Gene: UROD

7389
PCT|UPD
uroporphyrinogen decarboxylase
protein-coding
1p34.1
Ensembl:ENSG00000126088 MIM:613521 Vega:OTTHUMG00000008949 UniprotKB:P06132
NG_007122.2
PubMed
0   ANCO-SNPs
OD|ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.644e-1 (AD)  9.003e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMB70.959
PIH1D10.958
CUEDC20.951
MANBAL0.951
MRPS210.951
EIF60.95
NABP20.95
MCRS10.949
COMMD90.948
NDUFS30.946

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.761
OR4F29-0.722
MTRNR2L6-0.371
MTRNR2L9-0.347
PPBP-0.317
MTRNR2L10-0.308
KCNJ15-0.288
PABPC4L-0.284
EBF1-0.275
CXCR2-0.271

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03727Coproporphyrin ISmall MoleculeExperimentalTarget
DB04461Coproporphyrinogen IIISmall Molecule2624-63-7ExperimentalTarget
ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of UROD mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of UROD mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of UROD protein16538041
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of UROD mRNA19770486
D000438AlcoholsAlcohols results in decreased activity of UROD protein12030801
D000622Aminolevulinic AcidAminolevulinic Acid results in decreased activity of UROD protein8937451
D000622Aminolevulinic AcidHexachlorobenzene promotes the reaction [Aminolevulinic Acid results in decreased activity of UROD protein]8937451
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UROD mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of UROD protein19364129
D001205Ascorbic AcidAscorbic Acid results in increased expression of UROD mRNA15372504
D001280AtrazineAtrazine results in decreased expression of UROD mRNA22378314
D001464BariumUROD protein affects the abundance of Barium16325539
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of UROD mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of UROD mRNA28159858
C006780bisphenol Abisphenol A affects the expression of UROD mRNA21786754
C006780bisphenol Abisphenol A results in decreased methylation of UROD promoter27312807
C006780bisphenol Abisphenol A affects the expression of UROD mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of UROD mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of UROD mRNA26496021
C006780bisphenol Abisphenol A results in increased methylation of UROD gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of UROD mRNA23741332
C100187chloropicrinchloropicrin results in increased expression of UROD mRNA26352163
C029892cupric chloridecupric chloride results in increased expression of UROD protein21641295
D016572CyclosporineCyclosporine results in increased expression of UROD mRNA19770486
D003976DiazinonDiazinon results in increased methylation of UROD gene22964155
D002945CisplatinUROD protein results in decreased susceptibility to Cisplatin21270338
C024629dimethyl phthalatedimethyl phthalate results in increased expression of UROD mRNA26924002
D004237DiuronDiuron results in increased expression of UROD mRNA21551480
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of UROD protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of UROD mRNA29097150
D004997Ethinyl EstradiolEthinyl Estradiol results in increased activity of UROD protein3945969
D004997Ethinyl EstradiolIron inhibits the reaction [Ethinyl Estradiol results in increased activity of UROD protein]3945969
D005472FluorouracilUROD protein results in decreased susceptibility to Fluorouracil21270338
C088563fomesafenfomesafen results in decreased activity of UROD protein12758057
D006581HexachlorobenzeneHexachlorobenzene promotes the reaction [Aminolevulinic Acid results in decreased activity of UROD protein]8937451
D006581HexachlorobenzeneHexachlorobenzene affects the expression of UROD mRNA15159207
D007213IndomethacinIndomethacin results in increased expression of UROD mRNA28201806
D007501IronIron results in decreased activity of UROD protein12030801
D007501IronIron inhibits the reaction [Ethinyl Estradiol results in increased activity of UROD protein]3945969
D007505Iron-Dextran ComplexIron-Dextran Complex promotes the reaction [Tetrachlorodibenzodioxin results in decreased activity of UROD protein]9443932
C544151jinfukangjinfukang results in increased expression of UROD mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UROD mRNA23086925|2343069
C410337K 7174K 7174 results in decreased expression of UROD mRNA24086573
D008274MagnesiumUROD protein affects the abundance of Magnesium16325539
D008628MercuryMercury results in decreased activity of UROD protein15967199
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of UROD mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of UROD mRNA23649840
D009151Mustard GasMustard Gas results in increased expression of UROD mRNA15674844
C017096n-butoxyethanoln-butoxyethanol results in increased expression of UROD mRNA19812364
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of UROD mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of UROD mRNA25729387
D017239PaclitaxelUROD protein results in decreased susceptibility to Paclitaxel21270338
D010758PhosphorusUROD protein affects the abundance of Phosphorus16325539
C006253pirinixic acidpirinixic acid results in increased expression of UROD mRNA17426115
D010936Plant ExtractsPlant Extracts results in increased expression of UROD mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls results in increased expression of UROD protein15845371
D011794QuercetinQuercetin results in increased expression of UROD mRNA21632981
D017382Reactive Oxygen SpeciesUROD protein results in decreased abundance of Reactive Oxygen Species21270338
D012969Sodium FluorideSodium Fluoride results in decreased expression of UROD protein28918527
D013455SulfurUROD protein affects the abundance of Sulfur16325539
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of UROD mRNA26496021
D013749TetrachlorodibenzodioxinIron-Dextran Complex promotes the reaction [Tetrachlorodibenzodioxin results in decreased activity of UROD protein]9443932
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UROD mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased activity of UROD protein9443932
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UROD mRNA18163543|2821309
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of UROD mRNA25729387
D019772TopotecanTopotecan results in decreased expression of UROD mRNA25729387
D014577UroporphyrinogensUroporphyrinogens metabolite results in decreased activity of UROD protein17360334
D014635Valproic AcidValproic Acid results in decreased expression of UROD mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of UROD mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of UROD gene25560391
D014750VincristineVincristine results in decreased expression of UROD mRNA23649840
D014810Vitamin EVitamin E results in increased activity of UROD protein12030801

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004853uroporphyrinogen decarboxylase activity-IBA21873635  
GO:0004853uroporphyrinogen decarboxylase activity-IDA18004775  
GO:0004853uroporphyrinogen decarboxylase activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006782protoporphyrinogen IX biosynthetic process-IEA-  
GO:0006783heme biosynthetic process-IBA21873635  
GO:0006783heme biosynthetic process-IC18004775  
GO:0006783heme biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00860Porphyrin and chlorophyll metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-189445Metabolism of porphyrinsTAS
R-HSA-189451Heme biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24470839Hepatitis C- and HIV-induced porphyria cutanea tarda. (2014)Quansah RAm J Case Rep
23741761Familial Porphyria Cutanea Tarda (1993)Liu LU-
19948245Associations among behavior-related susceptibility factors in porphyria cutanea tarda. (2010 Mar)Jalil SClin Gastroenterol Hepatol
24175354Hepatoerythropoietic Porphyria (1993)Liu LU-
20957336CYP1A2*1F and GSTM1 alleles are associated with susceptibility to porphyria cutanea tarda. (2011 Mar-Apr)Wickliffe JKMol Med
20163457Smoking but not homozygosity for CYP1A2 g-163A allelic variant leads to earlier disease onset in patients with sporadic porphyria cutanea tarda. (2010 Aug)Fontanellas AExp Dermatol