Gene: C9

735
ARMD15|C9D
complement C9
protein-coding
5p13.1
Ensembl:ENSG00000113600 MIM:120940 Vega:OTTHUMG00000094767 UniprotKB:P02748
NG_009894.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.428e-1 (AD)  1.656e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLNK0.6
NLRP130.548
MBL20.545
OR14J10.543
AADACL30.534
OR1I10.531
TDRD150.529
OR2H10.521
TRIM600.519
PCAT40.515

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TJP3-0.224
CNKSR1-0.219
TMEM81-0.219
CPO-0.217
ZNF341-0.215
SPON2-0.214
TEX29-0.209
MYOM2-0.207
CACNG3-0.206
WNT2-0.204

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of C9 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of C9 mRNA"28903501
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of C9 mRNA20566314
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of C9 mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of C9 mRNA"19114083
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of C9 mRNA"25710175
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of C9 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of C9 mRNA"18648102
C0415944-nonylphenol4-nonylphenol affects the expression of C9 mRNA15792627
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of C9 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of C9 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of C9 mRNA16483693
D001151ArsenicArsenic affects the expression of C9 mRNA28793237
D001151Arsenic[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of C9 mRNA28793237
D053119BenzophenanthridinesBenzophenanthridines analog results in decreased expression of C9 mRNA22120849
D004958EstradiolEstradiol affects the expression of C9 mRNA23557687
C006780bisphenol Abisphenol A results in increased expression of C9 mRNA27104808
C006780bisphenol Abisphenol A results in decreased expression of C9 mRNA25181051
C032036bromobenzenebromobenzene results in decreased expression of C9 mRNA12628495
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of C9 mRNA18804290
D002101Cacodylic Acid[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of C9 mRNA28793237
D002104CadmiumCadmium results in increased expression of C9 mRNA24084258
D019256Cadmium ChlorideCadmium Chloride results in increased expression of C9 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride affects the expression of C9 mRNA22110744
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of C9 mRNA16239168
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of C9 mRNA18804290
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of C9 mRNA27344345
C019304ciprofibrateciprofibrate results in decreased expression of C9 mRNA12771043
C018021cobaltous chloridecobaltous chloride results in decreased expression of C9 mRNA24386269
C016310cobra venom factorcobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]9250166
D003300CopperC9 protein binds to Copper23896426
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of C9 mRNA17383702
D016572CyclosporineCyclosporine results in decreased expression of C9 mRNA27989131
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased expression of C9 mRNA18709148
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of C9 mRNA28962523
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of C9 mRNA19245819
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of C9 mRNA12771043
D000431EthanolEthanol results in decreased expression of C9 mRNA19167417
D000431EthanolEthanol results in increased expression of C9 protein19609968
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of C9 mRNA17108234
C024565ethylene dichlorideethylene dichloride results in decreased expression of C9 mRNA28189721
D011345FenofibrateFenofibrate results in decreased expression of C9 mRNA11798191
D005485FlutamideFlutamide results in decreased expression of C9 mRNA24136188
C039281furanfuran results in decreased expression of C9 mRNA25539665
D005897GlafenineGlafenine results in increased expression of C9 mRNA24136188
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of C9 mRNA22467014
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of C9 mRNA20566314
D007545IsoproterenolIsoproterenol results in increased expression of C9 mRNA24286936
C008261lead acetatelead acetate results in decreased expression of C9 mRNA22609695
C052901lemongrass oillemongrass oil affects the expression of C9 mRNA25976427
D008627Mercuric ChlorideMercuric Chloride affects the expression of C9 mRNA20353558
D008727MethotrexateMethotrexate affects the expression of C9 mRNA18502557
C005219methyl cellosolvemethyl cellosolve results in increased expression of C9 mRNA19643169
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of C9 mRNA23103053
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of C9 mRNA27544571
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of C9 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of C9 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased secretion of C9 protein"25598225
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of C9 mRNA27344345
C051752nefazodonenefazodone results in decreased expression of C9 mRNA24136188
D009532NickelC9 protein binds to Nickel23896426
D009532NickelNickel results in increased expression of C9 mRNA24084258
C022838nickel chloridenickel chloride affects the expression of C9 mRNA22546817
C012655nimesulidenimesulide results in decreased expression of C9 mRNA24136188
C025589ochratoxin Aochratoxin A results in increased expression of C9 mRNA22124623
C076029olanzapineolanzapine affects the phosphorylation of C9 protein25821032
D053610Opiate AlkaloidsC9 gene SNP affects the susceptibility to Opiate Alkaloids18438686
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of C9 mRNA21984479
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of C9 mRNA20936131
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of C9 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of C9 mRNA25868421
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of C9 mRNA18467677|2093613
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of C9 mRNA]18467677
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of C9 mRNA19162173
D010634PhenobarbitalPhenobarbital results in decreased expression of C9 mRNA19084549
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of C9 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of C9 mRNA19136022
D010634PhenobarbitalPhenobarbital results in decreased expression of C9 mRNA19482888|2309116
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of C9 mRNA]17950772
C006253pirinixic acidpirinixic acid affects the expression of C9 mRNA19136022
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of C9 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of C9 mRNA11798191|1530286
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of C9 mRNA]17950772|1846767
C045950propiconazolepropiconazole results in decreased expression of C9 mRNA19363144
D011692Puromycin AminonucleosideCR1 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]9250166
D011692Puromycin Aminonucleosidecobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]9250166
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]9250166
C539676rEV576 protein, tick"rEV576 protein, tick affects the expression of and affects the activity of C9 protein"17215252
C539676rEV576 protein, tick"rEV576 protein, tick affects the expression of and affects the activity of C9 protein"19194881
C009277sodium arsenatesodium arsenate results in increased expression of C9 mRNA23922661
C017947sodium arsenitesodium arsenite affects the expression of C9 mRNA19590694
C016104sodium bichromatesodium bichromate results in decreased expression of C9 mRNA24612858
C016104sodium bichromatesodium bichromate affects the expression of C9 mRNA22110744
D018038Sodium SeleniteSodium Selenite results in decreased expression of C9 mRNA18175754
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of C9 mRNA22467014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of C9 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of C9 mRNA16267337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of C9 mRNA22298810
D014241TrichloroethyleneTrichloroethylene results in decreased expression of C9 mRNA25549359
C012589trichostatin Atrichostatin A results in decreased expression of C9 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of C9 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of C9 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of C9 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001906cell killing-IDA26841934  
GO:0006957complement activation, alternative pathway-IEA-  
GO:0006958complement activation, classical pathway-IEA-  
GO:0019836hemolysis by symbiont of host erythrocytes-TAS2426252  
GO:0030449regulation of complement activation-TAS-  
GO:0051260protein homooligomerization-IDA26841934  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005579membrane attack complex-IDA22832194  26841934  
GO:0005615extracellular space-IDA22832194  26841934  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA26841934  
GO:0005887integral component of plasma membrane-TAS2426252  
GO:0044218other organism cell membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa05020Prion diseases
hsa05146Amoebiasis
hsa05322Systemic lupus erythematosus
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-166665Terminal pathway of complementTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26394123Serum apolipoprotein A-1 quantification by LC-MS with a SILAC internal standard reveals reduced levels in smokers. (2015)Wang QBioanalysis
3465543Effects of smoking on inflammatory mediators and their relationship to pulmonary dysfunction. (1986)Bridges RBEur J Respir Dis Suppl
3871890Increased plasma concentrations of C9, C1-inhibitor and alpha 1-protease inhibitor associated with cigarette smoking. (1985 Mar 11)Bridges RBLife Sci
28671968Systemic complement activation in central serous chorioretinopathy. (2017)van Dijk EHCPLoS One