Gene: UCHL1

7345
HEL-117|HEL-S-53|NDGOA|PARK5|PGP 9.5|PGP9.5|PGP95|SPG79|Uch-L1
ubiquitin C-terminal hydrolase L1
protein-coding
4p13
Ensembl:ENSG00000154277 MIM:191342 Vega:OTTHUMG00000099377 UniprotKB:P09936
NG_012931.1
PubMed
ND
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.011e-1 (AD)  5.568e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BSCL20.979
TAGLN30.979
AP2M10.977
RTN30.975
PITHD10.975
BASP10.975
ENO20.975
RTN10.974
SCG50.974
ATP6V1E10.974

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.681
OR4F29-0.649
TFPI2-0.428
KCNJ15-0.417
REST-0.416
CXCR2-0.408
IL18RAP-0.405
FZD10-0.402
MAGEA12-0.396
ASB4-0.394

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB12695Phenethyl IsothiocyanateSmall Molecule2257-09-2InvestigationalTarget
ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of UCHL1 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of UCHL1 mRNA]"27071940
C0407561,2-naphthoquinone"1,2-naphthoquinone results in increased metabolism of and results in decreased activity of UCHL1 protein"24582816
C0407561,2-naphthoquinone"Glutathione inhibits the reaction [1,2-naphthoquinone results in increased metabolism of and results in decreased activity of UCHL1 protein]"24582816
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of UCHL1 mRNA"20206263
C0179063-dinitrobenzene3-dinitrobenzene affects the expression of UCHL1 mRNA16988215
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of UCHL1 mRNA19191707
C0185994-methylcatechol4-methylcatechol inhibits the reaction [resiniferatoxin results in decreased expression of UCHL1 protein]18219259
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of UCHL1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of UCHL1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of UCHL1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of UCHL1 mRNA27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UCHL1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of UCHL1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of UCHL1 mRNA15725085
C015001arsenitearsenite results in decreased expression of UCHL1 mRNA23974009
C015001arsenitearsenite results in increased methylation of UCHL1 promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of UCHL1 mRNA"19446018
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of UCHL1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UCHL1 mRNA21871943
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UCHL1 mRNA21569818|2261060
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of UCHL1 mRNA20061341
C038328BEP protocolBEP protocol results in increased expression of UCHL1 mRNA18987330
C480180beta-1,3-D-glucan"beta-1,3-D-glucan results in increased expression of UCHL1 protein"28117141
C006780bisphenol Abisphenol A affects the expression of UCHL1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of UCHL1 mRNA12075121
C006780bisphenol Abisphenol A results in increased expression of UCHL1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of UCHL1 mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of UCHL1 protein24419708
D019256Cadmium ChlorideCadmium Chloride results in increased expression of UCHL1 mRNA20061341
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of UCHL1 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UCHL1 mRNA]"20230807
D002220CarbamazepineCarbamazepine results in decreased expression of UCHL1 mRNA22982570
D002509CephaloridineCephaloridine results in increased expression of UCHL1 mRNA18500788
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of UCHL1 mRNA26272509
C100187chloropicrinchloropicrin results in decreased expression of UCHL1 mRNA26352163
D002737ChloropreneChloroprene results in increased expression of UCHL1 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UCHL1 mRNA20938992
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in increased expression of UCHL1 mRNA23052192
D003042CocaineCocaine results in decreased expression of UCHL1 mRNA12629581
D003300CopperCopper results in increased expression of UCHL1 mRNA20875833
D003300CopperCopper results in increased expression of UCHL1 mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of UCHL1 mRNA19549813
D016578Crack CocaineCrack Cocaine results in increased expression of UCHL1 mRNA12629581
C030973cupric oxidecupric oxide results in decreased activity of UCHL1 protein25470785
D016572CyclosporineCyclosporine results in increased expression of UCHL1 mRNA27989131
C004742daidzein[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of UCHL1 mRNA16963248
C014347decitabine[[decitabine co-treated with trichostatin A] affects the methylation of UCHL1 promoter] which affects the expression of UCHL1 mRNA18666234|1866623
C014347decitabinedecitabine results in increased expression of UCHL1 mRNA19194470|2185625
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of UCHL1 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of UCHL1 mRNA25047013
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of UCHL1 protein19550292
D003976DiazinonDiazinon affects the expression of UCHL1 mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of UCHL1 mRNA18042831
D004237DiuronDiuron results in decreased expression of UCHL1 mRNA21551480
D007980LevodopaLevodopa inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA]25129099
D004317DoxorubicinDoxorubicin affects the expression of UCHL1 protein29385562
D004731EndotoxinsEndotoxins results in increased expression of UCHL1 protein28117141
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of UCHL1 protein23301498
D000431EthanolEthanol results in decreased expression of UCHL1 protein23702218
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of UCHL1 mRNA12075121
D005411Flame RetardantsFlame Retardants results in decreased expression of UCHL1 protein18550172
D005419FlavonoidsFlavonoids results in increased expression of UCHL1 mRNA18035473
D005472FluorouracilUCHL1 protein affects the susceptibility to Fluorouracil16217747
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UCHL1 mRNA20938992
C039281furanfuran results in increased expression of UCHL1 mRNA27387713
D019833Genistein[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of UCHL1 mRNA16963248
D019833GenisteinGenistein results in decreased expression of UCHL1 mRNA12075121
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of UCHL1 mRNA22634610
D005978Glutathione"Glutathione inhibits the reaction [1,2-naphthoquinone results in increased metabolism of and results in decreased activity of UCHL1 protein]"24582816
C086566glycitein[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of UCHL1 mRNA16963248
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of UCHL1 mRNA20044591
D007213IndomethacinIndomethacin results in increased expression of UCHL1 mRNA28201806
D007545IsoproterenolIsoproterenol results in increased expression of UCHL1 mRNA20003209
C016527isoquercitrinisoquercitrin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA]25129099
D007608Kainic AcidKainic Acid results in increased expression of UCHL1 protein22790971
D007657Ketone BodiesKetone Bodies results in increased expression of UCHL1 mRNA16807920
D018021Lithium ChlorideLithium Chloride results in increased expression of UCHL1 mRNA22982570
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of UCHL1 protein23562983
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of UCHL1 mRNA18386188
D008345ManganeseManganese results in decreased expression of UCHL1 protein20798247
C025340manganese chloridemanganese chloride results in decreased expression of UCHL1 protein20798247
C042720mercuric bromidemercuric bromide results in increased expression of UCHL1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
D008694MethamphetamineMethamphetamine results in decreased expression of UCHL1 protein16181420
D008694MethamphetamineMethamphetamine results in increased expression of UCHL1 protein19826936
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UCHL1 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of UCHL1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of UCHL1 mRNA20061341
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased activity of UCHL1 protein26558469
D008767Methylmercury CompoundsMethylmercury Compounds results in increased metabolism of UCHL1 protein26558469
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of UCHL1 mRNA26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of UCHL1 mRNA26011545
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of UCHL1 mRNA12634122
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UCHL1 mRNA"15329391|2023080
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UCHL1 protein"23643664
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of UCHL1 mRNA"22342763
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of UCHL1 protein"22342763
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of UCHL1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UCHL1 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of UCHL1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UCHL1 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"UCHL1 protein results in decreased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"23643664
D008777MethyltestosteroneMethyltestosterone results in decreased expression of UCHL1 mRNA29191790
D016685MitomycinUCHL1 protein affects the susceptibility to Mitomycin16217747
D008942MitoxantroneUCHL1 protein affects the susceptibility to Mitoxantrone16217747
C523799MRK 003UCHL1 results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of UCHL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of UCHL1 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of UCHL1 mRNA18687389|1897830
C031721naphthalenenaphthalene results in increased expression of UCHL1 protein18687389
C022838nickel chloridenickel chloride affects the expression of UCHL1 mRNA22546817
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of UCHL1 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UCHL1 mRNA]"20230807
C007350nitrofennitrofen results in decreased expression of UCHL1 protein21952554
C007350nitrofenTretinoin inhibits the reaction [nitrofen results in decreased expression of UCHL1 protein]21952554
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of UCHL1 mRNA"18616865
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of UCHL1 protein"18616865
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of UCHL1 mRNA]"18616865
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of UCHL1 protein]"18616865
D016627Oxidopamineisoquercitrin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA]25129099
D016627OxidopamineLevodopa inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA]25129099
D016627OxidopamineOxidopamine results in increased expression of UCHL1 mRNA25129099
D016627OxidopamineRutin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA]25129099
D017239PaclitaxelPaclitaxel results in increased expression of UCHL1 protein16797537
D000073878Palm OilPalm Oil results in increased expression of UCHL1 mRNA18042831
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of UCHL1 protein23562983
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of UCHL1 mRNA18386188
D010269ParaquatParaquat results in decreased expression of UCHL1 mRNA21371552
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of UCHL1 protein18550172
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of UCHL1 protein19954255
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of UCHL1 protein19954255
D010416PentachlorophenolPentachlorophenol results in increased expression of UCHL1 mRNA24642059
D010424PentobarbitalPentobarbital results in decreased expression of UCHL1 mRNA22982570
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of UCHL1 mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of UCHL1 mRNA19162173
C058305phenethyl isothiocyanateUCHL1 protein binds to phenethyl isothiocyanate21838287
D010656PhenylephrinePhenylephrine results in increased expression of UCHL1 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of UCHL1 mRNA26272509
C049032pinosylvinpinosylvin results in increased expression of UCHL1 mRNA23333577
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of UCHL1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of UCHL1 mRNA16985257
D011374ProgesteroneProgesterone results in decreased expression of UCHL1 mRNA20726854
D011441PropylthiouracilPropylthiouracil results in increased expression of UCHL1 mRNA24780913
D011748PyrogallolPyrogallol results in increased expression of UCHL1 mRNA20362636
C024353resiniferatoxin4-methylcatechol inhibits the reaction [resiniferatoxin results in decreased expression of UCHL1 protein]18219259
C024353resiniferatoxinresiniferatoxin results in decreased expression of UCHL1 protein18219259
D012402RotenoneRotenone results in decreased expression of UCHL1 mRNA23186747
D012431RutinRutin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA]25129099
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of UCHL1 mRNA21427059
D012524SarinSarin affects the expression of UCHL1 protein28973502
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of UCHL1 protein27613482
D012834SilverSilver results in increased expression of UCHL1 mRNA27131904
C080703SK&F 83959SK&F 83959 results in increased expression of UCHL1 protein25852303
D012906SmokeSmoke results in increased expression of UCHL1 mRNA21095227
C017947sodium arsenitesodium arsenite results in decreased methylation of UCHL1 gene25199682
C017947sodium arsenitesodium arsenite results in increased expression of UCHL1 mRNA21281968
C017947sodium arsenitesodium arsenite results in increased expression of UCHL1 mRNA16014739|2527062
C028982sodium chromate(VI)ERRFI1 protein inhibits the reaction [sodium chromate(VI) results in increased expression of UCHL1 protein]28688920
C028982sodium chromate(VI)sodium chromate(VI) results in increased expression of UCHL1 protein28688920
D012969Sodium FluorideSodium Fluoride results in decreased expression of UCHL1 protein28918527
D013605T-2 ToxinT-2 Toxin affects the expression of UCHL1 protein26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UCHL1 mRNA18495758
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UCHL1 mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UCHL1 mRNA22298810
D013806TheophyllineTheophylline affects the expression of UCHL1 mRNA16988215
C009495titanium dioxidetitanium dioxide results in decreased expression of UCHL1 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of UCHL1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of UCHL1 mRNA28065790
C024746tobacco tartobacco tar results in increased expression of UCHL1 mRNA19559774
D019772TopotecanUCHL1 protein affects the susceptibility to Topotecan16217747
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of UCHL1 mRNA"17951470
D014212TretinoinTretinoin inhibits the reaction [nitrofen results in decreased expression of UCHL1 protein]21952554
C012589trichostatin Atrichostatin A results in increased expression of UCHL1 mRNA15901671
C012589trichostatin A[[decitabine co-treated with trichostatin A] affects the methylation of UCHL1 promoter] which affects the expression of UCHL1 mRNA18666234|1866623
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in increased expression of UCHL1 mRNA23052192
D014635Valproic AcidValproic Acid results in increased expression of UCHL1 mRNA15901671|2298257
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of UCHL1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of UCHL1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of UCHL1 mRNA19136453|2142705
D014750VincristineVincristine results in increased expression of UCHL1 protein16797537
D014810Vitamin EVitamin E results in increased expression of UCHL1 mRNA19244175
D019287Zinc Sulfate"Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of UCHL1 mRNA]"18616865
D019287Zinc Sulfate"Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of UCHL1 protein]"18616865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004197cysteine-type endopeptidase activity-IDA8639624  
GO:0004843thiol-dependent ubiquitin-specific protease activity-IBA21873635  
GO:0004843thiol-dependent ubiquitin-specific protease activity-IDA9521656  
GO:0005515protein binding-IPI12082530  20029029  21044950  
GO:0008242omega peptidase activity-IDA9521656  
GO:0016874ligase activity-IEA-  
GO:0031625ubiquitin protein ligase binding-IPI19725078  
GO:0031694alpha-2A adrenergic receptor binding-IPI19477270  
GO:0036459thiol-dependent ubiquitinyl hydrolase activity-TAS-  
GO:0043130ubiquitin binding-IDA9521656  
GO ID GO Term Qualifier Evidence PubMed
GO:0002931response to ischemia-IEA-  
GO:0007412axon target recognition-IEA-  
GO:0007628adult walking behavior-IEA-  
GO:0008283cell proliferation-IEA-  
GO:0016241regulation of macroautophagy-TAS24879150  
GO:0016579protein deubiquitination-IBA21873635  
GO:0016579protein deubiquitination-IDA9521656  
GO:0016579protein deubiquitination-TAS-  
GO:0019233sensory perception of pain-IEA-  
GO:0019896axonal transport of mitochondrion-IEA-  
GO:0042755eating behavior-IEA-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-NAS24252804  
GO:0043407negative regulation of MAP kinase activity-IDA19477270  
GO:0048747muscle fiber development-IEA-  
GO:0050905neuromuscular process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA19477270  
GO:0005737cytoplasm-ISS-  
GO:0005737cytoplasm-TAS16130169  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membranecolocalizes_withIDA19477270  
GO:0043025neuronal cell body-IEA-  
GO:0043209myelin sheath-IEA-  
GO:0044306neuron projection terminus-IEA-  
GO:1904115axon cytoplasm-IEA-  
KEGG ID KEGG Term
hsa05012Parkinson's disease
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689603UCH proteinasesTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28117141Influence of exposure to coarse, fine and ultrafine urban particulate matter and their biological constituents on neural biomarkers in a randomized controlled crossover study. (2017 Apr)Liu LEnviron Int
22083596Stool DNA testing for the detection of pancreatic cancer: assessment of methylation marker candidates. (2012 May 15)Kisiel JBCancer
17108109Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers. (2006 Nov 15)Carolan BJCancer Res
19472401The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)Oka DCancer
26317789LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation. (2015 Sep 22)Lee CHOncotarget
22839974UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan. (2012 Jul 28)Miyake YBMC Neurol
18210157Exploring gene-environment interactions in Parkinson's disease. (2008 Apr)McCulloch CCHum Genet
22414467Preliminary study analyzing the methylated genes in the plasma of patients with pancreatic cancer. (2012)Park JWScand J Surg
2082567Warthin's tumour in Jamaica. Incidence, electron microscopy and immunoenzyme studies. (1990 Dec)Shah DWest Indian Med J