Gene: UCP1

7350
SLC25A7|UCP
uncoupling protein 1
protein-coding
4q31.1
Ensembl:ENSG00000109424 MIM:113730 Vega:OTTHUMG00000133415 UniprotKB:P25874
NG_012139.1
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.822e-1 (AD)  4.038e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEU20.618
ZIM30.616
POU5F20.605
MTRNR2L50.6
OMP0.593
APOBEC40.591
POU4F10.582
PCAT40.573
OR56A40.572
TAS2R300.57

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFTPD-0.303
CCDC175-0.278
CPO-0.272
MESP2-0.27
CIDEA-0.269
NME9-0.265
FAAH-0.264
SPAG8-0.261
OMG-0.26
HENMT1-0.26

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of UCP1 mRNA23792671
C0620781-(carboxymethylthio)tetradecane1-(carboxymethylthio)tetradecane results in decreased expression of UCP1 mRNA23226405
C0620781-(carboxymethylthio)tetradecane[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of UCP1 mRNA23226405
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]11742803
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]11742803
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]11742803
C5451212-((4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy)methyl)quinoline2-((4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy)methyl)quinoline results in increased expression of UCP1 mRNA27247380
C5451212-((4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy)methyl)quinoline2-((4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy)methyl)quinoline results in increased expression of UCP1 mRNA27247380
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]11742803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]11742803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]11742803
C4086042-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [alitretinoin results in increased expression of UCP1 mRNA]12414803
C4086042-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [rosiglitazone results in increased expression of UCP1 mRNA]12414803
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of UCP1 mRNA"23829299
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]27805061
C0978693-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [amibegron results in increased expression of UCP1 mRNA]"9718277
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of UCP1 mRNA"10600643
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased expression of UCP1 protein]"25761413
C106538abacavirabacavir results in increased expression of UCP1 mRNA14518702
D000082AcetaminophenAcetaminophen affects the expression of UCP1 mRNA25064622
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of UCP1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of UCP1 mRNA]17585979
D000255Adenosine TriphosphateUCP1 protein promotes the reaction [PPARG protein mutant form results in decreased abundance of Adenosine Triphosphate]26670611
D000255Adenosine TriphosphateUCP1 protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]26670611
D000255Adenosine TriphosphateUCP1 results in decreased abundance of Adenosine Triphosphate26670611
D000255Adenosine TriphosphateAdenosine Triphosphate inhibits the reaction [UCP1 protein results in increased transport of Protons]12734183
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of UCP1 mRNA19920212
C412373AG 1879AG 1879 promotes the reaction [Norepinephrine results in increased expression of UCP1 mRNA]10788502
D000420AlbuterolAlbuterol results in increased expression of UCP1 protein10465291
C103303alitretinoinalitretinoin results in increased expression of UCP1 mRNA10600643
C103303alitretinoin2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [alitretinoin results in increased expression of UCP1 mRNA]12414803
C103303alitretinoinalitretinoin results in increased expression of UCP1 mRNA12414803
C103303alitretinoinGlutathione inhibits the reaction [alitretinoin results in increased expression of UCP1 mRNA]12414803
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of UCP1 mRNA21298039
C076252amibegron"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [amibegron results in increased expression of UCP1 mRNA]"9718277
C076252amibegronamibegron results in increased expression of UCP1 mRNA9718277
D000638AmiodaroneAmiodarone affects the expression of UCP1 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UCP1 mRNA16483693
D001151ArsenicArsenic results in increased expression of UCP1 mRNA19654921
C006632arsenic trioxidearsenic trioxide results in increased expression of UCP1 mRNA24356939
C517975AZD 6244AZD 6244 inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]27805061
D001507BeclomethasoneBeclomethasone results in increased expression of UCP1 mRNA23656298
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of UCP1 mRNA27858113
D001554BenzeneBenzene results in decreased expression of UCP1 mRNA15929907
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of UCP1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of UCP1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in decreased expression of UCP1 mRNA24356939
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UCP1 mRNA17879257
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of UCP1 mRNA27858113
D004958EstradiolEstradiol results in decreased expression of UCP1 mRNA19484750
D004958EstradiolEstradiol results in increased expression of UCP1 mRNA21683088
C495703bis(2-chloroethoxy)methanebis(2-chloroethoxy)methane affects the expression of UCP1 mRNA16844662
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]11742803
C070515bisindolylmaleimide Ibisindolylmaleimide I promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]11742803
C070515bisindolylmaleimide Ibisindolylmaleimide I promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]11742803
C006780bisphenol Abisphenol A affects the expression of UCP1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of UCP1 mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of UCP124726836
C006780bisphenol Abisphenol A results in increased expression of UCP1 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of UCP1 mRNA27104808
C006780bisphenol Abisphenol A results in decreased expression of UCP1 mRNA25181051
C057368BRL 37344BRL 37344 results in increased expression of UCP1 protein10465291
D019256Cadmium ChlorideCadmium Chloride results in increased expression of UCP1 mRNA17961207
D002211CapsaicinCapsaicin promotes the reaction [Dietary Fats results in increased expression of UCP1 mRNA]20359164
D002211CapsaicinCapsaicin results in decreased expression of UCP1 mRNA18079164
D002211CapsaicinCapsaicin results in decreased expression of UCP1 protein18079164
D002746ChlorpromazineChlorpromazine affects the expression of UCP1 mRNA25064622
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of UCP1 mRNA]16940432
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of UCP1 mRNA27858113
D002976ClenbuterolClenbuterol results in increased expression of UCP1 protein10465291
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of UCP1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of UCP1 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of UCP1 mRNA21139344
D003300CopperCopper results in decreased expression of UCP1 mRNA26293553
D003474CurcuminCurcumin affects the expression of UCP1 mRNA27208389
C000541cyclopamine"cyclopamine inhibits the reaction [N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in increased expression of UCP1 mRNA]"25487280
C000541cyclopaminecyclopamine inhibits the reaction [tofacitinib results in increased expression of UCP1 mRNA]25487280
D003520CyclophosphamideCyclophosphamide metabolite results in decreased expression of UCP1 mRNA24356939
D016572CyclosporineCyclosporine affects the expression of UCP1 mRNA25064622
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UCP1 mRNA28659758
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased expression of UCP1 mRNA12659879
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased expression of UCP1 mRNA12659879
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased expression of UCP1 protein12659879
D003907DexamethasoneDexamethasone results in increased expression of UCP1 mRNA19853017
D003907Dexamethasone(+)-JQ1 compound inhibits the reaction [[Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA]26972250
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 mRNA29288687
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein29288687
D003907DexamethasoneN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein]29288687
D003907Dexamethasone[PRKACA protein affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 mRNA29288687
D003907DexamethasonePRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 mRNA]29288687
D003907DexamethasonePRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein]29288687
D003907Dexamethasone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 mRNA29288687
D003907Dexamethasone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein29288687
D003907Dexamethasone[Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA26972250
D003994BucladesineBucladesine results in increased expression of UCP1 mRNA12414803
D003994BucladesineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of UCP1 mRNA]12414803
D018119StavudineStavudine results in increased expression of UCP116038477
D018119StavudineStavudine results in decreased expression of UCP1 mRNA17926646
D004041Dietary Fats"[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of UCP1 mRNA"24872412
D004041Dietary FatsANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of UCP1 mRNA]28842503
D004041Dietary FatsDietary Fats affects the expression of UCP1 mRNA27805061|2884250
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of UCP1 mRNA28611668
D004041Dietary FatsDietary Fats results in decreased expression of UCP1 mRNA18042831|2446501
D004041Dietary FatsHarmine affects the reaction [Dietary Fats affects the expression of UCP1 mRNA]27805061
D004041Dietary Fats[INT 131 co-treated with Dietary Fats co-treated with Dietary Sugars] results in increased expression of UCP1 mRNA28611668
D004041Dietary FatsINT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of UCP1 mRNA]28611668
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA]24465016
D004041Dietary Fats[rosiglitazone co-treated with Dietary Fats co-treated with Dietary Sugars] results in increased expression of UCP1 mRNA28611668
D004041Dietary Fatsrosiglitazone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of UCP1 mRNA]28611668
D004041Dietary FatsCapsaicin promotes the reaction [Dietary Fats results in increased expression of UCP1 mRNA]20359164
D004041Dietary FatsDietary Fats results in increased expression of UCP1 mRNA20359164
D000073417Dietary Sugars[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of UCP1 mRNA28611668
D000073417Dietary Sugars[INT 131 co-treated with Dietary Fats co-treated with Dietary Sugars] results in increased expression of UCP1 mRNA28611668
D000073417Dietary SugarsINT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of UCP1 mRNA]28611668
D000073417Dietary Sugars[rosiglitazone co-treated with Dietary Fats co-treated with Dietary Sugars] results in increased expression of UCP1 mRNA28611668
D000073417Dietary Sugarsrosiglitazone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of UCP1 mRNA]28611668
C076126disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate"disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of UCP1 mRNA"20184727
D0192972,4-Dinitrophenol"[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of UCP1 mRNA"24872412
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of UCP1 mRNA25064622
D005227Fatty AcidsUCP1 protein results in decreased abundance of Fatty Acids10973929
D005230Fatty Acids, Nonesterified"UCP1 protein promotes the reaction [PPARG protein mutant form results in increased abundance of Fatty Acids, Nonesterified]"26670611
D005230Fatty Acids, Nonesterified"UCP1 protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in increased abundance of Fatty Acids, Nonesterified]]"26670611
D005419FlavonoidsFlavonoids results in decreased expression of UCP1 mRNA18035473
D004397FonofosFonofos results in increased methylation of UCP1 promoter22847954
D005947Glucose[UCP1 protein results in decreased chemical synthesis of Superoxides] inhibits the reaction [Glucose results in decreased activity of NOS3 protein]11696579
D005947Glucose[UCP1 protein results in decreased chemical synthesis of Superoxides] inhibits the reaction [Glucose results in decreased phosphorylation of NOS3 protein]11696579
D005947Glucose[UCP1 protein results in decreased chemical synthesis of Superoxides] inhibits the reaction [Glucose results in increased O-linked glycosylation of NOS3 protein]11696579
D005947GlucoseUCP1 protein results in decreased susceptibility to Glucose11696579
D005947GlucoseUCP1 inhibits the reaction [Glucose results in decreased expression of GLO1 protein]19833897
D005947GlucoseUCP1 inhibits the reaction [Glucose results in increased expression of AGER mRNA]19833897
D005947GlucoseUCP1 inhibits the reaction [Glucose results in increased expression of AGER protein]19833897
D005947GlucoseUCP1 inhibits the reaction [Glucose results in increased expression of and results in increased secretion of HMGB1 protein]19833897
D005947GlucoseUCP1 inhibits the reaction [Glucose results in increased expression of HMGB1 mRNA]19833897
D005947GlucoseUCP1 inhibits the reaction [Glucose results in increased expression of S100A12 mRNA]19833897
D005947GlucoseUCP1 inhibits the reaction [Glucose results in increased expression of S100A8 mRNA]19833897
D005947GlucoseUCP1 inhibits the reaction [Glucose results in increased expression of S100A8 protein]19833897
D005947GlucoseUCP1 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]11050244
D005947GlucoseUCP1 protein inhibits the reaction [Glucose results in increased chemical synthesis of Dinoprostone]14514642
D005947GlucoseUCP1 protein inhibits the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species]14514642
D005947GlucoseUCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]11050244
D005947GlucoseUCP1 protein inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]11050244
D005947GlucoseUCP1 protein inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]11050244
D005947GlucoseUCP1 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein]11050244
D005947GlucoseUCP1 protein results in decreased susceptibility to Glucose11050244
D005978GlutathioneGlutathione inhibits the reaction [alitretinoin results in increased expression of UCP1 mRNA]12414803
D005978GlutathioneGlutathione inhibits the reaction [rosiglitazone results in increased expression of UCP1 mRNA]12414803
D006247Harmine2-chloro-5-nitrobenzanilide inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]27805061
D006247HarmineAZD 6244 inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]27805061
D006247HarmineHarmine affects the reaction [Dietary Fats affects the expression of UCP1 mRNA]27805061
D006247HarmineHarmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]27805061
D006247HarmineHarmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]27805061
D006247HarmineHarmine results in increased expression of UCP1 mRNA27805061
D006247HarmineHarmine results in increased expression of UCP1 protein27805061
D006247Harmine"N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholin-4-ylpropyl)-pyrimidine-2,4-diamine inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]"27805061
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of UCP1 mRNA26846883
C540383INCB018424INCB018424 results in increased expression of UCP1 mRNA25487280
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of UCP1 mRNA"26377693
D019469IndinavirIndinavir results in decreased expression of UCP1 mRNA17926646
C541917INT 131[INT 131 co-treated with Dietary Fats co-treated with Dietary Sugars] results in increased expression of UCP1 mRNA28611668
C541917INT 131INT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of UCP1 mRNA]28611668
C541917INT 131INT 131 results in increased expression of UCP1 mRNA28611668
D007480Iopanoic AcidIopanoic Acid results in decreased expression of UCP1 protein11521740
D0150561-Methyl-3-isobutylxanthine(+)-JQ1 compound inhibits the reaction [[Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA]26972250
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 mRNA29288687
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein29288687
D0150561-Methyl-3-isobutylxanthineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein]29288687
D0150561-Methyl-3-isobutylxanthine[PRKACA protein affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 mRNA29288687
D0150561-Methyl-3-isobutylxanthinePRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 mRNA]29288687
D0150561-Methyl-3-isobutylxanthinePRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein]29288687
D0150561-Methyl-3-isobutylxanthine[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 mRNA29288687
D0150561-Methyl-3-isobutylxanthine[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein29288687
D0150561-Methyl-3-isobutylxanthine[Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA26972250
D007545IsoproterenolIsoproterenol results in increased expression of UCP1 protein17250927
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of UCP1 mRNA15618438
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA]26972250
C052901lemongrass oillemongrass oil affects the expression of UCP1 mRNA25976427
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 mRNA29288687
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein29288687
C432503licarin AN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein]29288687
C432503licarin APRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 mRNA]29288687
C432503licarin APRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein]29288687
D008713MethimazoleMethimazole results in decreased expression of UCP1 protein11521740
D008726MethopreneMethoprene results in increased expression of UCP1 mRNA10600643
D008727MethotrexateMethotrexate results in increased expression of UCP1 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of UCP1 mRNA28001369
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein]29288687
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of UCP1 mRNA]12414803
C510788N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine"cyclopamine inhibits the reaction [N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in increased expression of UCP1 mRNA]"25487280
C510788N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine"N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine inhibits the reaction [TNF protein results in decreased expression of UCP1 mRNA]"25487280
C510788N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine"N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in increased expression of UCP1 mRNA"25487280
C510788N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine"N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in increased expression of UCP1 protein"25487280
C572775N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholin-4-ylpropyl)-pyrimidine-2,4-diamine"N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholin-4-ylpropyl)-pyrimidine-2,4-diamine inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]"27805061
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of UCP1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of UCP1 mRNA"25554681
D019829NevirapineNevirapine results in increased expression of UCP116038477
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of UCP1 mRNA]16940432
C028007nickel monoxidenickel monoxide results in increased expression of UCP1 mRNA19167457
C029938nickel sulfate[nickel sulfate co-treated with Particulate Matter] results in decreased expression of UCP1 mRNA23126276
C029938nickel sulfate[nickel sulfate co-treated with Particulate Matter] results in decreased expression of UCP1 protein23126276
D009638NorepinephrineAG 1879 promotes the reaction [Norepinephrine results in increased expression of UCP1 mRNA]10788502
D009638NorepinephrineNorepinephrine results in increased expression of UCP1 mRNA10465291|1078850
D009638Norepinephrine[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]11742803
D009638Norepinephrine[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]11742803
D009638Norepinephrine[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]11742803
D009638Norepinephrine[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]11742803
D009638Norepinephrine[EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA11742803
D009638Norepinephrine[FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA11742803
D009638Norepinephrine[Triiodothyronine co-treated with Norepinephrine] results in increased expression of UCP1 mRNA11742803
C025589ochratoxin Aochratoxin A metabolite results in decreased expression of UCP1 mRNA24356939
C076029olanzapine[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of UCP1 mRNA23226405
D010100OxygenOxygen deficiency results in increased expression of UCP1 mRNA23539316
D019308Palmitic AcidPalmitic Acid results in increased expression of UCP1 mRNA28027979
D000073878Palm OilPalm Oil results in decreased expression of UCP1 mRNA18042831
D010269ParaquatParaquat affects the expression of UCP1 mRNA25064622
D010278ParathionParathion results in increased methylation of UCP1 promoter22847954
D052638Particulate MatterLTA protein affects the reaction [Particulate Matter results in decreased expression of UCP1]28917655
D052638Particulate Matter[nickel sulfate co-treated with Particulate Matter] results in decreased expression of UCP1 mRNA23126276
D052638Particulate Matter[nickel sulfate co-treated with Particulate Matter] results in decreased expression of UCP1 protein23126276
D052638Particulate MatterParticulate Matter results in decreased expression of UCP128917655
D052638Particulate MatterParticulate Matter results in decreased expression of UCP1 mRNA21873646
D052638Particulate MatterParticulate Matter results in decreased expression of UCP1 protein21873646
D052638Particulate MatterTNF protein affects the reaction [Particulate Matter results in decreased expression of UCP1]28917655
C506614PD 0325901PD 0325901 inhibits the reaction [Protein Kinase Inhibitors inhibits the reaction [FASN protein results in increased expression of UCP1 protein]]26670611
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of and results in increased activity of UCP1 protein26001964
C076994perfluorooctane sulfonic acidUCP1 gene mutant form affects the susceptibility to perfluorooctane sulfonic acid26001964
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of UCP1 mRNA21251948
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of and results in increased activity of UCP1 protein26001964
C023036perfluorooctanoic acidUCP1 gene mutant form affects the susceptibility to perfluorooctanoic acid26001964
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UCP1 mRNA28659758
D015232DinoprostoneUCP1 protein inhibits the reaction [Glucose results in increased chemical synthesis of Dinoprostone]14514642
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of UCP1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of UCP1 mRNA16306350
C006253pirinixic acidpirinixic acid inhibits the reaction [rosiglitazone results in increased expression of UCP1 mRNA]10529360
C006253pirinixic acidpirinixic acid results in increased activity of UCP1 promoter10529360
D010936Plant ExtractsPlant Extracts results in increased expression of UCP1 mRNA23684756
D011294PrenalterolPrenalterol results in increased expression of UCP1 protein10465291
D047428Protein Kinase InhibitorsPD 0325901 inhibits the reaction [Protein Kinase Inhibitors inhibits the reaction [FASN protein results in increased expression of UCP1 protein]]26670611
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [FASN protein results in increased expression of UCP1 mRNA]26670611
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [FASN protein results in increased expression of UCP1 protein]26670611
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors results in decreased expression of UCP1 mRNA26670611
D011522ProtonsAdenosine Triphosphate inhibits the reaction [UCP1 protein results in increased transport of Protons]12734183
D011522ProtonsUCP1 protein results in increased transport of Protons12734183
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UCP1 mRNA28659758
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA]24465016
D017382Reactive Oxygen SpeciesUCP1 protein inhibits the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species]14514642
D017382Reactive Oxygen SpeciesUCP1 protein inhibits the reaction [TNF protein results in increased chemical synthesis of Reactive Oxygen Species]16644673
D017382Reactive Oxygen SpeciesUCP1 protein inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]11342529
C059514resveratrol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased expression of UCP1 protein]"25761413
C059514resveratrolPRKAA1 gene mutant form inhibits the reaction [resveratrol results in increased expression of UCP1 mRNA]25761413
C059514resveratrolPRKAA1 gene mutant form inhibits the reaction [resveratrol results in increased expression of UCP1 protein]25761413
C059514resveratrolPRKAA1 protein promotes the reaction [resveratrol results in increased expression of UCP1 mRNA]19934007
C059514resveratrolPRKAA2 protein promotes the reaction [resveratrol results in increased expression of UCP1 mRNA]19934007
C059514resveratrolresveratrol results in increased expression of UCP1 mRNA19934007|2110941
C059514resveratrolresveratrol results in increased expression of UCP1 protein20561979|2576141
C059514resveratrolresveratrol results in increased expression of UCP1 protein23790948
C089730rosiglitazoneUCP1 protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]26670611
C089730rosiglitazone"UCP1 protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in increased abundance of Fatty Acids, Nonesterified]]"26670611
C089730rosiglitazone(+)-JQ1 compound inhibits the reaction [[Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA]26972250
C089730rosiglitazonePPARGC1A affects the reaction [rosiglitazone results in increased expression of UCP1 mRNA]22087241
C089730rosiglitazonePPARGC1A affects the reaction [rosiglitazone results in increased expression of UCP1 protein]22087241
C089730rosiglitazonePPARGC1A protein promotes the reaction [rosiglitazone results in increased expression of UCP1 mRNA]16513826
C089730rosiglitazonerosiglitazone affects the expression of UCP1 mRNA22013433
C089730rosiglitazone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 mRNA29288687
C089730rosiglitazone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein29288687
C089730rosiglitazone[rosiglitazone co-treated with Dietary Fats co-treated with Dietary Sugars] results in increased expression of UCP1 mRNA28611668
C089730rosiglitazonerosiglitazone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of UCP1 mRNA]28611668
C089730rosiglitazonerosiglitazone results in decreased expression of UCP1 mRNA16306350
C089730rosiglitazonerosiglitazone results in increased expression of UCP1 mRNA15520860|1651382
C089730rosiglitazonerosiglitazone results in increased expression of UCP1 protein22087241|2667061
C089730rosiglitazone[Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA26972250
C089730rosiglitazoneUCP1 protein promotes the reaction [rosiglitazone results in increased expression of FASN protein]26670611
C089730rosiglitazone2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [rosiglitazone results in increased expression of UCP1 mRNA]12414803
C089730rosiglitazoneGlutathione inhibits the reaction [rosiglitazone results in increased expression of UCP1 mRNA]12414803
C089730rosiglitazonepirinixic acid inhibits the reaction [rosiglitazone results in increased expression of UCP1 mRNA]10529360
C089730rosiglitazonerosiglitazone results in increased activity of UCP1 promoter10529360
C089730rosiglitazonerosiglitazone results in increased expression of UCP1 mRNA10529360|1241480
C089730rosiglitazonerosiglitazone results in increased expression of UCP1 protein15887043
C089730rosiglitazonerosiglitazone results in increased activity of UCP1 promoter12414803
C009277sodium arsenatesodium arsenate results in decreased expression of UCP1 mRNA23922661
C016104sodium bichromatesodium bichromate results in decreased expression of UCP1 mRNA24612858
D053260SootSoot results in increased expression of UCP1 mRNA26551751
D013481SuperoxidesUCP1 protein results in decreased chemical synthesis of Superoxides11696579
D013481Superoxides[UCP1 protein results in decreased chemical synthesis of Superoxides] inhibits the reaction [Glucose results in decreased activity of NOS3 protein]11696579
D013481Superoxides[UCP1 protein results in decreased chemical synthesis of Superoxides] inhibits the reaction [Glucose results in decreased phosphorylation of NOS3 protein]11696579
D013481Superoxides[UCP1 protein results in decreased chemical synthesis of Superoxides] inhibits the reaction [Glucose results in increased O-linked glycosylation of NOS3 protein]11696579
D013481SuperoxidesUCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]11050244
D014284Triiodothyronine(+)-JQ1 compound inhibits the reaction [[Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA]26972250
D014284Triiodothyronine[Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA26972250
D014284Triiodothyronine[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]11742803
D014284Triiodothyronine[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]11742803
D014284Triiodothyronine[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]11742803
D014284Triiodothyronine[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]11742803
D014284TriiodothyronineAVP protein inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]11742803
D014284TriiodothyronineAVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]11742803
D014284TriiodothyronineAVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]11742803
D014284TriiodothyronineAVP protein inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]11742803
D014284Triiodothyronine[EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA11742803
D014284Triiodothyronine[FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA11742803
D014284Triiodothyronine[Triiodothyronine co-treated with Norepinephrine] results in increased expression of UCP1 mRNA11742803
D014284TriiodothyronineTriiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]11742803
D014284TriiodothyronineTriiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]11742803
D014284TriiodothyronineTriiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]11742803
D014284TriiodothyronineTriiodothyronine results in increased expression of UCP1 mRNA11742803
C084178telmisartanPPARD promotes the reaction [telmisartan results in increased expression of UCP1 protein]20176998
C084178telmisartantelmisartan results in increased expression of UCP1 protein20176998
C012568terbufosterbufos results in increased methylation of UCP1 promoter22847954
D013739TestosteroneTestosterone deficiency results in decreased expression of UCP1 mRNA21045173
D013739TestosteroneTestosterone inhibits the reaction [Testosterone deficiency results in decreased expression of UCP1 mRNA]21045173
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UCP1 mRNA27618130
D013752TetracyclineTetracycline affects the expression of UCP1 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of UCP1 mRNA25064622
C009495titanium dioxidetitanium dioxide results in increased expression of UCP1 mRNA23557971
C479163tofacitinibcyclopamine inhibits the reaction [tofacitinib results in increased expression of UCP1 mRNA]25487280
C479163tofacitinibtofacitinib inhibits the reaction [TNF protein results in decreased expression of UCP1 mRNA]25487280
C479163tofacitinibtofacitinib results in increased expression of UCP1 mRNA25487280
C479163tofacitinibtofacitinib results in increased expression of UCP1 protein25487280
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of UCP1 mRNA"15888570
D014212TretinoinTretinoin results in increased expression of UCP1 mRNA10600643|1684054
D014212TretinoinTretinoin results in increased expression of UCP1 protein15646024
D014212TretinoinTretinoin results in increased expression of UCP1 mRNA28689802
C011559tributyltintributyltin results in increased expression of UCP1 mRNA21683088
C012589trichostatin Atrichostatin A results in increased expression of UCP1 mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of UCP1 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of UCP1 mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of UCP1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of UCP1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of UCP1 mRNA24383497|2493525
D014639VanadiumVanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein]16195403
C066075vanadium pentoxidevanadium pentoxide results in decreased expression of UCP1 mRNA26210822
D001335Vehicle EmissionsVehicle Emissions affects the methylation of UCP1 gene25560391
D014801Vitamin ALEP gene mutant form promotes the reaction [Vitamin A results in increased expression of UCP1 mRNA]16493122
D015215ZidovudineZidovudine results in increased expression of UCP1 mRNA14518702
D015215ZidovudineZidovudine results in decreased expression of UCP1 mRNA17926646

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0017077oxidative phosphorylation uncoupler activity-IBA21873635  
GO:0017077oxidative phosphorylation uncoupler activity-ISS-  
GO:0022857transmembrane transporter activity-IDA24196960  
GO:0032555purine ribonucleotide binding-ISS-  
GO:0036041long-chain fatty acid binding-ISS-  
GO:1901612cardiolipin binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002024diet induced thermogenesis-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0009266response to temperature stimulus-ISS-  
GO:0009409response to cold-IBA21873635  
GO:0031667response to nutrient levels-ISS-  
GO:0032870cellular response to hormone stimulus-ISS-  
GO:0034614cellular response to reactive oxygen species-ISS-  
GO:0050873brown fat cell differentiation-ISS-  
GO:0071398cellular response to fatty acid-ISS-  
GO:1902600proton transmembrane transport-IDA24196960  
GO:1903426regulation of reactive oxygen species biosynthetic process-ISS-  
GO:1990542mitochondrial transmembrane transport-IBA21873635  
GO:1990542mitochondrial transmembrane transport-ISS-  
GO:1990845adaptive thermogenesis-IBA21873635  
GO:1990845adaptive thermogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA9054939  
GO:0005743mitochondrial inner membrane-ISS-  
GO:0005743mitochondrial inner membrane-TAS-  
KEGG ID KEGG Term
hsa03320PPAR signaling pathway
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-166187Mitochondrial Uncoupling ProteinsTAS
R-HSA-167826The fatty acid cycling modelTAS
R-HSA-167827The proton buffering modelTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22087257Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque. (2011)Dong CPLoS One
11916758Racial differences in the relation between uncoupling protein genes and resting energy expenditure. (2002 Apr)Kimm SYAm J Clin Nutr
29694503Neonatal tobacco smoke reduces thermogenesis capacity in brown adipose tissue in adult rats. (2018)Peixoto TCBraz J Med Biol Res
18619427Long-term cigarette smoke exposure increases uncoupling protein expression but reduces energy intake. (2008 Sep 4)Chen HBrain Res
12075579Genetic factors as predictors of weight gain in young adult Dutch men and women. (2002 Apr)van Rossum CTInt J Obes Relat Metab Disord
15508020Effect of short-term cigarette smoke exposure on body weight, appetite and brain neuropeptide Y in mice. (2005 Apr)Chen HNeuropsychopharmacology