Gene: UCP3

7352
SLC25A9
uncoupling protein 3
protein-coding
11q13.4
Ensembl:ENSG00000175564 MIM:602044 Vega:OTTHUMG00000168109 UniprotKB:P55916
NG_011515.1
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.816e-1 (AD)  4.749e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NOP20.755
SRRM50.728
ZDHHC180.721
CHRNA100.719
LSMEM10.714
LRRC660.693
PLAGL20.687
ZSCAN220.664
TDRG10.658
HAS30.657

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PIP-0.256
MUC7-0.256
OR4F5-0.244
LYZ-0.234
P2RY12-0.233
GSDMC-0.231
HAPLN1-0.222
OR4F29-0.221
ECM2-0.217
CCT6B-0.216

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of UCP3 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of UCP3 mRNA"23962555
C5307733,5-diethoxycarbonyl-1,4-dihydrocollidine"3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of UCP3 mRNA"20512997
C5307733,5-diethoxycarbonyl-1,4-dihydrocollidine"3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of UCP3 protein"20512997
C027696acipimoxacipimox results in decreased expression of UCP3 mRNA25352640
C027696acipimox[Albuterol co-treated with acipimox] results in decreased expression of UCP3 mRNA12824081
D000255Adenosine TriphosphateAdenosine Triphosphate inhibits the reaction [UCP3 protein results in increased transport of Protons]12734183
D000420Albuterol[Albuterol co-treated with acipimox] results in decreased expression of UCP3 mRNA12824081
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UCP3 mRNA16483693
D001629BezafibrateBezafibrate results in increased expression of UCP3 mRNA10342807|1090998
D001629BezafibrateBezafibrate results in decreased expression of UCP3 mRNA10403804
D001629BezafibrateBezafibrate results in increased expression of UCP3 mRNA10933891|1147305
C006780bisphenol Abisphenol A results in decreased expression of UCP3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of UCP3 gene28505145
C006780bisphenol Abisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of UCP3 mRNA]19228888
D002211CapsaicinCapsaicin inhibits the reaction [Dietary Fats results in increased expression of UCP3 protein]20517883
C470213capsiatecapsiate results in decreased expression of UCP3 mRNA17264228
D002392CatechinCatechin inhibits the reaction [Dietary Fats results in decreased expression of UCP3 mRNA]23365609
C039671ciglitazoneciglitazone results in decreased expression of UCP3 mRNA11056218
D002994ClofibrateClofibrate results in increased expression of UCP3 mRNA10342807
D003471CuprizoneCuprizone results in decreased expression of UCP3 mRNA27523638
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased expression of UCP3 mRNA12659879
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased expression of UCP3 mRNA12659879
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of UCP3 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of UCP3 mRNA17884810
D003907DexamethasoneEP300 protein promotes the reaction [Dexamethasone results in increased expression of UCP3 mRNA]17884810
D003907DexamethasoneHDAC1 protein inhibits the reaction [Dexamethasone results in increased expression of UCP3 mRNA]17884810
D003907Dexamethasoneresveratrol inhibits the reaction [Dexamethasone results in increased expression of UCP3 mRNA]17884810
D003907DexamethasoneSIRT1 protein inhibits the reaction [Dexamethasone results in increased expression of UCP3 mRNA]17884810
D003907DexamethasoneSIRT1 protein inhibits the reaction [EP300 protein promotes the reaction [Dexamethasone results in increased expression of UCP3 mRNA]]17884810
D064730DexrazoxaneDexrazoxane results in decreased expression of UCP3 mRNA26873546
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of UCP3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of UCP3 mRNA27392435
D018119StavudineStavudine results in decreased expression of UCP3 mRNA14518702
D004026DieldrinDieldrin results in decreased expression of UCP3 mRNA23041725
D004041Dietary Fats[AGT protein affects the susceptibility to Dietary Fats] which affects the expression of UCP3 mRNA26704350
D004041Dietary FatsDietary Fats results in decreased expression of UCP3 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of UCP3 mRNA10909982|2041284
D004041Dietary FatsDietary Fats results in increased expression of UCP3 protein10909982
D004041Dietary FatsCapsaicin inhibits the reaction [Dietary Fats results in increased expression of UCP3 protein]20517883
D004041Dietary FatsCatechin inhibits the reaction [Dietary Fats results in decreased expression of UCP3 mRNA]23365609
D004041Dietary FatsDietary Fats results in decreased expression of UCP3 mRNA23365609
D004041Dietary FatsDietary Fats results in increased expression of UCP3 protein20517883
D004041Dietary FatsPlant Extracts inhibits the reaction [Dietary Fats results in decreased expression of UCP3 mRNA]23365609
C076126disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate"disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of UCP3 mRNA"20184727
D004317DoxorubicinDoxorubicin results in decreased expression of UCP3 mRNA26873546
D004317DoxorubicinDoxorubicin results in increased expression of UCP3 mRNA21040762
D004317DoxorubicinDoxorubicin results in increased expression of UCP3 protein23695218
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of UCP3 mRNA21040762
D004317DoxorubicinDoxorubicin results in decreased expression of UCP3 mRNA19915844
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UCP3 mRNA23550701
C054207etomoxiretomoxir results in increased expression of UCP3 protein16306367
C054207etomoxir[pirinixic acid co-treated with etomoxir] results in increased expression of UCP3 protein16306367
C054207etomoxirPPARA affects the reaction [[pirinixic acid co-treated with etomoxir] results in increased expression of UCP3 protein]16306367
C054207etomoxirPPARA protein affects the reaction [etomoxir results in increased expression of UCP3 protein]16306367
D005227Fatty AcidsFatty Acids affects the expression of UCP310909982
D005227Fatty AcidsFatty Acids results in increased expression of UCP3 protein16306367
D011345FenofibrateFenofibrate results in increased expression of UCP3 mRNA16595124
D005419FlavonoidsFlavonoids results in decreased expression of UCP3 mRNA18035473
D005632FructoseFructose results in increased expression of UCP3 protein11934685
D005947GlucoseGlucose results in decreased expression of UCP3 protein18167556
D005947GlucoseUCP3 protein promotes the reaction [Glucose results in increased secretion of INS protein]18167556
C453899GW 7647GW 7647 results in increased expression of UCP3 mRNA21324916
C453899GW 7647PPARA protein promotes the reaction [GW 7647 results in increased expression of UCP3 mRNA]21324916
D017313FenretinideFenretinide results in decreased expression of UCP3 mRNA28973697
D007545IsoproterenolIsoproterenol results in decreased expression of UCP3 mRNA24286936
D007545IsoproterenolIsoproterenol results in increased expression of UCP3 mRNA24286936
D007545IsoproterenolIsoproterenol results in decreased expression of UCP3 mRNA24286936
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of UCP3 mRNA27392435
C006552kaempferolkaempferol results in increased expression of UCP3 mRNA17327447
C052901lemongrass oillemongrass oil affects the expression of UCP3 mRNA25976427
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of UCP3 mRNA17379010
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA]19109942
D014975LuteinLutein results in increased expression of UCP3 mRNA24865317
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of UCP3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of UCP3 mRNA"25620056
D019829NevirapineNevirapine metabolite results in increased expression of UCP3 mRNA23947594
C028007nickel monoxidenickel monoxide results in decreased expression of UCP3 mRNA19167457
C025589ochratoxin Aochratoxin A results in increased expression of UCP3 mRNA17316727|2212462
D019301Oleic AcidOleic Acid inhibits the reaction [troglitazone results in decreased expression of UCP3 mRNA]11056218
D019301Oleic AcidOleic Acid results in increased expression of UCP3 mRNA11056218
D019301Oleic AcidOleic Acid results in increased expression of UCP3 mRNA12630940
C108709oleoyl-estroneoleoyl-estrone results in decreased expression of UCP3 mRNA20184727
D010100OxygenATF1 protein promotes the reaction [Oxygen deficiency results in increased expression of UCP3 protein]18579531
D010100OxygenOxygen deficiency promotes the reaction [[ATF1 protein binds to UCP3 promoter] which results in increased expression of UCP3 mRNA]18579531|1857953
D010100OxygenOxygen deficiency results in increased expression of UCP3 protein18579531
D010100OxygenSB 203580 inhibits the reaction [Oxygen deficiency results in increased expression of UCP3 protein]18579531
D010100OxygenUCP3 protein inhibits the reaction [Oxygen deficiency results in increased abundance of Reactive Oxygen Species]18579531
D000073878Palm OilPalm Oil results in decreased expression of UCP3 mRNA18042831
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of UCP3 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of UCP3 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of UCP3 mRNA23500012
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of UCP3 mRNA21251948
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of UCP3 protein21251948
D010833Phytic Acid[resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of UCP3 mRNA18657603
C030614picolinic acidpicolinic acid results in increased expression of UCP3 mRNA19283340
D010852PicrotoxinPicrotoxin results in increased expression of UCP3 mRNA15170462
C006253pirinixic acid[pirinixic acid co-treated with etomoxir] results in increased expression of UCP3 protein16306367
C006253pirinixic acidpirinixic acid results in increased expression of UCP3 mRNA10342807|1090998
C006253pirinixic acidpirinixic acid results in increased expression of UCP3 protein16306367|2055891
C006253pirinixic acidPPARA affects the reaction [[pirinixic acid co-treated with etomoxir] results in increased expression of UCP3 protein]16306367
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of UCP3]10342807
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of UCP3 protein]16306367
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of UCP3 mRNA]17950772
C006253pirinixic acidpirinixic acid results in increased expression of UCP3 mRNA10933891|1241480
D010936Plant ExtractsPlant Extracts inhibits the reaction [Dietary Fats results in decreased expression of UCP3 mRNA]23365609
D011192Potassium DichromatePotassium Dichromate results in decreased expression of UCP3 mRNA23608068
C005556propionaldehydepropionaldehyde results in decreased expression of UCP3 mRNA26079696
D011522ProtonsAdenosine Triphosphate inhibits the reaction [UCP3 protein results in increased transport of Protons]12734183
D011522ProtonsUCP3 protein results in increased transport of Protons12734183
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of UCP3 protein19264907
D011794Quercetin[resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of UCP3 mRNA18657603
D017382Reactive Oxygen SpeciesUCP3 protein inhibits the reaction [Oxygen deficiency results in increased abundance of Reactive Oxygen Species]18579531
C059514resveratrolPRKAA1 protein promotes the reaction [resveratrol results in increased expression of UCP3 mRNA]19934007
C059514resveratrolPRKAA2 protein promotes the reaction [resveratrol results in increased expression of UCP3 mRNA]19934007
C059514resveratrol[resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of UCP3 mRNA18657603
C059514resveratrolresveratrol results in increased expression of UCP3 mRNA18657603|1993400
C059514resveratrolresveratrol inhibits the reaction [Dexamethasone results in increased expression of UCP3 mRNA]17884810
C059514resveratrolresveratrol results in increased expression of UCP3 protein23790948
C089730rosiglitazonerosiglitazone affects the expression of UCP3 mRNA22013433
C089730rosiglitazonerosiglitazone results in increased expression of UCP3 mRNA12414803|1588704
C093642SB 203580SB 203580 inhibits the reaction [Oxygen deficiency results in increased expression of UCP3 protein]18579531
D053260SootSoot results in increased expression of UCP3 mRNA26551751
D053260SootSoot results in increased expression of UCP3 mRNA21914721
D013311StreptozocinStreptozocin results in increased expression of UCP3 protein16306367
D014284Triiodothyroninebisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of UCP3 mRNA]19228888
D014284TriiodothyronineTriiodothyronine results in decreased expression of UCP3 mRNA19228888
C084178telmisartanPPARD promotes the reaction [telmisartan results in increased expression of UCP3 protein]20176998
C084178telmisartantelmisartan results in increased expression of UCP3 protein20176998
D013739TestosteroneTestosterone results in increased expression of UCP3 mRNA21045173
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UCP3 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UCP3 mRNA19770486
D013970ThyroninesThyronines results in increased expression of UCP3 mRNA10823916
D013970ThyroninesThyronines results in increased expression of UCP3 protein10823916
C009495titanium dioxidetitanium dioxide affects the expression of UCP3 mRNA17656681
C009495titanium dioxidetitanium dioxide results in increased expression of UCP3 mRNA29128614
C052342topiramatetopiramate results in decreased expression of UCP3 mRNA16979414
D014118Toxins, Biological"Toxins, Biological affects the expression of UCP3 mRNA"19682533
C034613triacsin Ctriacsin C results in increased expression of UCP3 mRNA11056218
D014241TrichloroethyleneTrichloroethylene results in increased expression of UCP3 mRNA25549359
C057693troglitazoneOleic Acid inhibits the reaction [troglitazone results in decreased expression of UCP3 mRNA]11056218
C057693troglitazonetroglitazone affects the expression of UCP3 mRNA12920214
C057693troglitazonetroglitazone results in decreased expression of UCP3 mRNA11056218
C057693troglitazonetroglitazone results in increased expression of UCP3 mRNA10909982
C057693troglitazonetroglitazone results in decreased expression of UCP3 mRNA11118623
C057693troglitazonetroglitazone results in increased expression of UCP3 mRNA11118623
D014635Valproic AcidValproic Acid results in increased methylation of UCP3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of UCP3 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of UCP3 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of UCP3 mRNA25423262
C025643vinclozolinvinclozolin results in decreased expression of UCP3 mRNA23034163
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of UCP3 mRNA18593933
D015032ZincZinc results in increased expression of UCP3 mRNA17074742
D019287Zinc SulfateZinc Sulfate results in increased expression of UCP3 mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-TAS9196039  
GO:0005515protein binding-IPI24008843  
GO:0017077oxidative phosphorylation uncoupler activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000303response to superoxide-IEA-  
GO:0001666response to hypoxia-IEA-  
GO:0006629lipid metabolic process-TAS10935638  
GO:0006631fatty acid metabolic process-IEA-  
GO:0007568aging-IEA-  
GO:0007584response to nutrient-IEA-  
GO:0007585respiratory gaseous exchange-TAS9180264  
GO:0009409response to cold-IBA21873635  
GO:0014823response to activity-IEA-  
GO:0032868response to insulin-IEA-  
GO:0032870cellular response to hormone stimulus-IEA-  
GO:0051384response to glucocorticoid-IEA-  
GO:1902600proton transmembrane transport-TAS9196039  
GO:1990542mitochondrial transmembrane transport-IBA21873635  
GO:1990845adaptive thermogenesis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-TAS9180264  
GO:0005743mitochondrial inner membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-166187Mitochondrial Uncoupling ProteinsTAS
R-HSA-167826The fatty acid cycling modelTAS
R-HSA-167827The proton buffering modelTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22087257Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque. (2011)Dong CPLoS One
17786284Identification of a polymorphism of UCP3 associated with recurrent in-stent restenosis of coronary arteries. (2007 Oct)Oguri MInt J Mol Med
23681825Heme-related gene expression signatures of meat intakes in lung cancer tissues. (2014 Jul)Lam TKMol Carcinog
22038464Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet-gene interaction on body fat content. (2012 Oct)Barth SWEur J Nutr
11916758Racial differences in the relation between uncoupling protein genes and resting energy expenditure. (2002 Apr)Kimm SYAm J Clin Nutr
21074158Mitochondrial uncoupling protein gene cluster variation (UCP2-UCP3) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study. (2011 Jan)Zee RYAtherosclerosis
15508020Effect of short-term cigarette smoke exposure on body weight, appetite and brain neuropeptide Y in mice. (2005 Apr)Chen HNeuropsychopharmacology