Gene info: ID 7349

Gene: UCN

GENE ID: 7349

Synonyms: UI|UROC

Description: urocortin

Gene type: protein-coding

Location: 2p23.3

dbXrefs: Ensembl:ENSG00000163794 MIM:600945 Vega:OTTHUMG00000097068 UniprotKB:P55089

RefSeq: NG_033055.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|AD

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.088e-1 (AD) 2.581e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C1orf35	0.842
UBAP1L	0.835
MZF1	0.833
RFNG	0.822
PIAS4	0.813
ANKRD13B	0.803
GLI4	0.8
ZNF692	0.795
PTDSS2	0.795
CDK10	0.789

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FER1L6	-0.465
GSDMA	-0.417
OR4F5	-0.416
UNC45B	-0.41
PDE5A	-0.406
PABPC4L	-0.401
SUCNR1	-0.4
OR4F29	-0.399
ARHGEF35	-0.395
COL14A1	-0.395

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased susceptibility to UCN protein	20237592
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of UCN mRNA"	19114083
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of UCN mRNA	16483693
C104416	astressin	astressin inhibits the reaction [UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Calcium]]	17885217
C104416	astressin	astressin inhibits the reaction [UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Manganese]]	17885217
C104416	astressin	astressin results in decreased susceptibility to UCN protein	20237592
C528574	astressin-2B	astressin-2B results in decreased activity of UCN protein	12010772
C120841	astressin B	astressin B inhibits the reaction [UCN protein inhibits the reaction [CGB3 results in increased abundance of Testosterone]]	18719027
C120841	astressin B	astressin B results in decreased activity of UCN protein	12010772
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of UCN mRNA	15034205
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of UCN protein	20833230
D004958	Estradiol	Estradiol results in increased expression of UCN mRNA	20833230
D004958	Estradiol	Progesterone inhibits the reaction [Estradiol results in increased expression of UCN mRNA]	20833230
C006780	bisphenol A	bisphenol A results in decreased expression of UCN mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of UCN gene	28505145
D002104	Cadmium	Cadmium results in increased expression of UCN mRNA	24376830
C034939	cadmium sulfide	[cadmium telluride co-treated with cadmium sulfide] results in decreased expression of UCN mRNA	20596552
C028337	cadmium telluride	[cadmium telluride co-treated with cadmium sulfide] results in decreased expression of UCN mRNA	20596552
D002118	Calcium	astressin inhibits the reaction [UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Calcium]]	17885217
D002118	Calcium	UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Calcium]	17885217
D019327	Copper Sulfate	Copper Sulfate results in increased expression of UCN mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in increased expression of UCN mRNA	25562108
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of UCN mRNA	28412506
C082360	fipronil	fipronil results in decreased expression of UCN mRNA	23962444
D005419	Flavonoids	Flavonoids results in increased expression of UCN mRNA	18035473
C039281	furan	furan results in increased methylation of UCN gene	22079235
C544151	jinfukang	jinfukang results in increased expression of UCN mRNA	27392435
C057416	KT 5720	KT 5720 inhibits the reaction [UCN protein results in decreased expression of PLA2G6 protein]	17885217
D008070	Lipopolysaccharides	Lipopolysaccharides affects the localization of UCN protein	12559087
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of UCN protein	12559087
D008345	Manganese	astressin inhibits the reaction [UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Manganese]]	17885217
D008345	Manganese	UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Manganese]	17885217
C028007	nickel monoxide	nickel monoxide results in decreased expression of UCN mRNA	19167457
D009569	Nitric Oxide	UCN protein results in increased abundance of Nitric Oxide	20237592
D010656	Phenylephrine	UCN protein affects the susceptibility to Phenylephrine	17885217
D010936	Plant Extracts	Plant Extracts results in decreased expression of UCN mRNA	23557933
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of UCN protein	20833230
D011374	Progesterone	Progesterone inhibits the reaction [Estradiol results in increased expression of UCN mRNA]	20833230
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of UCN mRNA	24780913
C428725	pyridaben	pyridaben results in decreased expression of UCN mRNA	22563483
D011794	Quercetin	Quercetin results in increased expression of UCN mRNA	21632981
D012834	Silver	Silver analog results in decreased expression of UCN mRNA	22727896
D012835	Silver Nitrate	Silver Nitrate results in increased expression of UCN mRNA	22727896
D013739	Testosterone	astressin B inhibits the reaction [UCN protein inhibits the reaction [CGB3 results in increased abundance of Testosterone]]	18719027
D013739	Testosterone	UCN protein inhibits the reaction [CGB3 results in increased abundance of Testosterone]	18719027
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of UCN mRNA	15034205
D019284	Thapsigargin	astressin inhibits the reaction [UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Calcium]]	17885217
D019284	Thapsigargin	astressin inhibits the reaction [UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Manganese]]	17885217
D019284	Thapsigargin	UCN protein inhibits the reaction [Thapsigargin results in increased activity of PLA2G6 protein]	17885217
D019284	Thapsigargin	UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Calcium]	17885217
D019284	Thapsigargin	UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Manganese]	17885217
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of UCN gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005184	neuropeptide hormone activity	-	TAS	8612563
GO:0005515	protein binding	-	IPI	18234674
GO:0017045	corticotropin-releasing hormone activity	-	IBA	21873635
GO:0046811	histone deacetylase inhibitor activity	-	IEA	-
GO:0051430	corticotropin-releasing hormone receptor 1 binding	-	IEA	-
GO:0051431	corticotropin-releasing hormone receptor 2 binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001964	startle response	-	IEA	-
GO:0006954	inflammatory response	-	IEA	-
GO:0006979	response to oxidative stress	-	IEA	-
GO:0007165	signal transduction	-	IBA	21873635
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	8612563
GO:0007218	neuropeptide signaling pathway	-	IEA	-
GO:0007565	female pregnancy	-	IEA	-
GO:0007605	sensory perception of sound	-	IEA	-
GO:0008306	associative learning	-	IEA	-
GO:0009060	aerobic respiration	-	IEA	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0010629	negative regulation of gene expression	-	IEA	-
GO:0010996	response to auditory stimulus	-	IEA	-
GO:0030157	pancreatic juice secretion	-	IEA	-
GO:0030307	positive regulation of cell growth	-	IEA	-
GO:0031064	negative regulation of histone deacetylation	-	IEA	-
GO:0031175	neuron projection development	-	IEA	-
GO:0032099	negative regulation of appetite	-	IEA	-
GO:0032355	response to estradiol	-	IEA	-
GO:0032755	positive regulation of interleukin-6 production	-	IEA	-
GO:0032811	negative regulation of epinephrine secretion	-	IBA	21873635
GO:0032967	positive regulation of collagen biosynthetic process	-	IEA	-
GO:0033138	positive regulation of peptidyl-serine phosphorylation	-	IEA	-
GO:0034199	activation of protein kinase A activity	-	IEA	-
GO:0035176	social behavior	-	IEA	-
GO:0035483	gastric emptying	-	IEA	-
GO:0042756	drinking behavior	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IEA	-
GO:0043117	positive regulation of vascular permeability	-	IEA	-
GO:0043950	positive regulation of cAMP-mediated signaling	-	IEA	-
GO:0045727	positive regulation of translation	-	IEA	-
GO:0045740	positive regulation of DNA replication	-	IEA	-
GO:0045776	negative regulation of blood pressure	-	IEA	-
GO:0045792	negative regulation of cell size	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0046888	negative regulation of hormone secretion	-	IEA	-
GO:0048265	response to pain	-	IEA	-
GO:0051384	response to glucocorticoid	-	IEA	-
GO:0051461	positive regulation of corticotropin secretion	-	IDA	11329063
GO:0051464	positive regulation of cortisol secretion	-	IBA	21873635
GO:0051966	regulation of synaptic transmission, glutamatergic	-	IEA	-
GO:0060452	positive regulation of cardiac muscle contraction	-	IEA	-
GO:0060455	negative regulation of gastric acid secretion	-	IEA	-
GO:0060547	negative regulation of necrotic cell death	-	IEA	-
GO:0070093	negative regulation of glucagon secretion	-	IBA	21873635
GO:0090280	positive regulation of calcium ion import	-	IEA	-
GO:0097755	positive regulation of blood vessel diameter	-	IEA	-
GO:1901215	negative regulation of neuron death	-	IEA	-
GO:2000252	negative regulation of feeding behavior	-	IBA	21873635
GO:2000987	positive regulation of behavioral fear response	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0030425	dendrite	-	IEA	-
GO:0043196	varicosity	-	IEA	-
GO:0043204	perikaryon	-	IEA	-
GO:0043679	axon terminus	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-2980736	Peptide hormone metabolism	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373080	Class B/2 (Secretin family receptors)	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-422085	Synthesis, secretion, and deacylation of Ghrelin	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
15659593	Chronic cocaine administration switches corticotropin-releasing factor2 receptor-mediated depression to facilitation of glutamatergic transmission in the lateral septum. (2005 Jan 19)	Liu J	J Neurosci
16766036	The urocortin 1 neurocircuit: ethanol-sensitivity and potential involvement in alcohol consumption. (2006 Sep)	Ryabinin AE	Brain Res Rev
12657708	The Edinger-Westphal-lateral septum urocortin pathway and its relationship to alcohol consumption. (2003 Mar 15)	Bachtell RK	J Neurosci
22444954	Urocortins: CRF's siblings and their potential role in anxiety, depression and alcohol drinking behavior. (2012 Jun)	Ryabinin AE	Alcohol
29056154	Contribution of Urocortin to the Development of Excessive Drinking. (2017)	Ryabinin AE	Int Rev Neurobiol