results in decreased expression of UBE2N mRNA	22570695\|2261537
C025643	vinclozolin	vinclozolin results in increased expression of UBE2N mRNA	22615374
C111237	vorinostat	vorinostat results in increased expression of UBE2N mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22681889
GO:0004842	ubiquitin-protein transferase activity	-	IDA	20061386
GO:0005515	protein binding	-	IPI	11057907 11473255 14695475 15231748 16129784 16307917 17108083 18316726 18719106 19203578 19340006 19465916 19549727 19615732 19690564 20725033 21659603 22266820 22367539 22407319 25036637 25260751 26752685 27173435
GO:0005524	ATP binding	-	IEA	-
GO:0043130	ubiquitin binding	-	IDA	16122702
GO:0061631	ubiquitin conjugating enzyme activity	-	IBA	21873635
GO:0061631	ubiquitin conjugating enzyme activity	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000187	activation of MAPK activity	-	TAS	-
GO:0000724	double-strand break repair via homologous recombination	-	IMP	17349954
GO:0000729	DNA double-strand break processing	-	IMP	17349954
GO:0006282	regulation of DNA repair	-	TAS	10089880
GO:0006301	postreplication repair	-	IBA	21873635
GO:0006301	postreplication repair	-	IMP	17349954
GO:0006303	double-strand break repair via nonhomologous end joining	-	TAS	-
GO:0006464	cellular protein modification process	-	TAS	8902611
GO:0006508	proteolysis	-	TAS	8902611
GO:0007254	JNK cascade	-	TAS	-
GO:0016567	protein ubiquitination	-	IMP	17349954
GO:0016567	protein ubiquitination	-	TAS	16129784
GO:0016574	histone ubiquitination	-	IMP	17349954
GO:0031058	positive regulation of histone modification	-	IMP	17349954
GO:0033182	regulation of histone ubiquitination	-	IMP	17349954
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IMP	16129784
GO:0045739	positive regulation of DNA repair	-	IMP	16129784
GO:0050852	T cell receptor signaling pathway	-	IMP	15125833
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IMP	14695475 16129784
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	TAS	-
GO:0051443	positive regulation of ubiquitin-protein transferase activity	-	IMP	17349954
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	-	TAS	-
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	-
GO:0070534	protein K63-linked ubiquitination	-	IBA	21873635
GO:0070534	protein K63-linked ubiquitination	-	IDA	16307917 20061386 21512573
GO:0070534	protein K63-linked ubiquitination	-	IMP	25936802

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000151	ubiquitin ligase complex	-	IDA	16307917
GO:0001650	fibrillar center	-	IDA	-
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	16129784 19340006
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IDA	19340006
GO:0005737	cytoplasm	-	TAS	16129784 16130169
GO:0005829	cytosol	-	TAS	-
GO:0031372	UBC13-MMS2 complex	-	IDA	16129784
GO:0032991	protein-containing complex	-	IDA	22797923
GO:0035370	UBC13-UEV1A complex	-	IDA	16307917
GO:0070062	extracellular exosome	-	HDA	20458337 23533145

KEGG ID	KEGG Term
hsa04120	Ubiquitin mediated proteolysis

Reactome ID	Reactome Term	Evidence
R-HSA-1169408	ISG15 antiviral mechanism	TAS
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168638	NOD1/2 Signaling Pathway	TAS
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-168927	TICAM1, RIP1-mediated IKK complex recruitment	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-202403	TCR signaling	TAS
R-HSA-202424	Downstream TCR signaling	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2871837	FCERI mediated NF-kB activation	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-448424	Interleukin-17 signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450294	MAP kinase activation	TAS
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	TAS
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	TAS
R-HSA-5607764	CLEC7A (Dectin-1) signaling	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-5693532	DNA Double-Strand Break Repair	TAS
R-HSA-5693538	Homology Directed Repair	TAS
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	TAS
R-HSA-5693567	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	TAS
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	TAS
R-HSA-5693606	DNA Double Strand Break Response	TAS
R-HSA-5693607	Processing of DNA double-strand break ends	TAS
R-HSA-5696395	Formation of Incision Complex in GG-NER	TAS
R-HSA-5696398	Nucleotide Excision Repair	TAS
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-69473	G2/M DNA damage checkpoint	TAS
R-HSA-69481	G2/M Checkpoints	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-8852135	Protein ubiquitination	TAS
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	TAS
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-913531	Interferon Signaling	TAS
R-HSA-937039	IRAK1 recruits IKK complex	TAS
R-HSA-937041	IKK complex recruitment mediated by RIP1	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975144	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22649255	Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males. (2012 Jul)	Wernimont SM	J Nutr
22382497	Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. (2012 May)	Kazma R	Carcinogenesis