Gene: NR1H2

7376
LXR-b|LXRB|NER|NER-I|RIP15|UNR
nuclear receptor subfamily 1 group H member 2
protein-coding
19q13.33
Ensembl:ENSG00000131408 MIM:600380 Vega:OTTHUMG00000183036 UniprotKB:P55055
NC_000019.10
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.577e-1 (AD)  9.623e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB11B0.917
CCDC1240.917
MAP2K20.908
CTDNEP10.907
AURKAIP10.906
GIPC10.904
USF20.902
TXN20.901
DRAP10.9
NDUFB70.898

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.847
OR4F29-0.803
MTRNR2L6-0.211
OR6C74-0.198
KRTAP2-3-0.198
MTRNR2L9-0.198
HMHB1-0.185
HIST2H4A-0.18
KCNJ15-0.178
MTRNR2L10-0.178

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03791(3-{3-[[2-Chloro-3-(Trifluoromethyl)Benzyl](2,2-Diphenylethyl)Amino]Propoxy}Phenyl)Acetic AcidSmall MoleculeExperimentalTarget
DB03848Benzenesulfinic acidSmall Molecule618-41-7ExperimentalTarget
DB07080N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDESmall MoleculeExperimentalTarget
DB070821,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OLSmall MoleculeExperimentalTarget
DB11994DiacereinSmall Molecule13739-02-1Approved|InvestigationalTarget
DB13174RheinSmall Molecule478-43-3ExperimentalTarget
ID Drug Name Action PubMed
C00358522-hydroxycholesterol[alitretinoin co-treated with 22-hydroxycholesterol] affects the localization of NR1H2 protein16888799
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of NR1H2 mRNA]"23756648
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NR1H2 mRNA"21346803
C099958acanthoic acidacanthoic acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of NR1H2 protein]24802811
C099958acanthoic acidacanthoic acid inhibits the reaction [TGFB1 protein results in increased expression of NR1H2 protein]24802811
D000082AcetaminophenAcetaminophen affects the expression of NR1H2 mRNA17562736
C103303alitretinoin[alitretinoin co-treated with 22-hydroxycholesterol] affects the localization of NR1H2 protein16888799
D017962alpha-Linolenic Acidalpha-Linolenic Acid binds to and results in increased activity of NR1H2 protein16731579
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NR1H2 mRNA16483693
D001151ArsenicArsenic results in increased methylation of NR1H2 promoter21291286
C006632arsenic trioxidearsenic trioxide results in decreased expression of NR1H2 mRNA27622732
C006632arsenic trioxidearsenic trioxide results in decreased expression of NR1H2 protein27622732
C006632arsenic trioxidearsenic trioxide results in increased expression of NR1H2 mRNA15073043
C006632arsenic trioxidearsenic trioxide results in decreased expression of NR1H2 protein21851829
C006632arsenic trioxide"Cholesterol, Dietary promotes the reaction [arsenic trioxide results in decreased expression of NR1H2 protein]"21851829
C006632arsenic trioxidearsenic trioxide results in decreased activity of NR1H2 protein20339114
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of NR1H2 mRNA18164116
D004958EstradiolEstradiol results in decreased expression of NR1H2 mRNA15223131|1602987
D001629BezafibrateBezafibrate results in increased expression of NR1H2 mRNA19201410
C006780bisphenol Abisphenol A results in decreased expression of NR1H2 mRNA15223131
C006780bisphenol Abisphenol A affects the methylation of NR1H2 promoter27334623
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of NR1H2 mRNA]"23756648
C006780bisphenol Abisphenol A results in increased expression of NR1H2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NR1H2 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of NR1H2 mRNA22079614
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H2 mRNA]17070507
D002251Carbon Tetrachlorideacanthoic acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of NR1H2 protein]24802811
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of NR1H2 protein24802811
C534918CAY 10499NR1H2 protein affects the reaction [CAY 10499 inhibits the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein]]23362264
C534918CAY 10499NR1H2 protein affects the reaction [CAY 10499 inhibits the reaction [Bucladesine results in increased phosphorylation of LIPE protein]]23362264
D002784CholesterolCholesterol results in increased activity of NR1H2 protein21543282
D002784Cholesterol[RXRB protein binds to NR1H2 protein] which affects the metabolism of Cholesterol14993927
D002784CholesterolNR1H2 protein affects the abundance of Cholesterol15914710
D002784CholesterolNR1H2 protein affects the transport of Cholesterol15725701
D002791Cholesterol, Dietary"Cholesterol, Dietary promotes the reaction [arsenic trioxide results in decreased expression of NR1H2 protein]"21851829
D002791Cholesterol, Dietary"Cholesterol, Dietary results in decreased expression of NR1H2 protein"21851829
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NR1H2 gene20938992
D002994ClofibrateClofibrate results in decreased expression of NR1H2 mRNA23811191
D003907DexamethasoneNR1H2 affects the susceptibility to Dexamethasone21123945
D003994BucladesineNR1H2 protein affects the reaction [Bucladesine results in increased phosphorylation of LIPE protein]23362264
D003994BucladesineNR1H2 protein affects the reaction [CAY 10499 inhibits the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein]]23362264
D003994BucladesineNR1H2 protein affects the reaction [CAY 10499 inhibits the reaction [Bucladesine results in increased phosphorylation of LIPE protein]]23362264
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NR1H2 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of NR1H2 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of NR1H2 mRNA18457598|2375664
D004041Dietary Fats"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of NR1H2 mRNA]"23756648
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of NR1H2 mRNA]"23756648
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of NR1H2 gene23968726
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of NR1H2 mRNA18164116
C024629dimethyl phthalatedimethyl phthalate affects the expression of NR1H2 mRNA26924002
D005047EtoposideEtoposide affects the localization of NR1H2 protein25914138
D005047EtoposideEtoposide promotes the reaction [NR1H2 protein results in increased expression of CETP mRNA]25914138
D005047EtoposideNR1H2 mutant form inhibits the reaction [Etoposide results in increased expression of CETP mRNA]25914138
D005047EtoposideNR1H2 protein affects the susceptibility to Etoposide25914138
D000069438EzetimibeEzetimibe results in decreased expression of NR1H2 mRNA16177187
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency promotes the reaction [NR1H2 gene mutant form results in increased expression of CD68 mRNA]"23333450
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency promotes the reaction [NR1H2 gene mutant form results in increased expression of TNF mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in decreased expression of ACAT1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in decreased expression of CYP3A11 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in decreased expression of ECI1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in decreased expression of NR1I3 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ACACA mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ACACA protein]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ACACB mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ACLY mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of AGPAT1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of CYP39A1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ELOVL6 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ELOVL6 protein]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of FADS2 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of FASN mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of FASN protein]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of LDLR mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ME1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of PLTP mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of PNPLA3 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of PPARD mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of SCD1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of SCD1 protein]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of THRSP mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential results in increased phosphorylation of ACLY protein]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of CD36 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of CYP51 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of FDFT1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of HSD17B7 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of IL1B mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of MSMO1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of NPC1L1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of NSDHL mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of SCD2 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of UCP2 mRNA]"23333450
D011345FenofibrateFenofibrate results in increased expression of NR1H2 mRNA19201410
D011345FenofibrateNR1H2 gene mutant form affects the reaction [Fenofibrate results in increased expression of ACACB mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form affects the reaction [Fenofibrate results in increased expression of SCD1 mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A10 mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A14 mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FDFT1 mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LSS mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of PPARA mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SQLE mRNA]23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA]23063693
D018120FinasterideFinasteride results in increased expression of NR1H2 mRNA24136188
D005485FlutamideFlutamide results in increased expression of NR1H2 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NR1H2 gene20938992
D015248GemfibrozilGemfibrozil results in increased expression of NR1H2 mRNA19201410
C504517GSK 3987GSK 3987 binds to and results in increased activity of NR1H2 protein16107141
C425931GW 501516GW 501516 results in increased expression of NR1H2 mRNA19201410
C070164homocastasterone[homocastasterone analog co-treated with Streptozocin] results in increased expression of NR1H2 mRNA28822685
C070164homocastasteronehomocastasterone analog inhibits the reaction [Streptozocin results in decreased expression of NR1H2 protein]28822685
C070164homocastasteronehomocastasterone analog results in increased expression of NR1H2 mRNA28822685
C051140iron(II)-ascorbic acid complexButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H2 mRNA]17070507
C051140iron(II)-ascorbic acid complexiron(II)-ascorbic acid complex results in decreased expression of NR1H2 mRNA17070507
C410337K 7174K 7174 results in increased expression of NR1H2 mRNA24086573
D007654KetoconazoleKetoconazole inhibits the reaction [TO-901317 results in increased activity of NR1H2 protein]16819505
D064747LansoprazoleLansoprazole results in increased activity of NR1H2 protein20060385
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of NR1H2 mRNA16847310
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of NR1H2 mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of NR1H2 mRNA21939782
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of NR1H2 protein21939782
C479889LY 518674LY 518674 results in increased expression of NR1H2 mRNA19201410
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NR1H2 gene20938992
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1H2 protein]27551952
C471400monoisononylphthalatemonoisononylphthalate promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1H2 protein]27551952
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NR1H2 mRNA26924002
C051752nefazodonenefazodone results in increased expression of NR1H2 mRNA24136188
C031492octanoic acidoctanoic acid binds to and results in increased activity of NR1H2 protein16731579
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 promotes the reaction [NR1H2 gene mutant form results in increased expression of TNF mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of ELOVL5 mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of FASN protein]"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of IL1B mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of NR1I2 mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of PCK1 mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of PNPLA3 mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of ACACB mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of and results in decreased phosphorylation of ACLY protein]"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of CRP mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of FADS2 mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of MLXIPL mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of SCD1 mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of SCD1 protein]"23333450
D000073878Palm OilPalm Oil results in decreased expression of NR1H2 mRNA18042831
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of NR1H2 mRNA21705711
D010575PesticidesPesticides results in increased activity of NR1H2 protein20143881
C060836pioglitazonepioglitazone results in increased expression of NR1H2 mRNA19201410
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of NR1H2 gene23968726
D059808PolyphenolsPolyphenols results in decreased expression of NR1H2 mRNA16293270
C017947sodium arsenitesodium arsenite results in decreased expression of NR1H2 mRNA19822182
D013311Streptozocin[homocastasterone analog co-treated with Streptozocin] results in increased expression of NR1H2 mRNA28822685
D013311Streptozocinhomocastasterone analog inhibits the reaction [Streptozocin results in decreased expression of NR1H2 protein]28822685
D013311StreptozocinStreptozocin results in decreased expression of NR1H2 protein28822685
D013713TeniposideNR1H2 mutant form inhibits the reaction [Teniposide results in increased expression of CETP mRNA]25914138
D013713TeniposideNR1H2 protein affects the susceptibility to Teniposide25914138
D013713TeniposideTeniposide affects the localization of NR1H2 protein25914138
D013713TeniposideTeniposide promotes the reaction [NR1H2 protein results in increased expression of CETP mRNA]25914138
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NR1H2 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NR1H2 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of NR1H2 mRNA]"23756648
C423915TO-901317Ketoconazole inhibits the reaction [TO-901317 results in increased activity of NR1H2 protein]16819505
C423915TO-901317TO-901317 binds to and results in increased activity of NR1H2 protein16731579
C423915TO-901317TO-901317 promotes the reaction [[NR1H3 protein binds to NR1H2 protein] which binds to SREBF1 promoter]15548517
C423915TO-901317TO-901317 results in increased activity of NR1H2 protein16819505|2154328
C423915TO-901317TO-901317 results in increased expression of NR1H2 protein25980575
C423915TO-901317TO-901317 binds to and results in increased activity of NR1H2 protein21291553
C423915TO-901317NR1H2 gene mutant form inhibits the reaction [TO-901317 results in increased expression of ACACA mRNA]23063693|2333345
C423915TO-901317NR1H2 gene mutant form inhibits the reaction [TO-901317 results in increased expression of ACACB mRNA]23063693
C423915TO-901317NR1H2 gene mutant form inhibits the reaction [TO-901317 results in increased expression of ACLY mRNA]23063693|2333345
C423915TO-901317NR1H2 gene mutant form inhibits the reaction [TO-901317 results in increased expression of ELOVL6 mRNA]23063693|2333345
C423915TO-901317NR1H2 gene mutant form inhibits the reaction [TO-901317 results in increased expression of FASN mRNA]23063693|2333345
C423915TO-901317NR1H2 gene mutant form inhibits the reaction [TO-901317 results in increased expression of ME1 mRNA]23063693|2333345
C423915TO-901317NR1H2 gene mutant form inhibits the reaction [TO-901317 results in increased expression of PNPLA3 mRNA]23333450
C423915TO-901317NR1H2 gene mutant form inhibits the reaction [TO-901317 results in increased expression of SCD1 mRNA]23063693|2333345
C423915TO-901317NR1H2 gene mutant form inhibits the reaction [TO-901317 results in increased expression of SCD2 mRNA]23063693
C423915TO-901317NR1H2 gene mutant form inhibits the reaction [TO-901317 results in increased expression of THRSP mRNA]23333450
C423915TO-901317TO-901317 binds to and results in increased activity of NR1H2 protein16731579|2228935
C423915TO-901317TO-901317 results in increased activity of NR1H2 protein27026705
C423915TO-901317TO-901317 binds to and results in increased activity of NR1H2 protein16731579
C012589trichostatin Atrichostatin A affects the expression of NR1H2 mRNA28542535
C113580U 0126U 0126 inhibits the reaction [TNF protein results in decreased expression of NR1H2 mRNA]19883121
D014501UraniumUranium results in decreased expression of NR1H2 mRNA17118558
D014635Valproic AcidValproic Acid results in decreased expression of NR1H2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of NR1H2 gene29154799
C025643vinclozolinvinclozolin affects the expression of NR1H2 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of NR1H2 mRNA22496781
D015054ZymosanZymosan results in decreased expression of NR1H2 mRNA16847310

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA9013544  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001076transcription factor activity, RNA polymerase II transcription factor binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA9013544  
GO:0003677DNA binding-TAS7926814  
GO:0003700DNA-binding transcription factor activityCONTRIBUTES_TOIBA21873635  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0004879nuclear receptor activity-IBA21873635  
GO:0004879nuclear receptor activity-IEA-  
GO:0005515protein binding-IPI12393874  16189514  19060904  21331046  23931754  25661920  
26120082  
GO:0008134transcription factor binding-IBA21873635  
GO:0008270zinc ion binding-IEA-  
GO:0008289lipid binding-IBA21873635  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IBA21873635  
GO:0034191apolipoprotein A-I receptor binding-IPI23931754  
GO:0046965retinoid X receptor binding-IEA-  
GO:0051117ATPase binding-IPI23931754  
GO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006629lipid metabolic process-IBA21873635  
GO:0007275multicellular organism development-IBA21873635  
GO:0010745negative regulation of macrophage derived foam cell differentiation-IC17693624  
GO:0010867positive regulation of triglyceride biosynthetic process-IMP17186944  
GO:0010875positive regulation of cholesterol efflux-IMP17186944  
GO:0010884positive regulation of lipid storage-IEA-  
GO:0010887negative regulation of cholesterol storage-IMP17693624  
GO:0030154cell differentiation-IBA21873635  
GO:0032270positive regulation of cellular protein metabolic process-IMP17186944  
GO:0032369negative regulation of lipid transport-IMP17693624  
GO:0032376positive regulation of cholesterol transport-IDA16141411  
GO:0033993response to lipid-IBA21873635  
GO:0042632cholesterol homeostasis-IBA21873635  
GO:0042632cholesterol homeostasis-ISS-  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0044255cellular lipid metabolic process-IEA-  
GO:0045723positive regulation of fatty acid biosynthetic process-IMP17186944  
GO:0045861negative regulation of proteolysis-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IDA12393874  
GO:0045893positive regulation of transcription, DNA-templated-IDA25661920  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA9013544  16141411  20219900  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP17186944  
GO:0048384retinoic acid receptor signaling pathway-IEA-  
GO:0048550negative regulation of pinocytosis-IMP17693624  
GO:0051006positive regulation of lipoprotein lipase activity-IMP17186944  
GO:0055088lipid homeostasis-IBA21873635  
GO:0060336negative regulation of interferon-gamma-mediated signaling pathway-NAS21268089  
GO:0071222cellular response to lipopolysaccharide-IBA21873635  
GO:0090108positive regulation of high-density lipoprotein particle assembly-IEA-  
GO:0090187positive regulation of pancreatic juice secretion-IEA-  
GO:0090340positive regulation of secretion of lysosomal enzymes-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA12393874  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA12393874  
GO:0090575RNA polymerase II transcription factor complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1368082RORA activates gene expressionTAS
R-HSA-1430728MetabolismTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-400253Circadian ClockTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8866427VLDLR internalisation and degradationTAS
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-8964043Plasma lipoprotein clearanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21245992Polymorphisms in NF-kappaB, PXR, LXR, PPARgamma and risk of inflammatory bowel disease. (2011 Jan 14)Andersen VWorld J Gastroenterol
28624040Hyperglycemia attenuates receptor activator of NF-kappaB ligand-induced macrophage activation by suppressing insulin signaling. (2017 Jun 15)Kurihara CJ Surg Res