Gene: UGT8

7368
CGT|UGT4
UDP glycosyltransferase 8
protein-coding
4q26
Ensembl:ENSG00000174607 MIM:601291 Vega:OTTHUMG00000132915 UniprotKB:Q16880
NC_000004.12
PubMed
0   ANCO-SNPs
AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.846e-1 (AD)  6.542e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENPP20.964
FA2H0.947
GPR370.93
TF0.927
EVI2A0.918
CLDN110.918
ERBB30.917
KLK60.913
GJB10.908
TRIM590.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAX2-0.319
NEUROD1-0.311
LTK-0.305
SHISA8-0.299
GOLGA6L1-0.297
CUX2-0.296
GRB14-0.286
WTIP-0.282
CHRNA2-0.272
ABCA4-0.27

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of UGT8 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of UGT8 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 affects the expression of UGT8 protein20106945
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UGT8 mRNA16483693
C015001arsenitearsenite results in decreased expression of UGT8 mRNA23974009
D001280AtrazineAtrazine results in decreased expression of UGT8 mRNA25929836
C487081belinostatbelinostat results in increased expression of UGT8 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C006780bisphenol Abisphenol A results in decreased expression of UGT8 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of UGT8 mRNA18958704
C018475butyraldehydebutyraldehyde results in increased expression of UGT8 mRNA26079696
D002330CarmustineCarmustine results in increased expression of UGT8 mRNA15980968
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of UGT8 mRNA20008804
D003471CuprizoneCuprizone results in decreased expression of UGT8 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of UGT8 mRNA20106945
D013759DronabinolDronabinol results in decreased expression of UGT8 mRNA17578508
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of UGT8 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of UGT8 mRNA27392435
C118739entinostatentinostat results in increased expression of UGT8 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of UGT8 mRNA19118595
D005419FlavonoidsFlavonoids results in increased expression of UGT8 mRNA18035473
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of UGT8 mRNA]15016801
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of UGT8 mRNA15159207
C544151jinfukangjinfukang results in decreased expression of UGT8 mRNA27392435
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of UGT8 mRNA25119042
C008261lead acetatelead acetate results in increased expression of UGT8 mRNA22641619
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of UGT8 mRNA23179753|2718838
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of UGT8 mRNA23179753
D009532NickelNickel results in decreased expression of UGT8 mRNA25583101
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of UGT8 mRNA26272509
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of UGT8 mRNA25119042
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of UGT8 mRNA22714537
D011441PropylthiouracilPropylthiouracil results in decreased expression of UGT8 mRNA24780913
D012402RotenoneRotenone results in decreased expression of UGT8 mRNA27900601
D013849ThimerosalThimerosal results in decreased expression of UGT8 mRNA27188386
D019772TopotecanTopotecan results in decreased expression of UGT8 mRNA25729387
D014212TretinoinTretinoin results in increased expression of UGT8 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of UGT8 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of UGT8 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of UGT8 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased expression of UGT8 mRNA23665938
D014810Vitamin EVitamin E results in decreased expression of UGT8 mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UGT8 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of UGT8 mRNA27188386
C088658zoledronic acidzoledronic acid results in decreased expression of UGT8 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008194UDP-glycosyltransferase activity-IBA21873635  
GO:0008489UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity-TAS8661025  
GO:0047263N-acylsphingosine galactosyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002175protein localization to paranode region of axon-IEA-  
GO:0006682galactosylceramide biosynthetic process-IEA-  
GO:0006687glycosphingolipid metabolic process-TAS-  
GO:0007010cytoskeleton organization-IEA-  
GO:0007417central nervous system development-TAS8661025  
GO:0007422peripheral nervous system development-TAS8661025  
GO:0030913paranodal junction assembly-IEA-  
GO:0048812neuron projection morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa00600Sphingolipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1660662Glycosphingolipid metabolismTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24890784Exon microarray analysis of human dorsolateral prefrontal cortex in alcoholism. (2014 Jun)Manzardo AMAlcohol Clin Exp Res
23747354Over-expression of the miRNA cluster at chromosome 14q32 in the alcoholic brain correlates with suppression of predicted target mRNA required for oligodendrocyte proliferation. (2013 Sep 10)Manzardo AMGene
23981442Stress-response pathways are altered in the hippocampus of chronic alcoholics. (2013 Nov)McClintick JNAlcohol