Gene: UGP2

7360
UDPG|UDPGP|UDPGP2|UGP1|UGPP1|UGPP2|pHC379
UDP-glucose pyrophosphorylase 2
protein-coding
2p15
Ensembl:ENSG00000169764 MIM:191760 Vega:OTTHUMG00000129513 UniprotKB:Q16851
NC_000002.12
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.661e-1 (AD)  4.243e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2287361chr2:63890506 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12993544chr2:63878419 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12988017chr2:63844466 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARL6IP10.949
CALM10.941
GHITM0.939
GNB10.938
EIF4A20.937
RNF110.932
MORF4L10.932
PFN20.932
KCMF10.93
ARL8B0.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.768
OR4F29-0.729
TFPI2-0.337
VNN3-0.316
CSAG1-0.306
KCNJ15-0.306
KLRB1-0.296
CXCR2-0.292
IL18RAP-0.291
FOLR3-0.286

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of UGP2 mRNA20566314
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of UGP2 mRNA"21394737
C0502243,5,5-trimethylhexanoylferrocene"3,5,5-trimethylhexanoylferrocene results in increased expression of UGP2 protein"22649188
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of UGP2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGP2 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of UGP2 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGP2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of UGP2 mRNA21420995|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of UGP2 mRNA19770486
D0150812-Naphthylamine2-Naphthylamine results in increased expression of UGP2 mRNA18247414
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of UGP2 mRNA"24160326
C547126AZM551248AZM551248 results in increased expression of UGP2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UGP2 mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UGP2 mRNA19770486
C044887beta-methylcholinebeta-methylcholine affects the expression of UGP2 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of UGP2 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of UGP2 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of UGP2 protein28903499
D019256Cadmium ChlorideCadmium Chloride results in increased expression of UGP2 protein24527689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of UGP2 mRNA24794047
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of UGP2 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of UGP2 mRNA17484886
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of UGP2 mRNA17178418
D002994ClofibrateClofibrate results in decreased expression of UGP2 protein19952500
D002994ClofibrateClofibrate results in decreased expression of UGP2 mRNA23811191
D002994ClofibrateClofibrate results in decreased expression of UGP2 mRNA22300585
D002994ClofibrateClofibrate results in decreased expression of UGP2 protein16470657
D002995Clofibric AcidClofibric Acid affects the expression of UGP2 mRNA17602206
D019327Copper SulfateCopper Sulfate results in decreased expression of UGP2 mRNA19549813
C057862cyanoginosin LRcyanoginosin LR results in increased expression of UGP2 mRNA17654400
D016572CyclosporineCyclosporine results in increased expression of UGP2 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of UGP2 mRNA19770486
C014347decitabinedecitabine affects the expression of UGP2 mRNA23300844
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of UGP2 mRNA]21095227
D003907DexamethasoneDexamethasone results in increased expression of UGP2 mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of UGP2 mRNA21266533
D002945CisplatinCisplatin affects the expression of UGP2 mRNA23300844
D004006DichlorvosDichlorvos results in decreased activity of UGP2 protein222008
C000944dicrotophosdicrotophos results in decreased expression of UGP2 mRNA28302478
D004026DieldrinDieldrin results in increased expression of UGP2 mRNA20438755
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of UGP2 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of UGP2 mRNA]19850644
D004052Diethylnitrosamine[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of UGP2 protein20935162
D004610Ellagic AcidEllagic Acid results in decreased expression of UGP2 mRNA12002526
C118739entinostatentinostat results in increased expression of UGP2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGP2 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UGP2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UGP2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UGP2 mRNA23550701
D005485FlutamideFlutamide results in decreased expression of UGP2 mRNA24793618
D005839GentamicinsGentamicins results in increased expression of UGP2 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of UGP2 mRNA24136188
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of UGP2 mRNA20566314
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of UGP2 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of UGP2 mRNA27392435
C002950methylformamidemethylformamide analog results in increased expression of UGP2 mRNA17040096
C002950methylformamidemethylformamide results in increased expression of UGP2 mRNA17040096
D009151Mustard GasMustard Gas results in increased expression of UGP2 mRNA18988085
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of UGP2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of UGP2 mRNA"25620056
D009538NicotineNicotine results in increased expression of UGP2 mRNA18247414
C464660obeticholic acidobeticholic acid results in increased expression of UGP2 mRNA27939613
C016030pantogabpantogab results in decreased expression of UGP2 mRNA17379144
D010634Phenobarbital[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of UGP2 protein20935162
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of UGP2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of UGP2 mRNA18445702|2081375
D010936Plant ExtractsPlant Extracts results in increased expression of UGP2 mRNA23557933
D011794QuercetinQuercetin results in decreased expression of UGP2 mRNA21632981
C059514resveratrolresveratrol results in decreased expression of UGP2 mRNA12002526
C089730rosiglitazonerosiglitazone results in decreased expression of UGP2 mRNA19211718
C089730rosiglitazonerosiglitazone results in increased expression of UGP2 mRNA19201733|1939791
D017632Asbestos, Serpentine"Asbestos, Serpentine affects the expression of UGP2 mRNA"24160326
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of UGP2 mRNA]21095227
C009277sodium arsenatesodium arsenate results in increased expression of UGP2 mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UGP2 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UGP2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UGP2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGP2 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UGP2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of UGP2 mRNA25613284
C012589trichostatin Atrichostatin A results in decreased expression of UGP2 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of UGP2 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of UGP2 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGP2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of UGP2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of UGP2 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of UGP2 mRNA17963808
D014640VancomycinVancomycin results in increased expression of UGP2 mRNA18930951
C100058vanillinvanillin results in increased expression of UGP2 mRNA17178418
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of UGP2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of UGP2 mRNA23034163|2355583

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003983UTP:glucose-1-phosphate uridylyltransferase activity-EXP5427280  
GO:0003983UTP:glucose-1-phosphate uridylyltransferase activity-IBA21873635  
GO:0003983UTP:glucose-1-phosphate uridylyltransferase activity-TAS8354390  
GO:0005515protein binding-IPI16189514  17474147  25416956  
GO:0005536glucose binding-IEA-  
GO:0032557pyrimidine ribonucleotide binding-IEA-  
GO:0042802identical protein binding-IPI16189514  21988832  25416956  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005977glycogen metabolic process-IBA21873635  
GO:0005978glycogen biosynthetic process-TAS-  
GO:0006011UDP-glucose metabolic process-IBA21873635  
GO:0006065UDP-glucuronate biosynthetic process-TAS-  
GO:0019255glucose 1-phosphate metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
KEGG ID KEGG Term
hsa00040Pentose and glucuronate interconversions
hsa00052Galactose metabolism
hsa00500Starch and sucrose metabolism
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156588GlucuronidationTAS
R-HSA-173599Formation of the active cofactor, UDP-glucuronateTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-3322077Glycogen synthesisTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-8982491Glycogen metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal