Gene info: ID 7351

Gene: UCP2

GENE ID: 7351

Synonyms: BMIQ4|SLC25A8|UCPH

Description: uncoupling protein 2

Gene type: protein-coding

Location: 11q13.4

dbXrefs: Ensembl:ENSG00000175567 MIM:601693 Vega:OTTHUMG00000168095 UniprotKB:P55851

RefSeq: NG_011478.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 8

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.797e-1 (AD) 5.167e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SPI1	0.904
FCER1G	0.882
ARHGAP30	0.879
PTPN6	0.876
IFI30	0.876
CD300A	0.873
HAVCR2	0.872
HCST	0.871
VAMP8	0.871
LAPTM5	0.87

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MARCH4	-0.432
KCNB2	-0.426
WNT7A	-0.424
SLC7A4	-0.419
NEUROD6	-0.418
ADRA1D	-0.416
RTN4R	-0.414
ABCC12	-0.414
CALHM1	-0.413
KCNIP3	-0.413

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of UCP2 mRNA"	21856379
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of UCP2 mRNA	19933214
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of UCP2 mRNA"	25614096
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]	12588051
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]"	12588051
C022776	2-bromopalmitate	2-bromopalmitate results in increased expression of UCP2 mRNA	11341955
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of UCP2 mRNA]	23500012
C097869	3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate	"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [lipid mobilizing substance results in increased expression of UCP2 protein]"	15026812
C005975	3,4-dihydroxyphenylethanol	"3,4-dihydroxyphenylethanol inhibits the reaction [sodium arsenite results in decreased expression of UCP2 mRNA]"	28225195
C520164	4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid	[4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid co-treated with Oxygen deficiency] results in increased expression of UCP2 protein	21113404
C520164	4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid	4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Oxygen deficiency results in decreased expression of UCP2 mRNA]	21113404
D000082	Acetaminophen	Acetaminophen affects the expression of UCP2 mRNA	25064622
D000082	Acetaminophen	Acetaminophen results in increased expression of UCP2 mRNA	25704631
D000082	Acetaminophen	Acetaminophen affects the expression of UCP2 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]	18183618
C027696	acipimox	acipimox results in increased expression of UCP2 mRNA	25352640
D000255	Adenosine Triphosphate	Adenosine Triphosphate inhibits the reaction [UCP2 protein results in increased transport of Protons]	12734183
D000255	Adenosine Triphosphate	[SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate]	16366736
C031143	AICA ribonucleotide	AICA ribonucleotide inhibits the reaction [Indican results in decreased expression of UCP2 mRNA]	25703824
D017962	alpha-Linolenic Acid	alpha-Linolenic Acid results in increased expression of UCP2 mRNA	11341955
D000638	Amiodarone	Amiodarone affects the expression of UCP2 mRNA	25064622
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of UCP2 mRNA	16483693
D000968	Antimycin A	Antimycin A results in increased expression of UCP2 protein	18082129
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of UCP2 mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of UCP2 mRNA	24905690
C006632	arsenic trioxide	arsenic trioxide results in increased expression of UCP2 mRNA	15761015
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of UCP2 mRNA"	25351596
D001280	Atrazine	Atrazine results in increased expression of UCP2 mRNA	20036412
D001280	Atrazine	Atrazine results in decreased expression of UCP2 mRNA	27114639
D001280	Atrazine	Atrazine results in increased expression of UCP2 mRNA	22378314
D001280	Atrazine	Atrazine results in increased expression of UCP2 mRNA	27114639
C547126	AZM551248	AZM551248 results in increased expression of UCP2 mRNA	22323515
C030233	benzo(a)pyrene-1,6-quinone	"[[benzo(a)pyrene-1,6-quinone results in increased abundance of Superoxides] co-treated with [benzo(a)pyrene-1,6-quinone results in decreased abundance of Hydrogen Peroxide]] results in increased expression of UCP2 mRNA"	10860543
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of UCP2 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]	20412841
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [Dietary Fats results in increased expression of UCP2 mRNA]	20412841
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of UCP2 mRNA	21569818\|2429135
D001564	Benzo(a)pyrene	Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]	28533128
D001564	Benzo(a)pyrene	cyanidin inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]	28533128
D001564	Benzo(a)pyrene	Quercetin inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]	28533128
D001564	Benzo(a)pyrene	resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]	28533128
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of UCP2 mRNA"	19150397
D001599	Berberine	Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]	28533128
C044887	beta-methylcholine	beta-methylcholine affects the expression of UCP2 mRNA	21179406
C095105	bexarotene	bexarotene promotes the reaction [rosiglitazone results in increased expression of UCP2 mRNA]	10548525
D001629	Bezafibrate	Bezafibrate results in increased expression of UCP2 mRNA	11056218
D001629	Bezafibrate	Bezafibrate affects the expression of UCP2 mRNA	10933891
D001629	Bezafibrate	[Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA	11341955
D001629	Bezafibrate	Bezafibrate results in increased expression of UCP2 mRNA	11473052\|1258805
D001629	Bezafibrate	Triiodothyronine promotes the reaction [Bezafibrate results in increased expression of UCP2 mRNA]	12588052
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of UCP2 mRNA	27685785
C006780	bisphenol A	bisphenol A results in decreased expression of UCP2 mRNA	27685785
C006780	bisphenol A	bisphenol A results in decreased expression of UCP2 mRNA	28079927
C006780	bisphenol A	bisphenol A results in decreased expression of UCP2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of UCP2 mRNA	22946080\|2332866
D001786	Blood Glucose	[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of UCP2 mRNA	27693381
C584509	C646 compound	C646 compound results in decreased expression of UCP2 mRNA	26191083
D002104	Cadmium	Cadmium results in increased expression of UCP2 mRNA	24376830
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of UCP2 mRNA	17961207
C081643	candesartan	candesartan inhibits the reaction [Palmitic Acid results in increased expression of UCP2 mRNA]	20667613
C081643	candesartan	candesartan results in decreased expression of UCP2 mRNA	16685210
C459604	candoxin	candoxin results in decreased expression of UCP2 mRNA	16309724
D002211	Capsaicin	UCP2 protein polymorphism affects the susceptibility to Capsaicin analog	19056576
D002211	Capsaicin	Capsaicin inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]	20359164
D002220	Carbamazepine	Carbamazepine affects the expression of UCP2 mRNA	25979313
D002248	Carbon Monoxide	UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]	22046279
D002248	Carbon Monoxide	UCP2 protein promotes the reaction [Carbon Monoxide results in increased abundance of Reactive Oxygen Species]	22046279
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of UCP2 mRNA	18314881\|1842032
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of UCP2 protein	18314881
D002251	Carbon Tetrachloride	gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of UCP2 mRNA]	18314881
D002251	Carbon Tetrachloride	Vitamin E inhibits the reaction [Carbon Tetrachloride results in increased expression of UCP2 mRNA]	18314881
C026678	carboprostacyclin	carboprostacyclin results in increased expression of UCP2 mRNA	11341955\|1258805
C026678	carboprostacyclin	Triiodothyronine promotes the reaction [carboprostacyclin results in increased expression of UCP2 mRNA]	12588052
D002273	Carcinogens	Carcinogens results in increased expression of UCP2 mRNA	16316942
D002392	Catechin	Catechin inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]	23365609
D002395	Catecholamines	Catecholamines results in increased expression of UCP2 mRNA	15855228
C026690	cerous chloride	[cerous chloride co-treated with lanthanum chloride] affects the expression of UCP2 mRNA	28954213
C026690	cerous chloride	cerous chloride results in decreased expression of UCP2 mRNA	28954213
D002737	Chloroprene	Chloroprene results in increased expression of UCP2 mRNA	23125180
D002746	Chlorpromazine	Chlorpromazine affects the expression of UCP2 mRNA	25064622
D004390	Chlorpyrifos	[Copper co-treated with Chlorpyrifos] results in decreased expression of UCP2 mRNA	21356183
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UCP2 mRNA	20938992
C039671	ciglitazone	ciglitazone results in decreased expression of UCP2 mRNA	11056218
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of UCP2 mRNA	12032628\|1937684
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of UCP2 mRNA	24386269
D003300	Copper	[Copper co-treated with Chlorpyrifos] results in decreased expression of UCP2 mRNA	21356183
D003300	Copper	Copper results in decreased expression of UCP2 mRNA	21356183
C030865	copper bis(3,5-diisopropylsalicylate)	"[copper bis(3,5-diisopropylsalicylate) co-treated with Glucose] results in increased expression of UCP2 protein"	23795780
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of UCP2 mRNA	19549813
D003471	Cuprizone	Cuprizone results in decreased expression of UCP2 mRNA	26577399
D003486	Cyanides	UCP2 protein affects the susceptibility to Cyanides	16782780
C017154	cyanidin	cyanidin inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]	28533128
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]	12588051
D016572	Cyclosporine	Cyclosporine affects the expression of UCP2 mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in increased expression of UCP2 mRNA	25562108
C089948	darglitazone	darglitazone results in increased expression of UCP2 mRNA	12588052
C089948	darglitazone	Thyroxine promotes the reaction [darglitazone results in increased expression of UCP2 mRNA]	12588052
C089948	darglitazone	Triiodothyronine promotes the reaction [darglitazone results in increased expression of UCP2 mRNA]	12588052
D003671	DEET	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UCP2 mRNA	28659758
D003676	Deferoxamine	Deferoxamine results in decreased expression of UCP2 mRNA	12032628
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in decreased expression of UCP2 mRNA	12659879
D015230	Prostaglandin D2	UCP2 protein affects the chemical synthesis of Prostaglandin D2	19846869
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of UCP2 mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in increased expression of UCP2 mRNA	19853017
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of UCP2 mRNA	28628672
D003907	Dexamethasone	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of UCP2 mRNA	23428407
D003907	Dexamethasone	Dexamethasone results in increased expression of UCP2 mRNA	17998272
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of UCP2 mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of UCP2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of UCP2 mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased expression of UCP2 mRNA	27392435
D002945	Cisplatin	[Quercetin co-treated with Cisplatin] results in increased expression of UCP2 mRNA	24999622
D002945	Cisplatin	UCP2 protein affects the susceptibility to Cisplatin	16217747
D004008	Diclofenac	Diclofenac results in increased expression of UCP2 mRNA	26934552
C000944	dicrotophos	dicrotophos results in increased expression of UCP2 mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of UCP2 mRNA	26924002
D018119	Stavudine	Stavudine results in decreased expression of UCP2 mRNA	14518702
D004041	Dietary Fats	[resveratrol analog co-treated with Dietary Fats] results in increased expression of UCP2 mRNA	24759758
D004041	Dietary Fats	Benzo(a)pyrene inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]	20412841
D004041	Dietary Fats	Benzo(a)pyrene promotes the reaction [Dietary Fats results in increased expression of UCP2 mRNA]	20412841
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UCP2 mRNA	21462320
D004041	Dietary Fats	Dietary Fats results in decreased expression of UCP2 mRNA	18042831\|2041284
D004041	Dietary Fats	Dietary Fats results in decreased expression of UCP2 protein	25549548\|2563768
D004041	Dietary Fats	Dietary Fats results in increased expression of UCP2 mRNA	16357043\|1849283
D004041	Dietary Fats	Ethanol promotes the reaction [Dietary Fats results in decreased expression of UCP2 protein]	25549548
D004041	Dietary Fats	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in decreased expression of UCP2 protein]"	25637688
D004041	Dietary Fats	naringin inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]	22198281
D004041	Dietary Fats	Quercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UCP2 mRNA]	21462320
D004041	Dietary Fats	Capsaicin inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]	20359164
D004041	Dietary Fats	Catechin inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]	23365609
D004041	Dietary Fats	Dietary Fats results in decreased expression of UCP2 mRNA	20359164\|2232705
D004041	Dietary Fats	Dietary Fats results in increased expression of UCP2 mRNA	11934670\|2522814
D004041	Dietary Fats	Dietary Fats results in increased expression of UCP2 protein	25228148
D004041	Dietary Fats	[Dietary Sucrose co-treated with Dietary Fats] results in increased expression of UCP2 mRNA	23529981
D004041	Dietary Fats	Plant Extracts inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]	23365609
D004041	Dietary Fats	resveratrol inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]	25228148
D004041	Dietary Fats	resveratrol inhibits the reaction [Dietary Fats results in increased expression of UCP2 protein]	25228148
D004041	Dietary Fats	Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]	22327056\|2246414
D004042	Dietary Fats, Unsaturated	"Dietary Fats, Unsaturated results in increased expression of UCP2 mRNA"	11341955
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UCP2 mRNA	21462320
D019422	Dietary Sucrose	Quercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UCP2 mRNA]	21462320
D019422	Dietary Sucrose	[Dietary Sucrose co-treated with Dietary Fats] results in increased expression of UCP2 mRNA	23529981
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of UCP2 mRNA	19245819
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of UCP2 mRNA	25280772
D002117	Calcitriol	Calcitriol results in decreased expression of UCP2 protein	15231722
C118756	dihydroxy-vitamin D3	dihydroxy-vitamin D3 inhibits the reaction [pirinixic acid promotes the reaction [Potassium Cyanide results in increased expression of UCP2 protein]]	18183618
C118756	dihydroxy-vitamin D3	dihydroxy-vitamin D3 inhibits the reaction [Potassium Cyanide results in increased expression of UCP2 protein]	18183618
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of UCP2 mRNA	26924002
D004147	Dioxins	Dioxins affects the expression of UCP2 mRNA	20463971
C076126	disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate	"disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of UCP2 mRNA"	20184727
D004221	Disulfiram	Disulfiram results in increased expression of UCP2 mRNA	20530235
D004050	Ditiocarb	Ditiocarb results in increased expression of UCP2 protein	18082129
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids results in increased expression of UCP2 mRNA	11341955
D004317	Doxorubicin	Doxorubicin results in decreased expression of UCP2 mRNA	28940058
D004317	Doxorubicin	Doxorubicin results in decreased expression of UCP2 protein	26781513
D004317	Doxorubicin	Doxorubicin results in increased expression of UCP2 protein	26781513
D004317	Doxorubicin	PPARGC1A affects the reaction [Doxorubicin results in decreased expression of UCP2 protein]	26781513
D004317	Doxorubicin	PPARGC1A affects the reaction [Doxorubicin results in increased expression of UCP2 protein]	26781513
D004317	Doxorubicin	Doxorubicin results in decreased expression of UCP2 mRNA	19915844
D004317	Doxorubicin	Doxorubicin results in decreased expression of UCP2 protein	26678157
C042986	ebselen	[ebselen co-treated with Glucose] results in decreased expression of UCP2 protein	23795780
D015118	Eicosapentaenoic Acid	Eicosapentaenoic Acid results in increased expression of UCP2 mRNA	11341955
D000431	Ethanol	Ethanol promotes the reaction [Dietary Fats results in decreased expression of UCP2 protein]	25549548
D000431	Ethanol	Ethanol results in decreased expression of UCP2 mRNA	20007851
D000431	Ethanol	rosiglitazone inhibits the reaction [Ethanol results in decreased expression of UCP2 mRNA]	20007851
D000431	Ethanol	[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in decreased expression of UCP2 protein	26854922
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of UCP2 mRNA	25064622
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of UCP2 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of UCP2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UCP2 mRNA	17942748
C054207	etomoxir	etomoxir promotes the reaction [pirinixic acid results in increased expression of UCP2 protein]	16306367
C054207	etomoxir	etomoxir results in increased expression of UCP2 protein	16306367
D005228	Fatty Acids, Essential	"Fatty Acids, Essential deficiency results in increased expression of UCP2 mRNA"	23333450
D005228	Fatty Acids, Essential	"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of UCP2 mRNA]"	23333450
D005228	Fatty Acids, Essential	"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of UCP2 mRNA]"	23333450
D011345	Fenofibrate	[Fenofibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA	11341955
D011345	Fenofibrate	Fenofibrate results in increased expression of UCP2 mRNA	16595124
D005395	Fish Oils	Fish Oils results in increased expression of UCP2 mRNA	11341955
D005485	Flutamide	Flutamide results in decreased expression of UCP2 mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UCP2 mRNA	20938992
C039281	furan	furan results in increased expression of UCP2 mRNA	15120968
C038958	gadolinium chloride	gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of UCP2 mRNA]	18314881
D005944	Glucosamine	Glucosamine results in decreased expression of UCP2 mRNA	11893929
D005947	Glucose	Glucose results in increased expression of UCP2 protein	18167556
D005947	Glucose	"[copper bis(3,5-diisopropylsalicylate) co-treated with Glucose] results in increased expression of UCP2 protein"	23795780
D005947	Glucose	[ebselen co-treated with Glucose] results in decreased expression of UCP2 protein	23795780
D005947	Glucose	[Sodium Selenite co-treated with Glucose] results in decreased expression of UCP2 protein	23795780
D005947	Glucose	Glucose results in increased expression of UCP2 mRNA	28027979
D005947	Glucose	[SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate]	16366736
D005947	Glucose	UCP2 protein inhibits the reaction [SIRT1 protein promotes the reaction [Glucose results in increased expression of INS1 protein]]	16366736
D005978	Glutathione	Glutathione inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide]	19361538
D006046	Gold	[Polyethyleneimine binds to Gold] which results in increased expression of UCP2 mRNA	28433809
C425931	GW 501516	GW 501516 results in increased expression of UCP2 mRNA	16239165
C000625835	HFPO2 compound	HFPO2 compound results in increased expression of UCP2 mRNA	27553808
C000625836	HFPO4 compound	HFPO4 compound results in increased expression of UCP2 mRNA	27553808
D006632	Histamine	UCP2 protein results in decreased secretion of Histamine	19846869
D006632	Histamine	UCP2 protein affects the abundance of Histamine	19846869
D006632	Histamine	UCP2 protein affects the secretion of Histamine	19846869
D017313	Fenretinide	Fenretinide results in decreased expression of UCP2 mRNA	28973697
D006854	Hydrocortisone	Hydrocortisone results in increased expression of UCP2 mRNA	15855228\|1596141
D006861	Hydrogen Peroxide	"[[benzo(a)pyrene-1,6-quinone results in increased abundance of Superoxides] co-treated with [benzo(a)pyrene-1,6-quinone results in decreased abundance of Hydrogen Peroxide]] results in increased expression of UCP2 mRNA"	10860543
D006861	Hydrogen Peroxide	Glutathione inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide]	19361538
D006861	Hydrogen Peroxide	[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide	19361538
D006861	Hydrogen Peroxide	[[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide] which results in decreased expression of BCL2 protein	19361538
D006861	Hydrogen Peroxide	Potassium Cyanide promotes the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide]	19361538
D020155	3-Hydroxybutyric Acid	3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of UCP2 protein]	25440059
D007200	Indican	AICA ribonucleotide inhibits the reaction [Indican results in decreased expression of UCP2 mRNA]	25703824
D007200	Indican	Indican results in decreased expression of UCP2 mRNA	25703824
D007200	Indican	UCP2 protein results in decreased susceptibility to Indican	25703824
D007213	Indomethacin	Indomethacin results in increased expression of UCP2 mRNA	16984733
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of UCP2 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of UCP2 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of UCP2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of UCP2 mRNA	23428407
D007545	Isoproterenol	Isoproterenol results in increased expression of UCP2 mRNA	20003209
D007545	Isoproterenol	Isoproterenol results in increased expression of UCP2 mRNA	16580698
D007545	Isoproterenol	Isoproterenol results in increased expression of UCP2 protein	16580698
D007545	Isoproterenol	phenylmethylpyrazolone inhibits the reaction [Isoproterenol results in increased expression of UCP2 mRNA]	16580698
D007545	Isoproterenol	phenylmethylpyrazolone inhibits the reaction [Isoproterenol results in increased expression of UCP2 protein]	16580698
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of UCP2 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of UCP2 mRNA	27392435
C067713	lactacystin	lactacystin inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]	19361538
C028521	lanthanum chloride	[cerous chloride co-treated with lanthanum chloride] affects the expression of UCP2 mRNA	28954213
C028521	lanthanum chloride	lanthanum chloride results in decreased expression of UCP2 mRNA	28954213
D007854	Lead	Lead affects the expression of UCP2 mRNA	28903495
C052901	lemongrass oil	lemongrass oil affects the expression of UCP2 mRNA	25976427
C052901	lemongrass oil	lemongrass oil results in increased expression of UCP2 mRNA	25458622
C008287	lipid mobilizing substance	"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [lipid mobilizing substance results in increased expression of UCP2 protein]"	15026812
C008287	lipid mobilizing substance	lipid mobilizing substance results in increased expression of UCP2 protein	15026812
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of UCP2 mRNA	15650415
D008070	Lipopolysaccharides	Sodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of UCP2 mRNA]	15650415
D008070	Lipopolysaccharides	UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]	22046279
D019808	Losartan	Losartan results in decreased expression of UCP2 mRNA	17508912
D019808	Losartan	Losartan results in decreased expression of UCP2 protein	17508912
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]	19109942
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of UCP2 mRNA	21641980
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of UCP2 mRNA	20353558
D008687	Metformin	Metformin results in increased expression of UCP2 mRNA	22815988
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UCP2 mRNA	20938992
D008727	Methotrexate	Methotrexate results in increased expression of UCP2 mRNA	25575725
C445068	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in decreased expression of UCP2 protein]"	25637688
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of UCP2 mRNA	23458150
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of UCP2 mRNA	27544571
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of UCP2 mRNA	24694518
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of UCP2 mRNA	26011545
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of UCP2 mRNA	19840844
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium affects the expression of UCP2 mRNA	15948157
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of UCP2 protein	15948157
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of UCP2 mRNA	19763737
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of UCP2 protein	19763737
D015655	1-Methyl-4-phenylpyridinium	UCP2 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC25A27 mRNA]	19763737
D015655	1-Methyl-4-phenylpyridinium	UCP2 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA]	19763737
C060893	MK-886	MK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 mRNA]	16782780
C060893	MK-886	MK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]	16782780
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of UCP2 mRNA	26924002
C500085	muraglitazar	muraglitazar results in increased expression of UCP2 mRNA	21515302
C030517	myxothiazol	myxothiazol results in increased expression of UCP2 protein	18082129
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of UCP2 mRNA"	25554681
C005274	naringin	naringin inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]	22198281
D009532	Nickel	Nickel results in increased expression of UCP2 mRNA	25583101
C028007	nickel monoxide	nickel monoxide results in increased expression of UCP2 mRNA	19167457
C025256	nonylphenol	nonylphenol results in increased expression of UCP2 mRNA	22946080
D009638	Norepinephrine	Norepinephrine results in increased expression of UCP2 mRNA	12588052\|8593794
C025589	ochratoxin A	ochratoxin A results in decreased expression of UCP2 mRNA	19287073\|2212462
C025589	ochratoxin A	ochratoxin A results in increased expression of UCP2 mRNA	17316727
C025589	ochratoxin A	ochratoxin A results in decreased expression of UCP2 mRNA	22124623
D019787	Linoleic Acid	Linoleic Acid results in increased expression of UCP2 mRNA	11341955
D019301	Oleic Acid	[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in decreased expression of UCP2 protein	26854922
D019301	Oleic Acid	Oleic Acid results in decreased expression of UCP2 mRNA	24349266
D019301	Oleic Acid	Oleic Acid results in increased expression of UCP2 mRNA	11341955\|1258805
D019319	Okadaic Acid	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of UCP2 mRNA	19840844
C108709	oleoyl-estrone	oleoyl-estrone results in decreased expression of UCP2 mRNA	20184727
C488250	oleoylethanolamide	oleoylethanolamide results in increased expression of UCP2 mRNA	15910890
D010100	Oxygen	Oxygen deficiency results in decreased expression of UCP2 mRNA	12032628
D010100	Oxygen	[4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid co-treated with Oxygen deficiency] results in increased expression of UCP2 protein	21113404
D010100	Oxygen	4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Oxygen deficiency results in decreased expression of UCP2 mRNA]	21113404
D010100	Oxygen	Oxygen deficiency results in decreased expression of UCP2 mRNA	21113404
D010100	Oxygen	Oxygen deficiency results in increased expression of UCP2 mRNA	22629407
D010100	Oxygen	Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of UCP2 mRNA]	22629407
D010100	Oxygen	[resveratrol co-treated with Oxygen deficiency] results in increased expression of UCP2 protein	21113404
D010100	Oxygen	rosiglitazone inhibits the reaction [Oxygen deficiency results in decreased expression of UCP2 mRNA]	21113404
D010100	Oxygen	[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of UCP2 mRNA	27693381
D010168	Palmitates	Palmitates results in increased expression of UCP2 mRNA	16620699
D010168	Palmitates	rosiglitazone inhibits the reaction [Palmitates results in increased expression of UCP2 mRNA]	16620699
D019308	Palmitic Acid	Palmitic Acid results in increased activity of UCP2 protein	12858170
D019308	Palmitic Acid	candesartan inhibits the reaction [Palmitic Acid results in increased expression of UCP2 mRNA]	20667613
D019308	Palmitic Acid	Palmitic Acid results in increased expression of UCP2 mRNA	20667613
D019308	Palmitic Acid	[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in decreased expression of UCP2 protein	26854922
D000073878	Palm Oil	Palm Oil results in decreased expression of UCP2 mRNA	18042831
C016030	pantogab	pantogab results in increased expression of UCP2 mRNA	17379144
D010269	Paraquat	[HSF-1 protein co-treated with LYZ protein co-treated with AAKG-2 protein co-treated with UCP2 protein] results in decreased susceptibility to Paraquat	22737090
D010269	Paraquat	[UCP2 protein co-treated with AAKG-2 protein co-treated with LYZ protein] results in decreased susceptibility to Paraquat	22737090
D010269	Paraquat	[UCP2 protein co-treated with AAKG-2 protein] results in decreased susceptibility to Paraquat	22737090
D010269	Paraquat	Paraquat affects the expression of UCP2 mRNA	25064622
D010269	Paraquat	UCP2 protein results in decreased susceptibility to Paraquat	16054055
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of UCP2 mRNA	23892564
C036567	perfluorodecanoic acid	perfluorodecanoic acid results in increased expression of UCP2 mRNA	27344344
C036567	perfluorodecanoic acid	PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UCP2 mRNA]	27344344
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of UCP2 mRNA	22613580
C076994	perfluorooctane sulfonic acid	2-chloro-5-nitrobenzanilide inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of UCP2 mRNA]	23500012
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of UCP2 mRNA	23500012
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of UCP2 mRNA	21499893
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of UCP2 mRNA	19162173\|2851185
D026023	Permethrin	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UCP2 mRNA	28659758
D010634	Phenobarbital	Phenobarbital affects the expression of UCP2 mRNA	23091169
C030299	phenylhydrazine	UCP2 protein affects the susceptibility to phenylhydrazine	18687678
C005435	phenylmethylpyrazolone	phenylmethylpyrazolone inhibits the reaction [Isoproterenol results in increased expression of UCP2 mRNA]	16580698
C005435	phenylmethylpyrazolone	phenylmethylpyrazolone inhibits the reaction [Isoproterenol results in increased expression of UCP2 protein]	16580698
C029217	phenyl-N-tert-butylnitrone	phenyl-N-tert-butylnitrone inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]	18183618
D010852	Picrotoxin	Picrotoxin results in increased expression of UCP2 mRNA	15170462
C006253	pirinixic acid	etomoxir promotes the reaction [pirinixic acid results in increased expression of UCP2 protein]	16306367
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA	19710929
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in increased expression of UCP2 mRNA	20813756
C006253	pirinixic acid	[pirinixic acid co-treated with rosiglitazone] results in increased expression of UCP2 mRNA	16306350
C006253	pirinixic acid	pirinixic acid results in increased expression of UCP2 mRNA	11056218\|1630635
C006253	pirinixic acid	pirinixic acid results in increased expression of UCP2 protein	16306367
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of UCP2 protein]	16306367
C006253	pirinixic acid	Acetylcysteine inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]	18183618
C006253	pirinixic acid	dihydroxy-vitamin D3 inhibits the reaction [pirinixic acid promotes the reaction [Potassium Cyanide results in increased expression of UCP2 protein]]	18183618
C006253	pirinixic acid	Glutathione inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide]	19361538
C006253	pirinixic acid	lactacystin inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]	19361538
C006253	pirinixic acid	MK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 mRNA]	16782780
C006253	pirinixic acid	MK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]	16782780
C006253	pirinixic acid	phenyl-N-tert-butylnitrone inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]	18183618
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA	11341955
C006253	pirinixic acid	pirinixic acid promotes the reaction [Potassium Cyanide results in increased expression of UCP2 protein]	18183618
C006253	pirinixic acid	pirinixic acid results in increased expression of UCP2 mRNA	16782780\|1916217
C006253	pirinixic acid	pirinixic acid results in increased expression of UCP2 protein	16782780\|1818361
C006253	pirinixic acid	[[pirinixic acid results in increased expression of UCP2 protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Potassium Cyanide	19361538
C006253	pirinixic acid	[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide	19361538
C006253	pirinixic acid	[[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide] which results in decreased expression of BCL2 protein	19361538
C006253	pirinixic acid	[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein	19361538
C006253	pirinixic acid	Potassium Cyanide promotes the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide]	19361538
C006253	pirinixic acid	Potassium Cyanide promotes the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]	19361538
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of UCP2 mRNA]	16782780
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of UCP2 protein]	16782780
C006253	pirinixic acid	SN50 peptide inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]	18183618
C006253	pirinixic acid	UCP2 protein affects the susceptibility to pirinixic acid	16782780
D010936	Plant Extracts	UCP2 protein polymorphism affects the susceptibility to Plant Extracts	19056576
D010936	Plant Extracts	Plant Extracts results in increased expression of UCP2 protein	20132043
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]	23365609
D010936	Plant Extracts	Plant Extracts results in increased expression of UCP2 mRNA	23306787
D011094	Polyethyleneimine	[Polyethyleneimine binds to Gold] which results in increased expression of UCP2 mRNA	28433809
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of UCP2 mRNA	22714537
D011190	Potassium Cyanide	dihydroxy-vitamin D3 inhibits the reaction [pirinixic acid promotes the reaction [Potassium Cyanide results in increased expression of UCP2 protein]]	18183618
D011190	Potassium Cyanide	dihydroxy-vitamin D3 inhibits the reaction [Potassium Cyanide results in increased expression of UCP2 protein]	18183618
D011190	Potassium Cyanide	pirinixic acid promotes the reaction [Potassium Cyanide results in increased expression of UCP2 protein]	18183618
D011190	Potassium Cyanide	[[pirinixic acid results in increased expression of UCP2 protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Potassium Cyanide	19361538
D011190	Potassium Cyanide	Potassium Cyanide promotes the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide]	19361538
D011190	Potassium Cyanide	Potassium Cyanide promotes the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]	19361538
D011190	Potassium Cyanide	Potassium Cyanide results in increased expression of UCP2 protein	18183618
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of UCP2 mRNA	28903501
D011374	Progesterone	Progesterone results in decreased expression of UCP2 mRNA	23018184
C005556	propionaldehyde	propionaldehyde results in increased expression of UCP2 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil affects the expression of UCP2 mRNA	24780913
D011522	Protons	Adenosine Triphosphate inhibits the reaction [UCP2 protein results in increased transport of Protons]	12734183
D011522	Protons	UCP2 protein results in increased transport of Protons	12734183
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of UCP2 mRNA	27029645
D011729	Pyridostigmine Bromide	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UCP2 mRNA	28659758
D011794	Quercetin	[Quercetin co-treated with Cisplatin] results in increased expression of UCP2 mRNA	24999622
D011794	Quercetin	Quercetin results in increased expression of UCP2 mRNA	21632981
D011794	Quercetin	Quercetin inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]	28533128
D011794	Quercetin	Quercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UCP2 mRNA]	21462320
D017382	Reactive Oxygen Species	UCP2 protein results in increased abundance of Reactive Oxygen Species	12858170
D017382	Reactive Oxygen Species	UCP2 protein promotes the reaction [Carbon Monoxide results in increased abundance of Reactive Oxygen Species]	22046279
D017382	Reactive Oxygen Species	Reactive Oxygen Species results in increased expression of UCP2	10860543
C059514	resveratrol	[resveratrol analog co-treated with Dietary Fats] results in increased expression of UCP2 mRNA	24759758
C059514	resveratrol	PRKAA1 protein promotes the reaction [resveratrol results in increased expression of UCP2 mRNA]	19934007
C059514	resveratrol	PRKAA2 protein promotes the reaction [resveratrol results in increased expression of UCP2 mRNA]	19934007
C059514	resveratrol	[resveratrol co-treated with Oxygen deficiency] results in increased expression of UCP2 protein	21113404
C059514	resveratrol	resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]	28533128
C059514	resveratrol	resveratrol results in increased expression of UCP2 mRNA	19934007\|2287864
C059514	resveratrol	resveratrol inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]	25228148
C059514	resveratrol	resveratrol inhibits the reaction [Dietary Fats results in increased expression of UCP2 protein]	25228148
C089730	rosiglitazone	bexarotene promotes the reaction [rosiglitazone results in increased expression of UCP2 mRNA]	10548525
C089730	rosiglitazone	rosiglitazone results in increased expression of UCP2 mRNA	10548525\|1561907
C089730	rosiglitazone	rosiglitazone results in increased expression of UCP2 protein	17255338
C089730	rosiglitazone	[pirinixic acid co-treated with rosiglitazone] results in increased expression of UCP2 mRNA	16306350
C089730	rosiglitazone	rosiglitazone affects the expression of UCP2 mRNA	22013433
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Ethanol results in decreased expression of UCP2 mRNA]	20007851
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Oxygen deficiency results in decreased expression of UCP2 mRNA]	21113404
C089730	rosiglitazone	rosiglitazone results in increased expression of UCP2 mRNA	17245590
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Palmitates results in increased expression of UCP2 mRNA]	16620699
C089730	rosiglitazone	rosiglitazone results in increased expression of UCP2 mRNA	21172411\|2151530
C089730	rosiglitazone	rosiglitazone results in increased expression of UCP2 protein	17052689
C089730	rosiglitazone	UCP2 mRNA affects the susceptibility to rosiglitazone	20404217
D012402	Rotenone	Rotenone results in increased expression of UCP2 mRNA	22447502
D012402	Rotenone	Rotenone results in increased expression of UCP2 mRNA	22447502
D012402	Rotenone	Rotenone results in increased expression of UCP2 mRNA	23186747
D012402	Rotenone	Rotenone results in increased expression of UCP2 protein	18082129
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of UCP2 mRNA	25351596
D012906	Smoke	Smoke results in increased expression of UCP2 protein	23069111
C118258	SN50 peptide	SN50 peptide inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]	18183618
C009277	sodium arsenate	sodium arsenate results in increased expression of UCP2 mRNA	23922661
C017947	sodium arsenite	sodium arsenite results in increased expression of UCP2 mRNA	28229933
C017947	sodium arsenite	"3,4-dihydroxyphenylethanol inhibits the reaction [sodium arsenite results in decreased expression of UCP2 mRNA]"	28225195
C017947	sodium arsenite	sodium arsenite results in decreased expression of UCP2 mRNA	25764338\|2822519
C017947	sodium arsenite	sodium arsenite results in decreased expression of UCP2 protein	25764338
C016104	sodium bichromate	sodium bichromate results in increased expression of UCP2 mRNA	24612858
D018038	Sodium Selenite	[Sodium Selenite co-treated with Glucose] results in decreased expression of UCP2 protein	23795780
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of UCP2 mRNA]	15650415
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of UCP2 mRNA	15650415
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of UCP2 protein	15650415
D012999	Soman	Soman results in increased expression of UCP2 mRNA	19281266
D053260	Soot	Soot results in increased expression of UCP2 mRNA	26551751
C075117	squalestatin 1	squalestatin 1 results in increased expression of UCP2 mRNA	27225895
C075117	squalestatin 1	squalestatin 1 results in increased expression of UCP2 mRNA	27225895
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of UCP2 mRNA	21641980
D013481	Superoxides	UCP2 protein results in decreased abundance of Superoxides	25440059
D013481	Superoxides	"[[benzo(a)pyrene-1,6-quinone results in increased abundance of Superoxides] co-treated with [benzo(a)pyrene-1,6-quinone results in decreased abundance of Hydrogen Peroxide]] results in increased expression of UCP2 mRNA"	10860543
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of UCP2 mRNA"	26680231
D014284	Triiodothyronine	Triiodothyronine results in increased expression of UCP2 mRNA	15961419
D014284	Triiodothyronine	THRA protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]	12588052
D014284	Triiodothyronine	THRB protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]	12588052
D014284	Triiodothyronine	Triiodothyronine promotes the reaction [Bezafibrate results in increased expression of UCP2 mRNA]	12588052
D014284	Triiodothyronine	Triiodothyronine promotes the reaction [carboprostacyclin results in increased expression of UCP2 mRNA]	12588052
D014284	Triiodothyronine	Triiodothyronine promotes the reaction [darglitazone results in increased expression of UCP2 mRNA]	12588052
D013629	Tamoxifen	Tamoxifen affects the expression of UCP2 mRNA	17555576
C084178	telmisartan	PPARD promotes the reaction [telmisartan results in increased expression of UCP2 protein]	20176998
C084178	telmisartan	telmisartan results in increased expression of UCP2 protein	20176998
C001803	tempol	tempol results in decreased expression of UCP2 mRNA	16685210
C001803	tempol	tempol results in increased expression of UCP2 protein	24591154
C505333	TEMPOL-H	TEMPOL-H results in increased expression of UCP2 protein	24591154
C501413	tesaglitazar	tesaglitazar results in increased expression of UCP2 mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of UCP2 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of UCP2 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of UCP2 mRNA	16214954
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UCP2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of UCP2 mRNA	15328365\|1816354
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of UCP2 mRNA	28973375
D013752	Tetracycline	Tetracycline affects the expression of UCP2 mRNA	25064622
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of UCP2 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in decreased expression of UCP2 mRNA	22378314
D045162	Thiazolidinediones	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]	12588051
D045162	Thiazolidinediones	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]"	12588051
D045162	Thiazolidinediones	Cycloheximide inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]	12588051
D045162	Thiazolidinediones	Thiazolidinediones results in increased expression of UCP2 mRNA	12588051
D045162	Thiazolidinediones	U 0126 inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]	12588051
D045162	Thiazolidinediones	THRA protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]	12588052
D045162	Thiazolidinediones	THRB protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]	12588052
D013849	Thimerosal	Thimerosal results in decreased expression of UCP2 mRNA	27188386
D013853	Thioacetamide	Thioacetamide affects the expression of UCP2 mRNA	25064622
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]	22327056\|2246414
D013974	Thyroxine	Thyroxine promotes the reaction [darglitazone results in increased expression of UCP2 mRNA]	12588052
C009495	titanium dioxide	titanium dioxide results in increased expression of UCP2 mRNA	29128614
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of UCP2 mRNA	22363418\|2806579
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of UCP2 mRNA	27255386
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in increased expression of UCP2 mRNA"	15888570
D014212	Tretinoin	Tretinoin results in decreased expression of UCP2 mRNA	20530235
D014212	Tretinoin	Tretinoin results in decreased expression of UCP2 mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of UCP2 mRNA	16840543
C011559	tributyltin	tributyltin results in increased expression of UCP2 mRNA	23428407
D014241	Trichloroethylene	Trichloroethylene results in increased expression of UCP2 mRNA	25549359
C012589	trichostatin A	trichostatin A results in increased expression of UCP2 mRNA	12588052
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of UCP2 mRNA	29024780
C057693	troglitazone	troglitazone results in decreased expression of UCP2 mRNA	11056218
C057693	troglitazone	[troglitazone results in increased activity of PPARG protein] which results in increased expression of UCP2 mRNA	11089532
C057693	troglitazone	troglitazone results in increased expression of UCP2 mRNA	11089532\|1295317
C057693	troglitazone	troglitazone results in increased expression of UCP2 mRNA	21515302\|9268716
D014415	Tunicamycin	Tunicamycin results in decreased expression of UCP2 mRNA	22378314
C113580	U 0126	U 0126 inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]	12588051
D014520	Urethane	Urethane results in decreased expression of UCP2 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of UCP2 mRNA	25064622
D014635	Valproic Acid	Valproic Acid affects the expression of UCP2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of UCP2 mRNA	24935251
D014635	Valproic Acid	Valproic Acid results in increased expression of UCP2 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of UCP2 mRNA	24896083
D014638	Vanadates	Vanadates results in decreased expression of UCP2 mRNA	22714537
D014640	Vancomycin	Vancomycin results in decreased expression of UCP2 mRNA	18930951
C025643	vinclozolin	vinclozolin results in decreased expression of UCP2 mRNA	23034163
D014750	Vincristine	Vincristine results in decreased expression of UCP2 mRNA	23649840
C029297	vinylidene chloride	vinylidene chloride results in increased expression of UCP2 mRNA	26682919
D009536	Niacinamide	Niacinamide inhibits the reaction [[SIRT1 protein binds to UCP2 promoter] which results in decreased expression of UCP2 mRNA]	16366736\|1636673
D014810	Vitamin E	Vitamin E inhibits the reaction [Carbon Tetrachloride results in increased expression of UCP2 mRNA]	18314881
D024483	Vitamin K 3	Vitamin K 3 affects the expression of UCP2 mRNA	20044591

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	25416956
GO:0017077	oxidative phosphorylation uncoupler activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000303	response to superoxide	-	IEA	-
GO:0001666	response to hypoxia	-	IDA	22292025
GO:0007565	female pregnancy	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0009409	response to cold	-	IBA	21873635
GO:0010942	positive regulation of cell death	-	IEA	-
GO:0032869	cellular response to insulin stimulus	-	IEA	-
GO:0034198	cellular response to amino acid starvation	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IEA	-
GO:0051881	regulation of mitochondrial membrane potential	-	IEA	-
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	-	IEA	-
GO:0070542	response to fatty acid	-	IEA	-
GO:0071333	cellular response to glucose stimulus	-	IEA	-
GO:0097421	liver regeneration	-	IEA	-
GO:1902600	proton transmembrane transport	-	TAS	9054939
GO:1990542	mitochondrial transmembrane transport	-	IBA	21873635
GO:1990845	adaptive thermogenesis	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IDA	-
GO:0005743	mitochondrial inner membrane	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	TAS
R-HSA-166187	Mitochondrial Uncoupling Proteins	TAS
R-HSA-167826	The fatty acid cycling model	TAS
R-HSA-167827	The proton buffering model	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17555951	Interaction between the uncoupling protein 2 -866G>A gene variant and cigarette smoking to increase oxidative stress in subjects with diabetes. (2008 Jan)	Stephens JW	Nutr Metab Cardiovasc Dis
12075579	Genetic factors as predictors of weight gain in young adult Dutch men and women. (2002 Apr)	van Rossum CT	Int J Obes Relat Metab Disord
11916758	Racial differences in the relation between uncoupling protein genes and resting energy expenditure. (2002 Apr)	Kimm SY	Am J Clin Nutr
21029457	Uncoupling protein 2 G(-866)A polymorphism: a new gene polymorphism associated with C-reactive protein in type 2 diabetic patients. (2010 Oct 28)	Lapice E	Cardiovasc Diabetol
16622580	Leptin resistance conferred by a combination of single nucleotide polymorphism and the adoption of a Western lifestyle in urban areas of Thailand. (2006 May-Jun)	Yanagisawa Y	J Nutr Health Aging
29254145	Bile acid and cigarette smoke enhance the aggressive phenotype of esophageal adenocarcinoma cells by downregulation of the mitochondrial uncoupling protein-2. (2017 Nov 24)	Xu Y	Oncotarget
17130180	Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men. (2007 Jan)	Humphries SE	Clin Chem
21074158	Mitochondrial uncoupling protein gene cluster variation (UCP2-UCP3) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study. (2011 Jan)	Zee RY	Atherosclerosis