Gene: UGT2B4

7363
HLUG25|UDPGT2B4|UDPGTH1|UDPGTh-1|UGT2B11
UDP glucuronosyltransferase family 2 member B4
protein-coding
4q13.3
Ensembl:ENSG00000156096 MIM:600067 Vega:OTTHUMG00000058891 UniprotKB:P06133
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.180e-2 (AD)  7.134e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C8B0.632
PLA2G2E0.618
FUT60.612
CPN20.61
MUC170.602
FAM83C0.577
OTOR0.565
UGT1A70.547
LAMB40.524
DEFB1150.524

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HYKK-0.218
LRTOMT-0.215
WDR88-0.211
MRO-0.207
ACOT1-0.2
MDH1B-0.188
UTS2B-0.181
LYPD6-0.179
ACVR1C-0.177
TBC1D16-0.177

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00295MorphineSmall Molecule57-27-2Approved|InvestigationalEnzyme
DB00318CodeineSmall Molecule76-57-3Approved|IllicitEnzyme
DB00712FlurbiprofenSmall Molecule5104-49-4Approved|InvestigationalEnzyme
DB01050IbuprofenSmall Molecule15687-27-1ApprovedEnzyme
DB06292DapagliflozinSmall Molecule461432-26-8ApprovedEnzyme
DB06741GavestinelSmall Molecule153436-22-7InvestigationalEnzyme
DB08907CanagliflozinSmall Molecule842133-18-0ApprovedEnzyme
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of UGT2B4 mRNA"19695238
C5830744,4'-hexafluorisopropylidene diphenol"UGT2B4 protein results in increased glucuronidation of and results in decreased activity of 4,4'-hexafluorisopropylidene diphenol"24349450
D000082AcetaminophenAcetaminophen results in decreased expression of UGT2B4 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of UGT2B4 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of UGT2B4 gene27153756
C038491allyl sulfideallyl sulfide results in increased expression of UGT2B4 mRNA19695238
D000654AmobarbitalUGT2B4 protein results in increased glycosylation of Amobarbital15013842
D001507BeclomethasoneBeclomethasone results in increased expression of UGT2B4 mRNA15370884
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UGT2B4 mRNA20106945|2163298
D004958EstradiolEstradiol results in decreased expression of UGT2B4 mRNA20106945
C006780bisphenol AUGT2B4 protein results in increased glucuronidation of bisphenol A18990428
C006780bisphenol Abisphenol A results in decreased expression of UGT2B4 mRNA25181051
C043211carvedilolUGT2B4 protein results in increased glucuronidation of carvedilol14744946
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of UGT2B4 mRNA17058234|2717416
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of UGT2B4 mRNA17851650
D019327Copper SulfateCopper Sulfate results in decreased expression of UGT2B4 mRNA19549813
D016572CyclosporineCyclosporine affects the expression of UGT2B4 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of UGT2B4 mRNA25562108|2798913
D016572CyclosporineCyclosporine results in increased expression of UGT2B4 mRNA21632981
C007262deoxynivalenolUGT2B4 protein results in increased glucuronidation of deoxynivalenol24927789
C573133deoxynivalenol-15-glucuronideUGT2B4 protein results in increased chemical synthesis of deoxynivalenol-15-glucuronide24927789
C000944dicrotophosdicrotophos results in decreased expression of UGT2B4 mRNA28302478
D004317DoxorubicinDoxorubicin results in decreased expression of UGT2B4 mRNA16404146
D004391DustDust results in increased expression of UGT2B4 mRNA17805423
D004964EstriolUGT2B4 protein results in increased glucuronidation of Estriol1909626
D005204FarnesolUGT2B4 protein results in increased glucuronidation of Farnesol15320866
D011345FenofibrateFenofibrate results in increased expression of UGT2B4 mRNA17058234
D005480FlurbiprofenUGT2B4 protein results in increased glucuronidation of Flurbiprofen15843492
C007845gingerolUGT2B4 protein results in increased glucuronidation of gingerol25393417
D005978GlutathioneGlutathione deficiency results in increased expression of UGT2B4 mRNA15345336
D006923HymecromoneHymecromone results in increased activity of UGT2B4 protein26875642
D006923Hymecromonelicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B4 protein]26875642
C010471hyodeoxycholic acidUGT2B4 protein results in increased glucuronidation of hyodeoxycholic acid1909626
D007052IbuprofenUGT2B4 protein results in increased glucuronidation of Ibuprofen15843492
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UGT2B4 mRNA26752646
D007657Ketone BodiesKetone Bodies results in decreased expression of UGT2B4 mRNA16807920
D007660KetoprofenUGT2B4 protein results in increased glucuronidation of Ketoprofen15843492
C070840licochalcone Alicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B4 protein]26875642
C016599mono-(2-ethylhexyl)phthalateUGT2B4 protein results in increased glucuronidation of mono-(2-ethylhexyl)phthalate27071666
C004821muricholic acidUGT2B4 protein results in increased glucuronidation of muricholic acid1909626
D009288NaproxenUGT2B4 protein results in increased glucuronidation of Naproxen15843492
D010634PhenobarbitalPhenobarbital results in increased expression of UGT2B4 protein19952500
D010634PhenobarbitalPhenobarbital results in increased expression of UGT2B4 mRNA8399210
D010634PhenobarbitalPhenobarbital results in decreased expression of UGT2B4 mRNA19084549
D011794QuercetinQuercetin results in decreased expression of UGT2B4 mRNA21632981
C115070ranirestatUGT2B4 protein results in increased glycosylation of ranirestat15013842
C064294sarpogrelateUGT2B4 protein results in increased glucuronidation of sarpogrelate metabolite23704698
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UGT2B4 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UGT2B4 mRNA20558275
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in decreased expression of UGT2B4 mRNA29024780
D014520UrethaneUrethane results in decreased expression of UGT2B4 mRNA28818685
D014810Vitamin EVitamin E results in decreased expression of UGT2B4 mRNA28923436

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001972retinoic acid bindingNOTIDA20308471  
GO:0008194UDP-glycosyltransferase activity-IBA21873635  
GO:0015020glucuronosyltransferase activity-IDA18052087  20056724  
GO ID GO Term Qualifier Evidence PubMed
GO:0052695cellular glucuronidation-IDA20056724  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa00040Pentose and glucuronate interconversions
hsa00053Ascorbate and aldarate metabolism
hsa00140Steroid hormone biosynthesis
hsa00500Starch and sucrose metabolism
hsa00514Other types of O-glycan biosynthesis
hsa00830Retinol metabolism
hsa00860Porphyrin and chlorophyll metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156588GlucuronidationTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24408517Simultaneous quantification of the abundance of several cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase enzymes in human liver microsomes using multiplexed targeted proteomics. (2014 Apr)Achour BDrug Metab Dispos