Gene: UPP1

7378
UDRPASE|UP|UPASE|UPP
uridine phosphorylase 1
protein-coding
7p12.3
Ensembl:ENSG00000183696 MIM:191730 Vega:OTTHUMG00000129253 UniprotKB:Q16831
NG_051802.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.595e-1 (AD)  8.149e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6463462chr7:48102597 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POLR2H0.856
ZYX0.838
SRA10.833
CCDC1300.832
DXO0.828
SLC52A20.823
E2F40.817
FADS30.811
AKAP8L0.809
UNC45A0.803

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.61
OR4F29-0.575
CHP2-0.237
PDE11A-0.231
CTNNA3-0.218
CRYBG3-0.21
MYZAP-0.207
TRPV5-0.203
OR9A2-0.194
SH2D1A-0.191

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05041RP101Small Molecule-InvestigationalTarget
DB074371-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4(1H,3H)-DIONESmall MoleculeExperimentalTarget
DB00544FluorouracilSmall Molecule51-21-8ApprovedEnzyme
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of UPP1 mRNA"25614096
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of UPP1 mRNA"20713471
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of UPP1 mRNA"21346803
C0127962-butenal2-butenal results in increased expression of UPP1 mRNA20471460
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of UPP1 protein26194647
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of UPP1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UPP1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of UPP1 mRNA"19561079
C0347535-benzylacyclouridine5-benzylacyclouridine inhibits the reaction [[TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine]16397116
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UPP1 mRNA"27188386
C5294318-2 fluorotelomer alcohol8-2 fluorotelomer alcohol results in increased expression of UPP1 mRNA21984479
D000082AcetaminophenAcetaminophen results in increased expression of UPP1 mRNA29067470
D000241AdenosineUPP1 protein results in increased metabolism of Adenosine15772079
D016604Aflatoxin B1Aflatoxin B1 affects the expression of UPP1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of UPP1 mRNA27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of UPP1 mRNA24449571
D001151ArsenicArsenic affects the methylation of UPP1 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of UPP1 mRNA27829220
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of UPP1 mRNA"25757056
D001379AzathioprineAzathioprine results in increased expression of UPP1 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of UPP1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UPP1 mRNA21632981|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UPP1 mRNA22228805|2373587
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UPP1 mRNA22300585
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of UPP1 mRNA20660070
D004958EstradiolEstradiol results in increased expression of UPP1 mRNA20106945
D004958EstradiolEstradiol results in decreased expression of UPP1 mRNA21984479
C053541bicalutamidebicalutamide results in increased expression of UPP1 mRNA15638997
C006780bisphenol Abisphenol A affects the expression of UPP1 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of UPP1 mRNA20678512
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of UPP1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of UPP1 mRNA25181051
C025703bleomycetinbleomycetin results in decreased expression of UPP1 mRNA21040473
D000069286BortezomibBortezomib inhibits the reaction [TNF protein results in increased activity of UPP1 protein]16397116
D000069286BortezomibBortezomib inhibits the reaction [TNF protein results in increased expression of UPP1 mRNA]16397116
D000069286BortezomibBortezomib results in decreased activity of UPP1 protein16397116
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of UPP1 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of UPP1 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of UPP1 mRNA26191083
D002104CadmiumCadmium results in increased expression of UPP1 mRNA21172416
C059041calyculin Acalyculin A results in increased expression of UPP1 mRNA25270620
D002220CarbamazepineCarbamazepine affects the expression of UPP1 mRNA25979313
D002509CephaloridineCephaloridine results in increased expression of UPP1 mRNA18500788
C100187chloropicrinchloropicrin affects the expression of UPP1 mRNA26352163
D002737ChloropreneChloroprene results in decreased expression of UPP1 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in increased expression of UPP1 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of UPP1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of UPP1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of UPP1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of UPP1 mRNA20106945|2163298
C089595cylindrospermopsincylindrospermopsin results in increased expression of UPP1 mRNA24921660
D003562CytidineUPP1 protein results in increased metabolism of Cytidine15772079
C515055darinaparsindarinaparsin results in increased expression of UPP1 mRNA22535156
C515055darinaparsinOxygen inhibits the reaction [darinaparsin results in increased expression of UPP1 mRNA]22535156
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of UPP1 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of UPP1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of UPP1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of UPP1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of UPP1 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of UPP1 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of UPP1 mRNA25016146
D004178DiquatDiquat results in increased expression of UPP1 mRNA21172416
C025034doxifluridine5-benzylacyclouridine inhibits the reaction [[TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine]16397116
C025034doxifluridine[TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine16397116
C025034doxifluridine[TNF protein results in increased expression of UPP1 mRNA] which results in increased susceptibility to doxifluridine16397116
D004317DoxorubicinDoxorubicin results in decreased expression of UPP1 mRNA18510171
D004726EndosulfanEndosulfan results in increased expression of UPP1 mRNA26615145
D000431EthanolEthanol results in increased expression of UPP1 mRNA28986285
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UPP1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UPP1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UPP1 mRNA17557909
D005472FluorouracilFluorouracil results in increased expression of UPP1 mRNA15109396
D005472FluorouracilFluorouracil results in increased expression of UPP1 protein15331170
D005472FluorouracilUPP1 affects the susceptibility to Fluorouracil15067352
D005472FluorouracilUPP1 protein affects the susceptibility to Fluorouracil15772079
D005472Fluorouracil[UPP1 protein results in increased metabolism of Uridine] which affects the susceptibility to Fluorouracil15772079
D005557FormaldehydeFormaldehyde results in increased expression of UPP1 mRNA27664576
D006151GuanosineUPP1 protein results in increased metabolism of Guanosine15772079
D017313FenretinideFenretinide results in increased expression of UPP1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of UPP1 mRNA20044591
C492448ICG 001ICG 001 results in increased expression of UPP1 mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of UPP1 mRNA16984733
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of UPP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of UPP1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of UPP1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UPP1 mRNA23086925
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of UPP1 mRNA"18930950
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of UPP1 mRNA21641980
D008627Mercuric ChlorideMercuric Chloride results in increased expression of UPP1 mRNA16507785
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of UPP1 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of UPP1 mRNA19564919
D008727MethotrexateMethotrexate results in increased expression of UPP1 mRNA17379860
D008748MethylcholanthreneMethylcholanthrene results in increased expression of UPP1 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of UPP1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of UPP1 mRNA26011545
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of UPP1 mRNA25270620
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of UPP1 mRNA17412507
C028577monobutyl phthalatemonobutyl phthalate affects the expression of UPP1 mRNA19162170
C517284monomethyl phthalatemonomethyl phthalate affects the expression of UPP1 mRNA26924002
C523799MRK 003UPP1 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of UPP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of UPP1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of UPP1 mRNA"25554681
D009532NickelNickel results in increased expression of UPP1 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of UPP1 mRNA18651567
D009538NicotineNicotine results in increased expression of UPP1 mRNA23825647
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of UPP1 mRNA20971185
C464660obeticholic acidobeticholic acid results in increased expression of UPP1 mRNA27939613
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of UPP1 mRNA25729387
D010081OxazoloneOxazolone results in increased expression of UPP1 mRNA21893156
D010100OxygenOxygen inhibits the reaction [darinaparsin results in increased expression of UPP1 mRNA]22535156
D010424PentobarbitalUPP1 protein affects the susceptibility to Pentobarbital15772079
D010424Pentobarbital[UPP1 protein results in increased metabolism of Uridine] which affects the susceptibility to Pentobarbital15772079
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of UPP1 mRNA21984479
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of UPP1 mRNA21984479
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of UPP1 mRNA21984479
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of UPP1 mRNA21984479
D010634PhenobarbitalPhenobarbital affects the expression of UPP1 mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of UPP1 mRNA19084549
C006253pirinixic acidpirinixic acid results in decreased expression of UPP1 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of UPP1 mRNA18301758|2081375
D010936Plant ExtractsPlant Extracts results in increased expression of UPP1 mRNA23557933
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of UPP1 mRNA20660070
D011441PropylthiouracilPropylthiouracil results in decreased expression of UPP1 mRNA24780913
C030986pyrimidineUPP1 protein results in increased metabolism of pyrimidine15772079
C059514resveratrolresveratrol results in increased expression of UPP1 mRNA25905778
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of UPP1 mRNA19564919
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of UPP1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of UPP1 mRNA23221170
C009277sodium arsenatesodium arsenate results in increased expression of UPP1 mRNA12727804
D018038Sodium SeleniteSodium Selenite results in increased expression of UPP1 mRNA24383545
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of UPP1 mRNA21641980
C025462sulindac sulfidesulindac sulfide results in increased expression of UPP1 mRNA16184548
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of UPP1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UPP1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UPP1 mRNA16704738
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UPP1 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UPP1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UPP1 mRNA26290441
D013792ThalidomideThalidomide results in decreased expression of UPP1 mRNA26217789
D013849ThimerosalThimerosal results in increased expression of UPP1 mRNA16870260
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of UPP1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of UPP1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of UPP1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of UPP1 mRNA23724009|2383079
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UPP1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of UPP1 mRNA26272509
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of UPP1 mRNA21893156
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of UPP1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in increased expression of UPP1 mRNA29024780
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of UPP1 mRNA"18930950
D014520UrethaneUrethane results in increased expression of UPP1 mRNA28818685
D014529UridineUPP1 protein affects the abundance of Uridine15772079
D014529UridineUPP1 protein results in increased metabolism of Uridine15772079
D014529Uridine[UPP1 protein results in increased metabolism of Uridine] which affects the susceptibility to Fluorouracil15772079
D014529Uridine[UPP1 protein results in increased metabolism of Uridine] which affects the susceptibility to Pentobarbital15772079
D014635Valproic AcidValproic Acid results in increased expression of UPP1 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in decreased expression of UPP1 mRNA19136453
D014638VanadatesVanadates results in increased expression of UPP1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of UPP1 gene25560391
D002762CholecalciferolCholecalciferol results in decreased expression of UPP1 mRNA16508948
D024483Vitamin K 3Vitamin K 3 affects the expression of UPP1 mRNA20044591
D024483Vitamin K 3Vitamin K 3 results in decreased expression of UPP1 mRNA25270620
C088658zoledronic acidzoledronic acid results in decreased expression of UPP1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004850uridine phosphorylase activity-EXP7488099  
GO ID GO Term Qualifier Evidence PubMed
GO:0006139nucleobase-containing compound metabolic process-TAS7488099  
GO:0006218uridine catabolic process-IEA-  
GO:0009166nucleotide catabolic process-IEA-  
GO:0042149cellular response to glucose starvation-IEA-  
GO:0043097pyrimidine nucleoside salvage-TAS-  
GO:0044206UMP salvage-IEA-  
GO:0046135pyrimidine nucleoside catabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00240Pyrimidine metabolism
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-73614Pyrimidine salvageTAS
R-HSA-73621Pyrimidine catabolismTAS
R-HSA-8956319Nucleobase catabolismTAS
R-HSA-8956321Nucleotide salvageTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal