Gene: SCGB1A1

7356
CC10|CC16|CCPBP|CCSP|UGB|UP-1|UP1
secretoglobin family 1A member 1
protein-coding
11q12.3
Ensembl:ENSG00000149021 MIM:192020 Vega:OTTHUMG00000167526 UniprotKB:P11684
NG_021331.1
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.162e-1 (AD)  7.420e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFTPB0.696
SFTPA10.685
SFTPA20.638
SLC34A20.606
OR56A30.579
MROH90.578
HOXC120.556
TPO0.554
KRT730.553
CXCL170.553

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM207A-0.269
HDDC3-0.254
TMEM187-0.251
TMEM53-0.251
CSDC2-0.249
QRFPR-0.247
CLEC11A-0.245
BOLA1-0.242
C1orf53-0.241
FICD-0.24

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB083734,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYLSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SCGB1A1 mRNA"19114083
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SCGB1A1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of SCGB1A1 mRNA22230336
D000082AcetaminophenAcetaminophen results in increased expression of SCGB1A1 mRNA15030884
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SCGB1A1 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of SCGB1A1 protein"24679086
D000535AluminumAluminum results in decreased expression of SCGB1A1 protein16099050
D000535AluminumAluminum results in decreased expression of SCGB1A1 protein16052892
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SCGB1A1 mRNA16483693
D001151ArsenicArsenic results in decreased expression of SCGB1A1 protein24679086
D001152ArsenicalsArsenicals results in decreased expression of SCGB1A1 mRNA28625800
D017638Asbestos, Crocidolite"MAP2K1 protein affects the reaction [Asbestos, Crocidolite results in increased expression of SCGB1A1 mRNA]"18192500
D001280AtrazineAtrazine results in increased expression of SCGB1A1 mRNA22378314
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of SCGB1A1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SCGB1A1 mRNA22228805
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in increased expression of SCGB1A1 mRNA26945725
D004958EstradiolEstradiol results in increased expression of SCGB1A1 mRNA26945725
C006780bisphenol Abisphenol A results in increased expression of SCGB1A1 mRNA23757601
C006780bisphenol Abisphenol A results in increased expression of SCGB1A1 protein23757601
D001761BleomycinBleomycin results in decreased expression of SCGB1A1 protein25933445
D003931DiacetylDiacetyl results in decreased expression of SCGB1A1 protein21464978
D002104CadmiumCadmium results in increased export of SCGB1A1 protein17687258
D002118CalciumCalcium results in increased expression of SCGB1A1 mRNA16237193
D002118CalciumCalcium results in increased expression of SCGB1A1 protein16237193
C026690cerous chloridecerous chloride results in increased expression of SCGB1A1 mRNA23573234
D002922CiguatoxinsCiguatoxins affects the expression of SCGB1A1 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of SCGB1A1 mRNA17585979
D003300CopperCopper analog results in decreased expression of SCGB1A1 protein21279893
D003471CuprizoneCuprizone results in decreased expression of SCGB1A1 mRNA27523638
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SCGB1A1 mRNA23640034
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SCGB1A1 protein16439099
D004317DoxorubicinDoxorubicin results in decreased expression of SCGB1A1 protein18440303
D004391DustDust analog results in decreased expression of SCGB1A1 protein21279893
D004391DustDust results in decreased expression of SCGB1A1 protein23573920
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of SCGB1A1 protein23573920
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SCGB1A1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SCGB1A1 mRNA15834898
C069837fullerene C60fullerene C60 results in increased expression of SCGB1A1 mRNA19167457
C039281furanfuran results in decreased expression of SCGB1A1 mRNA25539665
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring results in decreased expression of SCGB1A1 mRNA"26833564
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring results in decreased expression of SCGB1A1 protein"26833564
D006851Hydrochloric AcidHydrochloric Acid results in increased expression of SCGB1A1 protein24122261
D006851Hydrochloric AcidQuercetin inhibits the reaction [Hydrochloric Acid results in increased expression of SCGB1A1 protein]24122261
D015735MifepristoneMifepristone results in decreased expression of SCGB1A1 mRNA19439560
D015735MifepristoneMifepristone results in increased expression of SCGB1A1 mRNA19439560
D009151Mustard GasMustard Gas results in increased expression of SCGB1A1 mRNA15674844
D009151Mustard GasMustard Gas results in decreased expression of SCGB1A1 protein28402575
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SCGB1A1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SCGB1A1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased secretion of SCGB1A1 protein"25598225
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SCGB1A1 mRNA"25620056
C031721naphthaleneASCL1 protein inhibits the reaction [naphthalene results in decreased expression of SCGB1A1 protein]20554700
C031721naphthalenenaphthalene results in decreased expression of SCGB1A1 mRNA18757308|1897830
C031721naphthalenenaphthalene results in decreased expression of SCGB1A1 protein18978301|2055470
C017557nickel subsulfidenickel subsulfide results in decreased expression of SCGB1A1 mRNA21086188
C029938nickel sulfatenickel sulfate affects the expression of SCGB1A1 mRNA12718980
D009569Nitric OxideNitric Oxide results in decreased expression of SCGB1A1 protein15764486
C007350nitrofennitrofen results in decreased expression of SCGB1A1 mRNA12194114
C007350nitrofennitrofen results in decreased expression of SCGB1A1 mRNA10751355|1761888
D005996NitroglycerinNitroglycerin results in decreased expression of SCGB1A1 mRNA12102619
D010100OxygenSCGB1A1 protein affects the reaction [Oxygen results in increased expression of CCL11 mRNA]10027076
D010100OxygenSCGB1A1 protein affects the reaction [Oxygen results in increased expression of CCL3 mRNA]10027076
D010100OxygenSCGB1A1 protein affects the reaction [Oxygen results in increased expression of CCL4 mRNA]10027076
D010100OxygenSCGB1A1 protein affects the reaction [Oxygen results in increased expression of CXCL2 mRNA]10027076
D010100OxygenSCGB1A1 protein affects the reaction [Oxygen results in increased expression of HCAR2 mRNA]10027076
D010126OzoneOzone results in decreased expression of SCGB1A1 mRNA14515223
D010126OzoneOzone results in decreased expression of SCGB1A1 protein14515223
D010126OzoneOzone results in increased expression of SCGB1A1 protein14515223
D010126OzoneOzone results in increased secretion of SCGB1A1 protein14515223
D010126OzoneSCGB1A1 gene mutant form results in increased susceptibility to Ozone16226776
D010126OzoneSCGB1A1 protein affects the reaction [Ozone results in increased expression of CCL11 mRNA]10027076
D010126OzoneSCGB1A1 protein affects the reaction [Ozone results in increased expression of CCL3 mRNA]10027076
D010126OzoneSCGB1A1 protein affects the reaction [Ozone results in increased expression of CXCL2 mRNA]10027076
D010126OzoneSCGB1A1 protein affects the reaction [Ozone results in increased expression of IL6 mRNA]9700096
D010126OzoneSCGB1A1 protein affects the reaction [Ozone results in increased expression of MT1 mRNA]9700096
D010126OzoneOzone affects the secretion of SCGB1A1 protein10486303
D010126OzoneOzone results in increased expression of SCGB1A1 mRNA9028799
D010126OzoneOzone results in increased expression of SCGB1A1 protein9028799
D010269ParaquatParaquat results in increased expression of SCGB1A1 protein17174135
C006253pirinixic acidpirinixic acid results in decreased expression of SCGB1A1 mRNA20813756
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in increased expression of SCGB1A1 mRNA26945725
D011441PropylthiouracilPropylthiouracil results in decreased expression of SCGB1A1 mRNA24780913
D011794QuercetinQuercetin inhibits the reaction [Hydrochloric Acid results in increased expression of SCGB1A1 protein]24122261
C022088silicon carbidesilicon carbide results in decreased expression of SCGB1A1 mRNA14580898
C022088silicon carbidesilicon carbide results in decreased expression of SCGB1A1 protein14580898
C017947sodium arsenitesodium arsenite affects the expression of SCGB1A1 mRNA17450228
D020058StyreneStyrene results in decreased expression of SCGB1A1 mRNA19428955
C013690styrene oxidestyrene oxide results in decreased expression of SCGB1A1 mRNA19428955
C013690styrene oxidestyrene oxide results in decreased expression of SCGB1A1 protein19428955
D013629TamoxifenTamoxifen results in increased expression of SCGB1A1 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SCGB1A1 mRNA19372248
C009495titanium dioxidetitanium dioxide results in increased expression of SCGB1A1 mRNA23131501
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SCGB1A1 protein23757602
D022882TrihalomethanesTrihalomethanes affects the expression of SCGB1A1 protein20833607
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of SCGB1A1 protein29186624
C025643vinclozolinvinclozolin affects the expression of SCGB1A1 mRNA19015723
C017963vinyl carbamatevinyl carbamate results in decreased expression of SCGB1A1 mRNA17849452
D015032ZincZinc deficiency results in increased expression of SCGB1A1 mRNA19111725
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of SCGB1A1 mRNA]19111725

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18243143  21516116  25416956  
GO:0019834phospholipase A2 inhibitor activity-IEA-  
GO:0097160polychlorinated biphenyl binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0007165signal transduction-IEA-  
GO:0007565female pregnancy-NAS10587371  
GO:0007566embryo implantation-TAS10587371  
GO:0009410response to xenobiotic stimulus-IEA-  
GO:0010193response to ozone-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0032689negative regulation of interferon-gamma production-IEA-  
GO:0032696negative regulation of interleukin-13 production-IEA-  
GO:0032713negative regulation of interleukin-4 production-IEA-  
GO:0032714negative regulation of interleukin-5 production-IEA-  
GO:0034021response to silicon dioxide-IEA-  
GO:0034097response to cytokine-IEA-  
GO:0042130negative regulation of T cell proliferation-IEA-  
GO:0043086negative regulation of catalytic activity-IEA-  
GO:0043488regulation of mRNA stability-IEA-  
GO:0050727regulation of inflammatory response-IEA-  
GO:0051384response to glucocorticoid-IEA-  
GO:0071774response to fibroblast growth factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA21805676  
GO:0005635nuclear envelope-IEA-  
GO:0005791rough endoplasmic reticulum-IEA-  
GO:0030141secretory granule-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26937342NGS meta data analysis for identification of SNP and INDEL patterns in human airway transcriptome: A preliminary indicator for lung cancer. (2015 Mar)B SAppl Transl Genom
20397810Non-invasive assessment of small airway remodelling in smokers. (2010 Apr)Bourdin ACOPD
23144326Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. (2012 Dec 15)Kim DKAm J Respir Crit Care Med
23818594EGF shifts human airway basal cell fate toward a smoking-associated airway epithelial phenotype. (2013 Jul 16)Shaykhiev RProc Natl Acad Sci U S A
22375630RNA-Seq quantification of the human small airway epithelium transcriptome. (2012 Feb 29)Hackett NRBMC Genomics
26159408Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study. (2015 Aug)Guerra SLancet Respir Med