Gene: SUMO1

7341
DAP1|GMP1|OFC10|PIC1|SENP2|SMT3|SMT3C|SMT3H3|UBL1
small ubiquitin-like modifier 1
protein-coding
2q33.1
Ensembl:ENSG00000116030 MIM:601912 Vega:OTTHUMG00000132839 UniprotKB:P63165
NG_011679.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.814e-1 (AD)  7.587e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VPS290.968
MOCS20.96
EID10.959
TCEAL80.957
POLR2K0.957
THOC70.956
MORF4L10.955
EIF1B0.955
MRPS350.955
MATR30.954

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.774
OR4F29-0.75
MAGEA12-0.276
ZBTB20-0.267
CSAG1-0.259
VNN3-0.252
RUNX3-0.249
C8orf74-0.245
MTRNR2L10-0.244
CXCR2-0.238

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SUMO1 mRNA"19162173
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride affects the localization of SUMO1 protein]12508112
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SUMO1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SUMO1 mRNA"21346803
D000966Antimony Potassium TartrateAntimony Potassium Tartrate affects the localization of SUMO1 protein9834237
D000966Antimony Potassium TartrateAntimony Potassium Tartrate promotes the reaction [SUMO1 protein binds to PML protein]9834237
C037554antimony trioxideantimony trioxide affects the localization of SUMO1 protein9834237
C037554antimony trioxideantimony trioxide promotes the reaction [SUMO1 protein binds to PML protein]9834237
C006632arsenic trioxidearsenic trioxide affects the localization of SUMO1 protein9834237
C006632arsenic trioxide[arsenic trioxide affects the reaction [SUMO2 protein binds to PML protein]] promotes the reaction [SUMO1 protein binds to PML protein]26060329
C006632arsenic trioxidearsenic trioxide promotes the reaction [SUMO1 protein binds to PML protein]20943951|2606032
C006632arsenic trioxide[arsenic trioxide promotes the reaction [SUMO1 protein binds to PML protein]] which results in increased ubiquitination of PML protein26060329
C006632arsenic trioxidearsenic trioxide promotes the reaction [Tretinoin results in increased expression of SUMO1 mRNA]10673743
C006632arsenic trioxidearsenic trioxide results in decreased expression of SUMO1 mRNA17530438
C006632arsenic trioxidearsenic trioxide results in increased localization of [MECOM protein co-treated with SUMO1 protein]23770046
C006632arsenic trioxideSENP1 protein promotes the reaction [arsenic trioxide promotes the reaction [SUMO1 protein binds to PML protein]]26060329
C006632arsenic trioxideSUMO1 protein promotes the reaction [arsenic trioxide results in increased ubiquitination of PML protein]26060329
C006632arsenic trioxideSUMO2 protein mutant form inhibits the reaction [arsenic trioxide promotes the reaction [SUMO1 protein binds to PML protein]]26060329
C006632arsenic trioxidearsenic trioxide promotes the reaction [PML protein binds to SUMO1 protein]11413191
D001241AspirinAspirin results in decreased expression of SUMO1 mRNA11906190
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SUMO1 mRNA21632981
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of SUMO1 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SUMO1 mRNA15034205
D004958EstradiolEstradiol results in decreased expression of SUMO1 mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of SUMO1 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of SUMO1 mRNA20977926
D019256Cadmium Chloride2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride affects the localization of SUMO1 protein]12508112
D019256Cadmium ChlorideCadmium Chloride affects the localization of SUMO1 protein12508112
D019256Cadmium ChlorideSB 203580 inhibits the reaction [Cadmium Chloride affects the localization of SUMO1 protein]12508112
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SUMO1 mRNA21297351
C099555CD 437CD 437 results in decreased expression of SUMO1 mRNA12958071
D003035CobaltCobalt promotes the reaction [SUMO1 protein results in increased expression of POU5F1 protein]24497960
C018021cobaltous chloridecobaltous chloride results in decreased expression of SUMO1 mRNA19376846
D003300CopperMT1 affects the reaction [Copper results in increased expression of SUMO1 mRNA]16629173
D003300CopperMT2 affects the reaction [Copper results in increased expression of SUMO1 mRNA]16629173
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of SUMO1 mRNA21878529
C004742daidzein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of SUMO1 mRNA27424125
C013908daidzin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of SUMO1 mRNA27424125
D013759DronabinolDronabinol results in increased expression of SUMO1 protein19819240
C000944dicrotophosdicrotophos results in decreased expression of SUMO1 mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of SUMO1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of SUMO1 mRNA]19850644
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of SUMO1 mRNA24834073
D004147DioxinsDioxins affects the expression of SUMO1 mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SUMO1 mRNA17555576
C024565ethylene dichlorideethylene dichloride results in decreased expression of SUMO1 mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SUMO1 mRNA23649840
D005485FlutamideFlutamide results in increased expression of SUMO1 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of SUMO1 mRNA23649840
D019833Genistein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of SUMO1 mRNA27424125
C040641genistin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of SUMO1 mRNA27424125
C086566glycitein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of SUMO1 mRNA27424125
C433283glycitin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of SUMO1 mRNA27424125
D006062GonadotropinsGonadotropins results in decreased expression of SUMO1 protein14500579
D006062GonadotropinsPentobarbital inhibits the reaction [Gonadotropins results in decreased expression of SUMO1 protein]14500579
D006063Chorionic GonadotropinChorionic Gonadotropin affects the expression of SUMO1 protein14500579
D006063Chorionic GonadotropinChorionic Gonadotropin inhibits the reaction [Pentobarbital results in increased expression of SUMO1 protein]14500579
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SUMO1 mRNA25613284
C017461lead nitratelead nitrate affects the reaction [SUMO1 affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [SUMO1 affects the expression of MT2 mRNA]11891201
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of SUMO1 mRNA18386188
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of SUMO1 protein26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SUMO1 protein26558463
D015735MifepristoneMifepristone results in increased expression of SUMO1 protein14500579
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideSUMO1 protein affects the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [resveratrol results in decreased expression of CCND1 mRNA]]29242151
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideSUMO1 protein affects the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [resveratrol results in decreased expression of MYC mRNA]]29242151
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideSUMO1 protein affects the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [resveratrol results in increased expression of CASP2 mRNA]]29242151
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideSUMO1 protein affects the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [resveratrol results in increased expression of PTGS2 mRNA]]29242151
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideSUMO1 protein affects the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CCND1 mRNA]29242151
D015739NocodazoleNocodazole results in increased phosphorylation of [SUMO1 protein binds to RANGAP1 protein]21646468
C025256nonylphenolnonylphenol results in decreased expression of SUMO1 mRNA22982499
C025589ochratoxin Aochratoxin A results in decreased expression of SUMO1 mRNA14994279
C507134ON 01910ON 01910 results in increased phosphorylation of [SUMO1 protein binds to RANGAP1 protein]21646468
C076196Org 31710Org 31710 results in increased expression of SUMO1 protein14500579
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of SUMO1 mRNA18386188
D010424PentobarbitalChorionic Gonadotropin inhibits the reaction [Pentobarbital results in increased expression of SUMO1 protein]14500579
D010424PentobarbitalPentobarbital inhibits the reaction [Gonadotropins results in decreased expression of SUMO1 protein]14500579
D010424PentobarbitalPentobarbital results in increased expression of SUMO1 protein14500579
C006253pirinixic acidpirinixic acid results in decreased expression of SUMO1 mRNA18445702
D011374ProgesteroneProgesterone results in increased expression of SUMO1 mRNA18070364
C005266quinomethionatequinomethionate affects the expression of SUMO1 mRNA15387888
C059514resveratrolBCL2 protein inhibits the reaction [resveratrol promotes the reaction [PML protein binds to SUMO1 protein]]19631782
C059514resveratrolresveratrol promotes the reaction [PML protein binds to SUMO1 protein]19631782
C059514resveratrolSUMO1 protein affects the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [resveratrol results in decreased expression of CCND1 mRNA]]29242151
C059514resveratrolSUMO1 protein affects the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [resveratrol results in decreased expression of MYC mRNA]]29242151
C059514resveratrolSUMO1 protein affects the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [resveratrol results in increased expression of CASP2 mRNA]]29242151
C059514resveratrolSUMO1 protein affects the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [resveratrol results in increased expression of PTGS2 mRNA]]29242151
C059514resveratrolSUMO1 protein affects the reaction [resveratrol results in decreased expression of CCND1 mRNA]29242151
C059514resveratrolSUMO1 protein affects the reaction [resveratrol results in decreased expression of MYC mRNA]29242151
C059514resveratrolSUMO1 protein affects the reaction [resveratrol results in increased expression of CASP2 mRNA]29242151
C059514resveratrolSUMO1 protein affects the reaction [resveratrol results in increased expression of PTGS2 mRNA]29242151
C059514resveratrolSUMO1 protein affects the reaction [resveratrol results in increased expression of TP53 mRNA]29242151
C059514resveratrolresveratrol results in decreased expression of SUMO1 protein25505154
C547185riccardin Driccardin D results in decreased expression of SUMO1 mRNA24069304
D012293RifampinRifampin results in increased expression of SUMO1 protein28132806
D012402RotenoneRotenone results in decreased expression of SUMO1 mRNA23186747
C093642SB 203580SB 203580 inhibits the reaction [Cadmium Chloride affects the localization of SUMO1 protein]12508112
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SUMO1 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SUMO1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SUMO1 mRNA15034205
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SUMO1 mRNA25613284
D008063Thioctic AcidThioctic Acid results in increased expression of SUMO1 protein24975507
D014212Tretinoinarsenic trioxide promotes the reaction [Tretinoin results in increased expression of SUMO1 mRNA]10673743
D014212TretinoinSUMO1 mutant form inhibits the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]24819975
D014212TretinoinSUMO1 mutant form inhibits the reaction [Tretinoin results in increased expression of EGR1 mRNA]24819975
D014212TretinoinSUMO1 mutant form inhibits the reaction [Tretinoin results in increased expression of PXN mRNA]24819975
D014212TretinoinSUMO1 mutant form inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]24819975
D014212TretinoinTretinoin affects the localization of SUMO1 protein9834237
D014212TretinoinTretinoin results in decreased expression of SUMO1 mRNA17218384
D014212TretinoinTretinoin results in decreased expression of SUMO1 protein24819975
D014212TretinoinTretinoin results in decreased expression of SUMO1 protein modified form24819975
D014212TretinoinTretinoin results in increased expression of SUMO1 mRNA10673743
D014635Valproic AcidValproic Acid results in increased expression of SUMO1 mRNA29154799
C111237vorinostatvorinostat promotes the reaction [PML protein binds to SUMO1 protein]19631782

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001222transcription corepressor binding-IPI17081986  
GO:0003723RNA binding-HDA22658674  
GO:0005515protein binding-IPI9885291  11112409  11735126  11948183  12072434  14516784  
15296745  15848177  15896780  15983381  16154161  16189514  
16494873  16732283  17000644  17036045  17066076  17081985  
17081986  17099698  17099700  17353931  17491593  17535915  
17942705  17956732  18264111  18408014  18617892  19684601  
19779455  20016594  20016603  20164921  20224576  20414307  
20498050  20534433  20661221  20802522  21057547  21212807  
21242980  21722636  21811235  21880768  21965678  21988832  
22555612  22748127  22878415  23395904  24434214  24819975  
25416956  25497731  25910212  26496610  26871637  
GO:0008022protein C-terminus binding-IDA15959518  
GO:0008022protein C-terminus binding-IMP17081986  
GO:0008134transcription factor binding-ISS-  
GO:0015459potassium channel regulator activity-IDA19223394  
GO:0019789SUMO transferase activity-EXP19744555  20209145  
GO:0019899enzyme binding-IPI11889051  15959518  
GO:0030674protein binding, bridging-IMP17081986  
GO:0031386protein tag-IBA21873635  
GO:0031625ubiquitin protein ligase binding-IPI18408734  
GO:0035259glucocorticoid receptor binding-IPI17081986  
GO:0044388small protein activating enzyme binding-IPI15660128  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS-  
GO:0006281DNA repair-TAS8812453  
GO:0006303double-strand break repair via nonhomologous end joining-TAS-  
GO:0016032viral process-IEA-  
GO:0016925protein sumoylation-IBA21873635  
GO:0016925protein sumoylation-IDA11889051  14752048  15572661  15637059  15959518  17696781  19223394  21965678  24651376  
GO:0016925protein sumoylation-IMP17081986  
GO:0016925protein sumoylation-TAS-  
GO:0030578PML body organization-IEA-  
GO:0031334positive regulation of protein complex assembly-IDA18579533  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IDA18408734  
GO:0032880regulation of protein localization-TAS15637059  
GO:0034605cellular response to heat-IDA11514557  
GO:0043392negative regulation of DNA binding-IDA16626738  
GO:0043392negative regulation of DNA binding-IMP15637059  
GO:0043433negative regulation of DNA-binding transcription factor activity-IMP12072434  
GO:0045759negative regulation of action potential-IDA19223394  
GO:0045892negative regulation of transcription, DNA-templated-IDA15572661  
GO:0045892negative regulation of transcription, DNA-templated-IMP12072434  
GO:0050821protein stabilization-IDA21968017  
GO:0060021roof of mouth development-ISS-  
GO:0060334regulation of interferon-gamma-mediated signaling pathway-TAS-  
GO:0071276cellular response to cadmium ion-IDA11514557  
GO:0086004regulation of cardiac muscle cell contraction-IEA-  
GO:0090204protein localization to nuclear pore-IEA-  
GO:1901896positive regulation of calcium-transporting ATPase activity-IEA-  
GO:1902260negative regulation of delayed rectifier potassium channel activity-IDA19223394  
GO ID GO Term Qualifier Evidence PubMed
GO:0000792heterochromatin-IEA-  
GO:0001650fibrillar center-IEA-  
GO:0001741XY body-IEA-  
GO:0005634nucleus-HDA16791210  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9412458  24651376  
GO:0005643nuclear pore-TAS9019411  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IDA19223394  
GO:0008076voltage-gated potassium channel complexcolocalizes_withIDA19223394  
GO:0016604nuclear body-IDA24651376  
GO:0016605PML body-IDA22406621  
GO:0016605PML bodycolocalizes_withIDA9412458  
GO:0016607nuclear speck-IEA-  
GO:0030425dendrite-IEA-  
GO:0031510SUMO activating enzyme complex-IDA15660128  
GO:0031965nuclear membrane-IDA-  
GO:0045202synapse-IEA-  
GO:0097165nuclear stress granule-IDA11514557  
KEGG ID KEGG Term
hsa03013RNA transport
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1640170Cell CycleTAS
R-HSA-168256Immune SystemTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2990846SUMOylationTAS
R-HSA-2990846SUMOylationIEA
R-HSA-3065676SUMO is conjugated to E1 (UBA2:SAE1)TAS
R-HSA-3065678SUMO is transferred from E1 to E2 (UBE2I, UBC9)TAS
R-HSA-3065679SUMO is proteolytically processedTAS
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsIEA
R-HSA-3215018Processing and activation of SUMOTAS
R-HSA-3232118SUMOylation of transcription factorsIEA
R-HSA-3232118SUMOylation of transcription factorsTAS
R-HSA-3899300SUMOylation of transcription cofactorsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-4551638SUMOylation of chromatin organization proteinsTAS
R-HSA-4551638SUMOylation of chromatin organization proteinsIEA
R-HSA-4570464SUMOylation of RNA binding proteinsTAS
R-HSA-4615885SUMOylation of DNA replication proteinsTAS
R-HSA-4615885SUMOylation of DNA replication proteinsIEA
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693571Nonhomologous End-Joining (NHEJ)TAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-597592Post-translational protein modificationIEA
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-877312Regulation of IFNG signalingTAS
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsIEA
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsTAS
R-HSA-8866904Negative regulation of activity of TFAP2 (AP-2) family transcription factorsIEA
R-HSA-8866904Negative regulation of activity of TFAP2 (AP-2) family transcription factorsTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21189065Interactions between small ubiquitin-like modifier 1 and nonsyndromic orofacial clefts. (2011 Apr)Jia ZLDNA Cell Biol