Gene: UMOD

7369
ADMCKD2|FJHN|HNFJ|HNFJ1|MCKD2|THGP|THP
uromodulin
protein-coding
16p12.3
Ensembl:ENSG00000169344 MIM:191845 Vega:OTTHUMG00000131488 UniprotKB:P07911
NG_008151.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.424e-1 (AD)  3.791e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR6P10.595
UGT1A10.548
OR2Z10.542
OR4F60.539
AGXT20.513
OR1D40.508
CYLC10.503
PRAMEF20.492
RBMY1A10.484
OR5AR10.482

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOHLH1-0.217
AR-0.21
TBR1-0.209
FEZF2-0.208
RXFP1-0.205
PKD2L1-0.201
POU6F2-0.2
SULT1A3-0.198
TSHZ3-0.192
KRT31-0.19

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of UMOD mRNA]"19467301
C0642974-hydroxystilbene4-hydroxystilbene inhibits the reaction [potassium oxonate results in increased expression of UMOD protein]22865646
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of UMOD protein24567330
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of UMOD protein mutant form24567330
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of UMOD mRNA"19799885
D000082AcetaminophenAcetaminophen affects the expression of UMOD mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of UMOD mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of UMOD mRNA]17585979
D000086AcetazolamideAcetazolamide results in increased expression of UMOD protein2655449
D020106AcrylamideAcrylamide results in decreased expression of UMOD mRNA28959563
C036658acrylic acidacrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of and affects the localization of UMOD protein]27018375
D000493AllopurinolAllopurinol inhibits the reaction [potassium oxonate affects the expression of UMOD protein]21909718
D000493AllopurinolAllopurinol inhibits the reaction [potassium oxonate results in increased expression of UMOD mRNA]21909718
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of UMOD mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UMOD mRNA16483693
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of UMOD mRNA18585445
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of UMOD mRNA18585445
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UMOD mRNA22300585
C006780bisphenol Abisphenol A affects the methylation of UMOD promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of UMOD mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of UMOD mRNA16239168
D002922CiguatoxinsCiguatoxins affects the expression of UMOD mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of UMOD mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of UMOD mRNA]17585979
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of UMOD mRNA26033743
D003300CopperCopper deficiency results in increased expression of UMOD mRNA26033743
D016572CyclosporineCyclosporine results in decreased secretion of UMOD protein21354196
D064791Desoxycorticosterone Acetate"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of UMOD mRNA"22228705
D002945CisplatinCisplatin results in decreased expression of UMOD protein29051111
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of UMOD mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of UMOD mRNA19467301
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of UMOD mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of UMOD mRNA26033743
D004317DoxorubicinDoxorubicin results in decreased expression of UMOD protein18440303
D019855Ethylene Glycolacrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of and affects the localization of UMOD protein]27018375
D019855Ethylene GlycolEthylene Glycol results in increased expression of and affects the localization of UMOD protein27018375
D019855Ethylene GlycolEthylene Glycol results in increased expression of UMOD protein27241030
D019855Ethylene Glycol[Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of UMOD protein]27241030
D005419Flavonoids[Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of UMOD protein]27241030
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of UMOD mRNA25613284
C013592mangiferinmangiferin affects the expression of UMOD protein21348301
C420606mulberroside Amulberroside A inhibits the reaction [potassium oxonate results in increased expression of and results in decreased secretion of UMOD protein]22865646
D005996NitroglycerinNitroglycerin results in increased expression of UMOD mRNA12102619
D010936Plant Extracts[Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of UMOD protein]27241030
C058229polydatinpolydatin inhibits the reaction [potassium oxonate results in increased expression of and results in decreased secretion of UMOD protein]22865646
D011189Potassium Chloride"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of UMOD mRNA"22228705
C489337potassium oxonate4-hydroxystilbene inhibits the reaction [potassium oxonate results in increased expression of UMOD protein]22865646
C489337potassium oxonateAllopurinol inhibits the reaction [potassium oxonate affects the expression of UMOD protein]21909718
C489337potassium oxonateAllopurinol inhibits the reaction [potassium oxonate results in increased expression of UMOD mRNA]21909718
C489337potassium oxonatemulberroside A inhibits the reaction [potassium oxonate results in increased expression of and results in decreased secretion of UMOD protein]22865646
C489337potassium oxonatepolydatin inhibits the reaction [potassium oxonate results in increased expression of and results in decreased secretion of UMOD protein]22865646
C489337potassium oxonatepotassium oxonate affects the expression of UMOD protein21909718
C489337potassium oxonatepotassium oxonate results in increased expression of and results in decreased secretion of UMOD protein22865646
C489337potassium oxonatepotassium oxonate results in increased expression of UMOD mRNA21909718
C489337potassium oxonateProbenecid inhibits the reaction [potassium oxonate results in increased expression of and results in decreased secretion of UMOD protein]22865646
C489337potassium oxonatepterostilbene inhibits the reaction [potassium oxonate results in increased expression of UMOD protein]22865646
C489337potassium oxonateQuercetin inhibits the reaction [potassium oxonate affects the expression of UMOD protein]21909718
C489337potassium oxonateQuercetin inhibits the reaction [potassium oxonate results in increased expression of UMOD mRNA]21909718
C489337potassium oxonateStilbenes analog inhibits the reaction [potassium oxonate results in increased expression of UMOD protein]22865646
D011339ProbenecidProbenecid inhibits the reaction [potassium oxonate results in increased expression of and results in decreased secretion of UMOD protein]22865646
D011441PropylthiouracilPropylthiouracil results in decreased expression of UMOD mRNA24780913
C107773pterostilbenepterostilbene inhibits the reaction [potassium oxonate results in increased expression of UMOD protein]22865646
D011794QuercetinQuercetin inhibits the reaction [potassium oxonate affects the expression of UMOD protein]21909718
D011794QuercetinQuercetin inhibits the reaction [potassium oxonate results in increased expression of UMOD mRNA]21909718
D017673Sodium Chloride, Dietary"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of UMOD mRNA"22228705
D013267StilbenesStilbenes analog inhibits the reaction [potassium oxonate results in increased expression of UMOD protein]22865646
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of UMOD mRNA25613284
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of UMOD gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of UMOD mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0019864IgG binding-IDA20798515  
GO ID GO Term Qualifier Evidence PubMed
GO:0006968cellular defense response-TAS2409603  
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-IDA20798515  
GO:0007159leukocyte cell-cell adhesion-IDA20798515  
GO:0007588excretion-IEA-  
GO:0008285negative regulation of cell proliferation-TAS2409603  
GO:0050801ion homeostasis-IEA-  
GO:0072218metanephric ascending thin limb development-IEA-  
GO:0072221metanephric distal convoluted tubule development-IEA-  
GO:0072233metanephric thick ascending limb development-IEA-  
GO:1990266neutrophil migration-IDA20798515  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IDA20172860  
GO:0005796Golgi lumen-TAS-  
GO:0005929cilium-IDA20172860  
GO:0016323basolateral plasma membrane-IDA7028707  20798515  
GO:0016324apical plasma membrane-IDA7028707  18025791  20798515  
GO:0019898extrinsic component of membrane-TAS7873609  
GO:0031225anchored component of membrane-IDA2249987  
GO:0060170ciliary membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21738052Uromodulin gene variant is associated with type 2 diabetic nephropathy. (2011 Sep)Ahluwalia TSJ Hypertens
21082022Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. (2010 Oct 28)Padmanabhan SPLoS Genet