Gene: UCP2

7351
BMIQ4|SLC25A8|UCPH
uncoupling protein 2
protein-coding
11q13.4
Ensembl:ENSG00000175567 MIM:601693 Vega:OTTHUMG00000168095 UniprotKB:P55851
NG_011478.1
PubMed
ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.797e-1 (AD)  5.167e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPI10.904
FCER1G0.882
ARHGAP300.879
PTPN60.876
IFI300.876
CD300A0.873
HAVCR20.872
HCST0.871
VAMP80.871
LAPTM50.87

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.432
KCNB2-0.426
WNT7A-0.424
SLC7A4-0.419
NEUROD6-0.418
ADRA1D-0.416
RTN4R-0.414
ABCC12-0.414
CALHM1-0.413
KCNIP3-0.413

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of UCP2 mRNA"21856379
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of UCP2 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of UCP2 mRNA"25614096
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]12588051
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]"12588051
C0227762-bromopalmitate2-bromopalmitate results in increased expression of UCP2 mRNA11341955
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of UCP2 mRNA]23500012
C0978693-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [lipid mobilizing substance results in increased expression of UCP2 protein]"15026812
C0059753,4-dihydroxyphenylethanol"3,4-dihydroxyphenylethanol inhibits the reaction [sodium arsenite results in decreased expression of UCP2 mRNA]"28225195
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid[4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid co-treated with Oxygen deficiency] results in increased expression of UCP2 protein21113404
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Oxygen deficiency results in decreased expression of UCP2 mRNA]21113404
D000082AcetaminophenAcetaminophen affects the expression of UCP2 mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of UCP2 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of UCP2 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]18183618
C027696acipimoxacipimox results in increased expression of UCP2 mRNA25352640
D000255Adenosine TriphosphateAdenosine Triphosphate inhibits the reaction [UCP2 protein results in increased transport of Protons]12734183
D000255Adenosine Triphosphate[SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate]16366736
C031143AICA ribonucleotideAICA ribonucleotide inhibits the reaction [Indican results in decreased expression of UCP2 mRNA]25703824
D017962alpha-Linolenic Acidalpha-Linolenic Acid results in increased expression of UCP2 mRNA11341955
D000638AmiodaroneAmiodarone affects the expression of UCP2 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UCP2 mRNA16483693
D000968Antimycin AAntimycin A results in increased expression of UCP2 protein18082129
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of UCP2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of UCP2 mRNA24905690
C006632arsenic trioxidearsenic trioxide results in increased expression of UCP2 mRNA15761015
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of UCP2 mRNA"25351596
D001280AtrazineAtrazine results in increased expression of UCP2 mRNA20036412
D001280AtrazineAtrazine results in decreased expression of UCP2 mRNA27114639
D001280AtrazineAtrazine results in increased expression of UCP2 mRNA22378314
D001280AtrazineAtrazine results in increased expression of UCP2 mRNA27114639
C547126AZM551248AZM551248 results in increased expression of UCP2 mRNA22323515
C030233benzo(a)pyrene-1,6-quinone"[[benzo(a)pyrene-1,6-quinone results in increased abundance of Superoxides] co-treated with [benzo(a)pyrene-1,6-quinone results in decreased abundance of Hydrogen Peroxide]] results in increased expression of UCP2 mRNA"10860543
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UCP2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]20412841
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [Dietary Fats results in increased expression of UCP2 mRNA]20412841
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UCP2 mRNA21569818|2429135
D001564Benzo(a)pyreneBerberine inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]28533128
D001564Benzo(a)pyrenecyanidin inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]28533128
D001564Benzo(a)pyreneQuercetin inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]28533128
D001564Benzo(a)pyreneresveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]28533128
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of UCP2 mRNA"19150397
D001599BerberineBerberine inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]28533128
C044887beta-methylcholinebeta-methylcholine affects the expression of UCP2 mRNA21179406
C095105bexarotenebexarotene promotes the reaction [rosiglitazone results in increased expression of UCP2 mRNA]10548525
D001629BezafibrateBezafibrate results in increased expression of UCP2 mRNA11056218
D001629BezafibrateBezafibrate affects the expression of UCP2 mRNA10933891
D001629Bezafibrate[Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA11341955
D001629BezafibrateBezafibrate results in increased expression of UCP2 mRNA11473052|1258805
D001629BezafibrateTriiodothyronine promotes the reaction [Bezafibrate results in increased expression of UCP2 mRNA]12588052
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of UCP2 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of UCP2 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of UCP2 mRNA28079927
C006780bisphenol Abisphenol A results in decreased expression of UCP2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of UCP2 mRNA22946080|2332866
D001786Blood Glucose[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of UCP2 mRNA27693381
C584509C646 compoundC646 compound results in decreased expression of UCP2 mRNA26191083
D002104CadmiumCadmium results in increased expression of UCP2 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in increased expression of UCP2 mRNA17961207
C081643candesartancandesartan inhibits the reaction [Palmitic Acid results in increased expression of UCP2 mRNA]20667613
C081643candesartancandesartan results in decreased expression of UCP2 mRNA16685210
C459604candoxincandoxin results in decreased expression of UCP2 mRNA16309724
D002211CapsaicinUCP2 protein polymorphism affects the susceptibility to Capsaicin analog19056576
D002211CapsaicinCapsaicin inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]20359164
D002220CarbamazepineCarbamazepine affects the expression of UCP2 mRNA25979313
D002248Carbon MonoxideUCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]22046279
D002248Carbon MonoxideUCP2 protein promotes the reaction [Carbon Monoxide results in increased abundance of Reactive Oxygen Species]22046279
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of UCP2 mRNA18314881|1842032
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of UCP2 protein18314881
D002251Carbon Tetrachloridegadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of UCP2 mRNA]18314881
D002251Carbon TetrachlorideVitamin E inhibits the reaction [Carbon Tetrachloride results in increased expression of UCP2 mRNA]18314881
C026678carboprostacyclincarboprostacyclin results in increased expression of UCP2 mRNA11341955|1258805
C026678carboprostacyclinTriiodothyronine promotes the reaction [carboprostacyclin results in increased expression of UCP2 mRNA]12588052
D002273CarcinogensCarcinogens results in increased expression of UCP2 mRNA16316942
D002392CatechinCatechin inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]23365609
D002395CatecholaminesCatecholamines results in increased expression of UCP2 mRNA15855228
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] affects the expression of UCP2 mRNA28954213
C026690cerous chloridecerous chloride results in decreased expression of UCP2 mRNA28954213
D002737ChloropreneChloroprene results in increased expression of UCP2 mRNA23125180
D002746ChlorpromazineChlorpromazine affects the expression of UCP2 mRNA25064622
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of UCP2 mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UCP2 mRNA20938992
C039671ciglitazoneciglitazone results in decreased expression of UCP2 mRNA11056218
C018021cobaltous chloridecobaltous chloride results in decreased expression of UCP2 mRNA12032628|1937684
C018021cobaltous chloridecobaltous chloride results in decreased expression of UCP2 mRNA24386269
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of UCP2 mRNA21356183
D003300CopperCopper results in decreased expression of UCP2 mRNA21356183
C030865copper bis(3,5-diisopropylsalicylate)"[copper bis(3,5-diisopropylsalicylate) co-treated with Glucose] results in increased expression of UCP2 protein"23795780
D019327Copper SulfateCopper Sulfate results in decreased expression of UCP2 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of UCP2 mRNA26577399
D003486CyanidesUCP2 protein affects the susceptibility to Cyanides16782780
C017154cyanidincyanidin inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]28533128
D003513CycloheximideCycloheximide inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]12588051
D016572CyclosporineCyclosporine affects the expression of UCP2 mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of UCP2 mRNA25562108
C089948darglitazonedarglitazone results in increased expression of UCP2 mRNA12588052
C089948darglitazoneThyroxine promotes the reaction [darglitazone results in increased expression of UCP2 mRNA]12588052
C089948darglitazoneTriiodothyronine promotes the reaction [darglitazone results in increased expression of UCP2 mRNA]12588052
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UCP2 mRNA28659758
D003676DeferoxamineDeferoxamine results in decreased expression of UCP2 mRNA12032628
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased expression of UCP2 mRNA12659879
D015230Prostaglandin D2UCP2 protein affects the chemical synthesis of Prostaglandin D219846869
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of UCP2 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of UCP2 mRNA19853017
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of UCP2 mRNA28628672
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of UCP2 mRNA23428407
D003907DexamethasoneDexamethasone results in increased expression of UCP2 mRNA17998272
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of UCP2 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of UCP2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of UCP2 mRNA27594783
D002945CisplatinCisplatin results in increased expression of UCP2 mRNA27392435
D002945Cisplatin[Quercetin co-treated with Cisplatin] results in increased expression of UCP2 mRNA24999622
D002945CisplatinUCP2 protein affects the susceptibility to Cisplatin16217747
D004008DiclofenacDiclofenac results in increased expression of UCP2 mRNA26934552
C000944dicrotophosdicrotophos results in increased expression of UCP2 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of UCP2 mRNA26924002
D018119StavudineStavudine results in decreased expression of UCP2 mRNA14518702
D004041Dietary Fats[resveratrol analog co-treated with Dietary Fats] results in increased expression of UCP2 mRNA24759758
D004041Dietary FatsBenzo(a)pyrene inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]20412841
D004041Dietary FatsBenzo(a)pyrene promotes the reaction [Dietary Fats results in increased expression of UCP2 mRNA]20412841
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UCP2 mRNA21462320
D004041Dietary FatsDietary Fats results in decreased expression of UCP2 mRNA18042831|2041284
D004041Dietary FatsDietary Fats results in decreased expression of UCP2 protein25549548|2563768
D004041Dietary FatsDietary Fats results in increased expression of UCP2 mRNA16357043|1849283
D004041Dietary FatsEthanol promotes the reaction [Dietary Fats results in decreased expression of UCP2 protein]25549548
D004041Dietary Fats"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in decreased expression of UCP2 protein]"25637688
D004041Dietary Fatsnaringin inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]22198281
D004041Dietary FatsQuercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UCP2 mRNA]21462320
D004041Dietary FatsCapsaicin inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]20359164
D004041Dietary FatsCatechin inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]23365609
D004041Dietary FatsDietary Fats results in decreased expression of UCP2 mRNA20359164|2232705
D004041Dietary FatsDietary Fats results in increased expression of UCP2 mRNA11934670|2522814
D004041Dietary FatsDietary Fats results in increased expression of UCP2 protein25228148
D004041Dietary Fats[Dietary Sucrose co-treated with Dietary Fats] results in increased expression of UCP2 mRNA23529981
D004041Dietary FatsPlant Extracts inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]23365609
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]25228148
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of UCP2 protein]25228148
D004041Dietary FatsThioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]22327056|2246414
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated results in increased expression of UCP2 mRNA"11341955
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UCP2 mRNA21462320
D019422Dietary SucroseQuercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UCP2 mRNA]21462320
D019422Dietary Sucrose[Dietary Sucrose co-treated with Dietary Fats] results in increased expression of UCP2 mRNA23529981
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of UCP2 mRNA19245819
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of UCP2 mRNA25280772
D002117CalcitriolCalcitriol results in decreased expression of UCP2 protein15231722
C118756dihydroxy-vitamin D3dihydroxy-vitamin D3 inhibits the reaction [pirinixic acid promotes the reaction [Potassium Cyanide results in increased expression of UCP2 protein]]18183618
C118756dihydroxy-vitamin D3dihydroxy-vitamin D3 inhibits the reaction [Potassium Cyanide results in increased expression of UCP2 protein]18183618
C024629dimethyl phthalatedimethyl phthalate results in increased expression of UCP2 mRNA26924002
D004147DioxinsDioxins affects the expression of UCP2 mRNA20463971
C076126disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate"disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of UCP2 mRNA"20184727
D004221DisulfiramDisulfiram results in increased expression of UCP2 mRNA20530235
D004050DitiocarbDitiocarb results in increased expression of UCP2 protein18082129
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in increased expression of UCP2 mRNA11341955
D004317DoxorubicinDoxorubicin results in decreased expression of UCP2 mRNA28940058
D004317DoxorubicinDoxorubicin results in decreased expression of UCP2 protein26781513
D004317DoxorubicinDoxorubicin results in increased expression of UCP2 protein26781513
D004317DoxorubicinPPARGC1A affects the reaction [Doxorubicin results in decreased expression of UCP2 protein]26781513
D004317DoxorubicinPPARGC1A affects the reaction [Doxorubicin results in increased expression of UCP2 protein]26781513
D004317DoxorubicinDoxorubicin results in decreased expression of UCP2 mRNA19915844
D004317DoxorubicinDoxorubicin results in decreased expression of UCP2 protein26678157
C042986ebselen[ebselen co-treated with Glucose] results in decreased expression of UCP2 protein23795780
D015118Eicosapentaenoic AcidEicosapentaenoic Acid results in increased expression of UCP2 mRNA11341955
D000431EthanolEthanol promotes the reaction [Dietary Fats results in decreased expression of UCP2 protein]25549548
D000431EthanolEthanol results in decreased expression of UCP2 mRNA20007851
D000431Ethanolrosiglitazone inhibits the reaction [Ethanol results in decreased expression of UCP2 mRNA]20007851
D000431Ethanol[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in decreased expression of UCP2 protein26854922
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of UCP2 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of UCP2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UCP2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UCP2 mRNA17942748
C054207etomoxiretomoxir promotes the reaction [pirinixic acid results in increased expression of UCP2 protein]16306367
C054207etomoxiretomoxir results in increased expression of UCP2 protein16306367
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of UCP2 mRNA"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of UCP2 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of UCP2 mRNA]"23333450
D011345Fenofibrate[Fenofibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA11341955
D011345FenofibrateFenofibrate results in increased expression of UCP2 mRNA16595124
D005395Fish OilsFish Oils results in increased expression of UCP2 mRNA11341955
D005485FlutamideFlutamide results in decreased expression of UCP2 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UCP2 mRNA20938992
C039281furanfuran results in increased expression of UCP2 mRNA15120968
C038958gadolinium chloridegadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of UCP2 mRNA]18314881
D005944GlucosamineGlucosamine results in decreased expression of UCP2 mRNA11893929
D005947GlucoseGlucose results in increased expression of UCP2 protein18167556
D005947Glucose"[copper bis(3,5-diisopropylsalicylate) co-treated with Glucose] results in increased expression of UCP2 protein"23795780
D005947Glucose[ebselen co-treated with Glucose] results in decreased expression of UCP2 protein23795780
D005947Glucose[Sodium Selenite co-treated with Glucose] results in decreased expression of UCP2 protein23795780
D005947GlucoseGlucose results in increased expression of UCP2 mRNA28027979
D005947Glucose[SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate]16366736
D005947GlucoseUCP2 protein inhibits the reaction [SIRT1 protein promotes the reaction [Glucose results in increased expression of INS1 protein]]16366736
D005978GlutathioneGlutathione inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide]19361538
D006046Gold[Polyethyleneimine binds to Gold] which results in increased expression of UCP2 mRNA28433809
C425931GW 501516GW 501516 results in increased expression of UCP2 mRNA16239165
C000625835HFPO2 compoundHFPO2 compound results in increased expression of UCP2 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of UCP2 mRNA27553808
D006632HistamineUCP2 protein results in decreased secretion of Histamine19846869
D006632HistamineUCP2 protein affects the abundance of Histamine19846869
D006632HistamineUCP2 protein affects the secretion of Histamine19846869
D017313FenretinideFenretinide results in decreased expression of UCP2 mRNA28973697
D006854HydrocortisoneHydrocortisone results in increased expression of UCP2 mRNA15855228|1596141
D006861Hydrogen Peroxide"[[benzo(a)pyrene-1,6-quinone results in increased abundance of Superoxides] co-treated with [benzo(a)pyrene-1,6-quinone results in decreased abundance of Hydrogen Peroxide]] results in increased expression of UCP2 mRNA"10860543
D006861Hydrogen PeroxideGlutathione inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide]19361538
D006861Hydrogen Peroxide[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide19361538
D006861Hydrogen Peroxide[[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide] which results in decreased expression of BCL2 protein19361538
D006861Hydrogen PeroxidePotassium Cyanide promotes the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide]19361538
D0201553-Hydroxybutyric Acid3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of UCP2 protein]25440059
D007200IndicanAICA ribonucleotide inhibits the reaction [Indican results in decreased expression of UCP2 mRNA]25703824
D007200IndicanIndican results in decreased expression of UCP2 mRNA25703824
D007200IndicanUCP2 protein results in decreased susceptibility to Indican25703824
D007213IndomethacinIndomethacin results in increased expression of UCP2 mRNA16984733
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of UCP2 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of UCP2 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of UCP2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of UCP2 mRNA23428407
D007545IsoproterenolIsoproterenol results in increased expression of UCP2 mRNA20003209
D007545IsoproterenolIsoproterenol results in increased expression of UCP2 mRNA16580698
D007545IsoproterenolIsoproterenol results in increased expression of UCP2 protein16580698
D007545Isoproterenolphenylmethylpyrazolone inhibits the reaction [Isoproterenol results in increased expression of UCP2 mRNA]16580698
D007545Isoproterenolphenylmethylpyrazolone inhibits the reaction [Isoproterenol results in increased expression of UCP2 protein]16580698
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of UCP2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of UCP2 mRNA27392435
C067713lactacystinlactacystin inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]19361538
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] affects the expression of UCP2 mRNA28954213
C028521lanthanum chloridelanthanum chloride results in decreased expression of UCP2 mRNA28954213
D007854LeadLead affects the expression of UCP2 mRNA28903495
C052901lemongrass oillemongrass oil affects the expression of UCP2 mRNA25976427
C052901lemongrass oillemongrass oil results in increased expression of UCP2 mRNA25458622
C008287lipid mobilizing substance"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [lipid mobilizing substance results in increased expression of UCP2 protein]"15026812
C008287lipid mobilizing substancelipid mobilizing substance results in increased expression of UCP2 protein15026812
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of UCP2 mRNA15650415
D008070LipopolysaccharidesSodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of UCP2 mRNA]15650415
D008070LipopolysaccharidesUCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]22046279
D019808LosartanLosartan results in decreased expression of UCP2 mRNA17508912
D019808LosartanLosartan results in decreased expression of UCP2 protein17508912
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]19109942
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of UCP2 mRNA21641980
D008627Mercuric ChlorideMercuric Chloride affects the expression of UCP2 mRNA20353558
D008687MetforminMetformin results in increased expression of UCP2 mRNA22815988
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UCP2 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of UCP2 mRNA25575725
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in decreased expression of UCP2 protein]"25637688
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of UCP2 mRNA23458150
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of UCP2 mRNA27544571
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of UCP2 mRNA24694518
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of UCP2 mRNA26011545
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of UCP2 mRNA19840844
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of UCP2 mRNA15948157
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of UCP2 protein15948157
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of UCP2 mRNA19763737
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of UCP2 protein19763737
D0156551-Methyl-4-phenylpyridiniumUCP2 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC25A27 mRNA]19763737
D0156551-Methyl-4-phenylpyridiniumUCP2 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA]19763737
C060893MK-886MK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 mRNA]16782780
C060893MK-886MK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]16782780
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of UCP2 mRNA26924002
C500085muraglitazarmuraglitazar results in increased expression of UCP2 mRNA21515302
C030517myxothiazolmyxothiazol results in increased expression of UCP2 protein18082129
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of UCP2 mRNA"25554681
C005274naringinnaringin inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]22198281
D009532NickelNickel results in increased expression of UCP2 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of UCP2 mRNA19167457
C025256nonylphenolnonylphenol results in increased expression of UCP2 mRNA22946080
D009638NorepinephrineNorepinephrine results in increased expression of UCP2 mRNA12588052|8593794
C025589ochratoxin Aochratoxin A results in decreased expression of UCP2 mRNA19287073|2212462
C025589ochratoxin Aochratoxin A results in increased expression of UCP2 mRNA17316727
C025589ochratoxin Aochratoxin A results in decreased expression of UCP2 mRNA22124623
D019787Linoleic AcidLinoleic Acid results in increased expression of UCP2 mRNA11341955
D019301Oleic Acid[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in decreased expression of UCP2 protein26854922
D019301Oleic AcidOleic Acid results in decreased expression of UCP2 mRNA24349266
D019301Oleic AcidOleic Acid results in increased expression of UCP2 mRNA11341955|1258805
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of UCP2 mRNA19840844
C108709oleoyl-estroneoleoyl-estrone results in decreased expression of UCP2 mRNA20184727
C488250oleoylethanolamideoleoylethanolamide results in increased expression of UCP2 mRNA15910890
D010100OxygenOxygen deficiency results in decreased expression of UCP2 mRNA12032628
D010100Oxygen[4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid co-treated with Oxygen deficiency] results in increased expression of UCP2 protein21113404
D010100Oxygen4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Oxygen deficiency results in decreased expression of UCP2 mRNA]21113404
D010100OxygenOxygen deficiency results in decreased expression of UCP2 mRNA21113404
D010100OxygenOxygen deficiency results in increased expression of UCP2 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of UCP2 mRNA]22629407
D010100Oxygen[resveratrol co-treated with Oxygen deficiency] results in increased expression of UCP2 protein21113404
D010100Oxygenrosiglitazone inhibits the reaction [Oxygen deficiency results in decreased expression of UCP2 mRNA]21113404
D010100Oxygen[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of UCP2 mRNA27693381
D010168PalmitatesPalmitates results in increased expression of UCP2 mRNA16620699
D010168Palmitatesrosiglitazone inhibits the reaction [Palmitates results in increased expression of UCP2 mRNA]16620699
D019308Palmitic AcidPalmitic Acid results in increased activity of UCP2 protein12858170
D019308Palmitic Acidcandesartan inhibits the reaction [Palmitic Acid results in increased expression of UCP2 mRNA]20667613
D019308Palmitic AcidPalmitic Acid results in increased expression of UCP2 mRNA20667613
D019308Palmitic Acid[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in decreased expression of UCP2 protein26854922
D000073878Palm OilPalm Oil results in decreased expression of UCP2 mRNA18042831
C016030pantogabpantogab results in increased expression of UCP2 mRNA17379144
D010269Paraquat[HSF-1 protein co-treated with LYZ protein co-treated with AAKG-2 protein co-treated with UCP2 protein] results in decreased susceptibility to Paraquat22737090
D010269Paraquat[UCP2 protein co-treated with AAKG-2 protein co-treated with LYZ protein] results in decreased susceptibility to Paraquat22737090
D010269Paraquat[UCP2 protein co-treated with AAKG-2 protein] results in decreased susceptibility to Paraquat22737090
D010269ParaquatParaquat affects the expression of UCP2 mRNA25064622
D010269ParaquatUCP2 protein results in decreased susceptibility to Paraquat16054055
D010416PentachlorophenolPentachlorophenol results in increased expression of UCP2 mRNA23892564
C036567perfluorodecanoic acidperfluorodecanoic acid results in increased expression of UCP2 mRNA27344344
C036567perfluorodecanoic acidPPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UCP2 mRNA]27344344
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of UCP2 mRNA22613580
C076994perfluorooctane sulfonic acid2-chloro-5-nitrobenzanilide inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of UCP2 mRNA]23500012
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of UCP2 mRNA23500012
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of UCP2 mRNA21499893
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of UCP2 mRNA19162173|2851185
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UCP2 mRNA28659758
D010634PhenobarbitalPhenobarbital affects the expression of UCP2 mRNA23091169
C030299phenylhydrazineUCP2 protein affects the susceptibility to phenylhydrazine18687678
C005435phenylmethylpyrazolonephenylmethylpyrazolone inhibits the reaction [Isoproterenol results in increased expression of UCP2 mRNA]16580698
C005435phenylmethylpyrazolonephenylmethylpyrazolone inhibits the reaction [Isoproterenol results in increased expression of UCP2 protein]16580698
C029217phenyl-N-tert-butylnitronephenyl-N-tert-butylnitrone inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]18183618
D010852PicrotoxinPicrotoxin results in increased expression of UCP2 mRNA15170462
C006253pirinixic acidetomoxir promotes the reaction [pirinixic acid results in increased expression of UCP2 protein]16306367
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of UCP2 mRNA20813756
C006253pirinixic acid[pirinixic acid co-treated with rosiglitazone] results in increased expression of UCP2 mRNA16306350
C006253pirinixic acidpirinixic acid results in increased expression of UCP2 mRNA11056218|1630635
C006253pirinixic acidpirinixic acid results in increased expression of UCP2 protein16306367
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of UCP2 protein]16306367
C006253pirinixic acidAcetylcysteine inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]18183618
C006253pirinixic aciddihydroxy-vitamin D3 inhibits the reaction [pirinixic acid promotes the reaction [Potassium Cyanide results in increased expression of UCP2 protein]]18183618
C006253pirinixic acidGlutathione inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide]19361538
C006253pirinixic acidlactacystin inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]19361538
C006253pirinixic acidMK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 mRNA]16782780
C006253pirinixic acidMK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]16782780
C006253pirinixic acidphenyl-N-tert-butylnitrone inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]18183618
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA11341955
C006253pirinixic acidpirinixic acid promotes the reaction [Potassium Cyanide results in increased expression of UCP2 protein]18183618
C006253pirinixic acidpirinixic acid results in increased expression of UCP2 mRNA16782780|1916217
C006253pirinixic acidpirinixic acid results in increased expression of UCP2 protein16782780|1818361
C006253pirinixic acid[[pirinixic acid results in increased expression of UCP2 protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Potassium Cyanide19361538
C006253pirinixic acid[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide19361538
C006253pirinixic acid[[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide] which results in decreased expression of BCL2 protein19361538
C006253pirinixic acid[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein19361538
C006253pirinixic acidPotassium Cyanide promotes the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide]19361538
C006253pirinixic acidPotassium Cyanide promotes the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]19361538
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of UCP2 mRNA]16782780
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of UCP2 protein]16782780
C006253pirinixic acidSN50 peptide inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]18183618
C006253pirinixic acidUCP2 protein affects the susceptibility to pirinixic acid16782780
D010936Plant ExtractsUCP2 protein polymorphism affects the susceptibility to Plant Extracts19056576
D010936Plant ExtractsPlant Extracts results in increased expression of UCP2 protein20132043
D010936Plant ExtractsPlant Extracts inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]23365609
D010936Plant ExtractsPlant Extracts results in increased expression of UCP2 mRNA23306787
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in increased expression of UCP2 mRNA28433809
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of UCP2 mRNA22714537
D011190Potassium Cyanidedihydroxy-vitamin D3 inhibits the reaction [pirinixic acid promotes the reaction [Potassium Cyanide results in increased expression of UCP2 protein]]18183618
D011190Potassium Cyanidedihydroxy-vitamin D3 inhibits the reaction [Potassium Cyanide results in increased expression of UCP2 protein]18183618
D011190Potassium Cyanidepirinixic acid promotes the reaction [Potassium Cyanide results in increased expression of UCP2 protein]18183618
D011190Potassium Cyanide[[pirinixic acid results in increased expression of UCP2 protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Potassium Cyanide19361538
D011190Potassium CyanidePotassium Cyanide promotes the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide]19361538
D011190Potassium CyanidePotassium Cyanide promotes the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]19361538
D011190Potassium CyanidePotassium Cyanide results in increased expression of UCP2 protein18183618
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of UCP2 mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of UCP2 mRNA23018184
C005556propionaldehydepropionaldehyde results in increased expression of UCP2 mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of UCP2 mRNA24780913
D011522ProtonsAdenosine Triphosphate inhibits the reaction [UCP2 protein results in increased transport of Protons]12734183
D011522ProtonsUCP2 protein results in increased transport of Protons12734183
C513428pyrachlostrobinpyrachlostrobin results in increased expression of UCP2 mRNA27029645
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UCP2 mRNA28659758
D011794Quercetin[Quercetin co-treated with Cisplatin] results in increased expression of UCP2 mRNA24999622
D011794QuercetinQuercetin results in increased expression of UCP2 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]28533128
D011794QuercetinQuercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of UCP2 mRNA]21462320
D017382Reactive Oxygen SpeciesUCP2 protein results in increased abundance of Reactive Oxygen Species12858170
D017382Reactive Oxygen SpeciesUCP2 protein promotes the reaction [Carbon Monoxide results in increased abundance of Reactive Oxygen Species]22046279
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of UCP210860543
C059514resveratrol[resveratrol analog co-treated with Dietary Fats] results in increased expression of UCP2 mRNA24759758
C059514resveratrolPRKAA1 protein promotes the reaction [resveratrol results in increased expression of UCP2 mRNA]19934007
C059514resveratrolPRKAA2 protein promotes the reaction [resveratrol results in increased expression of UCP2 mRNA]19934007
C059514resveratrol[resveratrol co-treated with Oxygen deficiency] results in increased expression of UCP2 protein21113404
C059514resveratrolresveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]28533128
C059514resveratrolresveratrol results in increased expression of UCP2 mRNA19934007|2287864
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]25228148
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of UCP2 protein]25228148
C089730rosiglitazonebexarotene promotes the reaction [rosiglitazone results in increased expression of UCP2 mRNA]10548525
C089730rosiglitazonerosiglitazone results in increased expression of UCP2 mRNA10548525|1561907
C089730rosiglitazonerosiglitazone results in increased expression of UCP2 protein17255338
C089730rosiglitazone[pirinixic acid co-treated with rosiglitazone] results in increased expression of UCP2 mRNA16306350
C089730rosiglitazonerosiglitazone affects the expression of UCP2 mRNA22013433
C089730rosiglitazonerosiglitazone inhibits the reaction [Ethanol results in decreased expression of UCP2 mRNA]20007851
C089730rosiglitazonerosiglitazone inhibits the reaction [Oxygen deficiency results in decreased expression of UCP2 mRNA]21113404
C089730rosiglitazonerosiglitazone results in increased expression of UCP2 mRNA17245590
C089730rosiglitazonerosiglitazone inhibits the reaction [Palmitates results in increased expression of UCP2 mRNA]16620699
C089730rosiglitazonerosiglitazone results in increased expression of UCP2 mRNA21172411|2151530
C089730rosiglitazonerosiglitazone results in increased expression of UCP2 protein17052689
C089730rosiglitazoneUCP2 mRNA affects the susceptibility to rosiglitazone20404217
D012402RotenoneRotenone results in increased expression of UCP2 mRNA22447502
D012402RotenoneRotenone results in increased expression of UCP2 mRNA22447502
D012402RotenoneRotenone results in increased expression of UCP2 mRNA23186747
D012402RotenoneRotenone results in increased expression of UCP2 protein18082129
D012822Silicon DioxideSilicon Dioxide results in decreased expression of UCP2 mRNA25351596
D012906SmokeSmoke results in increased expression of UCP2 protein23069111
C118258SN50 peptideSN50 peptide inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]18183618
C009277sodium arsenatesodium arsenate results in increased expression of UCP2 mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of UCP2 mRNA28229933
C017947sodium arsenite"3,4-dihydroxyphenylethanol inhibits the reaction [sodium arsenite results in decreased expression of UCP2 mRNA]"28225195
C017947sodium arsenitesodium arsenite results in decreased expression of UCP2 mRNA25764338|2822519
C017947sodium arsenitesodium arsenite results in decreased expression of UCP2 protein25764338
C016104sodium bichromatesodium bichromate results in increased expression of UCP2 mRNA24612858
D018038Sodium Selenite[Sodium Selenite co-treated with Glucose] results in decreased expression of UCP2 protein23795780
D018038Sodium SeleniteSodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of UCP2 mRNA]15650415
D018038Sodium SeleniteSodium Selenite results in decreased expression of UCP2 mRNA15650415
D018038Sodium SeleniteSodium Selenite results in decreased expression of UCP2 protein15650415
D012999SomanSoman results in increased expression of UCP2 mRNA19281266
D053260SootSoot results in increased expression of UCP2 mRNA26551751
C075117squalestatin 1squalestatin 1 results in increased expression of UCP2 mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of UCP2 mRNA27225895
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of UCP2 mRNA21641980
D013481SuperoxidesUCP2 protein results in decreased abundance of Superoxides25440059
D013481Superoxides"[[benzo(a)pyrene-1,6-quinone results in increased abundance of Superoxides] co-treated with [benzo(a)pyrene-1,6-quinone results in decreased abundance of Hydrogen Peroxide]] results in increased expression of UCP2 mRNA"10860543
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of UCP2 mRNA"26680231
D014284TriiodothyronineTriiodothyronine results in increased expression of UCP2 mRNA15961419
D014284TriiodothyronineTHRA protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]12588052
D014284TriiodothyronineTHRB protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]12588052
D014284TriiodothyronineTriiodothyronine promotes the reaction [Bezafibrate results in increased expression of UCP2 mRNA]12588052
D014284TriiodothyronineTriiodothyronine promotes the reaction [carboprostacyclin results in increased expression of UCP2 mRNA]12588052
D014284TriiodothyronineTriiodothyronine promotes the reaction [darglitazone results in increased expression of UCP2 mRNA]12588052
D013629TamoxifenTamoxifen affects the expression of UCP2 mRNA17555576
C084178telmisartanPPARD promotes the reaction [telmisartan results in increased expression of UCP2 protein]20176998
C084178telmisartantelmisartan results in increased expression of UCP2 protein20176998
C001803tempoltempol results in decreased expression of UCP2 mRNA16685210
C001803tempoltempol results in increased expression of UCP2 protein24591154
C505333TEMPOL-HTEMPOL-H results in increased expression of UCP2 protein24591154
C501413tesaglitazartesaglitazar results in increased expression of UCP2 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UCP2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UCP2 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of UCP2 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UCP2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UCP2 mRNA15328365|1816354
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of UCP2 mRNA28973375
D013752TetracyclineTetracycline affects the expression of UCP2 mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of UCP2 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of UCP2 mRNA22378314
D045162Thiazolidinediones2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]12588051
D045162Thiazolidinediones"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]"12588051
D045162ThiazolidinedionesCycloheximide inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]12588051
D045162ThiazolidinedionesThiazolidinediones results in increased expression of UCP2 mRNA12588051
D045162ThiazolidinedionesU 0126 inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]12588051
D045162ThiazolidinedionesTHRA protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]12588052
D045162ThiazolidinedionesTHRB protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]12588052
D013849ThimerosalThimerosal results in decreased expression of UCP2 mRNA27188386
D013853ThioacetamideThioacetamide affects the expression of UCP2 mRNA25064622
D008063Thioctic AcidThioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]22327056|2246414
D013974ThyroxineThyroxine promotes the reaction [darglitazone results in increased expression of UCP2 mRNA]12588052
C009495titanium dioxidetitanium dioxide results in increased expression of UCP2 mRNA29128614
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of UCP2 mRNA22363418|2806579
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of UCP2 mRNA27255386
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of UCP2 mRNA"15888570
D014212TretinoinTretinoin results in decreased expression of UCP2 mRNA20530235
D014212TretinoinTretinoin results in decreased expression of UCP2 mRNA23724009
D014212TretinoinTretinoin results in increased expression of UCP2 mRNA16840543
C011559tributyltintributyltin results in increased expression of UCP2 mRNA23428407
D014241TrichloroethyleneTrichloroethylene results in increased expression of UCP2 mRNA25549359
C012589trichostatin Atrichostatin A results in increased expression of UCP2 mRNA12588052
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of UCP2 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of UCP2 mRNA11056218
C057693troglitazone[troglitazone results in increased activity of PPARG protein] which results in increased expression of UCP2 mRNA11089532
C057693troglitazonetroglitazone results in increased expression of UCP2 mRNA11089532|1295317
C057693troglitazonetroglitazone results in increased expression of UCP2 mRNA21515302|9268716
D014415TunicamycinTunicamycin results in decreased expression of UCP2 mRNA22378314
C113580U 0126U 0126 inhibits the reaction [Thiazolidinediones results in increased expression of UCP2 mRNA]12588051
D014520UrethaneUrethane results in decreased expression of UCP2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of UCP2 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of UCP2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of UCP2 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of UCP2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of UCP2 mRNA24896083
D014638VanadatesVanadates results in decreased expression of UCP2 mRNA22714537
D014640VancomycinVancomycin results in decreased expression of UCP2 mRNA18930951
C025643vinclozolinvinclozolin results in decreased expression of UCP2 mRNA23034163
D014750VincristineVincristine results in decreased expression of UCP2 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of UCP2 mRNA26682919
D009536NiacinamideNiacinamide inhibits the reaction [[SIRT1 protein binds to UCP2 promoter] which results in decreased expression of UCP2 mRNA]16366736|1636673
D014810Vitamin EVitamin E inhibits the reaction [Carbon Tetrachloride results in increased expression of UCP2 mRNA]18314881
D024483Vitamin K 3Vitamin K 3 affects the expression of UCP2 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0017077oxidative phosphorylation uncoupler activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000303response to superoxide-IEA-  
GO:0001666response to hypoxia-IDA22292025  
GO:0007565female pregnancy-IEA-  
GO:0007568aging-IEA-  
GO:0009409response to cold-IBA21873635  
GO:0010942positive regulation of cell death-IEA-  
GO:0032869cellular response to insulin stimulus-IEA-  
GO:0034198cellular response to amino acid starvation-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0051881regulation of mitochondrial membrane potential-IEA-  
GO:0061179negative regulation of insulin secretion involved in cellular response to glucose stimulus-IEA-  
GO:0070542response to fatty acid-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0097421liver regeneration-IEA-  
GO:1902600proton transmembrane transport-TAS9054939  
GO:1990542mitochondrial transmembrane transport-IBA21873635  
GO:1990845adaptive thermogenesis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005743mitochondrial inner membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-166187Mitochondrial Uncoupling ProteinsTAS
R-HSA-167826The fatty acid cycling modelTAS
R-HSA-167827The proton buffering modelTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17555951Interaction between the uncoupling protein 2 -866G>A gene variant and cigarette smoking to increase oxidative stress in subjects with diabetes. (2008 Jan)Stephens JWNutr Metab Cardiovasc Dis
12075579Genetic factors as predictors of weight gain in young adult Dutch men and women. (2002 Apr)van Rossum CTInt J Obes Relat Metab Disord
11916758Racial differences in the relation between uncoupling protein genes and resting energy expenditure. (2002 Apr)Kimm SYAm J Clin Nutr
21029457Uncoupling protein 2 G(-866)A polymorphism: a new gene polymorphism associated with C-reactive protein in type 2 diabetic patients. (2010 Oct 28)Lapice ECardiovasc Diabetol
16622580Leptin resistance conferred by a combination of single nucleotide polymorphism and the adoption of a Western lifestyle in urban areas of Thailand. (2006 May-Jun)Yanagisawa YJ Nutr Health Aging
29254145Bile acid and cigarette smoke enhance the aggressive phenotype of esophageal adenocarcinoma cells by downregulation of the mitochondrial uncoupling protein-2. (2017 Nov 24)Xu YOncotarget
17130180Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men. (2007 Jan)Humphries SEClin Chem
21074158Mitochondrial uncoupling protein gene cluster variation (UCP2-UCP3) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study. (2011 Jan)Zee RYAtherosclerosis