Gene: UGT2B7

7364
UDPGT 2B7|UDPGT 2B9|UDPGT2B7|UDPGTH2|UDPGTh-2|UGT2B9
UDP glucuronosyltransferase family 2 member B7
protein-coding
4q13.2
Ensembl:ENSG00000171234 MIM:600068 Vega:OTTHUMG00000129404 UniprotKB:P16662
NC_000004.12
PubMed
0   ANCO-SNPs
OD|ND
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.818e-1 (AD)  8.159e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR14J10.762
MBL20.735
OR4K30.731
OR1I10.726
POTEC0.724
OR2J20.719
TRIM600.716
TDRD150.706
NLRP130.703
OR2H10.696

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC175-0.298
HDDC3-0.274
CPO-0.273
SPAG8-0.273
TIMM21-0.265
GKAP1-0.265
KLHL35-0.262
TMEM97-0.259
GDF10-0.258
CEP72-0.257

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00197TroglitazoneSmall Molecule97322-87-7Investigational|WithdrawnEnzyme
DB00227LovastatinSmall Molecule75330-75-5Approved|InvestigationalEnzyme
DB00295MorphineSmall Molecule57-27-2Approved|InvestigationalEnzyme
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalEnzyme
DB00318CodeineSmall Molecule76-57-3Approved|IllicitEnzyme
DB00328IndomethacinSmall Molecule53-86-1Approved|InvestigationalEnzyme
DB00445EpirubicinSmall Molecule56420-45-2ApprovedEnzyme
DB00495ZidovudineSmall Molecule30516-87-1ApprovedEnzyme
DB00564CarbamazepineSmall Molecule298-46-4Approved|InvestigationalEnzyme
DB00586DiclofenacSmall Molecule15307-86-5ApprovedEnzyme
DB00641SimvastatinSmall Molecule79902-63-9ApprovedEnzyme
DB00678LosartanSmall Molecule114798-26-4ApprovedEnzyme
DB00688Mycophenolate mofetilSmall Molecule128794-94-5Approved|InvestigationalEnzyme
DB00712FlurbiprofenSmall Molecule5104-49-4Approved|InvestigationalEnzyme
DB00749EtodolacSmall Molecule41340-25-4Approved|InvestigationalEnzyme
DB00788NaproxenSmall Molecule22204-53-1ApprovedEnzyme
DB00842OxazepamSmall Molecule604-75-1ApprovedEnzyme
DB00870SuprofenSmall Molecule40828-46-4Approved|WithdrawnEnzyme
DB00973EzetimibeSmall Molecule163222-33-1ApprovedEnzyme
DB01024Mycophenolic acidSmall Molecule24280-93-1ApprovedEnzyme
DB01050IbuprofenSmall Molecule15687-27-1ApprovedEnzyme
DB01076AtorvastatinSmall Molecule134523-00-5ApprovedEnzyme
DB01095FluvastatinSmall Molecule93957-54-1ApprovedEnzyme
DB01252MitiglinideSmall Molecule145375-43-5Approved|InvestigationalEnzyme
DB01544FlunitrazepamSmall Molecule1622-62-4Approved|IllicitEnzyme
DB06204TapentadolSmall Molecule175591-23-8ApprovedEnzyme
DB06207SilodosinSmall Molecule160970-54-7ApprovedEnzyme
DB06230NalmefeneSmall Molecule55096-26-9Approved|Investigational|WithdrawnEnzyme
DB06235VadimezanSmall MoleculeInvestigationalEnzyme
DB06292DapagliflozinSmall Molecule461432-26-8ApprovedEnzyme
DB06403AmbrisentanSmall Molecule177036-94-1Approved|InvestigationalEnzyme
DB06695Dabigatran etexilateSmall Molecule211915-06-9ApprovedEnzyme
DB06737ZaltoprofenSmall Molecule74711-43-6Approved|InvestigationalEnzyme
DB06777Chenodeoxycholic acidSmall Molecule474-25-9ApprovedEnzyme
DB08860PitavastatinSmall Molecule147511-69-1ApprovedEnzyme
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalEnzyme
DB11827ErtugliflozinSmall Molecule1210344-57-2Approved|InvestigationalEnzyme
DB13783AcemetacinSmall Molecule53164-05-9Approved|Experimental|InvestigationalEnzyme
DB13874EnasidenibSmall Molecule1446502-11-9Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C06571910-hydroxywarfarin10-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein25393417
C06571910-hydroxywarfarin[10-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine25393417
C06571910-hydroxywarfarin10-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]25393417
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [HNF4A protein results in increased expression of UGT2B7 mRNA]"21415305
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of UGT2B7 mRNA"21415305
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of UGT2B7 mRNA]"21415305
C0907681-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"UGT2B7 protein results in increased glucuronidation of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene"29285606
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"UGT2B7 protein results in increased glucuronidation of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"15231852
C4873661-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid"UGT2B7 protein polymorphism affects the chemical synthesis of 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid"29203276
C4873661-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid"[UGT2B7 protein polymorphism affects the glucuronidation of Diclofenac] which affects the chemical synthesis of 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid"29203276
C05598720-hydroxy-5,8,11,14-eicosatetraenoic acid"UGT2B7 protein results in increased glucuronidation of 20-hydroxy-5,8,11,14-eicosatetraenoic acid"15231852
C0549192,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene"2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of UGT2B7 mRNA"25542188
C0600802,2-bis(bromomethyl)-1,3-propanediol"UGT2B7 protein results in increased glucuronidation of 2,2-bis(bromomethyl)-1,3-propanediol"20200232
C0080122-hydroxyestriolUGT2B7 protein alternative form results in increased glucuronidation of 2-hydroxyestriol8423545
C0080122-hydroxyestriolUGT2B7 protein results in increased glucuronidation of 2-hydroxyestriol8517101
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of UGT2B7 mRNA10220484
C5830744,4'-hexafluorisopropylidene diphenol"UGT2B7 protein results in increased glucuronidation of and results in decreased activity of 4,4'-hexafluorisopropylidene diphenol"24349450
C0264184-hydroxyestroneUGT2B7 protein alternative form results in increased glucuronidation of 4-hydroxyestrone8423545
C0264184-hydroxyestroneUGT2B7 protein results in increased glucuronidation of 4-hydroxyestrone8517101
C0598534'-hydroxywarfarin4'-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein25393417
C0598534'-hydroxywarfarin[4'-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine25393417
C0598534'-hydroxywarfarin4'-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]25393417
C0995654-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-olUGT2B7 gene polymorphism affects the abundance of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol23142425
C0995654-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-olUGT2B7 protein results in increased glucuronidation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol11038164|2645212
C0995644-((methylnitrosoamino)-1-(3-pyridyl)but-1-yl)beta-omega-glucosiduronic acidUGT2B7 protein results in increased chemical synthesis of 4-((methylnitrosoamino)-1-(3-pyridyl)but-1-yl)beta-omega-glucosiduronic acid26452127
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneUGT2B7 gene polymorphism results in decreased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone14871856
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneUGT2B7 protein results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone14871856
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneUGT2B7 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone23142425
C1052604-tert-octylphenolUGT2B7 protein results in increased glucuronidation of 4-tert-octylphenol28500425
C0700584-trifluoromethylumbelliferyl iduronideUGT2B7 protein results in increased glucuronidation of 4-trifluoromethylumbelliferyl iduronide15357915
C0080916-hydroxywarfarin6-hydroxywarfarin binds to UGT2B7 protein25393417
C1217077,3'-dihydroxy-4'-methoxyisoflavone"UGT2B7 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone"25044472
C0842367-hydroxy-4-trifluoromethylcoumarinsilybin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]15155549
C0842367-hydroxy-4-trifluoromethylcoumarinUGT2B7 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin15155549
C0878377-hydroxywarfarin7-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein25393417
C0878377-hydroxywarfarin[7-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine25393417
C0878377-hydroxywarfarin7-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]25393417
C1014368-hydroxywarfarin8-hydroxywarfarin binds to UGT2B7 protein25393417
D000082AcetaminophenAcetaminophen results in decreased expression of UGT2B7 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of UGT2B7 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of UGT2B7 mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of UGT2B7 mRNA23630614
C084615alclofenacalclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C084615alclofenacalclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450Aldosteronealclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450Aldosterone"Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]"19740398
D000450Aldosteronecicloprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450AldosteroneDiclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450AldosteroneDiflunisal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450AldosteroneFenoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450AldosteroneIbuprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450AldosteroneIndomethacin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450AldosteroneKetoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450AldosteroneKetorolac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450AldosteroneMeclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450AldosteroneMefenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450AldosteroneNaproxen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450Aldosteronepirprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450Aldosteronetiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D000450AldosteroneUGT2B7 protein results in increased glucuronidation of Aldosterone19740398
C018447aldosterone 18-glucuronidealclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C018447aldosterone 18-glucuronide"Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]"19740398
C018447aldosterone 18-glucuronidecicloprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C018447aldosterone 18-glucuronideDiclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C018447aldosterone 18-glucuronideDiflunisal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C018447aldosterone 18-glucuronideFenoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C018447aldosterone 18-glucuronideIbuprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C018447aldosterone 18-glucuronideIndomethacin inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C018447aldosterone 18-glucuronideKetoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C018447aldosterone 18-glucuronideKetorolac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C018447aldosterone 18-glucuronideMeclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C018447aldosterone 18-glucuronideMefenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C018447aldosterone 18-glucuronideNaproxen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C018447aldosterone 18-glucuronidepirprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C018447aldosterone 18-glucuronidetiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C018447aldosterone 18-glucuronideUGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide19740398
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of UGT2B7 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UGT2B7 mRNA16483693
D000654AmobarbitalUGT2B7 protein results in increased glycosylation of Amobarbital15013842
D000894Anti-Inflammatory Agents, Non-Steroidal"Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]"19740398
D000894Anti-Inflammatory Agents, Non-Steroidal"Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]"19740398
D000738AndrosteroneAndrosterone inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Diethylstilbestrol]23126256
D000738AndrosteroneAndrosterone results in decreased activity of UGT2B7 protein26875642
D000738AndrosteroneUGT2B7 protein results in increased glucuronidation of Androsterone11186130
C526219apple polyphenol extractapple polyphenol extract results in increased expression of UGT2B7 mRNA18351577
D016718Arachidonic AcidUGT2B7 protein results in increased glucuronidation of Arachidonic Acid15231852
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of UGT2B7 mRNA23912714
C000228aristolochic acid Iaristolochic acid I results in increased expression of UGT2B7 mRNA17483316
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of UGT2B7 mRNA23912714
C011677benoxaprofenUGT2B7 affects the susceptibility to benoxaprofen17880178
C011677benoxaprofenUGT2B7 protein alternative form results in increased glucuronidation of benoxaprofen8423545
C029876benzidineUGT2B7 protein results in increased metabolism of benzidine15615884
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UGT2B7 mRNA16545412
D004958EstradiolUGT2B7 protein results in increased glucuronidation of Estradiol15472229|1605163
D004958EstradiolUGT2B7 protein results in increased glucuronidation of Estradiol analog15472229|1789815
D001629BezafibrateUGT2B7 results in increased susceptibility to Bezafibrate17880178
C006780bisphenol AUGT2B7 protein results in increased glucuronidation of bisphenol A18990428
C006780bisphenol Abisphenol A results in decreased expression of UGT2B7 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of UGT2B7 mRNA22079614
C028031cadmium acetatecadmium acetate affects the expression of UGT2B7 mRNA16249259
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of UGT2B7 promoter22457795
C043211carvedilolUGT2B7 gene polymorphism affects the glucuronidation of carvedilol16849011
C043211carvedilolUGT2B7 gene polymorphism affects the metabolism of carvedilol16849011|1732985
C043211carvedilolUGT2B7 protein results in increased glucuronidation of carvedilol14744946
D002509CephaloridineCephaloridine results in increased expression of UGT2B7 mRNA18500788
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of UGT2B7 mRNA15821044
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of UGT2B7 mRNA17851650
C025618cicloprofencicloprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C025618cicloprofencicloprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D002995Clofibric Acidisoborneol inhibits the reaction [UGT2B7 results in increased susceptibility to Clofibric Acid]17880178
D002995Clofibric Acidpimagedine inhibits the reaction [UGT2B7 results in increased susceptibility to Clofibric Acid]17880178
D002995Clofibric AcidUGT2B7 protein alternative form results in increased glucuronidation of Clofibric Acid8423545
D002995Clofibric AcidUGT2B7 protein results in increased glucuronidation of Clofibric Acid8517101
D002995Clofibric AcidUGT2B7 results in increased susceptibility to Clofibric Acid17880178
C018021cobaltous chloridecobaltous chloride results in increased expression of UGT2B7 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of UGT2B7 mRNA19549813
C031071decanoic acidUGT2B7 protein results in increased glucuronidation of decanoic acid16051554
C037293denopamineDiclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of denopamine]15608137
C037293denopamineUGT2B7 protein results in increased glucuronidation of denopamine15608137
C007262deoxynivalenolUGT2B7 protein results in increased glucuronidation of deoxynivalenol24927789
C573134deoxynivalenol-3-glucuronideUGT2B7 protein results in increased chemical synthesis of deoxynivalenol-3-glucuronide24927789
C041517dibenzo(a,l)pyrene"UGT2B7 protein results in increased glycosylation of dibenzo(a,l)pyrene"21780761
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of UGT2B7 mRNA27392435
D004008Diclofenac[CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac28762043
D004008DiclofenacDiclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
D004008DiclofenacDiclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D004008DiclofenacDiclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of denopamine]15608137
D004008DiclofenacUGT2B7 protein polymorphism affects the glucuronidation of Diclofenac29203276
D004008Diclofenac"[UGT2B7 protein polymorphism affects the glucuronidation of Diclofenac] which affects the chemical synthesis of 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid"29203276
D004008DiclofenacUGT2B7 protein polymorphism affects the susceptibility to Diclofenac29203276
D004008DiclofenacUGT2B7 protein results in increased glucuronidation of Diclofenac15608137|1584349
D004008DiclofenacUGT2B7 protein results in increased metabolism of Diclofenac24104198
C000944dicrotophosdicrotophos results in decreased expression of UGT2B7 mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of UGT2B7 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of UGT2B7 mRNA19638242
D004054DiethylstilbestrolAndrosterone inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Diethylstilbestrol]23126256
D004054DiethylstilbestrolUGT2B7 protein results in increased glucuronidation of Diethylstilbestrol23126256
D004061DiflunisalDiflunisal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
D004061DiflunisalDiflunisal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D004061DiflunisalUGT2B7 protein alternative form results in increased glucuronidation of Diflunisal8423545
D004061DiflunisalUGT2B7 protein results in increased glucuronidation of Diflunisal8517101
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of UGT2B7 mRNA27638505
D004923ErythrosineErythrosine results in decreased activity of UGT2B7 protein16009655
D004923ErythrosineErythrosine results in decreased activity of UGT2B7 protein20041016
D004964EstriolUGT2B7 protein alternative form results in increased glucuronidation of Estriol8423545
D004964EstriolUGT2B7 protein results in increased glucuronidation of Estriol8517101
D004970EstroneUGT2B7 protein results in increased glucuronidation of Estrone15472229
D004970EstroneUGT2B7 protein results in increased glucuronidation of Estrone analog15472229
D004997Ethinyl EstradiolUGT2B7 protein results in increased glucuronidation of Ethinyl Estradiol analog17898154
C052488ethyl 2-(4-chlorophenyl)-5-(2-furyl)-4-oxzoleacetateUGT2B7 protein results in increased glucuronidation of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-4-oxzoleacetate15988124
D017308EtodolacUGT2B7 protein results in increased glucuronidation of Etodolac15535975
D000069438EzetimibeUGT2B7 protein results in increased glucuronidation of Ezetimibe14977865
D005204FarnesolUGT2B7 protein results in increased glucuronidation of Farnesol15320866
D005279FenoprofenFenoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
D005279FenoprofenFenoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D005279FenoprofenUGT2B7 protein alternative form results in increased glucuronidation of Fenoprofen8423545
D005279FenoprofenUGT2B7 protein results in increased glucuronidation of Fenoprofen8517101
D015725FluconazoleFluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol]18098064
D015725FluconazoleFluconazole results in decreased activity of UGT2B7 protein20092275
D005480FlurbiprofenUGT2B7 protein results in increased glucuronidation of Flurbiprofen15843492
C039281furanfuran results in increased expression of UGT2B7 mRNA26194646|2738771
C107601glabridinUGT2B7 protein results in increased glucuronidation of glabridin25765239
D017313FenretinideFenretinide results in increased expression of UGT2B7 mRNA28973697
C001381hydroxycotinineUGT2B7 protein results in increased glucuronidation of hydroxycotinine16141602
D006923HymecromoneHymecromone results in increased activity of UGT2B7 protein26875642
D006923Hymecromonelicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B7 protein]26875642
C010471hyodeoxycholic acidUGT2B7 protein affects the metabolism of hyodeoxycholic acid21415305
C010471hyodeoxycholic acidUGT2B7 protein alternative form results in increased glucuronidation of hyodeoxycholic acid8423545
C010471hyodeoxycholic acidUGT2B7 protein results in increased glucuronidation of hyodeoxycholic acid12527334|8517101
C010471hyodeoxycholic acidUGT2B7 protein results in increased glycosylation of hyodeoxycholic acid12527334
D007052IbuprofenIbuprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
D007052IbuprofenIbuprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D007052IbuprofenUGT2B7 protein alternative form results in increased glucuronidation of Ibuprofen8423545
D007052IbuprofenUGT2B7 protein results in increased glucuronidation of Ibuprofen15843492|8517101
C093581indeneUGT2B7 protein results in increased glucuronidation of indene15843492
D007213IndomethacinIndomethacin inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
D007213IndomethacinIndomethacin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D007213IndomethacinUGT2B7 protein alternative form results in increased glucuronidation of Indomethacin8423545
D007213IndomethacinUGT2B7 protein results in increased glucuronidation of Indomethacin15843492|2226588
C022871isoborneolisoborneol inhibits the reaction [UGT2B7 results in increased susceptibility to Clofibric Acid]17880178
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of UGT2B7 mRNA27392435
D007660KetoprofenKetoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
D007660KetoprofenKetoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D007660KetoprofenUGT2B7 protein alternative form results in increased glucuronidation of Ketoprofen8423545
D007660KetoprofenUGT2B7 protein results in increased glucuronidation of Ketoprofen15535975|1584349
D020910KetorolacKetorolac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
D020910KetorolacKetorolac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D007741LabetalolFluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol]18098064
D007741Labetalol[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol18098064
C030358lauric acidUGT2B7 protein results in increased glucuronidation of lauric acid16051554
C070840licochalcone Alicochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B7 protein]26875642
D008095Lithocholic AcidLithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter]15821044
D008095Lithocholic Acid[Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter]] which results in decreased expression of UGT2B7 mRNA15821044|1582104
C506658lorcaserinUGT2B7 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin22259019
C013592mangiferinmangiferin results in decreased activity of UGT2B7 protein22815239
D008469Meclofenamic AcidMeclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
D008469Meclofenamic AcidMeclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D008528Mefenamic AcidMefenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
D008528Mefenamic AcidMefenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D008610MentholUGT2B7 protein results in increased glucuronidation of Menthol11186130
D008627Mercuric ChlorideMercuric Chloride results in increased expression of UGT2B7 mRNA16507785
D008748MethylcholanthreneMethylcholanthrene results in increased expression of UGT2B7 mRNA19118567
C518174MK-0524UGT2B7 protein results in increased glucuronidation of MK-052417132765
C548427monascusic acid Amonascusic acid A results in decreased activity of UGT2B7 protein16009655
C016599mono-(2-ethylhexyl)phthalateUGT2B7 protein results in increased glucuronidation of mono-(2-ethylhexyl)phthalate27071666
D009020MorphineUGT2B7 affects the metabolism of Morphine23748253
D009020MorphineUGT2B7 protein affects the metabolism of Morphine15286053
D009020MorphineUGT2B7 protein results in increased glucuronidation of Morphine11186130|1275620
C554954N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochlorideN-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of UGT2B7 mRNA28174063
D009270NaloxoneUGT2B7 protein affects the metabolism of Naloxone15286053
D009270NaloxoneUGT2B7 protein results in increased glucuronidation of Naloxone28762043
D009288NaproxenNaproxen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
D009288NaproxenNaproxen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D009288NaproxenUGT2B7 protein alternative form results in increased glucuronidation of Naproxen8423545
D009288NaproxenUGT2B7 protein results in increased glucuronidation of Naproxen15535975|1584349
C464660obeticholic acidobeticholic acid results in decreased expression of UGT2B7 mRNA27939613
D008939MitotaneMitotane results in decreased expression of UGT2B7 mRNA25542188
D010076OxazepamUGT2B7 protein results in increased glucuronidation of Oxazepam7773302
D010076OxazepamUGT2B7 protein results in increased metabolism of Oxazepam12386133
C026256oxazepam glucuronideUGT2B7 protein results in increased abundance of oxazepam glucuronide12386133
C026256oxazepam glucuronideUGT2B7 protein results in increased chemical synthesis of oxazepam glucuronide7773302
D010634PhenobarbitalPhenobarbital results in increased expression of UGT2B7 mRNA8399210
D010634PhenobarbitalPhenobarbital affects the expression of UGT2B7 mRNA19159669
D010634PhenobarbitalPhenobarbital results in decreased expression of UGT2B7 mRNA19084549
C004479pimagedinepimagedine inhibits the reaction [UGT2B7 results in increased susceptibility to Clofibric Acid]17880178
C008924pirprofenpirprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C008924pirprofenpirprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
D010936Plant ExtractsPlant Extracts results in increased expression of UGT2B7 mRNA18351577
D011339ProbenecidUGT2B7 affects the susceptibility to Probenecid17880178
C005556propionaldehydepropionaldehyde results in increased expression of UGT2B7 mRNA26079696
C034467prostaglandin B1UGT2B7 protein results in increased glucuronidation of prostaglandin B115231852
C115070ranirestatUGT2B7 protein results in increased glycosylation of ranirestat15013842
C059514resveratrolresveratrol results in increased expression of UGT2B7 mRNA17287390
C059514resveratrolresveratrol results in increased expression of UGT2B7 protein17287390
D020280SertralineUGT2B7 protein results in increased glucuronidation of and results in increased metabolism of Sertraline15547048
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of UGT2B7 mRNA23806026|2589566
C440975silybinsilybin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]15155549
C016104sodium bichromatesodium bichromate affects the expression of UGT2B7 mRNA22110744
C016104sodium bichromatesodium bichromate results in increased expression of UGT2B7 mRNA22561333|2599309
D018038Sodium SeleniteSodium Selenite results in increased expression of UGT2B7 mRNA24383545
D013467SulindacUGT2B7 protein results in increased glucuronidation of Sulindac15843492
C025463sulindac sulfoneUGT2B7 protein results in increased glucuronidation of sulindac sulfone15843492
D013739TestosteroneTestosterone results in increased expression of UGT2B7 mRNA21880219
D013749TetrachlorodibenzodioxinUGT2B7 protein results in increased glucuronidation of Tetrachlorodibenzodioxin metabolite15258113
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of UGT2B7 mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of UGT2B7 mRNA23411599|2622270
C021270tiaprofenic acidtiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]19740398
C021270tiaprofenic acidtiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]19740398
C021270tiaprofenic acidUGT2B7 protein alternative form results in increased glucuronidation of tiaprofenic acid8423545
C021270tiaprofenic acidUGT2B7 protein results in increased glucuronidation of tiaprofenic acid8517101
C052342topiramateUGT2B7 gene SNP affects the susceptibility to topiramate18686368
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in decreased expression of UGT2B7 mRNA29024780
D014520UrethaneUrethane results in decreased expression of UGT2B7 mRNA28818685
D014535Uridine Diphosphate Glucuronic AcidFluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol]18098064
D014535Uridine Diphosphate Glucuronic Acid[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol18098064
D014635Valproic AcidUGT2B7 protein alternative form results in increased glucuronidation of Valproic Acid8423545
D014635Valproic AcidUGT2B7 protein results in increased glucuronidation of Valproic Acid8517101
D014635Valproic AcidValproic Acid results in decreased methylation of UGT2B7 gene29154799
D014859WarfarinWarfarin binds to and results in decreased activity of UGT2B7 protein25393417
D014859Warfarin[Warfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine25393417
D014859WarfarinWarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]25393417
D015215Zidovudine[10-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine25393417
D015215Zidovudine10-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]25393417
D015215Zidovudine[4'-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine25393417
D015215Zidovudine4'-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]25393417
D015215Zidovudine[7-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine25393417
D015215Zidovudine7-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]25393417
D015215ZidovudineUGT2B7 protein results in increased glucuronidation of Zidovudine10772627|1789815
D015215Zidovudine[Warfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine25393417
D015215ZidovudineWarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]25393417
D015215ZidovudineZidovudine results in decreased expression of UGT2B7 mRNA24292225
D015215ZidovudineZidovudine results in decreased expression of UGT2B7 protein24292225
D015215ZidovudineZidovudine results in increased expression of UGT2B7 mRNA24292225
D015215ZidovudineZidovudine results in increased expression of UGT2B7 protein24292225
C020549zomepiracUGT2B7 protein alternative form results in increased glucuronidation of zomepirac8423545
C020549zomepiracUGT2B7 protein results in increased glucuronidation of zomepirac8517101

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001972retinoic acid bindingNOTIDA20308471  
GO:0008194UDP-glycosyltransferase activity-IBA21873635  
GO:0015020glucuronosyltransferase activity-IDA17442341  18052087  20056724  22579593  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-TAS2159463  
GO:0008209androgen metabolic process-IDA17442341  
GO:0052695cellular glucuronidation-IDA17442341  20056724  22579593  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016020membrane-TAS2159463  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa00040Pentose and glucuronate interconversions
hsa00053Ascorbate and aldarate metabolism
hsa00140Steroid hormone biosynthesis
hsa00500Starch and sucrose metabolism
hsa00514Other types of O-glycan biosynthesis
hsa00830Retinol metabolism
hsa00860Porphyrin and chlorophyll metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156588GlucuronidationTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17576790Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10. (2007 Sep)Kaivosaari SMol Pharmacol
28583088Uncovering the transcriptomic and epigenomic landscape of nicotinic receptor genes in non-neuronal tissues. (2017 Jun 5)Zhang BBMC Genomics
16221753Metabolism and disposition of varenicline, a selective alpha4beta2 acetylcholine receptor partial agonist, in vivo and in vitro. (2006 Jan)Obach RSDrug Metab Dispos
24408517Simultaneous quantification of the abundance of several cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase enzymes in human liver microsomes using multiplexed targeted proteomics. (2014 Apr)Achour BDrug Metab Dispos
22813462Deep understanding of the interaction between thienorphine and UDP-glucuronosyltransferase (UGT) isoforms. (2013 Feb)Dong RHXenobiotica
12167564N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases. (2002 Sep)Ghosheh ODrug Metab Dispos
16141602Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation. (2005 Aug)Nakajima MDrug Metab Pharmacokinet
27096250Pharmacokinetics of lamotrigine and its metabolite N-2-glucuronide: Influence of polymorphism of UDP-glucuronosyltransferases and drug transporters. (2016 Aug)Milosheska DBr J Clin Pharmacol
26802129Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo. (2016 Apr)Gufford BTDrug Metab Dispos