Gene: UCHL3

7347
UCH-L3
ubiquitin C-terminal hydrolase L3
protein-coding
13q22.2
Ensembl:ENSG00000118939 MIM:603090 Vega:OTTHUMG00000017090 UniprotKB:P15374
NC_000013.11
SNP Mapped
1   ANCO-SNPs
ND
0   
3.567e-1 (AD)  2.412e-2 (ND)   (Frontal_Cortex)
8.520e-1 (AD)  5.862e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4885322chr13:75597195 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARPC50.759
SSBP10.751
POMP0.746
NACA0.746
NPM10.74
GNG100.74
HSPB110.738
PPP1CB0.737
EIF3H0.735
HNRNPR0.735

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.596
OR4F29-0.567
SDIM1-0.213
HIST1H4C-0.19
S100A11P1-0.187
SPDYE1-0.187
LRRC52-0.186
OR2A14-0.182
ANKRD18B-0.181
PRAMEF17-0.18

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of UCHL3 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of UCHL3 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of UCHL3 mRNA27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UCHL3 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of UCHL3 protein25419056
D001622BetaineBetaine inhibits the reaction [Copper deficiency affects the expression of UCHL3 protein]25150618
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of UCHL3 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of UCHL3 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of UCHL3 mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of UCHL3 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride affects the localization of UCHL3 protein18261755
D004390ChlorpyrifosChlorpyrifos results in decreased expression of UCHL3 mRNA18668222
C018021cobaltous chloridecobaltous chloride results in decreased expression of UCHL3 mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in decreased expression of UCHL3 protein16622835
D003042CocaineCocaine affects the expression of UCHL3 mRNA20187946
D003300CopperBetaine inhibits the reaction [Copper deficiency affects the expression of UCHL3 protein]25150618
D003300CopperCopper deficiency affects the expression of UCHL3 protein25150618
D019327Copper SulfateCopper Sulfate results in increased expression of UCHL3 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of UCHL3 mRNA20106945|2556210
C016366dibenzothiophenedibenzothiophene results in decreased expression of UCHL3 mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of UCHL3 mRNA17361019
C000944dicrotophosdicrotophos results in decreased expression of UCHL3 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of UCHL3 mRNA26924002
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of UCHL3 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of UCHL3 mRNA]19850644
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of UCHL3 mRNA20360939
C024629dimethyl phthalatedimethyl phthalate affects the expression of UCHL3 mRNA26924002
D004237DiuronDiuron results in increased expression of UCHL3 mRNA21551480
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of UCHL3 mRNA19118595
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of UCHL3 mRNA20064776
D005839GentamicinsGentamicins results in increased expression of UCHL3 mRNA22061828
D005947GlucoseGlucose deficiency results in increased secretion of UCHL3 protein24802182
C492448ICG 001ICG 001 results in decreased expression of UCHL3 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of UCHL3 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of UCHL3 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of UCHL3 mRNA23458150
D052998MicrocystinsMicrocystins results in decreased expression of UCHL3 protein22430071
C517284monomethyl phthalatemonomethyl phthalate affects the expression of UCHL3 mRNA26924002
D010634PhenobarbitalPhenobarbital affects the expression of UCHL3 mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of UCHL3 mRNA26272509
D010695PhlorhizinPhlorhizin results in decreased expression of UCHL3 mRNA22538082
C006253pirinixic acidpirinixic acid results in increased expression of UCHL3 mRNA18301758|2381119
C031280pyrazolepyrazole results in increased expression of UCHL3 mRNA17945193
D011794QuercetinQuercetin results in decreased expression of UCHL3 mRNA21632981
D012524SarinSarin results in decreased expression of UCHL3 mRNA19522546
C009237senecioninesenecionine results in increased expression of UCHL3 mRNA26100227
C009238senkirkinesenkirkine results in increased expression of UCHL3 mRNA26100227
D012822Silicon DioxideSilicon Dioxide results in decreased expression of UCHL3 mRNA19073995
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UCHL3 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of UCHL3 mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of UCHL3 mRNA26217789
D014241TrichloroethyleneTrichloroethylene results in increased methylation of UCHL3 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of UCHL3 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of UCHL3 mRNA19042947
C022884undecaneundecane results in decreased expression of UCHL3 protein17337753
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UCHL3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of UCHL3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of UCHL3 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of UCHL3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004843thiol-dependent ubiquitin-specific protease activity-IBA21873635  
GO:0004843thiol-dependent ubiquitin-specific protease activity-IDA9521656  
GO:0005515protein binding-IPI21453705  
GO:0008233peptidase activity-IDA21762696  
GO:0019784NEDD8-specific protease activity-TAS-  
GO:0036459thiol-dependent ubiquitinyl hydrolase activity-TAS2530630  
GO:0043130ubiquitin binding-IDA19154770  
GO ID GO Term Qualifier Evidence PubMed
GO:0006511ubiquitin-dependent protein catabolic process-IEA-  
GO:0016579protein deubiquitination-IBA21873635  
GO:0016579protein deubiquitination-IDA9521656  
GO:0016579protein deubiquitination-TAS-  
GO:0030163protein catabolic process-IDA21762696  
GO:0043687post-translational protein modification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689603UCH proteinasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8852135Protein ubiquitinationTAS
R-HSA-8866652Synthesis of active ubiquitin: roles of E1 and E2 enzymesTAS
R-HSA-8951664NeddylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal